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ALDOA (human)

Overview ALDOA a glycolytic enzyme that catalyzes D-fructose 1,6-bisphosphate -> glycerone phosphate + D-glyceraldehyde 3-phosphate. Three forms of aldolase are found in vertebrates - aldolase A in muscle, aldolase B in liver and aldolase C in brain. Note: This description may include information from UniProtKB. Protein type: Carbohydrate Metabolism - pentose phosphate pathway; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Mitochondrial; Lyase; EC 4.1.2.13; Carbohydrate Metabolism - fructose and mannose Cellular Component: I band; extracellular region; cytosol; actin cytoskeleton Molecular Function: tubulin binding; identical protein binding; cytoskeletal protein binding; fructose-bisphosphate aldolase activity; actin binding Biological Process: platelet activation; striated muscle contraction; glycolysis; actin filament organization; glucose metabolic process; protein homotetramerization; gluconeogenesis; muscle maintenance; regulation of cell shape; fructose 1,6-bisphosphate metabolic process; platelet degranulation; ATP biosynthetic process; carbohydrate metabolic process; blood coagulation; fructose metabolic process Reference #:  P04075 (UniProtKB) Alt. Names/Synonyms: ALDA; ALDOA; aldolase A, fructose-bisphosphate; fructose-1,6-bisphosphate triosephosphate-lyase; Fructose-bisphosphate aldolase A; GSD12; Lung cancer antigen NY-LU-1; MGC10942; MGC17716; MGC17767; Muscle-type aldolase Gene Symbols: ALDOA Molecular weight: 39,420 Da Basal Isoelectric point: 8.3  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below ALDOA 1ALD - A=1-364 (human) 2ALD - A=1-364 (human) 4ALD - A=1-364 (human) 1ADO - A/B/C/D=1-364 (rabbit) 1EWD - A/B/C/D=1-364 (rabbit) 1EWE - A/B/C/D=1-364 (rabbit) 1EWG - A/B/C/D=1-364 (rabbit) 1EX5 - A/B/C/D=1-364 (rabbit) 1J4E - A/B/C/D=1-364 (rabbit) 1ZAH - A/B/C/D=1-364 (rabbit) 1ZAI - A/B/C/D=1-364 (rabbit) 1ZAJ - A/B/C/D=1-364 (rabbit) 1ZAL - A/B/C/D=1-364 (rabbit) 2OT0 - A/B/C/D=2-364 (rabbit) 2OT1 - A/B/C/D=2-364 (rabbit) 2QUT - A/B/C/D=2-364 (rabbit) 2QUU - A/B/C/D=2-364 (rabbit) 2QUV - A/B/C/D=2-364 (rabbit) 3B8D - A/B/C/D=2-364 (rabbit) 3BV4 - A=5-344 (rabbit) 