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Protein Page:
LDH-A (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
LDH-A Homotetramer. Belongs to the LDH/MDH superfamily. LDH family. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Oxidoreductase; Amino Acid Metabolism - cysteine and methionine; Carbohydrate Metabolism - pyruvate; EC 1.1.1.27; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - propanoate
Cellular Component: membrane; mitochondrion; cytosol; nucleus; cilium
Molecular Function: protein binding; L-lactate dehydrogenase activity
Biological Process: cellular metabolic process; glycolysis; substantia nigra development; cellular response to extracellular stimulus; cellular carbohydrate metabolic process; pyruvate metabolic process
Reference #:  P00338 (UniProtKB)
Alt. Names/Synonyms: cell proliferation-inducing gene 19 protein; GSD11; L-lactate dehydrogenase A chain; lactate dehydrogenase A; lactate dehydrogenase M; LDH muscle subunit; LDH-A; LDH-M; LDH1; LDHA; LDHM; PIG19; proliferation-inducing gene 19; Renal carcinoma antigen NY-REN-59
Gene Symbols: LDHA
Molecular weight: 36,689 Da
Basal Isoelectric point: 8.44  Predict pI for various phosphorylation states
CST Pathways:  Warburg Effect
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

LDH-A

Protein Structure Not Found.


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Sites Implicated In
carcinogenesis, induced: Y10‑p
cell growth, induced: Y10‑p
enzymatic activity, induced: Y10‑p, Y83‑p
molecular association, regulation: Y10‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 - gap
1 78 K5-ac ___MATLkDQLIyNL
0 3 K5-ub ___MATLkDQLIyNL
0 1 K5-sc ___MATLkDQLIyNL
1 373 Y10-p TLkDQLIyNLLkEEQ
0 7 K14-ac QLIyNLLkEEQtPQN
0 52 K14-ub QLIyNLLkEEQtPQN
0 1 K14-sc QLIyNLLkEEQtPQN
0 4 T18-p NLLkEEQtPQNkITV
0 1 K22-ac EEQtPQNkITVVGVG
0 1 S38 VGMACAISILMKDLA
1 1 K42 CAISILMKDLADELA
1 1 K42 CAISILMKDLADELA
0 3 K57-ac LVDVIEDkLkGEMMD
1 1 K57 LVDVIEDKLkGEMMD
0 10 K57-ub LVDVIEDkLkGEMMD
1 1 K59 DVIEDkLKGEMMDLQ
0 10 K59-ub DVIEDkLkGEMMDLQ
0 1 R73 QHGSLFLRTPkIVSG
0 45 K76-ub SLFLRTPkIVSGkDy
0 1 K76-sc SLFLRTPkIVSGkDy
0 23 K81-ac TPkIVSGkDyNVTAN
0 43 K81-ub TPkIVSGkDyNVTAN
0 1 K81-sc TPkIVSGkDyNVTAN
1 4 Y83-p kIVSGkDyNVTANsk
0 1 S89-p DyNVTANskLVIITA
0 2 K90-ub yNVTANskLVIITAG
