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RAB6A (human)

Overview RAB6A Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity. Interacts with CCDC64; leads to its accumulation in the pericentrosomal region. Interacts with SCYL1BP1. Interacts with VSP52 and RABGAP1. Interacts with GCC2 (via its GRIP domain). Interacts with RAB6IP1 (via its RUN 1 domain). Isoform 1 interacts with RAB6KIFL. Isoform 2 does not interact with RAB6KIFL. Isoform 1 interacts with BICD1. Isoform 2 interacts with BICD1. Isoform 1 interacts with BICD2. Isoform 2 interacts with BICD2. Interacts with TMF1. Isoform 1 (GTP-bound) interacts with DYNLRB1; the interaction is direct. Isoform 2 (GDP-bound) interacts with DYNLRB1; the interaction is direct. Interacts with PIFO/C1orf88. Ubiquitous. Belongs to the small GTPase superfamily. Rab family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; G protein, monomeric (Rab) Cellular Component: Golgi membrane; Golgi apparatus; membrane; cytoplasmic vesicle; trans-Golgi network; cytosol Molecular Function: GTPase activity; protein domain specific binding; protein binding; GTP binding Biological Process: GTP catabolic process; protein localization in Golgi apparatus; small GTPase mediated signal transduction; retrograde vesicle-mediated transport, Golgi to ER; peptidyl-cysteine methylation; protein targeting to Golgi Reference #:  P20340 (UniProtKB) Alt. Names/Synonyms: GTP-binding protein RAB6A'; GTP-binding protein RAB6B; Oncogene RAB6; Rab GTPase; Rab-6; RAB6; RAB6, member RAS oncogene family; RAB6A; Rab6A variant 3; RAB6A'; RAB6A, member RAS oncogene family; RAB6B; Ras-related protein Rab-6A Gene Symbols: RAB6A Molecular weight: 23,593 Da Basal Isoelectric point: 5.42  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below RAB6A 1YZQ - A=10-177 (human) 2GIL - A/D/C/B=12-173 (human) 3BBP - A/C/B=1-206 (human) 3CWZ - A=8-195 (human) 4DKX - A/B=1-208 (human)

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  RCSB PDB 1YZQ 2GIL 3BBP 3CWZ 4DKX  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	3		S2-p	______MstGGDFGN
0	1		T3-p	_____MstGGDFGNP
0	1		S23-p	LVFLGEQsVGKTSLI
0	1		S117	DVRTERGSDVIIMLV
0	3		K133	NKTDLADKRQVSIEE
0	1		S179	AALPGMESTQDRsRE
0	3		S184-p	MESTQDRsREDMIDI
0	1		K192-a	REDMIDIkLEKPQEQ

	RAB6A iso2
S2	______MSTGGDFGN
T3	_____MSTGGDFGNP
S23	LVFLGEQSVGKTSLI
S117	DVRTERGSDVIIMLV
K133	NKTDLADKRQVSIEE
S179	AALPGMESTQDRSRE
S184	MESTQDRSREDMIDI
K192	REDMIDIKLEKPQEQ

	mouse
S2-p	______MsAGGDFGN
A3	_____MsAGGDFGNP
S23-p	LVFLGEQsVGKTSLI
S117-p	DVRTERGsDVIIMLV
K133-u	NKTDLADkRQVSIEE
S179-p	AALPGMEsTQDRsRE
S184-p	MEsTQDRsREDMIDI
K192	REDMIDIKLEKPQEQ

	rat
S2	______MSAGGDFGN
A3	_____MSAGGDFGNP
S23	LVFLGEQSVGKTSLI
S117	DVRTERGSDVIIMLV
K133-u	NKTDLADkRQVSIEE
S179	AALPGMESTQDRSRE
S184	MESTQDRSREDMIDI
K192	REDMIDIKLEKPQEQ

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