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Protein Page:
ENO2 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
ENO2 an enzyme with 2-phospho-D-glycerate hydro-lyase activity. One of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates. Note: This description may include information from UniProtKB.
Protein type: EC 4.2.1.11; Lyase; Carbohydrate Metabolism - glycolysis and gluconeogenesis
Cellular Component: phosphopyruvate hydratase complex; photoreceptor inner segment; plasma membrane; perikaryon; cytosol
Molecular Function: protein homodimerization activity; protein heterodimerization activity; magnesium ion binding; phosphopyruvate hydratase activity
Biological Process: response to drug; glycolysis; carbohydrate metabolic process; glucose metabolic process; response to estradiol stimulus; gluconeogenesis
Reference #:  P09104 (UniProtKB)
Alt. Names/Synonyms: 2-phospho-D-glycerate hydro-lyase; 2-phospho-D-glycerate hydrolyase; ENO2; ENOG; Enolase 2; enolase 2 (gamma, neuronal); Gamma-enolase; Neural enolase; neuron specific gamma enolase; Neuron-specific enolase; neurone-specific enolase; NSE
Gene Symbols: ENO2
Molecular weight: 47,269 Da
Basal Isoelectric point: 4.91  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ENO2
Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

 
0 96 Y25-p PTVEVDLytAKGLFR
0 3 T26-p TVEVDLytAKGLFRA
0 2 S37-p LFRAAVPsGAstGIy
0 12 S40-p AAVPsGAstGIyEAL
0 58 T41-p AVPsGAstGIyEALE
1 1887 Y44-p sGAstGIyEALELRD
0 1 K54 LELRDGDKQRYLGKG
0 2 K64-u YLGKGVLkAVDHINS
0 1 S79 TIAPALISSGLSVVE
0 1 K105-u DGTENKSkFGANAIL
0 1 K120-u GVSLAVCkAGAAERE
0 2 Y131-p AERELPLyRHIAQLA
0 1 S141 IAQLAGNSDLILPVP
0 1 K193-a AEVYHTLkGVIkDKY
0 1 K193 AEVYHTLKGVIkDKY
0 9 K197 HTLkGVIKDKYGKDA
0 1 K197-a HTLkGVIkDKYGKDA
0 1 T205 DKYGKDATNVGDEGG
0 1 S221 APNILENSEALELVk
0 1 K228-a SEALELVkEAIDKAG
0 2 K228-u SEALELVkEAIDKAG
0 4 Y236-p EAIDKAGyTEKIVIG
0 22 S263-p KYDLDFKsPtDPSRY
0 2 T265-p DLDFKsPtDPSRYIT
0 4 K326-u DLTVTNPkRIERAVE
0 1 K326 DLTVTNPKRIERAVE
0 4 K343-u ACNCLLLkVNQIGSV
0 1 K343-a ACNCLLLkVNQIGSV
0 3 K394-u GLCTGQIkTGAPCRS
  mouse

 
Y25-p PTVEVDLyTAKGLFR
T26 TVEVDLyTAKGLFRA
S37-p LFRAAVPsGAstGIy
S40-p AAVPsGAstGIyEAL
T41-p AVPsGAstGIyEALE
Y44-p sGAstGIyEALELRD
K54-u LELRDGDkQRYLGKG
K64-u YLGKGVLkAVDHINS
S79-p RIAPALIsSGISVVE
K105 DGTENKSKFGANAIL
K120 GVSLAVCKAGAAERD
Y131 AERDLPLYRHIAQLA
S141-p IAQLAGNsDLILPVP
K193 AEVYHTLKGVIKDKY
K193-u AEVYHTLkGVIKDKY
K197 HTLkGVIKDKYGKDA
K197 HTLkGVIKDKYGKDA
T205-p DKYGKDAtNVGDEGG
S221-p APNILENsEALELVk
K228 sEALELVKEAIDKAG
K228-u sEALELVkEAIDKAG
Y236 EAIDKAGYTEKMVIG
S263-p KYDLDFKsPADPSRY
A265 DLDFKsPADPSRYIT
K326 DLTVTNPKRIERAVE
K326-a DLTVTNPkRIERAVE
K343-u ACNCLLLkVNQIGSV
K343 ACNCLLLKVNQIGSV
K394-u GLCTGQIkTGAPCRS
  rat

 
H25 PTVEVDLHTAKGLFR
T26 TVEVDLHTAKGLFRA
S37 LFRAAVPSGAsTGIy
S40-p AAVPSGAsTGIyEAL
T41 AVPSGAsTGIyEALE
Y44-p SGAsTGIyEALELRD
K54 LELRDGDKQRYLGKG
K64 YLGKGVLKAVDHINS
S79 TIAPALISSGLSVVE
K105 DGTENKSKFGANAIL
K120 GVSLAVCKAGAAEKD
Y131-p AEKDLPLyRHIAQLA
S141 IAQLAGNSDLILPVP
K193 AEVYHTLKGVIkDKY
K193 AEVYHTLKGVIkDKY
K197-u HTLKGVIkDKYGKDA
K197 HTLKGVIKDKYGKDA
T205 DKYGKDATNVGDEGG
S221 APNILENSEALELVk
K228 SEALELVKEAIDKAG
K228-u SEALELVkEAIDKAG
Y236 EAIDKAGYTEKMVIG
S263 KYDLDFKSPADPSRC
A265 DLDFKSPADPSRCIT
K326 DLTVTNPKRIERAVE
K326 DLTVTNPKRIERAVE
K343-u ACNCLLLkVNQIGSV
K343 ACNCLLLKVNQIGSV
K394 GLCTGQIKTGAPCRS
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