0 24 K118-ac QRNVNIFkFIIPNVV
0 83 K118-ub QRNVNIFkFIIPNVV
0 1 K118-sc QRNVNIFkFIIPNVV
0 20 K126-ac FIIPNVVkysPNCkL
0 22 K126-ub FIIPNVVkysPNCkL
0 1 K126-sc FIIPNVVkysPNCkL
0 43 Y127-p IIPNVVkysPNCkLL
0 3 S128-p IPNVVkysPNCkLLI
0 1 K132-ac VkysPNCkLLIVSNP
0 18 K132-ub VkysPNCkLLIVSNP
0 1 T144 SNPVDILTyVAWKIS
0 18 Y145-p NPVDILTyVAWKISG
0 1 K155 WKISGFPKNRVIGSG
0 3 K155-ub WKISGFPkNRVIGSG
0 1 K155 WKISGFPKNRVIGSG
0 21 Y172-p LDSARFRyLMGERLG
0 2 K222-ac HPDLGTDkDkEQWkE
0 4 K222-ub HPDLGTDkDkEQWkE
0 1 K222-sc HPDLGTDkDkEQWkE
0 2 K224 DLGTDkDKEQWkEVH
0 6 K224-ub DLGTDkDkEQWkEVH
0 1 K224 DLGTDkDKEQWkEVH
0 5 K228-ac DkDkEQWkEVHkQVV
0 2 K228-ub DkDkEQWkEVHkQVV
0 1 K228-sc DkDkEQWkEVHkQVV
0 2 K232-ac EQWkEVHkQVVEsAy
0 4 K232-ub EQWkEVHkQVVEsAy
0 1 K232-sc EQWkEVHkQVVEsAy
0 12 S237-p VHkQVVEsAyEVIkL
1 1062 Y239-p kQVVEsAyEVIkLkG
0 2 K243-ac EsAyEVIkLkGYtsW
0 19 K243-ub EsAyEVIkLkGYtsW
0 1 K245-ub AyEVIkLkGYtsWAI
1 1 T248-p VIkLkGYtsWAIGLS
1 1 S249-p IkLkGYtsWAIGLSV
0 2 K278-ac HPVSTMIkGLYGIkD
0 2 K278-ub HPVSTMIkGLYGIkD
0 1 K278-sc HPVSTMIkGLYGIkD
0 1 Y281 STMIkGLYGIkDDVF
0 13 K284-ub IkGLYGIkDDVFLSV
0 1 K284-sc IkGLYGIkDDVFLSV
0 2 T309 DLVKVTLTsEEEARL
0 2 S310-p LVKVTLTsEEEARLK
0 2 K318-ac EEEARLKksADTLWG
0 11 K318-ub EEEARLKksADTLWG
0 1 S319-p EEARLKksADTLWGI
0 2 K328-ac DTLWGIQkELQF___
0 31 K328-ub DTLWGIQkELQF___
0 1 K328-sc DTLWGIQkELQF___
0 1 - gap
0 1 - gap
8176 : Phospho-LDHA (Tyr10) Antibody
  LDH-A iso2  
- gap
K5 ___MATLKDQLIYNL
K5 ___MATLKDQLIYNL
K5 ___MATLKDQLIYNL
Y10 TLKDQLIYNLLKEEQ
K14 QLIYNLLKEEQTPQN
K14 QLIYNLLKEEQTPQN
K14 QLIYNLLKEEQTPQN
T18 NLLKEEQTPQNKITV
K22 EEQTPQNKITVVGVG
S38 VGMACAISILMKDLA
K42 CAISILMKDLADELA
K42 CAISILMKDLADELA
K57 LVDVIEDKLKGEMMD
K57 LVDVIEDKLKGEMMD
K57 LVDVIEDKLKGEMMD
K59 DVIEDKLKGEMMDLQ
K59 DVIEDKLKGEMMDLQ
R73 QHGSLFLRTPKIVSG
K76 SLFLRTPKIVSGKDY
K76 SLFLRTPKIVSGKDY
K81 TPKIVSGKDYNVTAN
K81 TPKIVSGKDYNVTAN
K81 TPKIVSGKDYNVTAN
Y83 KIVSGKDYNVTANSK
S89 DYNVTANSKLVIITA
K90 YNVTANSKLVIITAG
K118 QRNVNIFKFIIPNVV
K118 QRNVNIFKFIIPNVV
K118 QRNVNIFKFIIPNVV
K126 FIIPNVVKYSPNCKL
K126 FIIPNVVKYSPNCKL
K126 FIIPNVVKYSPNCKL
Y127 IIPNVVKYSPNCKLL
S128 IPNVVKYSPNCKLLI
K132 VKYSPNCKLLIVSNP
K132 VKYSPNCKLLIVSNP
T144 SNPVDILTYVAWKIS
Y145 NPVDILTYVAWKISG
K155 WKISGFPKNRVIGSG
K155 WKISGFPKNRVIGSG
K155 WKISGFPKNRVIGSG
Y172 LDSARFRYLMGERLG
