associated with autosomal recessive early onset parkinsonism. Involved in the oxidative stress response. Three cysteines in DJ-1 may be oxidized to cysteine sulphonic acid in the cellular response to H2O2. Loss of DJ-1 function may lead to neurodegeneration. Note: This description may include information from UniProtKB.
Protein type: Transcription regulation; Oncoprotein; EC 3.4.-.-; Nuclear receptor co-regulator
Molecular Function: identical protein binding; oxidoreductase activity, acting on peroxide as acceptor; protein homodimerization activity; transcription factor binding; mRNA binding; peptidase activity; protein binding; enzyme binding; peroxidase activity; peroxiredoxin activity; androgen receptor binding; cytokine binding; double-stranded DNA binding; superoxide dismutase copper chaperone activity; single-stranded DNA binding; receptor binding
Biological Process: mitochondrion organization and biogenesis; negative regulation of protein export from nucleus; protein stabilization; adult locomotory behavior; membrane hyperpolarization; regulation of TRAIL receptor biosynthetic process; proteolysis; positive regulation of interleukin-8 production; membrane depolarization; regulation of mitochondrial membrane potential; negative regulation of protein amino acid phosphorylation; single fertilization; regulation of inflammatory response; regulation of neuron apoptosis; hydrogen peroxide metabolic process; autophagy; negative regulation of protein kinase activity; dopamine uptake; positive regulation of transcription from RNA polymerase II promoter; negative regulation of neuron apoptosis; negative regulation of protein binding; inflammatory response
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.