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LDH-A (human)

Overview LDH-A Homotetramer. Belongs to the LDH/MDH superfamily. LDH family. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Carbohydrate Metabolism - pyruvate; Apoptosis; EC 1.1.1.27; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Amino Acid Metabolism - cysteine and methionine; Carbohydrate Metabolism - propanoate; Oxidoreductase Cellular Component: mitochondrion; flagellum; cytosol Molecular Function: nucleotide binding; L-lactate dehydrogenase activity Biological Process: glycolysis; cellular response to extracellular stimulus; cellular carbohydrate metabolic process; pyruvate metabolic process Reference #:  P00338 (UniProtKB) Alt. Names/Synonyms: Cell proliferation-inducing gene 19 protein; GSD11; L-lactate dehydrogenase A chain; lactate dehydrogenase A; lactate dehydrogenase M; LDH muscle subunit; LDH-A; LDH-M; LDH1; LDHA; LDHM; PIG19; proliferation-inducing gene 19; Renal carcinoma antigen NY-REN-59 Gene Symbols: LDHA Molecular weight: 36,689 Da Basal Isoelectric point: 8.44  Predict pI for various phosphorylation states CST Pathways:  Warburg Effect Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below LDH-A 1I10 - A/B/C/D/E/F/G/H=1-332 (human) 4AJP - A/D/C/B=2-332 (human) 4AJ1 - A/D/C/B=2-332 (rat) 4AJ2 - A/D/C/B=2-332 (rat) 4AJ4 - A/D/C/B=1-332 (rat) 4AJE - A/D/C/B=2-332 (rat) 4AJH - A/D/C/B=2-332 (rat) 4AJI - A/D/C/B=2-332 (rat) 4AJJ - A/D/C/B=2-332 (rat) 4AJK - A/D/C/B=2-332 (rat) 4AJL - A/D/C/B=2-332 (rat) 4AJN - A/D/C/B=2-332 (rat) 4AJO - A/D/C/B=2-332 (rat) 4AL4 - A/D/C/B=2-332 (rat)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1I10 4AJP  |  ENZYME  |  Phospho3D  |  DISEASE 150000 612933  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
carcinogenesis, induced: Y10‑p cell growth, induced: Y10‑p enzymatic activity, induced: Y10‑p, Y83‑p molecular association, regulation: Y10‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	1		-	gap
0	77		K5-a	___MATLkDQLIyNL
0	3		K5-u	___MATLkDQLIyNL
1	332		Y10-p	TLkDQLIyNLLkEEQ
0	6		K14-a	QLIyNLLkEEQtPQN
0	52		K14-u	QLIyNLLkEEQtPQN
