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Protein Page:
ALDOA (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ALDOA a glycolytic enzyme that catalyzes D-fructose 1,6-bisphosphate -> glycerone phosphate + D-glyceraldehyde 3-phosphate. Three forms of aldolase are found in vertebrates - aldolase A in muscle, aldolase B in liver and aldolase C in brain. Note: This description may include information from UniProtKB.
Protein type: Lyase; Carbohydrate Metabolism - fructose and mannose; Mitochondrial; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway; EC 4.1.2.13
Cellular Component: I band; extracellular space; membrane; extracellular region; M band; cytosol; nucleus; actin cytoskeleton
Molecular Function: tubulin binding; identical protein binding; protein binding; cytoskeletal protein binding; fructose-bisphosphate aldolase activity; actin binding
Biological Process: platelet activation; striated muscle contraction; glycolysis; actin filament organization; glucose metabolic process; gluconeogenesis; protein homotetramerization; muscle maintenance; regulation of cell shape; fructose 1,6-bisphosphate metabolic process; platelet degranulation; ATP biosynthetic process; carbohydrate metabolic process; blood coagulation; fructose metabolic process
Reference #:  P04075 (UniProtKB)
Alt. Names/Synonyms: ALDA; ALDOA; aldolase A, fructose-bisphosphate; fructose-1,6-bisphosphate triosephosphate-lyase; Fructose-bisphosphate aldolase A; GSD12; Lung cancer antigen NY-LU-1; MGC10942; MGC17716; MGC17767; Muscle-type aldolase
Gene Symbols: ALDOA
Molecular weight: 39,420 Da
Basal Isoelectric point: 8.3  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ALDOA

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 432 Y3-p _____MPyQyPALtP
0 186 Y5-p ___MPyQyPALtPEQ
0 12 T9-p PyQyPALtPEQkkEL
0 111 K13-ac PALtPEQkkELsDIA
0 1 K13-sc PALtPEQkkELsDIA
0 3 K14-ac ALtPEQkkELsDIAH
0 2 K14-ub ALtPEQkkELsDIAH
0 2 S17-p PEQkkELsDIAHRIV
0 95 K28-ub HRIVAPGkGILAADE
0 1 K28-sc HRIVAPGkGILAADE
0 24 S36-p GILAADEstGsIAkR
0 11 T37-p ILAADEstGsIAkRL
0 27 S39-p AADEstGsIAkRLQs
0 161 K42-ac EstGsIAkRLQsIGt
0 109 K42-ub EstGsIAkRLQsIGt
0 1 K42-sc EstGsIAkRLQsIGt
1 36 S46-p sIAkRLQsIGtENtE
0 2 T49-p kRLQsIGtENtEENR
0 2 T52-p QsIGtENtEENRRFY
