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Protein Page:
RAB6A (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
RAB6A Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity. Interacts with CCDC64; leads to its accumulation in the pericentrosomal region. Interacts with SCYL1BP1. Interacts with VSP52 and RABGAP1. Interacts with GCC2 (via its GRIP domain). Interacts with RAB6IP1 (via its RUN 1 domain). Isoform 1 interacts with RAB6KIFL. Isoform 2 does not interact with RAB6KIFL. Isoform 1 interacts with BICD1. Isoform 2 interacts with BICD1. Isoform 1 interacts with BICD2. Isoform 2 interacts with BICD2. Interacts with TMF1. Isoform 1 (GTP-bound) interacts with DYNLRB1; the interaction is direct. Isoform 2 (GDP-bound) interacts with DYNLRB1; the interaction is direct. Interacts with PIFO/C1orf88. Ubiquitous. Belongs to the small GTPase superfamily. Rab family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; G protein, monomeric, Rab; G protein, monomeric
Cellular Component: Golgi membrane; Golgi apparatus; membrane; cytoplasmic vesicle; trans-Golgi network; cytosol
Molecular Function: GTPase activity; protein domain specific binding; protein binding; GTP binding
Biological Process: antigen processing and presentation; GTP catabolic process; protein localization in Golgi apparatus; small GTPase mediated signal transduction; retrograde vesicle-mediated transport, Golgi to ER; peptidyl-cysteine methylation; protein targeting to Golgi
Reference #:  P20340 (UniProtKB)
Alt. Names/Synonyms: GTP-binding protein RAB6A'; GTP-binding protein RAB6B; Oncogene RAB6; Rab GTPase; Rab-6; RAB6; RAB6, member RAS oncogene family; RAB6A; Rab6A variant 3; RAB6A'; RAB6A, member RAS oncogene family; RAB6B; Ras-related protein Rab-6A
Gene Symbols: RAB6A
Molecular weight: 23,593 Da
Basal Isoelectric point: 5.42  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

RAB6A

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 3 S2-p ______MstGGDFGN
0 1 T3-p _____MstGGDFGNP
0 2 S23-p LVFLGEQsVGKTSLI
0 1 S117 DVRTERGSDVIIMLV
0 3 K133 NKTDLADKRQVSIEE
0 1 S179 AALPGMESTQDRsRE
0 7 S184-p MESTQDRsREDMIDI
0 1 K192-ac REDMIDIkLEKPQEQ
  RAB6A iso2  
S2 ______MSTGGDFGN
T3 _____MSTGGDFGNP
S23 LVFLGEQSVGKTSLI
S117 DVRTERGSDVIIMLV
K133 NKTDLADKRQVSIEE
S179 AALPGMESTQDRSRE
S184 MESTQDRSREDMIDI
K192 REDMIDIKLEKPQEQ
  mouse

 
S2-p ______MsAGGDFGN
A3 _____MsAGGDFGNP
S23-p LVFLGEQsVGKTSLI
S117-p DVRTERGsDVIIMLV
K133-ub NKTDLADkRQVSIEE
S179-p AALPGMEsTQDRsRE
S184-p MEsTQDRsREDMIDI
K192 REDMIDIKLEKPQEQ
  rat

 
S2 ______MSAGGDFGN
A3 _____MSAGGDFGNP
S23 LVFLGEQSVGKTSLI
S117 DVRTERGSDVIIMLV
K133-ub NKTDLADkRQVSIEE
S179 AALPGMESTQDRSRE
S184 MESTQDRSREDMIDI
K192 REDMIDIKLEKPQEQ
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