K222 HPDLGTDKDKEQWKE
K222 HPDLGTDKDKEQWKE
K222 HPDLGTDKDKEQWKE
K224 DLGTDKDKEQWKECR
K224 DLGTDKDKEQWKECR
K224 DLGTDKDKEQWKECR
K228 DKDKEQWKECRytLG
K228 DKDKEQWKECRytLG
K228 DKDKEQWKECRytLG
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
Y232-p EQWKECRytLGDPKG
T233-p QWKECRytLGDPKGA
  LDH-A iso3  
K27-ub AKIPFGSkSNMATLK
K34 kSNMATLKDQLIYNL
K34 kSNMATLKDQLIYNL
K34 kSNMATLKDQLIYNL
Y39 TLKDQLIYNLLKEEQ
K43 QLIYNLLKEEQTPQN
K43 QLIYNLLKEEQTPQN
K43 QLIYNLLKEEQTPQN
T47 NLLKEEQTPQNKITV
K51 EEQTPQNKITVVGVG
S67 VGMACAISILMKDLA
K71 CAISILMKDLADELA
K71 CAISILMKDLADELA
K86 LVDVIEDKLKGEMMD
K86 LVDVIEDKLKGEMMD
K86 LVDVIEDKLKGEMMD
K88 DVIEDKLKGEMMDLQ
K88 DVIEDKLKGEMMDLQ
R102 QHGSLFLRTPKIVSG
K105 SLFLRTPKIVSGKDY
K105 SLFLRTPKIVSGKDY
K110 TPKIVSGKDYNVTAN
K110 TPKIVSGKDYNVTAN
K110 TPKIVSGKDYNVTAN
Y112 KIVSGKDYNVTANSK
S118 DYNVTANSKLVIITA
K119 YNVTANSKLVIITAG
K147 QRNVNIFKFIIPNVV
K147 QRNVNIFKFIIPNVV
K147 QRNVNIFKFIIPNVV
K155 FIIPNVVKYSPNCKL
K155 FIIPNVVKYSPNCKL
K155 FIIPNVVKYSPNCKL
Y156 IIPNVVKYSPNCKLL
S157 IPNVVKYSPNCKLLI
K161 VKYSPNCKLLIVSNP
K161 VKYSPNCKLLIVSNP
T173 SNPVDILTYVAWKIS
Y174 NPVDILTYVAWKISG
K184 WKISGFPKNRVIGSG
K184 WKISGFPKNRVIGSG
K184 WKISGFPKNRVIGSG
Y201 LDSARFRYLMGERLG
K251 HPDLGTDKDKEQWKE
K251 HPDLGTDKDKEQWKE
K251 HPDLGTDKDKEQWKE
K253 DLGTDKDKEQWKEVH
K253 DLGTDKDKEQWKEVH
K253 DLGTDKDKEQWKEVH
K257 DKDKEQWKEVHKQVV
K257 DKDKEQWKEVHKQVV
K257 DKDKEQWKEVHKQVV
K261 EQWKEVHKQVVESAY
K261 EQWKEVHKQVVESAY
K261 EQWKEVHKQVVESAY
S266 VHKQVVESAYEVIKL
Y268 KQVVESAYEVIKLKG
K272 ESAYEVIKLKGYTSW
K272 ESAYEVIKLKGYTSW
K274 AYEVIKLKGYTSWAI
T277 VIKLKGYTSWAIGLS
S278 IKLKGYTSWAIGLSV
K307 HPVSTMIKGLYGIKD
K307 HPVSTMIKGLYGIKD
K307 HPVSTMIKGLYGIKD
Y310 STMIKGLYGIKDDVF
K313 IKGLYGIKDDVFLSV
K313 IKGLYGIKDDVFLSV
T338 DLVKVTLTSEEEARL
S339 LVKVTLTSEEEARLK
K347 EEEARLKKSADTLWG
K347 EEEARLKKSADTLWG
S348 EEARLKKSADTLWGI
K357 DTLWGIQKELQF___
K357 DTLWGIQKELQF___
K357 DTLWGIQKELQF___
- gap
- gap
8176 : Phospho-LDHA (Tyr10) Antibody
  mouse

 
- gap
K5-ac ___MATLkDQLIVNL
K5-ub ___MATLkDQLIVNL
K5-sc ___MATLkDQLIVNL
V10 TLkDQLIVNLLkEEQ
K14-ac QLIVNLLkEEQAPQN
K14-ub QLIVNLLkEEQAPQN
K14-sc QLIVNLLkEEQAPQN
A18 NLLkEEQAPQNKITV
K22 EEQAPQNKITVVGVG
S38-p VGMACAIsILMKDLA
K42 CAIsILMKDLADELA
K42 CAIsILMKDLADELA
K57-ac LVDVMEDkLkGEMMD
K57 LVDVMEDKLkGEMMD
K57-ub LVDVMEDkLkGEMMD
