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TH iso3 (human)

Overview TH iso3 an enzyme involved in the conversion of phenylalanine to dopamine. As the rate-limiting enzyme in the synthesis of catecholamines, tyrosine hydroxylase has a key role in the physiology of adrenergic neurons. Four splice variant isoforms have been described. Note: This description may include information from UniProtKB. Protein type: Oxidoreductase; Amino Acid Metabolism - tyrosine; EC 1.14.16.2; Endoplasmic reticulum; Mitochondrial; Vesicle protein Cellular Component: neuron projection; internal side of plasma membrane; smooth endoplasmic reticulum; mitochondrion; dendrite; melanosome membrane; terminal button; perikaryon; cytosol; synaptic vesicle; cytoplasm; cytoplasmic vesicle; nucleus Molecular Function: amino acid binding; protein domain specific binding; protein binding; ferric iron binding; ferrous iron binding; dopamine binding; oxygen binding; tyrosine 3-monooxygenase activity Biological Process: heart morphogenesis; heart development; response to lipopolysaccharide; dopamine biosynthetic process; phytoalexin metabolic process; norepinephrine biosynthetic process; dopamine biosynthetic process from tyrosine; catecholamine biosynthetic process; response to electrical stimulus; epinephrine biosynthetic process; response to corticosterone stimulus; neurotransmitter biosynthetic process; response to pyrethroid; response to light stimulus; anatomical structure morphogenesis; phthalate metabolic process; mating behavior; social behavior; organ morphogenesis; eye photoreceptor cell development; response to ethanol; circadian sleep/wake cycle; response to zinc ion; response to activity; cerebral cortex development; response to water deprivation; response to peptide hormone stimulus; synaptic transmission, dopaminergic; locomotory behavior; fatty acid metabolic process; response to salt stress; regulation of heart contraction; response to estradiol stimulus; sensory perception of sound; visual perception; response to nutrient levels; terpene metabolic process; sphingolipid metabolic process; eating behavior; response to amphetamine; multicellular organismal aging; isoquinoline alkaloid metabolic process; response to herbicide; learning; response to ether; memory; synaptic vesicle amine transport; pigmentation; response to hypoxia; embryonic camera-type eye morphogenesis Reference #:  P07101-3 (UniProtKB) Alt. Names/Synonyms: dystonia 14; DYT14; DYT5b; TH; TY3H; TYH; Tyrosine 3-hydroxylase; Tyrosine 3-monooxygenase; tyrosine hydroxylase Gene Symbols: TH Molecular weight: 55,612 Da Basal Isoelectric point: 5.75  Predict pI for various phosphorylation states CST Pathways:  GPCRs Signaling to MAPK/Erk  |  Parkinson's Disease

Select Structure to View Below TH iso3 2XSN - A/D/C/B=193-528 (human) 1TOH - A=156-498 (rat) 2TOH - A=156-498 (rat)

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	Sites Implicated In
enzymatic activity, induced: S31‑p, S40‑p molecular association, regulation: S19‑p phosphorylation: S31‑p

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
5	0		T8	MPTPDATTPQAKGFR
34	5		S19-p	KGFRRAVsELDAKQA
34	4		S62-p	SYTPTPRsPRFIGRR
49	9		S71-p	RFIGRRQsLIEDARK
1	0		S183	LSGVRQVSEDVRSPA
0	1		Y230-p	PGFSDQVyRQRRKLI
1	0		S435	GELLHCLSEEPEIRA
0	2		S502	LAIDVLDSPQAVRRS

	TH iso2
T8	MPTPDATTPQAKGFR
S19-p	KGFRRAVsELDAKQA
S58-p	SYTPTPRsPRFIGRR
S67-p	RFIGRRQsLIEDARK
S179	LSGVRQVSEDVRSPA
Y226-p	PGFSDQVyRQRRKLI
S431	GELLHCLSEEPEIRA
S498	LAIDVLDSPQAVRRS

	TH iso3
T8	MPTPDATTPQAKGFR
S19-p	KGFRRAVsELDAKQA
S31-p	KQAEAIMsPRFIGRR
S40-p	RFIGRRQsLIEDARK
S152	LSGVRQVSEDVRSPA
Y199-p	PGFSDQVyRQRRKLI
S404-p	GELLHCLsEEPEIRA
S471	LAIDVLDSPQAVRRS

	TH iso5
T8	MPTPDATTPQAKGFR
S19-p	KGFRRAVsELDAKQA
S35-p	AIMVRGQsPRFIGRR
S44-p	RFIGRRQsLIEDARK
S156	LSGVRQVSEDVRSPA
Y203-p	PGFSDQVyRQRRKLI
S408	GELLHCLSEEPEIRA
S475	LAIDVLDSPQAVRRS

	mouse
S8	MPTPSASSPQPKGFR
S19-p	KGFRRAVsEQDTKQA
S31-p	KQAEAVTsPRFIGRR
S40-p	RFIGRRQsLIEDARK
S153	LSSVRRVSDDVRSAR
Y200	PGFSDQAYRQRRKLI
S405	GELLHSLSEEPEVRA
S472-p	LAIDVLDsPHTIRRS

	rat
S8-p	MPTPSAPsPQPKGFR
S19-p	KGFRRAVsEQDAKQA
S31-p	KQAEAVTsPRFIGRR
S40-p	RFIGRRQsLIEDARK
S153-p	LSSVRRVsDDVRSAR
Y200	PGFSDQVYRQRRKLI
S405	GELLHSLSEEPEVRA
S472	LAIDVLDSPHTIQRS

	cow
S8	MPTPNAASPQAKGFR
S19-p	KGFRRAVsELDAKQA
S31-p	KQAEAIMsPRFVGRR
S40-p	RFVGRRQsLIQDARK
A146	LSALRRVAEDVRAAG
Y193	PGFSDQAYRQRRKLI
S398	GELLHSLSEEPEIRA
S465	LAIDVLDSPHAIRHA

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