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Protein Page:
PSMD14 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PSMD14 a component of the 26S proteasome. The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.19.-; Proteasome complex; Protease
Cellular Component: proteasome complex; nucleoplasm; nucleus; cytosol
Molecular Function: ubiquitin thiolesterase activity; metallopeptidase activity; metal ion binding
Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; ubiquitin-dependent protein catabolic process; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; protein polyubiquitination; viral reproduction; apoptosis; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; double-strand break repair via homologous recombination; double-strand break repair via nonhomologous end joining; mRNA metabolic process; regulation of apoptosis; antigen processing and presentation of peptide antigen via MHC class I; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; RNA metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; gene expression; mitotic cell cycle; regulation of amino acid metabolic process; G1/S transition of mitotic cell cycle; negative regulation of apoptosis
Reference #:  O00487 (UniProtKB)
Alt. Names/Synonyms: 26S proteasome non-ATPase regulatory subunit 14; 26S proteasome regulatory subunit rpn11; 26S proteasome-associated PAD1 homolog 1; PAD1; POH1; proteasome (prosome, macropain) 26S subunit, non-ATPase, 14; PSDE; PSMD14; RPN11
Gene Symbols: PSMD14
Molecular weight: 34,577 Da
Basal Isoelectric point: 6.06  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PSMD14

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 58 Y32-p VDTAEQVyIsSLALL
0 1 S34-p TAEQVyIsSLALLKM
0 4 K43-ub LALLKMLkHGRAGVP
0 1 K94-ub VDPVFQAkMLDMLKQ
0 1 S150-p VVVDPIQsVkGkVVI
0 24 K152-ub VDPIQsVkGkVVIDA
0 20 K154-ub PIQsVkGkVVIDAFR
0 4 K186-ub SNLGHLNkPSIQALI
0 2 K209-ub SITINYRkNELEQkM
0 1 K215-ub RkNELEQkMLLNLHk
0 3 K222-ub kMLLNLHkKsWMEGL
0 1 S224-p LLNLHkKsWMEGLTL
0 1 Y234-p EGLTLQDySEHCKHN
0 3 K246-ub KHNESVVkEMLELAk
0 5 K253-ub kEMLELAkNYNkAVE
0 10 K257-ub ELAkNYNkAVEEEDk
0 1 K264 kAVEEEDKMtPEQLA
0 1 K264-ub kAVEEEDkMtPEQLA
0 11 T266-p VEEEDkMtPEQLAIk
0 2 K273-ub tPEQLAIkNVGkQDP
0 2 K277-ub LAIkNVGkQDPKRHL
  mouse

 
Y32-p VDTAEQVyISSLALL
S34 TAEQVyISSLALLKM
K43 LALLKMLKHGRAGVP
K94 VDPVFQAKMLDMLKQ
S150 VVVDPIQSVkGKVVI
K152-ub VDPIQSVkGKVVIDA
K154 PIQSVkGKVVIDAFR
K186 SNLGHLNKPSIQALI
K209 SITINYRKNELEQKM
K215 RKNELEQKMLLNLHK
K222 KMLLNLHKKSWMEGL
S224 LLNLHKKSWMEGLTL
Y234 EGLTLQDYSEHCKHN
K246-ub KHNESVVkEMLELAK
K253 kEMLELAKNYNkAVE
K257-ub ELAKNYNkAVEEEDk
K264-ac kAVEEEDkMTPEQLA
K264 kAVEEEDKMTPEQLA
T266 VEEEDkMTPEQLAIk
K273-ub TPEQLAIkNVGKQDP
K277 LAIkNVGKQDPKRHL
  rat

 
Y32-p VDTAEQVyISSLALL
S34 TAEQVyISSLALLKM
K43 LALLKMLKHGRAGVP
K94 VDPVFQAKMLDMLKQ
S150 VVVDPIQSVKGKVVI
K152 VDPIQSVKGKVVIDA
K154 PIQSVKGKVVIDAFR
K186 SNLGHLNKPSIQALI
K209 SITINYRKNELEQKM
K215 RKNELEQKMLLNLHK
K222 KMLLNLHKKSWMEGL
S224 LLNLHKKSWMEGLTL
Y234 EGLTLQDYSEHCKHN
K246 KHNESVVKEMLELAK
K253 KEMLELAKNYNKAVE
K257 ELAKNYNKAVEEEDK
K264 KAVEEEDKMTPEQLA
K264 KAVEEEDKMTPEQLA
T266 VEEEDKMTPEQLAIK
K273 TPEQLAIKNVGKQDP
K277 LAIKNVGKQDPKRHL
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