K59 DVMEDkLKGEMMDLQ
K59-ub DVMEDkLkGEMMDLQ
K73-ub QHGSLFLkTPkIVSS
K76-ub SLFLkTPkIVSSkDY
K76 SLFLkTPKIVSSkDY
K81-ac TPkIVSSkDYCVTAN
K81-ub TPkIVSSkDYCVTAN
K81 TPkIVSSKDYCVTAN
Y83 kIVSSkDYCVTANSK
S89 DYCVTANSKLVIITA
K90 YCVTANSKLVIITAG
K118-ac QRNVNIFkFIIPNIV
K118-ub QRNVNIFkFIIPNIV
K118 QRNVNIFKFIIPNIV
K126 FIIPNIVKYSPHCKL
K126-ub FIIPNIVkYSPHCKL
K126 FIIPNIVKYSPHCKL
Y127 IIPNIVkYSPHCKLL
S128 IPNIVkYSPHCKLLI
K132 VkYSPHCKLLIVSNP
K132 VkYSPHCKLLIVSNP
T144-p SNPVDILtyVAWKIS
Y145-p NPVDILtyVAWKISG
K155-ac WKISGFPkNRVIGSG
K155 WKISGFPKNRVIGSG
K155-sc WKISGFPkNRVIGSG
Y172-p LDSARFRyLMGERLG
A222 NPELGTDADkEQWkE
A222 NPELGTDADkEQWkE
A222 NPELGTDADkEQWkE
K224-ac ELGTDADkEQWkEVH
K224-ub ELGTDADkEQWkEVH
K224-sc ELGTDADkEQWkEVH
K228-ac DADkEQWkEVHkQVV
K228-ub DADkEQWkEVHkQVV
K228-sc DADkEQWkEVHkQVV
K232-ac EQWkEVHkQVVDsAy
K232-ub EQWkEVHkQVVDsAy
K232-sc EQWkEVHkQVVDsAy
S237-p VHkQVVDsAyEVIkL
Y239-p kQVVDsAyEVIkLKG
K243-ac DsAyEVIkLKGYTSW
K243-ub DsAyEVIkLKGYTSW
K245 AyEVIkLKGYTSWAI
T248 VIkLKGYTSWAIGLS
S249 IkLKGYTSWAIGLSV
K278 HPISTMIKGLYGINE
K278 HPISTMIKGLYGINE
K278 HPISTMIKGLYGINE
Y281 STMIKGLYGINEDVF
N284 IKGLYGINEDVFLSV
N284 IKGLYGINEDVFLSV
T309-p DVVKVTLtPEEEARL
P310 VVKVTLtPEEEARLK
K318-ac EEEARLKkSADTLWG
K318-ub EEEARLKkSADTLWG
S319 EEARLKkSADTLWGI
K328-ac DTLWGIQkELQF___
K328-ub DTLWGIQkELQF___
K328 DTLWGIQKELQF___
- gap
- gap
  rat

 
- gap
K5 ___MAALKDQLIVNL
K5 ___MAALKDQLIVNL
K5 ___MAALKDQLIVNL
V10 ALKDQLIVNLLKEEQ
K14 QLIVNLLKEEQVPQN
K14 QLIVNLLKEEQVPQN
K14 QLIVNLLKEEQVPQN
V18 NLLKEEQVPQNKITV
K22 EEQVPQNKITVVGVG
S38 VGMACAISILMkDLA
K42-m1 CAISILMkDLADELA
K42-m2 CAISILMkDLADELA
K57 LVDVIEDKLkGEMMD
K57-m2 LVDVIEDkLkGEMMD
K57 LVDVIEDKLkGEMMD
K59-m2 DVIEDkLkGEMMDLQ
K59 DVIEDkLKGEMMDLQ
K73 QHGSLFLKTPKIVSS
K76 SLFLKTPKIVSSKDY
K76 SLFLKTPKIVSSKDY
K81 TPKIVSSKDYSVTAN
K81 TPKIVSSKDYSVTAN
K81 TPKIVSSKDYSVTAN
Y83 KIVSSKDYSVTANSK
S89 DYSVTANSKLVIITA
K90 YSVTANSKLVIITAG
K118 QRNVNIFKFIIPNVV
K118 QRNVNIFKFIIPNVV
K118 QRNVNIFKFIIPNVV
K126 FIIPNVVKYSPQCKL
K126 FIIPNVVKYSPQCKL
K126 FIIPNVVKYSPQCKL
Y127 IIPNVVKYSPQCKLL
S128 IPNVVKYSPQCKLLI
K132 VKYSPQCKLLIVSNP
K132 VKYSPQCKLLIVSNP
T144 SNPVDILTYVAWKIS
Y145 NPVDILTYVAWKISG
K155 WKISGFPKNRVIGSG
K155 WKISGFPKNRVIGSG
K155 WKISGFPKNRVIGSG
Y172 LDSARFRYLMGERLG
A222 NPQLGTDADKEQWKD
A222 NPQLGTDADKEQWKD
A222 NPQLGTDADKEQWKD