0 3 T65-p FYRQLLLtADDRVNP
0 2 K87-ub FHETLYQkADDGRPF
0 7 K99-ub RPFPQVIkskGGVVG
0 1 S100-p PFPQVIkskGGVVGI
0 5 K101-ub FPQVIkskGGVVGIk
0 4 K108-ac kGGVVGIkVDkGVVP
0 98 K108-ub kGGVVGIkVDkGVVP
0 1 K111-ac VVGIkVDkGVVPLAG
0 50 K111-ub VVGIkVDkGVVPLAG
0 1 K111-sc VVGIkVDkGVVPLAG
0 3 S132-p TQGLDGLsERCAQYk
0 9 K139-ac sERCAQYkKDGADFA
0 28 K147-ac KDGADFAkWRCVLkI
0 50 K147-ub KDGADFAkWRCVLkI
0 4 K153-ac AkWRCVLkIGEHTPS
0 51 K153-ub AkWRCVLkIGEHTPS
0 157 K200-ac PDGDHDLkRCQyVTE
0 31 K200-ub PDGDHDLkRCQyVTE
0 191 Y204-p HDLkRCQyVTEkVLA
0 2 K208-ac RCQyVTEkVLAAVYK
0 29 K208-ub RCQyVTEkVLAAVYK
0 13 S218-p AAVYKALsDHHIyLE
0 152 Y223-p ALsDHHIyLEGtLLk
0 1 T227-p HHIyLEGtLLkPNMV
0 14 K230-ac yLEGtLLkPNMVtPG
0 3 K230-ub yLEGtLLkPNMVtPG
0 2 T235-p LLkPNMVtPGHACtQ
0 1 T241-p VtPGHACtQKFSHEE
0 2 T269-p PPAVTGItFLsGGQs
0 8 S272-p VTGItFLsGGQsEEE
0 5 S276-p tFLsGGQsEEEASIN
0 8 K294-ac INKCPLLkPWALtFs
0 1 K294-m1 INKCPLLkPWALtFs
0 11 K294-ub INKCPLLkPWALtFs
0 11 T299-p LLkPWALtFsYGRAL
0 17 S301-p kPWALtFsYGRALQA
0 1 S309-p YGRALQAsALkAWGG
0 2 K312-ac ALQAsALkAWGGKkE
0 4 K312-ub ALQAsALkAWGGKkE
0 1 K312-sc ALQAsALkAWGGKkE
0 3 K318-ub LkAWGGKkENLkAAQ
0 1 K322-ac GGKkENLkAAQEEyV
0 1 K322 GGKkENLKAAQEEyV
0 52 K322-ub GGKkENLkAAQEEyV
0 6 Y328-p LkAAQEEyVkRALAN
0 13 K330-ac AAQEEyVkRALANsL
0 32 K330-ub AAQEEyVkRALANsL
0 12 S336-p VkRALANsLACQGky
0 8 K342-ac NsLACQGkytPsGQA
0 9 K342-ub NsLACQGkytPsGQA
0 1 Y343-p sLACQGkytPsGQAG
0 1 T344-p LACQGkytPsGQAGA
0 1 S346-p CQGkytPsGQAGAAA
0 1 S354-p GQAGAAAsEsLFVsN
0 1 S354 GQAGAAASEsLFVsN
0 1 S356-p AGAAAsEsLFVsNHA
0 3 S360-p AsEsLFVsNHAy___
1 0 H362 EsLFVsNHAy_____
0 76 Y364-p LFVsNHAy_______
  mouse

 
H3 _____MPHPyPALTP
Y5-p ___MPHPyPALTPEQ
T9 PHPyPALTPEQkkEL
K13-ac PALTPEQkkELSDIA
K13 PALTPEQKkELSDIA
K14-ac ALTPEQkkELSDIAH
K14-ub ALTPEQkkELSDIAH
S17 PEQkkELSDIAHRIV
K28-ub HRIVAPGkGILAADE
K28 HRIVAPGKGILAADE
S36-p GILAADEstGsIAkR
T37-p ILAADEstGsIAkRL
S39-p AADEstGsIAkRLQs
K42-ac EstGsIAkRLQsIGt
K42-ub EstGsIAkRLQsIGt
K42-sc EstGsIAkRLQsIGt
S46-p sIAkRLQsIGtENtE
T49-p kRLQsIGtENtEENR
T52-p QsIGtENtEENRRFY
T65 FYRQLLLTADDRVNP
K87-ub FHETLYQkADDGRPF
K99-ub RPFPQVIkSkGGVVG
S100 PFPQVIkSkGGVVGI
K101-ub FPQVIkSkGGVVGIk
K108 kGGVVGIKVDkGVVP
K108-ub kGGVVGIkVDkGVVP
K111 VVGIkVDKGVVPLAG
