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Protein Page:
PGK1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PGK1 an apparent multifunctional protein. A glycolytic enzyme and a polymerase alpha cofactor protein (primer recognition protein). Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - glycolysis and gluconeogenesis; Kinase, other; EC 2.7.2.3
Chromosomal Location of Human Ortholog: Xq13.3
Cellular Component: membrane; cytosol
Molecular Function: protein binding; phosphoglycerate kinase activity; ATP binding
Biological Process: glycolysis; epithelial cell differentiation; carbohydrate metabolic process; glucose metabolic process; phosphorylation; gluconeogenesis
Reference #:  P00558 (UniProtKB)
Alt. Names/Synonyms: Cell migration-inducing gene 10 protein; MGC117307; MGC142128; MGC8947; MIG10; PGK1; PGKA; Phosphoglycerate kinase 1; Primer recognition protein 2; PRP 2
Gene Symbols: PGK1
Molecular weight: 44,615 Da
Basal Isoelectric point: 8.3  Predict pI for various phosphorylation states
Select Structure to View Below

PGK1

Protein Structure Not Found.


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Sites Implicated In
cell growth, altered: Y76‑p
molecular association, regulation: Y76‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S2-p ______MsLsNkLTL
0 1 S4-p ____MsLsNkLTLDk
0 2 K6-ac __MsLsNkLTLDkLD
0 1 K6 __MsLsNKLTLDkLD
0 2 K11-ac sNkLTLDkLDVkGkR
0 2 K11-ub sNkLTLDkLDVkGkR
0 1 K11-sc sNkLTLDkLDVkGkR
0 8 K15-ub TLDkLDVkGkRVVMR
0 1 K17-ub DkLDVkGkRVVMRVD
0 3 K30-ac VDFNVPMkNNQItNN
0 63 K30-ub VDFNVPMkNNQItNN
0 1 T35-p PMkNNQItNNQRIKA
0 1 S46-p RIKAAVPsIkFCLDN
0 8 K48-ac KAAVPsIkFCLDNGA
0 2 K48-ub KAAVPsIkFCLDNGA
0 1 K56-ac FCLDNGAkSVVLMSH
0 1 S62 AkSVVLMSHLGRPDG
0 16 K75-ac DGVPMPDkysLEPVA
0 2 K75-ub DGVPMPDkysLEPVA
1 106 Y76-p GVPMPDkysLEPVAV
0 49 S77-p VPMPDkysLEPVAVE
0 2 K86-ac EPVAVELksLLGkDV
0 3 K86-ub EPVAVELksLLGkDV
0 5 S87-p PVAVELksLLGkDVL
0 3 K91-ac ELksLLGkDVLFLkD
0 3 K91-ub ELksLLGkDVLFLkD
0 7 K97-ac GkDVLFLkDCVGPEV
0 3 K97-ub GkDVLFLkDCVGPEV
0 1 K97-sc GkDVLFLkDCVGPEV
0 1 K106-ac CVGPEVEkACANPAA
0 20 K106-ub CVGPEVEkACANPAA
