Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
DJ-1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
DJ-1 associated with autosomal recessive early onset parkinsonism. Involved in the oxidative stress response. Three cysteines in DJ-1 may be oxidized to cysteine sulphonic acid in the cellular response to H2O2. Loss of DJ-1 function may lead to neurodegeneration. Note: This description may include information from UniProtKB.
Protein type: Transcription regulation; Nuclear receptor co-regulator; EC 3.4.-.-; Oncoprotein
Cellular Component: mitochondrion; cytoplasm; plasma membrane; cytosol; nucleus; lipid raft
Molecular Function: mRNA binding; peptidase activity; protein binding; peroxidase activity; protein homodimerization activity; peroxiredoxin activity; androgen receptor binding
Biological Process: cell death; mitochondrion organization and biogenesis; protein stabilization; adult locomotory behavior; membrane hyperpolarization; membrane depolarization; single fertilization; regulation of inflammatory response; regulation of neuron apoptosis; hydrogen peroxide metabolic process; autophagy; dopamine uptake; negative regulation of neuron apoptosis; inflammatory response; negative regulation of protein binding
Reference #:  Q99497 (UniProtKB)
Alt. Names/Synonyms: DJ-1; DJ1; FLJ27376; FLJ34360; FLJ92274; Oncogene DJ1; PARK7; Parkinson disease (autosomal recessive, early onset) 7; Parkinson disease protein 7; Protein DJ-1
Gene Symbols: PARK7
Molecular weight: 19,891 Da
Basal Isoelectric point: 6.33  Predict pI for various phosphorylation states
CST Pathways:  Parkinson's Disease
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

DJ-1

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  Phospho3D  |  DISEASE  |  Source  |  NURSA  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T19-p KGAEEMEtVIPVDVM
0 1 K32 VMRRAGIKVTVAGLA
0 3 K41-u TVAGLAGkDPVQCSR
0 1 S47 GkDPVQCSRDVVICP
0 12 K62-a DASLEDAkKEGPyDV
0 16 Y67-p DAkKEGPyDVVVLPG
4 0 K130-s VTTHPLAkDKMMNGG
0 1 K132 THPLAkDKMMNGGHy
0 3 Y139-p KMMNGGHyTySENRV
0 2 T140 MMNGGHyTySENRVE
0 2 Y141-p MNGGHyTySENRVEk
0 2 K148-a ySENRVEkDGLILTS
0 2 K148-u ySENRVEkDGLILTS
1 1 T154 EkDGLILTSRGPGTS
1 1 S155 kDGLILTSRGPGTSF
0 2 K175-u IVEALNGkEVAAQVK
0 1 K182 kEVAAQVKAPLVLKD
  mouse

 
T19 KGAEEMETVIPVDVM
K32-u VMRRAGIkVTVAGLA
K41-u TVAGLAGkDPVQCsR
S47-p GkDPVQCsRDVMICP
K62 DTSLEDAKTQGPYDV
Y67 DAKTQGPYDVVVLPG
K130 VTTHPLAKDkMMNGS
K132-u THPLAKDkMMNGSHY
Y139 kMMNGSHYsYSESRV
S140-p MMNGSHYsYSESRVE
Y141 MNGSHYsYSESRVEk
K148-a YSESRVEkDGLILTS
K148-u YSESRVEkDGLILTS
T154 EkDGLILTSRGPGTS
S155 kDGLILTSRGPGTSF
K175 IVEALVGKDMANQVk
K182-u KDMANQVkAPLVLKD
  rat

 
T19 KGAEEMETVIPVDIM
K32 IMRRAGIKVTVAGLA
K41 TVAGLAGKDPVQCSR
S47 GKDPVQCSRDVVICP
K62 DTSLEEAKTQGPYDV
Y67 EAKTQGPYDVVVLPG
K130 VTSHPLAKDKMMNGS
K132 SHPLAKDKMMNGSHY
Y139 KMMNGSHYSYSESRV
S140 MMNGSHYSYSESRVE
Y141 MNGSHYSYSESRVEK
K148 YSESRVEKDGLILts
K148 YSESRVEKDGLILts
T154-p EKDGLILtsRGPGTS
S155-p KDGLILtsRGPGTSF
K175 IVEALSGKDMANQVK
K182 KDMANQVKAPLVLKD
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.