K111-ub VVGIkVDkGVVPLAG
K111 VVGIkVDKGVVPLAG
S132 TQGLDGLSERCAQYk
K139-ac SERCAQYkKDGADFA
K147-ac KDGADFAkWRCVLkI
K147-ub KDGADFAkWRCVLkI
K153-ac AkWRCVLkIGEHTPS
K153-ub AkWRCVLkIGEHTPS
K200-ac PDGDHDLkRCQyVTE
K200-ub PDGDHDLkRCQyVTE
Y204-p HDLkRCQyVTEkVLA
K208 RCQyVTEKVLAAVYK
K208-ub RCQyVTEkVLAAVYK
S218 AAVYKALSDHHVyLE
Y223-p ALSDHHVyLEGTLLk
T227 HHVyLEGTLLkPNMV
K230 yLEGTLLKPNMVTPG
K230-ub yLEGTLLkPNMVTPG
T235 LLkPNMVTPGHACTQ
T241 VTPGHACTQKFSNEE
T269 PPAVTGVTFLsGGQs
S272-p VTGVTFLsGGQsEEE
S276-p TFLsGGQsEEEASIN
K294-ac INKCPLLkPWALtFS
K294 INKCPLLKPWALtFS
K294 INKCPLLKPWALtFS
T299-p LLkPWALtFSYGRAL
S301 kPWALtFSYGRALQA
S309 YGRALQASALkAWGG
K312 ALQASALKAWGGKKE
K312-ub ALQASALkAWGGKKE
K312 ALQASALKAWGGKKE
K318 LkAWGGKKENLkAAQ
K322 GGKKENLKAAQEEYI
K322-m1 GGKKENLkAAQEEYI
K322-ub GGKKENLkAAQEEYI
Y328 LkAAQEEYIkRALAN
K330-ac AAQEEYIkRALANsL
K330-ub AAQEEYIkRALANsL
S336-p IkRALANsLACQGkY
K342 NsLACQGKYTPSGQS
K342-ub NsLACQGkYTPSGQS
Y343 sLACQGkYTPSGQSG
T344 LACQGkYTPSGQSGA
S346 CQGkYTPSGQSGAAA
S354 GQSGAAASESLFIsN
S354-gl GQSGAAAsESLFIsN
S356 SGAAAsESLFIsNHA
S360-p AsESLFIsNHAY___
H362 ESLFIsNHAY_____
Y364 LFIsNHAY_______
  rat

 
H3 _____MPHPYPALTP
Y5 ___MPHPYPALTPEQ
T9 PHPYPALTPEQKKEL
K13 PALTPEQKKELADIA
K13 PALTPEQKKELADIA
K14 ALTPEQKKELADIAH
K14 ALTPEQKKELADIAH
A17 PEQKKELADIAHRIV
K28-ub HRIVAPGkGILAADE
K28 HRIVAPGKGILAADE
S36-p GILAADEsTGsIAkR
T37 ILAADEsTGsIAkRL
S39-p AADEsTGsIAkRLQs
K42 EsTGsIAKRLQsIGT
K42-ub EsTGsIAkRLQsIGT
K42 EsTGsIAKRLQsIGT
S46-p sIAkRLQsIGTENTE
T49 kRLQsIGTENTEENR
T52 QsIGTENTEENRRFY
T65 FYRQLLLTADDRVNP
K87 FHETLYQKADDGRPF
K99 RPFPQVIKSKGGVVG
S100 PFPQVIKSKGGVVGI
K101 FPQVIKSKGGVVGIk
K108 KGGVVGIKVDkGVVP
K108-ub KGGVVGIkVDkGVVP
K111 VVGIkVDKGVVPLAG
K111-ub VVGIkVDkGVVPLAG
K111 VVGIkVDKGVVPLAG
S132 TQGLDGLSERCAQYK
K139 SERCAQYKKDGADFA
K147-ac KDGADFAkWRCVLkI
K147 KDGADFAKWRCVLkI
K153 AkWRCVLKIGEHTPS
K153-ub AkWRCVLkIGEHTPS
K200-ac PDGDHDLkRCQyVTE
K200-ub PDGDHDLkRCQyVTE
Y204-p HDLkRCQyVTEKVLA
K208 RCQyVTEKVLAAVYK
K208 RCQyVTEKVLAAVYK
S218 AAVYKALSDHHVYLE
Y223 ALSDHHVYLEGTLLK
T227 HHVYLEGTLLKPNMV
K230 YLEGTLLKPNMVTPG
K230 YLEGTLLKPNMVTPG
T235 LLKPNMVTPGHACTQ
T241 VTPGHACTQKFSNEE
T269 PPAVPGVTFLSGGQS
S272 VPGVTFLSGGQSEEE
S276 TFLSGGQSEEEASIN
K294 INKCPLLKPWALTFS
K294 INKCPLLKPWALTFS
