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DJ-1 (human)

Overview DJ-1 associated with autosomal recessive early onset parkinsonism. Involved in the oxidative stress response. Three cysteines in DJ-1 may be oxidized to cysteine sulphonic acid in the cellular response to H2O2. Loss of DJ-1 function may lead to neurodegeneration. Note: This description may include information from UniProtKB. Protein type: Transcription regulation; Oncoprotein; EC 3.4.-.-; Nuclear receptor co-regulator Cellular Component: mitochondrion; axon; cytoplasm; nucleus; cytosol Molecular Function: peptidase activity; mRNA binding; protein binding; protein homodimerization activity; peroxidase activity; peroxiredoxin activity Biological Process: cell death; response to drug; mitochondrion organization and biogenesis; protein stabilization; adult locomotory behavior; membrane hyperpolarization; proteolysis; membrane depolarization; single fertilization; regulation of neuron apoptosis; regulation of inflammatory response; hydrogen peroxide metabolic process; autophagy; dopamine uptake; negative regulation of neuron apoptosis; inflammatory response; negative regulation of protein binding Reference #:  Q99497 (UniProtKB) Alt. Names/Synonyms: DJ-1; DJ1; FLJ27376; FLJ34360; FLJ92274; Oncogene DJ1; PARK7; Parkinson disease (autosomal recessive, early onset) 7; Parkinson disease protein 7; Protein DJ-1 Gene Symbols: PARK7 Molecular weight: 19,891 Da Basal Isoelectric point: 6.33  Predict pI for various phosphorylation states CST Pathways:  Parkinson's Disease Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below DJ-1 1J42 - A=1-189 (human) 1P5F - A=1-189 (human) 1PDV - A=1-189 (human) 1PDW - A/B/C/D/E/F/G/H=1-189 (human) 1PE0 - A/B=1-189 (human) 1PS4 - A=1-189 (human) 1Q2U - A=1-189 (human) 1SOA - A=1-189 (human) 1UCF - A/B=1-189 (human) 2OR3 - A/B=1-189 (human) 2R1T - A/B=2-188 (human) 2R1U - A/B=2-188 (human) 2R1V - A/B=2-188 (human) 2RK3 - A=1-189 (human) 2RK4 - A=1-189 (human) 2RK6 - A=1-189 (human) 3B36 - A=1-189 (human) 3B38 - A=1-189 (human) 3B3A - A=1-189 (human) 3BWE - F/A/D/C/G/E/B=1-189 (human) 3CY6 - A=1-189 (human) 3CYF - A=1-189 (human) 3CZ9 - A=1-189 (human) 3CZA - A=1-189 (human) 3EZG - A=1-189 (human) 3F71 - A=1-189 (human) 3SF8 - A/B=1-189 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1J42 1P5F 1PDV 1PDW 1PE0 1PS4 1Q2U 1SOA 1UCF 2OR3 2R1T 2R1U 2R1V 2RK3 2RK4 2RK6 3B36 3B38 3B3A 3BWE 3CY6 3CYF 3CZ9 3CZA 3EZG 3F71 3SF8  |  Phospho3D  |  DISEASE 602533 606324  |  Source  |  NURSA  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	3		K41-u	TVAGLAGkDPVQCSR
0	1		T19-p	KGAEEMEtVIPVDVM
0	1		K32	VMRRAGIKVTVAGLA
0	1		S47	GkDPVQCSRDVVICP
0	12		K62-a	DASLEDAkkEGPyDV
0	1		K63-a	ASLEDAkkEGPyDVV
0	16		Y67-p	DAkkEGPyDVVVLPG
4	0		K130-s	VTTHPLAkDKMMNGG
0	1		K132	THPLAkDKMMNGGHy
0	3		Y139-p	KMMNGGHytysENRV
0	2		T140-p	MMNGGHytysENRVE
0	2		Y141-p	MNGGHytysENRVEk
0	1		S142-p	NGGHytysENRVEkD
0	2		K148-a	ysENRVEkDGLILTS
0	2		K148-u	ysENRVEkDGLILTS
1	1		T154	EkDGLILTSRGPGTS
1	1		S155	kDGLILTSRGPGTSF
0	2		K175-u	IVEALNGkEVAAQVK
0	1		K182	kEVAAQVKAPLVLkD
0	1		K188-u	VKAPLVLkD______

	mouse
K41-u	TVAGLAGkDPVQCsR
T19	KGAEEMETVIPVDVM
K32-u	VMRRAGIkVTVAGLA
S47-p	GkDPVQCsRDVMICP
K62	DTSLEDAKTQGPYDV
T63	TSLEDAKTQGPYDVV
Y67	DAKTQGPYDVVVLPG
K130	VTTHPLAKDkMMNGS
K132-u	THPLAKDkMMNGSHY
Y139	kMMNGSHYsYsESRV
S140-p	MMNGSHYsYsESRVE
Y141	MNGSHYsYsESRVEk
S142-p	NGSHYsYsESRVEkD
K148-a	YsESRVEkDGLILTS
K148-u	YsESRVEkDGLILTS
T154	EkDGLILTSRGPGTS
S155	kDGLILTSRGPGTSF
K175	IVEALVGKDMANQVk
K182-u	KDMANQVkAPLVLKD
K188	VkAPLVLKD______

	rat
K41	TVAGLAGKDPVQCSR
T19	KGAEEMETVIPVDIM
K32	IMRRAGIKVTVAGLA
S47	GKDPVQCSRDVVICP
K62	DTSLEEAKTQGPYDV
T63	TSLEEAKTQGPYDVV
Y67	EAKTQGPYDVVVLPG
K130	VTSHPLAKDKMMNGS
K132	SHPLAKDKMMNGSHY
Y139	KMMNGSHYSYSESRV
S140	MMNGSHYSYSESRVE
Y141	MNGSHYSYSESRVEK
S142	NGSHYSYSESRVEKD
K148	YSESRVEKDGLILts
K148	YSESRVEKDGLILts
T154-p	EKDGLILtsRGPGTS
S155-p	KDGLILtsRGPGTSF
K175	IVEALSGKDMANQVK
K182	KDMANQVKAPLVLKD
K188	VKAPLVLKD______

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