0 1 S115-p CANPAAGsVILLENL
0 44 K131-ac FHVEEEGkGkDAsGN
0 2 K133-ac VEEEGkGkDAsGNKV
0 1 S136-p EGkGkDAsGNKVkAE
0 1 K141-ac DAsGNKVkAEPAkIE
0 22 K141-ub DAsGNKVkAEPAkIE
0 2 K146-ac KVkAEPAkIEAFRAs
0 4 K146-ub KVkAEPAkIEAFRAs
0 1 K146-sc KVkAEPAkIEAFRAs
0 3 S153-p kIEAFRAsLskLGDV
0 2 S155-p EAFRAsLskLGDVyV
0 2 K156-ac AFRAsLskLGDVyVN
0 3 K156-ub AFRAsLskLGDVyVN
0 17 Y161-p LskLGDVyVNDAFGt
0 2 T168-p yVNDAFGtAHRAHSs
0 2 S175-p tAHRAHSsMVGVNLP
0 6 K184-ub VGVNLPQkAGGFLMk
0 7 K191-ac kAGGFLMkkELNyFA
0 2 K191-ub kAGGFLMkkELNyFA
0 1 K191-sc kAGGFLMkkELNyFA
0 3 K192-ub AGGFLMkkELNyFAk
0 1 K192 AGGFLMkKELNyFAk
0 520 Y196-p LMkkELNyFAkALEs
0 2 K199-ac kELNyFAkALEsPER
0 15 K199-ub kELNyFAkALEsPER
0 59 S203-p yFAkALEsPERPFLA
0 3 K216-ac LAILGGAkVADkIQL
0 6 K216-ub LAILGGAkVADkIQL
0 2 K220-ac GGAkVADkIQLINNM
0 3 K220-ub GGAkVADkIQLINNM
0 1 T243-p IGGGMAFtFLKVLNN
0 3 S256-p NNMEIGTsLFDEEGA
0 1 K264-ac LFDEEGAkIVkDLMs
0 19 K264-ub LFDEEGAkIVkDLMs
0 2 K267-ac EEGAkIVkDLMskAE
0 5 K267-ub EEGAkIVkDLMskAE
0 1 S271-p kIVkDLMskAEkNGV
0 2 K272-ac IVkDLMskAEkNGVK
0 3 K272-ub IVkDLMskAEkNGVK
0 1 K275-ac DLMskAEkNGVKItL
0 1 K279 kAEkNGVKItLPVDF
0 1 K279 kAEkNGVKItLPVDF
0 1 T281-p EkNGVKItLPVDFVt
0 1 T288-p tLPVDFVtADkFDEN
0 3 K291-ac VDFVtADkFDENAKT
0 4 K291-ub VDFVtADkFDENAKT
0 1 K291-sc VDFVtADkFDENAKT
0 1 S320 GLDCGPESSkkYAEA
0 1 S321 LDCGPESSkkYAEAV
0 73 K322-ac DCGPESSkkYAEAVT
0 1 K322-ub DCGPESSkkYAEAVT
0 10 K323-ac CGPESSkkYAEAVTR
0 5 K323-ub CGPESSkkYAEAVTR
0 1 Y324 GPESSkkYAEAVTRA
0 8 K332-ub AEAVTRAkQIVWNGP
0 1 K353 EAFARGTKALMDEVV
0 4 A354 AFARGTKALMDEVVk
0 3 K361-ac ALMDEVVkATSRGCI
0 3 K361-ub ALMDEVVkATSRGCI
0 1 K361-sc ALMDEVVkATSRGCI
0 1 T378-p IGGGDTAtCCAkWNT
0 1 K382-ac DTAtCCAkWNTEDkV
0 1 K388-ac AkWNTEDkVSHVSTG
0 1 K388 AkWNTEDKVSHVSTG
0 1 S390 WNTEDkVSHVSTGGG
0 1 S399-p VSTGGGAsLELLEGk
0 2 K406-ac sLELLEGkVLPGVDA
0 4 S415-p LPGVDALsNI_____
  mouse

 
S2 ______MSLSNkLTL
S4 ____MSLSNkLTLDk
K6 __MSLSNKLTLDkLD
K6-ub __MSLSNkLTLDkLD
K11-ac SNkLTLDkLDVkGKR
K11-ub SNkLTLDkLDVkGKR
K11-sc SNkLTLDkLDVkGKR
K15-ub TLDkLDVkGKRVVMR
K17 DkLDVkGKRVVMRVD
K30-ac VDFNVPMkNNQITNN