K294 INKCPLLKPWALTFS
T299 LLKPWALTFSYGRAL
S301 KPWALTFSYGRALQA
S309 YGRALQASALkAWGG
K312 ALQASALKAWGGKkE
K312-ub ALQASALkAWGGKkE
K312 ALQASALKAWGGKkE
K318-ub LkAWGGKkENLkAAQ
K322 GGKkENLKAAQEEYI
K322 GGKkENLKAAQEEYI
K322-ub GGKkENLkAAQEEYI
Y328 LkAAQEEYIkRALAN
K330 AAQEEYIKRALANSL
K330-ub AAQEEYIkRALANSL
S336 IkRALANSLACQGKY
K342 NSLACQGKYTPSGQS
K342 NSLACQGKYTPSGQS
Y343 SLACQGKYTPSGQSG
T344 LACQGKYTPSGQSGA
S346 CQGKYTPSGQSGAAA
S354 GQSGAAASESLFISN
S354 GQSGAAASESLFISN
S356 SGAAASESLFISNHA
S360 ASESLFISNHAY___
H362 ESLFISNHAY_____
Y364 LFISNHAY_______
  rabbit

 
H3 _____MPHSHPALTP
H5 ___MPHSHPALTPEQ
T9 PHSHPALTPEQKKEL
K13 PALTPEQKKELSDIA
K13 PALTPEQKKELSDIA
K14 ALTPEQKKELSDIAH
K14 ALTPEQKKELSDIAH
S17 PEQKKELSDIAHRIV
K28 HRIVAPGKGILAADE
K28 HRIVAPGKGILAADE
S36 GILAADESTGSIAKR
T37 ILAADESTGSIAKRL
S39 AADESTGSIAKRLQS
K42 ESTGSIAKRLQSIGT
K42 ESTGSIAKRLQSIGT
K42 ESTGSIAKRLQSIGT
S46 SIAKRLQSIGTENTE
T49 KRLQSIGTENTEENR
T52 QSIGTENTEENRRFY
T65 FYRQLLLTADDRVNP
K87 FHETLYQKADDGRPF
K99 RPFPQVIKSKGGVVG
S100 PFPQVIKSKGGVVGI
K101 FPQVIKSKGGVVGIK
K108 KGGVVGIKVDKGVVP
K108 KGGVVGIKVDKGVVP
K111 VVGIKVDKGVVPLAG
K111 VVGIKVDKGVVPLAG
K111 VVGIKVDKGVVPLAG
S132 TQGLDGLSERCAQYK
K139 SERCAQYKKDGADFA
K147 KDGADFAKWRCVLKI
K147 KDGADFAKWRCVLKI
K153 AKWRCVLKIGEHTPS
K153 AKWRCVLKIGEHTPS
K200 PDGDHDLKRCQYVTE
K200 PDGDHDLKRCQYVTE
Y204 HDLKRCQYVTEKVLA
K208 RCQYVTEKVLAAVYK
K208 RCQYVTEKVLAAVYK
S218 AAVYKALSDHHIYLE
Y223 ALSDHHIYLEGTLLK
T227 HHIYLEGTLLKPNMV
K230 YLEGTLLKPNMVTPG
K230 YLEGTLLKPNMVTPG
T235 LLKPNMVTPGHACTQ
T241 VTPGHACTQKYSHEE
T269 PPAVTGVTFLSGGQS
S272 VTGVTFLSGGQSEEE
S276 TFLSGGQSEEEASIN
K294 INKCPLLKPWALTFS
K294 INKCPLLKPWALTFS
K294 INKCPLLKPWALTFS
T299 LLKPWALTFSYGRAL
S301 KPWALTFSYGRALQA
S309 YGRALQASALKAWGG
K312 ALQASALKAWGGKKE
K312 ALQASALKAWGGKKE
K312 ALQASALKAWGGKKE
K318 LKAWGGKKENLKAAQ
K322 GGKKENLKAAQEEYV
K322 GGKKENLKAAQEEYV
K322 GGKKENLKAAQEEYV
Y328 LKAAQEEYVKRALAN
K330 AAQEEYVKRALANSL
K330 AAQEEYVKRALANSL
S336 VKRALANSLACQGKY
K342 NSLACQGKYTPSGQA
K342 NSLACQGKYTPSGQA
Y343 SLACQGKYTPSGQAG
T344 LACQGKYTPSGQAGA
S346 CQGKYTPSGQAGAAA
S354 GQAGAAASESLFISN
S354 GQAGAAASESLFISN
S356 AGAAASESLFISNhA
S360 ASESLFISNhAY___
H362-p ESLFISNhAY_____
Y364 LFISNhAY_______
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