3DFN - A/D/C/B=2-364 (rabbit) 3DFO - A/D/C/B=2-364 (rabbit) 3DFP - A/D/C/B=2-364 (rabbit) 3DFQ - A/D/C/B=2-364 (rabbit) 3DFS - A/D/C/B=2-364 (rabbit) 3DFT - A/D/C/B=2-364 (rabbit) 3LGE - A/D/C/B=2-364 (rabbit) 3TU9 - A/D/C/B=2-364 (rabbit) 6ALD - A/B/C/D=1-364 (rabbit)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1ALD 2ALD 4ALD  |  ENZYME  |  Phospho3D  |  DISEASE 103850 611881  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	415		Y3-p	_____MPyQyPALtP
0	165		Y5-p	___MPyQyPALtPEQ
0	11		T9-p	PyQyPALtPEQkkEL
0	111		K13-a	PALtPEQkkELsDIA
0	3		K14-a	ALtPEQkkELsDIAH
0	2		K14-u	ALtPEQkkELsDIAH
0	2		S17-p	PEQkkELsDIAHRIV
0	95		K28-u	HRIVAPGkGILAADE
0	18		S36-p	GILAADEstGsIAkR
0	8		T37-p	ILAADEstGsIAkRL
0	22		S39-p	AADEstGsIAkRLQs
0	160		K42-a	EstGsIAkRLQsIGt
0	109		K42-u	EstGsIAkRLQsIGt
1	30		S46-p	sIAkRLQsIGtENTE
0	2		T49-p	kRLQsIGtENTEENR
0	3		T65-p	FYRQLLLtADDRVNP
0	2		K87-u	FHETLYQkADDGRPF
0	7		K99-u	RPFPQVIkskGGVVG
0	1		S100-p	PFPQVIkskGGVVGI
0	5		K101-u	FPQVIkskGGVVGIk
0	3		K108-a	kGGVVGIkVDkGVVP
0	98		K108-u	kGGVVGIkVDkGVVP
0	50		K111-u	VVGIkVDkGVVPLAG
0	9		K139-a	SERCAQYkKDGADFA
0	27		K147-a	KDGADFAkWRCVLkI
0	50		K147-u	KDGADFAkWRCVLkI
0	51		K153-u	AkWRCVLkIGEHTPs
0	3		K153-a	AkWRCVLkIGEHTPs
0	1		S160-p	kIGEHTPsALAIMEN
0	156		K200-a	PDGDHDLkRCQyVTE
0	31		K200-u	PDGDHDLkRCQyVTE
0	173		Y204-p	HDLkRCQyVTEkVLA
0	2		K208-a	RCQyVTEkVLAAVyK
0	29		K208-u	RCQyVTEkVLAAVyK
0	25		Y214-p	EkVLAAVyKALsDHH
0	12		S218-p	AAVyKALsDHHIyLE
0	139		Y223-p	ALsDHHIyLEGtLLk
0	1		T227-p	HHIyLEGtLLkPNMV
0	13		K230-a	yLEGtLLkPNMVtPG
0	3		K230-u	yLEGtLLkPNMVtPG
0	1		T235-p	LLkPNMVtPGHACtQ
0	1		T241-p	VtPGHACtQKFSHEE
0	1		T269-p	PPAVTGItFLsGGQs
0	6		S272-p	VTGItFLsGGQsEEE
0	5		S276-p	tFLsGGQsEEEASIN
0	8		K294-a	INKCPLLkPWALtFs
0	11		K294-u	INKCPLLkPWALtFs
0	10		T299-p	LLkPWALtFsYGRAL
0	16		S301-p	kPWALtFsYGRALQA
0	1		K312-a	ALQASALkAWGGKkE
0	4		K312-u	ALQASALkAWGGKkE
0	3		K318-u	LkAWGGKkENLkAAQ
0	52		K322-u	GGKkENLkAAQEEyV
0	1		K322	GGKkENLKAAQEEyV
0	3		Y328-p	LkAAQEEyVkRALAN
0	32		K330-u	AAQEEyVkRALANsL
0	13		K330-a	AAQEEyVkRALANsL
0	6		S336-p	VkRALANsLACQGkY
0	8		K342-a	NsLACQGkYTPSGQA
0	9		K342-u	NsLACQGkYTPSGQA
0	1		S354-p	GQAGAAAsEsLFVsN
0	1		S354	GQAGAAASEsLFVsN
