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PGK1 (human)

Overview PGK1 an apparent multifunctional protein. A glycolytic enzyme and a polymerase alpha cofactor protein (primer recognition protein). Note: This description may include information from UniProtKB. Protein type: EC 2.7.2.3; Kinase, other; Carbohydrate Metabolism - glycolysis and gluconeogenesis Cellular Component: cytosol Molecular Function: phosphoglycerate kinase activity; ATP binding Biological Process: glycolysis; carbohydrate metabolic process; glucose metabolic process; phosphorylation; gluconeogenesis Reference #:  P00558 (UniProtKB) Alt. Names/Synonyms: Cell migration-inducing gene 10 protein; MGC117307; MGC142128; MGC8947; MIG10; PGK1; PGKA; Phosphoglycerate kinase 1; Primer recognition protein 2; PRP 2 Gene Symbols: PGK1 Molecular weight: 44,615 Da Basal Isoelectric point: 8.3  Predict pI for various phosphorylation states

Select Structure to View Below PGK1 2WZB - A=2-417 (human) 2WZC - A=2-417 (human) 2WZD - A=1-417 (human) 2X13 - A=2-417 (human) 2X14 - A=2-417 (human) 2X15 - A=2-417 (human) 2XE6 - A=1-417 (human) 2XE7 - A=1-417 (human) 2XE8 - A=1-417 (human) 2Y3I - A/D=1-416 (human) 2YBE - A=1-417 (human) 2ZGV - A=1-417 (human) 3C39 - A/B=1-417 (human) 3C3A - A/B=1-417 (human) 3C3B - A/B=1-417 (human) 3C3C - A/B=1-417 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2WZB 2WZC 2WZD 2X13 2X14 2X15 2XE6 2XE7 2XE8 2Y3I 2YBE 2ZGV 3C39 3C3A 3C3B 3C3C  |  ENZYME  |  Phospho3D  |  DISEASE 300653 311800  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
cell growth, altered: Y76‑p molecular association, regulation: Y76‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		K6-a	__MSLSNkLTLDkLD
0	1		K6	__MSLSNKLTLDkLD
0	1		K11-a	SNkLTLDkLDVkGkR
0	2		K11-u	SNkLTLDkLDVkGkR
0	8		K15-u	TLDkLDVkGkRVVMR
0	1		K17-u	DkLDVkGkRVVMRVD
0	2		K30-a	VDFNVPMkNNQItNN
0	63		K30-u	VDFNVPMkNNQItNN
0	1		T35-p	PMkNNQItNNQRIKA
0	7		K48-a	KAAVPSIkFCLDNGA
0	2		K48-u	KAAVPSIkFCLDNGA
0	1		K56-a	FCLDNGAkSVVLMSH
0	1		S62	AkSVVLMSHLGRPDG
0	15		K75-a	DGVPMPDkysLEPVA
0	2		K75-u	DGVPMPDkysLEPVA
1	106		Y76-p	GVPMPDkysLEPVAV
0	50		S77-p	VPMPDkysLEPVAVE
0	1		K86-a	EPVAVELkSLLGkDV
0	3		K86-u	EPVAVELkSLLGkDV
0	2		S87	PVAVELkSLLGkDVL
0	2		K91-a	ELkSLLGkDVLFLkD
0	3		K91-u	ELkSLLGkDVLFLkD
0	6		K97-a	GkDVLFLkDCVGPEV
0	3		K97-u	GkDVLFLkDCVGPEV
0	20		K106-u	CVGPEVEkACANPAA
0	43		K131-a	FHVEEEGkGkDAsGN
0	1		K133-a	VEEEGkGkDAsGNKV
0	1		S136-p	EGkGkDAsGNKVkAE
0	1		K141-a	DAsGNKVkAEPAkIE
0	22		K141-u	DAsGNKVkAEPAkIE
0	1		K146-a	KVkAEPAkIEAFRAs
0	4		K146-u	KVkAEPAkIEAFRAs
0	1		S153-p	kIEAFRAsLskLGDV
0	1		S155-p	EAFRAsLskLGDVyV
0	3		K156-u	AFRAsLskLGDVyVN
0	17		Y161-p	LskLGDVyVNDAFGt
0	2		T168-p	yVNDAFGtAHRAHSs
0	2		S175-p	tAHRAHSsMVGVNLP
0	6		K184-u	VGVNLPQkAGGFLMk
0	7		K191-a	kAGGFLMkkELNyFA
0	2		K191-u	kAGGFLMkkELNyFA
0	3		K192-u	AGGFLMkkELNyFAk
0	482		Y196-p	LMkkELNyFAkALEs
0	1		K199-a	kELNyFAkALEsPER
0	15		K199-u	kELNyFAkALEsPER
0	43		S203-p	yFAkALEsPERPFLA
0	2		K216-a	LAILGGAkVADkIQL
0	6		K216-u	LAILGGAkVADkIQL
0	1		K220-a	GGAkVADkIQLINNM
0	3		K220-u	GGAkVADkIQLINNM
0	1		T243-p	IGGGMAFtFLKVLNN
0	2		S256-p	NNMEIGTsLFDEEGA
0	19		K264-u	LFDEEGAkIVkDLMS
0	1		K267-a	EEGAkIVkDLMSkAE
0	5		K267-u	EEGAkIVkDLMSkAE
0	1		K272-a	IVkDLMSkAEkNGVK
0	3		K272-u	IVkDLMSkAEkNGVK
0	1		K275-a	DLMSkAEkNGVKITL
0	1		K279	kAEkNGVKITLPVDF
0	2		K291-a	VDFVTADkFDENAKT
0	4		K291-u	VDFVTADkFDENAKT
0	1		S320	GLDCGPESSkkYAEA
0	1		S321	LDCGPESSkkYAEAV
0	73		K322-a	DCGPESSkkYAEAVT
0	1		K322-u	DCGPESSkkYAEAVT
0	10		K323-a	CGPESSkkYAEAVTR
0	5		K323-u	CGPESSkkYAEAVTR
0	2		Y324	GPESSkkYAEAVTRA
0	8		K332-u	AEAVTRAkQIVWNGP
0	1		K353	EAFARGTKALMDEVV
0	2		A354	AFARGTKALMDEVVk
0	2		K361-a	ALMDEVVkATSRGCI
0	3		K361-u	ALMDEVVkATSRGCI
0	1		K388	AKWNTEDKVSHVSTG
0	1		S390	WNTEDKVSHVSTGGG
0	1		K406-a	SLELLEGkVLPGVDA
0	2		S415-p	LPGVDALsNI_____