K224 QLGTDADKEQWKDVH
K224 QLGTDADKEQWKDVH
K224 QLGTDADKEQWKDVH
K228 DADKEQWKDVHKQVV
K228 DADKEQWKDVHKQVV
K228 DADKEQWKDVHKQVV
K232 EQWKDVHKQVVDSAy
K232 EQWKDVHKQVVDSAy
K232 EQWKDVHKQVVDSAy
S237 VHKQVVDSAyEVIKL
Y239-p KQVVDSAyEVIKLKG
K243 DSAyEVIKLKGYTSW
K243 DSAyEVIKLKGYTSW
K245 AyEVIKLKGYTSWAI
T248 VIKLKGYTSWAIGLS
S249 IKLKGYTSWAIGLSV
K278 HPISTMIKGLyGIKE
K278 HPISTMIKGLyGIKE
K278 HPISTMIKGLyGIKE
Y281-p STMIKGLyGIKEDVF
K284 IKGLyGIKEDVFLSV
K284 IKGLyGIKEDVFLSV
T309 DVVKVTLTPDEEARL
P310 VVKVTLTPDEEARLK
K318 DEEARLKKsADTLWG
K318 DEEARLKKsADTLWG
S319-p EEARLKKsADTLWGI
K328 DTLWGIQKELQF___
K328 DTLWGIQKELQF___
K328 DTLWGIQKELQF___
- gap
- gap
  chicken

 
- gap
K4 ____MSLKDHLIHNV
K4 ____MSLKDHLIHNV
K4 ____MSLKDHLIHNV
H9 SLKDHLIHNVHKEEH
K13 HLIHNVHKEEHAHAH
K13 HLIHNVHKEEHAHAH
K13 HLIHNVHKEEHAHAH
A17 NVHKEEHAHAHNKIS
K22 EHAHAHNKISVVGVG
S38 VGMACAISILMKDLA
K42 CAISILMKDLADELT
K42 CAISILMKDLADELT
K57 LVDVVEDKLKGEMLD
K57 LVDVVEDKLKGEMLD
K57 LVDVVEDKLKGEMLD
K59 DVVEDKLKGEMLDLQ
K59 DVVEDKLKGEMLDLQ
K73 QHGSLFLKTPKIISG
K76 SLFLKTPKIISGKDY
K76 SLFLKTPKIISGKDY
K81 TPKIISGKDYSVTAH
K81 TPKIISGKDYSVTAH
K81 TPKIISGKDYSVTAH
Y83 KIISGKDYSVTAHSK
S89 DYSVTAHSKLVIVTA
K90 YSVTAHSKLVIVTAG
K118 QRNVNIFKFIIPNVV
K118 QRNVNIFKFIIPNVV
K118 QRNVNIFKFIIPNVV
K126 FIIPNVVKYSPDCKL
K126 FIIPNVVKYSPDCKL
K126 FIIPNVVKYSPDCKL
Y127 IIPNVVKYSPDCKLL
S128 IPNVVKYSPDCKLLI
K132 VKYSPDCKLLIVSNP
K132 VKYSPDCKLLIVSNP
T144 SNPVDILTYVAWKIS
Y145 NPVDILTYVAWKISG
K155 WKISGFPKHRVIGSG
K155 WKISGFPKHRVIGSG
K155 WKISGFPKHRVIGSG
H172 LDSARFRHLMGERLG
A222 HPDMGTDADKEHWKE
A222 HPDMGTDADKEHWKE
A222 HPDMGTDADKEHWKE
K224 DMGTDADKEHWKEVH
K224 DMGTDADKEHWKEVH
K224 DMGTDADKEHWKEVH
K228 DADKEHWKEVHKQVV
K228 DADKEHWKEVHKQVV
K228 DADKEHWKEVHKQVV
K232 EHWKEVHKQVVDSAy
K232 EHWKEVHKQVVDSAy
K232 EHWKEVHKQVVDSAy
S237 VHKQVVDSAyEVIKL
Y239-p KQVVDSAyEVIKLKG
K243 DSAyEVIKLKGYTSW
K243 DSAyEVIKLKGYTSW
K245 AyEVIKLKGYTSWAI
T248 VIKLKGYTSWAIGLS
S249 IKLKGYTSWAIGLSV
K278 HPISTAVKGMHGIKD
K278 HPISTAVKGMHGIKD
K278 HPISTAVKGMHGIKD
H281 STAVKGMHGIKDDVF
K284 VKGMHGIKDDVFLSV
K284 VKGMHGIKDDVFLSV
K309 DVVKMILKPDEEEKI
P310 VVKMILKPDEEEKIK
K318 DEEEKIKKSADTLWG
K318 DEEEKIKKSADTLWG
S319 EEEKIKKSADTLWGI
K328 DTLWGIQKELQF___
K328 DTLWGIQKELQF___
K328 DTLWGIQKELQF___
- gap
- gap
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