0	1		S356-p	AGAAAsEsLFVsNHA
0	3		S360-p	AsEsLFVsNHAy___
1	0		H362	EsLFVsNHAy_____
0	75		Y364-p	LFVsNHAy_______

	mouse
H3	_____MPHPyPALTP
Y5-p	___MPHPyPALTPEQ
T9	PHPyPALTPEQkkEL
K13-a	PALTPEQkkELSDIA
K14-a	ALTPEQkkELSDIAH
K14-u	ALTPEQkkELSDIAH
S17	PEQkkELSDIAHRIV
K28-u	HRIVAPGkGILAADE
S36-p	GILAADEstGsIAkR
T37-p	ILAADEstGsIAkRL
S39-p	AADEstGsIAkRLQs
K42-a	EstGsIAkRLQsIGt
K42-u	EstGsIAkRLQsIGt
S46-p	sIAkRLQsIGtENTE
T49-p	kRLQsIGtENTEENR
T65	FYRQLLLTADDRVNP
K87-u	FHETLYQkADDGRPF
K99-u	RPFPQVIkSkGGVVG
S100	PFPQVIkSkGGVVGI
K101-u	FPQVIkSkGGVVGIk
K108	kGGVVGIKVDkGVVP
K108-u	kGGVVGIkVDkGVVP
K111-u	VVGIkVDkGVVPLAG
K139-a	SERCAQYkKDGADFA
K147-a	KDGADFAkWRCVLkI
K147-u	KDGADFAkWRCVLkI
K153-u	AkWRCVLkIGEHTPS
K153-a	AkWRCVLkIGEHTPS
S160	kIGEHTPSALAIMEN
K200-a	PDGDHDLkRCQyVTE
K200-u	PDGDHDLkRCQyVTE
Y204-p	HDLkRCQyVTEkVLA
K208	RCQyVTEKVLAAVYK
K208-u	RCQyVTEkVLAAVYK
Y214	EkVLAAVYKALSDHH
S218	AAVYKALSDHHVyLE
Y223-p	ALSDHHVyLEGTLLk
T227	HHVyLEGTLLkPNMV
K230	yLEGTLLKPNMVTPG
K230-u	yLEGTLLkPNMVTPG
T235	LLkPNMVTPGHACTQ
T241	VTPGHACTQKFSNEE
T269	PPAVTGVTFLsGGQs
S272-p	VTGVTFLsGGQsEEE
S276-p	TFLsGGQsEEEASIN
K294-a	INKCPLLkPWALtFS
K294	INKCPLLKPWALtFS
T299-p	LLkPWALtFSYGRAL
S301	kPWALtFSYGRALQA
K312	ALQASALKAWGGKKE
K312-u	ALQASALkAWGGKKE
K318	LkAWGGKKENLkAAQ
K322-u	GGKKENLkAAQEEYI
K322-m1	GGKKENLkAAQEEYI
Y328	LkAAQEEYIkRALAN
K330-u	AAQEEYIkRALANsL
K330-a	AAQEEYIkRALANsL
S336-p	IkRALANsLACQGkY
K342	NsLACQGKYTPSGQS
K342-u	NsLACQGkYTPSGQS
S354	GQSGAAASESLFIsN
S354-g	GQSGAAAsESLFIsN
S356	SGAAAsESLFIsNHA
S360-p	AsESLFIsNHAY___
H362	ESLFIsNHAY_____
Y364	LFIsNHAY_______

	rat
H3	_____MPHPYPALTP
Y5	___MPHPYPALTPEQ
T9	PHPYPALTPEQKKEL
K13	PALTPEQKKELADIA
K14	ALTPEQKKELADIAH
K14	ALTPEQKKELADIAH
A17	PEQKKELADIAHRIV
K28-u	HRIVAPGkGILAADE
S36-p	GILAADEsTGsIAkR
T37	ILAADEsTGsIAkRL
S39-p	AADEsTGsIAkRLQs
K42	EsTGsIAKRLQsIGT
K42-u	EsTGsIAkRLQsIGT
S46-p	sIAkRLQsIGTENTE
T49	kRLQsIGTENTEENR
T65	FYRQLLLTADDRVNP
K87	FHETLYQKADDGRPF
K99	RPFPQVIKSKGGVVG
S100	PFPQVIKSKGGVVGI
K101	FPQVIKSKGGVVGIk
K108	KGGVVGIKVDkGVVP
K108-u	KGGVVGIkVDkGVVP
K111-u	VVGIkVDkGVVPLAG
K139	SERCAQYKKDGADFA
K147-a	KDGADFAkWRCVLkI
K147	KDGADFAKWRCVLkI
K153-u	AkWRCVLkIGEHTPS
K153	AkWRCVLKIGEHTPS
S160	kIGEHTPSSLAIMEN
K200-a	PDGDHDLkRCQyVTE