	mouse
K6	__MSLSNKLTLDkLD
K6-u	__MSLSNkLTLDkLD
K11	SNkLTLDKLDVkGKR
K11-u	SNkLTLDkLDVkGKR
K15-u	TLDkLDVkGKRVVMR
K17	DkLDVkGKRVVMRVD
K30-a	VDFNVPMkNNQITNN
K30-u	VDFNVPMkNNQITNN
T35	PMkNNQITNNQRIKA
K48	KAAVPSIKFCLDNGA
K48-u	KAAVPSIkFCLDNGA
K56	FCLDNGAKSVVLMsH
S62-p	AKSVVLMsHLGRPDG
K75-a	DGVPMPDkysLEPVA
K75-u	DGVPMPDkysLEPVA
Y76-p	GVPMPDkysLEPVAA
S77-p	VPMPDkysLEPVAAE
K86	EPVAAELKsLLGkDV
K86-u	EPVAAELksLLGkDV
S87-p	PVAAELksLLGkDVL
K91-a	ELksLLGkDVLFLKD
K91-u	ELksLLGkDVLFLKD
K97	GkDVLFLKDCVGPEV
K97	GkDVLFLKDCVGPEV
N106	CVGPEVENACANPAA
K131-a	FHVEEEGkGKDASGN
K133	VEEEGkGKDASGNKV
S136	EGkGKDASGNKVkAE
K141	DASGNKVKAEPAkID
K141-u	DASGNKVkAEPAkID
K146	KVkAEPAKIDAFRAS
K146-u	KVkAEPAkIDAFRAS
S153	kIDAFRASLSkLGDV
S155	DAFRASLSkLGDVyV
K156-u	AFRASLSkLGDVyVN
Y161-p	LSkLGDVyVNDAFGt
T168-p	yVNDAFGtAHRAHSS
S175	tAHRAHSSMVGVNLP
K184-u	VGVNLPQkAGGFLMK
K191	kAGGFLMKkELNyFA
K191	kAGGFLMKkELNyFA
K192-u	AGGFLMKkELNyFAk
Y196-p	LMKkELNyFAkALEs
K199	kELNyFAKALEsPER
K199-u	kELNyFAkALEsPER
S203-p	yFAkALEsPERPFLA
K216	LAILGGAKVADkIQL
K216-u	LAILGGAkVADkIQL
K220	GGAkVADKIQLINNM
K220-u	GGAkVADkIQLINNM
T243	IGGGMAFTFLKVLNN
S256	NNMEIGTSLYDEEGA
K264-u	LYDEEGAkIVkDLMS
K267	EEGAkIVKDLMSkAE
K267-u	EEGAkIVkDLMSkAE
K272	IVkDLMSKAEKNGVk
K272-u	IVkDLMSkAEKNGVk
K275	DLMSkAEKNGVkITL
K279-u	kAEKNGVkITLPVDF
K291-a	VDFVTADkFDENAKT
K291-u	VDFVTADkFDENAKT
S320-p	GLDCGTEsskkyAEA
S321-p	LDCGTEsskkyAEAV
K322-a	DCGTEsskkyAEAVG
K322	DCGTEssKkyAEAVG
K323-a	CGTEsskkyAEAVGR
K323-u	CGTEsskkyAEAVGR
Y324-p	GTEsskkyAEAVGRA
K332	AEAVGRAKQIVWNGP
K353-u	EAFARGTksLMDEVV
S354-p	AFARGTksLMDEVVk
K361-a	sLMDEVVkATSRGCI
K361-u	sLMDEVVkATSRGCI
K388-u	AKWNTEDkVsHVSTG
S390-p	WNTEDkVsHVSTGGG
K406	SLELLEGKVLPGVDA
S415-p	LPGVDALsNV_____

