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PSMD14 (human)

Overview PSMD14 a component of the 26S proteasome. The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. Note: This description may include information from UniProtKB. Protein type: Protease; Proteasome complex; EC 3.4.19.- Cellular Component: nucleoplasm; proteasome complex; cytosol Molecular Function: ubiquitin thiolesterase activity; metallopeptidase activity; metal ion binding Biological Process: ubiquitin-dependent protein catabolic process; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; protein polyubiquitination; viral reproduction; apoptosis; M/G1 transition of mitotic cell cycle; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; double-strand break repair via nonhomologous end joining; double-strand break repair via homologous recombination; mRNA metabolic process; regulation of apoptosis; antigen processing and presentation of peptide antigen via MHC class I; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; RNA metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; gene expression; mitotic cell cycle; regulation of amino acid metabolic process; S phase of mitotic cell cycle; cell cycle checkpoint; G1/S transition of mitotic cell cycle Reference #:  O00487 (UniProtKB) Alt. Names/Synonyms: 26S proteasome non-ATPase regulatory subunit 14; 26S proteasome regulatory subunit rpn11; 26S proteasome-associated PAD1 homolog 1; PAD1; POH1; proteasome (prosome, macropain) 26S subunit, non-ATPase, 14; PSDE; PSMD14; RPN11 Gene Symbols: PSMD14 Molecular weight: 34,577 Da Basal Isoelectric point: 6.06  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PSMD14

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	53		Y32-p	VDTAEQVyIsSLALL
0	1		S34-p	TAEQVyIsSLALLKM
0	4		K43-u	LALLKMLkHGRAGVP
0	1		K94-u	VDPVFQAkMLDMLKQ
0	24		K152-u	VDPIQSVkGkVVIDA
0	20		K154-u	PIQSVkGkVVIDAFR
0	4		K186-u	SNLGHLNkPSIQALI
0	2		K209-u	SITINYRkNELEQkM
0	1		K215-u	RkNELEQkMLLNLHk
0	3		K222-u	kMLLNLHkKsWMEGL
0	1		S224-p	LLNLHkKsWMEGLTL
0	1		Y234-p	EGLTLQDySEHCKHN
0	3		K246-u	KHNESVVkEMLELAk
0	5		K253-u	kEMLELAkNYNkAVE
0	10		K257-u	ELAkNYNkAVEEEDk
0	1		K264-u	kAVEEEDkMtPEQLA
0	10		T266-p	VEEEDkMtPEQLAIk
0	2		K273-u	tPEQLAIkNVGkQDP
0	2		K277-u	LAIkNVGkQDPKRHL

	mouse
Y32-p	VDTAEQVyISSLALL
S34	TAEQVyISSLALLKM
K43	LALLKMLKHGRAGVP
K94	VDPVFQAKMLDMLKQ
K152-u	VDPIQSVkGKVVIDA
K154	PIQSVkGKVVIDAFR
K186	SNLGHLNKPSIQALI
K209	SITINYRKNELEQKM
K215	RKNELEQKMLLNLHK
K222	KMLLNLHKKSWMEGL
S224	LLNLHKKSWMEGLTL
Y234	EGLTLQDYSEHCKHN
K246-u	KHNESVVkEMLELAK
K253	kEMLELAKNYNkAVE
K257-u	ELAKNYNkAVEEEDK
K264	kAVEEEDKMTPEQLA
T266	VEEEDKMTPEQLAIk
K273-u	TPEQLAIkNVGKQDP
K277	LAIkNVGKQDPKRHL

	rat
Y32-p	VDTAEQVyISSLALL
S34	TAEQVyISSLALLKM
K43	LALLKMLKHGRAGVP
K94	VDPVFQAKMLDMLKQ
K152	VDPIQSVKGKVVIDA
K154	PIQSVKGKVVIDAFR
K186	SNLGHLNKPSIQALI
K209	SITINYRKNELEQKM
K215	RKNELEQKMLLNLHK
K222	KMLLNLHKKSWMEGL
S224	LLNLHKKSWMEGLTL
Y234	EGLTLQDYSEHCKHN
K246	KHNESVVKEMLELAK
K253	KEMLELAKNYNKAVE
K257	ELAKNYNKAVEEEDK
K264	KAVEEEDKMTPEQLA
T266	VEEEDKMTPEQLAIK
K273	TPEQLAIKNVGKQDP
K277	LAIKNVGKQDPKRHL

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