0	1		T18-p	NLLkEEQtPQNkITV
0	1		K22-a	EEQtPQNkITVVGVG
0	1		S38	VGMACAISILMKDLA
1	1		K42	CAISILMKDLADELA
1	1		K42	CAISILMKDLADELA
0	2		K57-a	LVDVIEDkLkGEMMD
1	1		K57	LVDVIEDKLkGEMMD
0	10		K57-u	LVDVIEDkLkGEMMD
1	1		K59	DVIEDkLKGEMMDLQ
0	10		K59-u	DVIEDkLkGEMMDLQ
0	1		R73	QHGSLFLRTPkIVSG
0	45		K76-u	SLFLRTPkIVSGkDy
0	22		K81-a	TPkIVSGkDyNVTAN
0	43		K81-u	TPkIVSGkDyNVTAN
1	4		Y83-p	kIVSGkDyNVTANSk
0	2		K90-u	yNVTANSkLVIITAG
0	23		K118-a	QRNVNIFkFIIPNVV
0	83		K118-u	QRNVNIFkFIIPNVV
0	19		K126-a	FIIPNVVkysPNCkL
0	22		K126-u	FIIPNVVkysPNCkL
0	44		Y127-p	IIPNVVkysPNCkLL
0	3		S128-p	IPNVVkysPNCkLLI
0	1		K132-a	VkysPNCkLLIVSNP
0	18		K132-u	VkysPNCkLLIVSNP
0	1		T144	SNPVDILTyVAWKIS
0	18		Y145-p	NPVDILTyVAWKISG
0	3		K155-u	WKISGFPkNRVIGSG
0	21		Y172-p	LDSARFRyLMGERLG
0	1		K222-a	HPDLGTDkDkEQWkE
0	4		K222-u	HPDLGTDkDkEQWkE
0	6		K224-u	DLGTDkDkEQWkEVH
0	1		K224	DLGTDkDKEQWkEVH
0	4		K228-a	DkDkEQWkEVHkQVV
0	2		K228-u	DkDkEQWkEVHkQVV
0	4		K232-u	EQWkEVHkQVVEsAy
0	1		K232	EQWkEVHKQVVEsAy
0	11		S237-p	VHkQVVEsAyEVIkL
1	1033		Y239-p	kQVVEsAyEVIkLkG
0	19		K243-u	EsAyEVIkLkGYtsW
0	1		K243	EsAyEVIKLkGYtsW
0	1		K245-u	AyEVIkLkGYtsWAI
1	1		T248-p	VIkLkGYtsWAIGLS
1	1		S249-p	IkLkGYtsWAIGLSV
0	1		K278-a	HPVSTMIkGLYGIkD
0	2		K278-u	HPVSTMIkGLYGIkD
0	1		Y281	STMIkGLYGIkDDVF
0	13		K284-u	IkGLYGIkDDVFLSV
0	1		T309	DLVKVTLTSEEEARL
0	1		K318-a	EEEARLKkSADTLWG
0	11		K318-u	EEEARLKkSADTLWG
0	1		K328-a	DTLWGIQkELQF___
0	31		K328-u	DTLWGIQkELQF___

	LDH-A iso3
K27-u	AKIPFGSkSNMATLK
K34	kSNMATLKDQLIYNL
K34	kSNMATLKDQLIYNL
Y39	TLKDQLIYNLLKEEQ
K43	QLIYNLLKEEQTPQN
K43	QLIYNLLKEEQTPQN
T47	NLLKEEQTPQNKITV
K51	EEQTPQNKITVVGVG
S67	VGMACAISILMKDLA
K71	CAISILMKDLADELA
K71	CAISILMKDLADELA
K86	LVDVIEDKLKGEMMD
K86	LVDVIEDKLKGEMMD
K86	LVDVIEDKLKGEMMD
K88	DVIEDKLKGEMMDLQ
K88	DVIEDKLKGEMMDLQ
R102	QHGSLFLRTPKIVSG
K105	SLFLRTPKIVSGKDY
K110	TPKIVSGKDYNVTAN
K110	TPKIVSGKDYNVTAN
Y112	KIVSGKDYNVTANSK
K119	YNVTANSKLVIITAG
K147	QRNVNIFKFIIPNVV
K147	QRNVNIFKFIIPNVV
K155	FIIPNVVKYSPNCKL
K155	FIIPNVVKYSPNCKL
Y156	IIPNVVKYSPNCKLL
S157	IPNVVKYSPNCKLLI
K161	VKYSPNCKLLIVSNP
K161	VKYSPNCKLLIVSNP
T173	SNPVDILTYVAWKIS
Y174	NPVDILTYVAWKISG
K184	WKISGFPKNRVIGSG