K200-u	PDGDHDLkRCQyVTE
Y204-p	HDLkRCQyVTEKVLA
K208	RCQyVTEKVLAAVYK
K208	RCQyVTEKVLAAVYK
Y214	EKVLAAVYKALSDHH
S218	AAVYKALSDHHVYLE
Y223	ALSDHHVYLEGTLLK
T227	HHVYLEGTLLKPNMV
K230	YLEGTLLKPNMVTPG
K230	YLEGTLLKPNMVTPG
T235	LLKPNMVTPGHACTQ
T241	VTPGHACTQKFSNEE
T269	PPAVPGVTFLSGGQS
S272	VPGVTFLSGGQSEEE
S276	TFLSGGQSEEEASIN
K294	INKCPLLKPWALTFS
K294	INKCPLLKPWALTFS
T299	LLKPWALTFSYGRAL
S301	KPWALTFSYGRALQA
K312	ALQASALKAWGGKkE
K312-u	ALQASALkAWGGKkE
K318-u	LkAWGGKkENLkAAQ
K322-u	GGKkENLkAAQEEYI
K322	GGKkENLKAAQEEYI
Y328	LkAAQEEYIkRALAN
K330-u	AAQEEYIkRALANSL
K330	AAQEEYIKRALANSL
S336	IkRALANSLACQGKY
K342	NSLACQGKYTPSGQS
K342	NSLACQGKYTPSGQS
S354	GQSGAAASESLFISN
S354	GQSGAAASESLFISN
S356	SGAAASESLFISNHA
S360	ASESLFISNHAY___
H362	ESLFISNHAY_____
Y364	LFISNHAY_______

	rabbit
H3	_____MPHSHPALTP
H5	___MPHSHPALTPEQ
T9	PHSHPALTPEQKKEL
K13	PALTPEQKKELSDIA
K14	ALTPEQKKELSDIAH
K14	ALTPEQKKELSDIAH
S17	PEQKKELSDIAHRIV
K28	HRIVAPGKGILAADE
S36	GILAADESTGSIAKR
T37	ILAADESTGSIAKRL
S39	AADESTGSIAKRLQS
K42	ESTGSIAKRLQSIGT
K42	ESTGSIAKRLQSIGT
S46	SIAKRLQSIGTENTE
T49	KRLQSIGTENTEENR
T65	FYRQLLLTADDRVNP
K87	FHETLYQKADDGRPF
K99	RPFPQVIKSKGGVVG
S100	PFPQVIKSKGGVVGI
K101	FPQVIKSKGGVVGIK
K108	KGGVVGIKVDKGVVP
K108	KGGVVGIKVDKGVVP
K111	VVGIKVDKGVVPLAG
K139	SERCAQYKKDGADFA
K147	KDGADFAKWRCVLKI
K147	KDGADFAKWRCVLKI
K153	AKWRCVLKIGEHTPS
K153	AKWRCVLKIGEHTPS
S160	KIGEHTPSALAIMEN
K200	PDGDHDLKRCQYVTE
K200	PDGDHDLKRCQYVTE
Y204	HDLKRCQYVTEKVLA
K208	RCQYVTEKVLAAVYK
K208	RCQYVTEKVLAAVYK
Y214	EKVLAAVYKALSDHH
S218	AAVYKALSDHHIYLE
Y223	ALSDHHIYLEGTLLK
T227	HHIYLEGTLLKPNMV
K230	YLEGTLLKPNMVTPG
K230	YLEGTLLKPNMVTPG
T235	LLKPNMVTPGHACTQ
T241	VTPGHACTQKYSHEE
T269	PPAVTGVTFLSGGQS
S272	VTGVTFLSGGQSEEE
S276	TFLSGGQSEEEASIN
K294	INKCPLLKPWALTFS
K294	INKCPLLKPWALTFS
T299	LLKPWALTFSYGRAL
S301	KPWALTFSYGRALQA
K312	ALQASALKAWGGKKE
K312	ALQASALKAWGGKKE
K318	LKAWGGKKENLKAAQ
K322	GGKKENLKAAQEEYV
K322	GGKKENLKAAQEEYV
Y328	LKAAQEEYVKRALAN
K330	AAQEEYVKRALANSL
K330	AAQEEYVKRALANSL
S336	VKRALANSLACQGKY
K342	NSLACQGKYTPSGQA
K342	NSLACQGKYTPSGQA
S354	GQAGAAASESLFISN
S354	GQAGAAASESLFISN
S356	AGAAASESLFISNhA
S360	ASESLFISNhAY___
H362-p	ESLFISNhAY_____
Y364	LFISNhAY_______

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