K30-ub VDFNVPMkNNQITNN
T35 PMkNNQITNNQRIKA
S46 RIKAAVPSIkFCLDN
K48 KAAVPSIKFCLDNGA
K48-ub KAAVPSIkFCLDNGA
K56 FCLDNGAKSVVLMsH
S62-p AKSVVLMsHLGRPDG
K75-ac DGVPMPDkysLEPVA
K75-ub DGVPMPDkysLEPVA
Y76-p GVPMPDkysLEPVAA
S77-p VPMPDkysLEPVAAE
K86-ac EPVAAELksLLGkDV
K86-ub EPVAAELksLLGkDV
S87-p PVAAELksLLGkDVL
K91-ac ELksLLGkDVLFLKD
K91-ub ELksLLGkDVLFLKD
K97 GkDVLFLKDCVGPEV
K97 GkDVLFLKDCVGPEV
K97 GkDVLFLKDCVGPEV
N106 CVGPEVENACANPAA
N106 CVGPEVENACANPAA
T115 CANPAAGTVILLENL
K131-ac FHVEEEGkGkDASGN
K133-ac VEEEGkGkDASGNKV
S136 EGkGkDASGNKVkAE
K141 DASGNKVKAEPAkID
K141-ub DASGNKVkAEPAkID
K146 KVkAEPAKIDAFRAS
K146-ub KVkAEPAkIDAFRAS
K146-sc KVkAEPAkIDAFRAS
S153 kIDAFRASLSkLGDV
S155 DAFRASLSkLGDVyV
K156-ac AFRASLSkLGDVyVN
K156-ub AFRASLSkLGDVyVN
Y161-p LSkLGDVyVNDAFGt
T168-p yVNDAFGtAHRAHSS
S175 tAHRAHSSMVGVNLP
K184-ub VGVNLPQkAGGFLMk
K191 kAGGFLMKkELNyFA
K191 kAGGFLMKkELNyFA
K191-sc kAGGFLMkkELNyFA
K192-ub AGGFLMkkELNyFAk
K192-sc AGGFLMkkELNyFAk
Y196-p LMkkELNyFAkALEs
K199-ac kELNyFAkALEsPER
K199-ub kELNyFAkALEsPER
S203-p yFAkALEsPERPFLA
K216 LAILGGAKVADkIQL
K216-ub LAILGGAkVADkIQL
K220-ac GGAkVADkIQLINNM
K220-ub GGAkVADkIQLINNM
T243 IGGGMAFTFLKVLNN
S256 NNMEIGTSLYDEEGA
K264-ac LYDEEGAkIVkDLMS
K264-ub LYDEEGAkIVkDLMS
K267-ac EEGAkIVkDLMSkAE
K267-ub EEGAkIVkDLMSkAE
S271 kIVkDLMSkAEKNGV
K272-ac IVkDLMSkAEKNGVk
K272-ub IVkDLMSkAEKNGVk
K275 DLMSkAEKNGVkITL
K279-ub kAEKNGVkITLPVDF
K279-sc kAEKNGVkITLPVDF
T281 EKNGVkITLPVDFVT
T288 TLPVDFVTADkFDEN
K291-ac VDFVTADkFDENAKT
K291-ub VDFVTADkFDENAKT
K291-sc VDFVTADkFDENAKT
S320-p GLDCGTEsskkyAEA
S321-p LDCGTEsskkyAEAV
K322-ac DCGTEsskkyAEAVG
K322 DCGTEssKkyAEAVG
K323-ac CGTEsskkyAEAVGR
K323-ub CGTEsskkyAEAVGR
Y324-p GTEsskkyAEAVGRA
K332 AEAVGRAKQIVWNGP
K353-ub EAFARGTksLMDEVV
S354-p AFARGTksLMDEVVk
K361-ac sLMDEVVkATSRGCI
K361-ub sLMDEVVkATSRGCI
K361 sLMDEVVKATSRGCI
T378 IGGGDTATCCAKWNT
K382 DTATCCAKWNTEDkV
K388-ac AKWNTEDkVsHVSTG
K388-ub AKWNTEDkVsHVSTG
S390-p WNTEDkVsHVSTGGG
S399 VSTGGGASLELLEGk
K406-ac SLELLEGkVLPGVDA
S415-p LPGVDALsNV_____
  rat

 
S2-p ______MsLSNkLTL
S4 ____MsLSNkLTLDk
K6-ac __MsLSNkLTLDkLD
K6 __MsLSNKLTLDkLD