Y201	LDSARFRYLMGERLG
K251	HPDLGTDKDKEQWKE
K251	HPDLGTDKDKEQWKE
K253	DLGTDKDKEQWKEVH
K253	DLGTDKDKEQWKEVH
K257	DKDKEQWKEVHKQVV
K257	DKDKEQWKEVHKQVV
K261	EQWKEVHKQVVESAY
K261	EQWKEVHKQVVESAY
S266	VHKQVVESAYEVIKL
Y268	KQVVESAYEVIKLKG
K272	ESAYEVIKLKGYTSW
K272	ESAYEVIKLKGYTSW
K274	AYEVIKLKGYTSWAI
T277	VIKLKGYTSWAIGLS
S278	IKLKGYTSWAIGLSV
K307	HPVSTMIKGLYGIKD
K307	HPVSTMIKGLYGIKD
Y310	STMIKGLYGIKDDVF
K313	IKGLYGIKDDVFLSV
T338	DLVKVTLTSEEEARL
K347	EEEARLKKSADTLWG
K347	EEEARLKKSADTLWG
K357	DTLWGIQKELQF___
K357	DTLWGIQKELQF___

	mouse
-	gap
K5-a	___MATLkDQLIVNL
K5-u	___MATLkDQLIVNL
V10	TLkDQLIVNLLkEEQ
K14-a	QLIVNLLkEEQAPQN
K14-u	QLIVNLLkEEQAPQN
A18	NLLkEEQAPQNKITV
K22	EEQAPQNKITVVGVG
S38-p	VGMACAIsILMKDLA
K42	CAIsILMKDLADELA
K42	CAIsILMKDLADELA
K57-a	LVDVMEDkLkGEMMD
K57	LVDVMEDKLkGEMMD
K57-u	LVDVMEDkLkGEMMD
K59	DVMEDkLKGEMMDLQ
K59-u	DVMEDkLkGEMMDLQ
K73-u	QHGSLFLkTPkIVSS
K76-u	SLFLkTPkIVSSkDY
K81-a	TPkIVSSkDYCVTAN
K81-u	TPkIVSSkDYCVTAN
Y83	kIVSSkDYCVTANSK
K90	YCVTANSKLVIITAG
K118-a	QRNVNIFkFIIPNIV
K118-u	QRNVNIFkFIIPNIV
K126	FIIPNIVKYSPHCKL
K126-u	FIIPNIVkYSPHCKL
Y127	IIPNIVkYSPHCKLL
S128	IPNIVkYSPHCKLLI
K132	VkYSPHCKLLIVSNP
K132	VkYSPHCKLLIVSNP
T144-p	SNPVDILtyVAWKIS
Y145-p	NPVDILtyVAWKISG
K155	WKISGFPKNRVIGSG
Y172-p	LDSARFRyLMGERLG
A222	NPELGTDADkEQWkE
A222	NPELGTDADkEQWkE
K224-u	ELGTDADkEQWkEVH
K224-a	ELGTDADkEQWkEVH
K228-a	DADkEQWkEVHkQVV
K228-u	DADkEQWkEVHkQVV
K232-u	EQWkEVHkQVVDsAy
K232-a	EQWkEVHkQVVDsAy
S237-p	VHkQVVDsAyEVIkL
Y239-p	kQVVDsAyEVIkLKG
K243-u	DsAyEVIkLKGYTSW
K243-a	DsAyEVIkLKGYTSW
K245	AyEVIkLKGYTSWAI
T248	VIkLKGYTSWAIGLS
S249	IkLKGYTSWAIGLSV
K278	HPISTMIKGLYGINE
K278	HPISTMIKGLYGINE
Y281	STMIKGLYGINEDVF
N284	IKGLYGINEDVFLSV
T309-p	DVVKVTLtPEEEARL
K318	EEEARLKKSADTLWG
K318-u	EEEARLKkSADTLWG
K328	DTLWGIQKELQF___
K328-u	DTLWGIQkELQF___

	rat
-	gap
K5	___MAALKDQLIVNL
K5	___MAALKDQLIVNL
V10	ALKDQLIVNLLKEEQ
K14	QLIVNLLKEEQVPQN
K14	QLIVNLLKEEQVPQN
V18	NLLKEEQVPQNKITV
K22	EEQVPQNKITVVGVG
S38	VGMACAISILMkDLA
K42-m1	CAISILMkDLADELA
K42-m2	CAISILMkDLADELA
K57	LVDVIEDKLkGEMMD
K57-m2	LVDVIEDkLkGEMMD
K57	LVDVIEDKLkGEMMD
K59-m2	DVIEDkLkGEMMDLQ
K59	DVIEDkLKGEMMDLQ