	rat
K6	__MSLSNKLTLDKLD
K6	__MSLSNKLTLDKLD
K11	SNKLTLDKLDVKGKR
K11	SNKLTLDKLDVKGKR
K15	TLDKLDVKGKRVVMR
K17	DKLDVKGKRVVMRVD
K30	VDFNVPMKNNQITNN
K30-u	VDFNVPMkNNQITNN
T35	PMkNNQITNNQRIKA
K48	KAAVPSIKFCLDNGA
K48	KAAVPSIKFCLDNGA
K56	FCLDNGAKSVVLMSH
S62	AKSVVLMSHLGRPDG
K75	DGVPMPDKySLEPVA
K75	DGVPMPDKySLEPVA
Y76-p	GVPMPDKySLEPVAA
S77	VPMPDKySLEPVAAE
K86	EPVAAELKSLLGKDV
K86	EPVAAELKSLLGKDV
S87	PVAAELKSLLGKDVL
K91	ELKSLLGKDVLFLKD
K91	ELKSLLGKDVLFLKD
K97	GKDVLFLKDCVGSEV
K97	GKDVLFLKDCVGSEV
N106	CVGSEVENACANPAA
K131	FHVEEEGKGKDASGN
K133	VEEEGKGKDASGNKV
S136	EGKGKDASGNKVkAE
K141	DASGNKVKAEPAKID
K141-u	DASGNKVkAEPAKID
K146	KVkAEPAKIDAFRAS
K146	KVkAEPAKIDAFRAS
S153	KIDAFRASLSKLGDV
S155	DAFRASLSKLGDVYV
K156	AFRASLSKLGDVYVN
Y161	LSKLGDVYVNDAFGT
T168	YVNDAFGTAHRAHSS
S175	TAHRAHSSMVGVNLP
K184	VGVNLPQKAGGFLMK
K191	KAGGFLMKKELNyFA
K191	KAGGFLMKKELNyFA
K192	AGGFLMKKELNyFAK
Y196-p	LMKKELNyFAKALEs
K199	KELNyFAKALEsPER
K199	KELNyFAKALEsPER
S203-p	yFAKALEsPERPFLA
K216	LAILGGAKVADKIQL
K216	LAILGGAKVADKIQL
K220	GGAKVADKIQLINNM
K220	GGAKVADKIQLINNM
T243	IGGGMAFTFLKVLNN
S256	NNMEIGTSLYDEEGA
K264	LYDEEGAKIVKDLMA
K267	EEGAKIVKDLMAKAE
K267	EEGAKIVKDLMAKAE
K272	IVKDLMAKAEKNGVK
K272	IVKDLMAKAEKNGVK
K275	DLMAKAEKNGVKITL
K279	KAEKNGVKITLPVDF
K291	VDFVTADKFDENAKT
K291	VDFVTADKFDENAKT
S320	GLDCGTESSKKYAEA
S321	LDCGTESSKKYAEAV
K322	DCGTESSKKYAEAVA
K322	DCGTESSKKYAEAVA
K323	CGTESSKKYAEAVAR
K323	CGTESSKKYAEAVAR
Y324	GTESSKKYAEAVARA
K332	AEAVARAKQIVWNGP
K353	EAFARGTKSLMDEVV
S354	AFARGTKSLMDEVVK
K361	SLMDEVVKATSRGCI
K361	SLMDEVVKATSRGCI
K388	AKWNTEDKVSHVSTG
S390	WNTEDKVSHVSTGGG
K406	SLELLEGKVLPGVDA
S415	LPGVDALSNV_____

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