K11-ac SNkLTLDkLDVKGKR
K11 SNkLTLDKLDVKGKR
K11 SNkLTLDKLDVKGKR
K15 TLDkLDVKGKRVVMR
K17 DkLDVKGKRVVMRVD
K30-ac VDFNVPMkNNQITNN
K30-ub VDFNVPMkNNQITNN
T35 PMkNNQITNNQRIKA
S46 RIKAAVPSIkFCLDN
K48-ac KAAVPSIkFCLDNGA
K48 KAAVPSIKFCLDNGA
K56 FCLDNGAKSVVLMSH
S62 AKSVVLMSHLGRPDG
K75-ac DGVPMPDkySLEPVA
K75 DGVPMPDKySLEPVA
Y76-p GVPMPDkySLEPVAA
S77 VPMPDkySLEPVAAE
K86-ac EPVAAELkSLLGkDV
K86 EPVAAELKSLLGkDV
S87 PVAAELkSLLGkDVL
K91-ac ELkSLLGkDVLFLKD
K91 ELkSLLGKDVLFLKD
K97 GkDVLFLKDCVGSEV
K97 GkDVLFLKDCVGSEV
K97 GkDVLFLKDCVGSEV
N106 CVGSEVENACANPAA
N106 CVGSEVENACANPAA
T115 CANPAAGTVILLENL
K131-ac FHVEEEGkGkDASGN
K133-ac VEEEGkGkDASGNKV
S136 EGkGkDASGNKVkAE
K141 DASGNKVKAEPAkID
K141-ub DASGNKVkAEPAkID
K146-ac KVkAEPAkIDAFRAS
K146 KVkAEPAKIDAFRAS
K146 KVkAEPAKIDAFRAS
S153 kIDAFRASLSkLGDV
S155 DAFRASLSkLGDVYV
K156-ac AFRASLSkLGDVYVN
K156 AFRASLSKLGDVYVN
Y161 LSkLGDVYVNDAFGT
T168 YVNDAFGTAHRAHSS
S175 TAHRAHSSMVGVNLP
K184 VGVNLPQKAGGFLMK
K191 KAGGFLMKKELNyFA
K191 KAGGFLMKKELNyFA
K191 KAGGFLMKKELNyFA
K192 AGGFLMKKELNyFAK
K192 AGGFLMKKELNyFAK
Y196-p LMKKELNyFAKALEs
K199 KELNyFAKALEsPER
K199 KELNyFAKALEsPER
S203-p yFAKALEsPERPFLA
K216-ac LAILGGAkVADkIQL
K216 LAILGGAKVADkIQL
K220-ac GGAkVADkIQLINNM
K220 GGAkVADKIQLINNM
T243 IGGGMAFTFLKVLNN
S256 NNMEIGTSLYDEEGA
K264-ac LYDEEGAkIVkDLMA
K264 LYDEEGAKIVkDLMA
K267-ac EEGAkIVkDLMAkAE
K267 EEGAkIVKDLMAkAE
- under review  
K272-ac IVkDLMAkAEKNGVK
K272 IVkDLMAKAEKNGVK
K275 DLMAkAEKNGVKITL
K279 kAEKNGVKITLPVDF
K279 kAEKNGVKITLPVDF
T281 EKNGVKITLPVDFVT
T288 TLPVDFVTADkFDEN
K291-ac VDFVTADkFDENAKT
K291 VDFVTADKFDENAKT
K291 VDFVTADKFDENAKT
S320 GLDCGTESSKkYAEA
S321 LDCGTESSKkYAEAV
K322 DCGTESSKkYAEAVA
K322 DCGTESSKkYAEAVA
K323-ac CGTESSKkYAEAVAR
K323 CGTESSKKYAEAVAR
Y324 GTESSKkYAEAVARA
K332 AEAVARAKQIVWNGP
K353 EAFARGTKsLMDEVV
S354-p AFARGTKsLMDEVVk
K361-ac sLMDEVVkATSRGCI
K361 sLMDEVVKATSRGCI
K361 sLMDEVVKATSRGCI
T378 IGGGDTATCCAKWNT
K382 DTATCCAKWNTEDkV
K388-ac AKWNTEDkVSHVSTG
K388 AKWNTEDKVSHVSTG
S390 WNTEDkVSHVSTGGG
S399 VSTGGGASLELLEGK
K406 SLELLEGKVLPGVDA
S415-p LPGVDALsNV_____
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