K73	QHGSLFLKTPKIVSS
K76	SLFLKTPKIVSSKDY
K81	TPKIVSSKDYSVTAN
K81	TPKIVSSKDYSVTAN
Y83	KIVSSKDYSVTANSK
K90	YSVTANSKLVIITAG
K118	QRNVNIFKFIIPNVV
K118	QRNVNIFKFIIPNVV
K126	FIIPNVVKYSPQCKL
K126	FIIPNVVKYSPQCKL
Y127	IIPNVVKYSPQCKLL
S128	IPNVVKYSPQCKLLI
K132	VKYSPQCKLLIVSNP
K132	VKYSPQCKLLIVSNP
T144	SNPVDILTYVAWKIS
Y145	NPVDILTYVAWKISG
K155	WKISGFPKNRVIGSG
Y172	LDSARFRYLMGERLG
A222	NPQLGTDADKEQWKD
A222	NPQLGTDADKEQWKD
K224	QLGTDADKEQWKDVH
K224	QLGTDADKEQWKDVH
K228	DADKEQWKDVHKQVV
K228	DADKEQWKDVHKQVV
K232	EQWKDVHKQVVDSAy
K232	EQWKDVHKQVVDSAy
S237	VHKQVVDSAyEVIKL
Y239-p	KQVVDSAyEVIKLKG
K243	DSAyEVIKLKGYTSW
K243	DSAyEVIKLKGYTSW
K245	AyEVIKLKGYTSWAI
T248	VIKLKGYTSWAIGLS
S249	IKLKGYTSWAIGLSV
K278	HPISTMIKGLyGIKE
K278	HPISTMIKGLyGIKE
Y281-p	STMIKGLyGIKEDVF
K284	IKGLyGIKEDVFLSV
T309	DVVKVTLTPDEEARL
K318	DEEARLKKSADTLWG
K318	DEEARLKKSADTLWG
K328	DTLWGIQKELQF___
K328	DTLWGIQKELQF___

	chicken
-	gap
K4	____MSLKDHLIHNV
K4	____MSLKDHLIHNV
H9	SLKDHLIHNVHKEEH
K13	HLIHNVHKEEHAHAH
K13	HLIHNVHKEEHAHAH
A17	NVHKEEHAHAHNKIS
K22	EHAHAHNKISVVGVG
S38	VGMACAISILMKDLA
K42	CAISILMKDLADELT
K42	CAISILMKDLADELT
K57	LVDVVEDKLKGEMLD
K57	LVDVVEDKLKGEMLD
K57	LVDVVEDKLKGEMLD
K59	DVVEDKLKGEMLDLQ
K59	DVVEDKLKGEMLDLQ
K73	QHGSLFLKTPKIISG
K76	SLFLKTPKIISGKDY
K81	TPKIISGKDYSVTAH
K81	TPKIISGKDYSVTAH
Y83	KIISGKDYSVTAHSK
K90	YSVTAHSKLVIVTAG
K118	QRNVNIFKFIIPNVV
K118	QRNVNIFKFIIPNVV
K126	FIIPNVVKYSPDCKL
K126	FIIPNVVKYSPDCKL
Y127	IIPNVVKYSPDCKLL
S128	IPNVVKYSPDCKLLI
K132	VKYSPDCKLLIVSNP
K132	VKYSPDCKLLIVSNP
T144	SNPVDILTYVAWKIS
Y145	NPVDILTYVAWKISG
K155	WKISGFPKHRVIGSG
H172	LDSARFRHLMGERLG
A222	HPDMGTDADKEHWKE
A222	HPDMGTDADKEHWKE
K224	DMGTDADKEHWKEVH
K224	DMGTDADKEHWKEVH
K228	DADKEHWKEVHKQVV
K228	DADKEHWKEVHKQVV
K232	EHWKEVHKQVVDSAy
K232	EHWKEVHKQVVDSAy
S237	VHKQVVDSAyEVIKL
Y239-p	KQVVDSAyEVIKLKG
K243	DSAyEVIKLKGYTSW
K243	DSAyEVIKLKGYTSW
K245	AyEVIKLKGYTSWAI
T248	VIKLKGYTSWAIGLS
S249	IKLKGYTSWAIGLSV
K278	HPISTAVKGMHGIKD
K278	HPISTAVKGMHGIKD
H281	STAVKGMHGIKDDVF
K284	VKGMHGIKDDVFLSV
K309	DVVKMILKPDEEEKI
K318	DEEEKIKKSADTLWG
K318	DEEEKIKKSADTLWG
K328	DTLWGIQKELQF___
K328	DTLWGIQKELQF___

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