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Protein Page:
mGluR1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
mGluR1 Receptor for glutamate. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol- calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum. Homodimer; disulfide-linked. The PPXXF motif binds HOMER1, HOMER2 and HOMER3. Interacts with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3 and GRASP. Belongs to the G-protein coupled receptor 3 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 3; Receptor, GPCR
Cellular Component: integral to plasma membrane; postsynaptic density; dendrite; plasma membrane; nucleus
Molecular Function: G-protein coupled receptor activity; protein binding; glutamate receptor activity
Biological Process: cell death; G-protein coupled receptor protein signaling pathway; synaptic transmission; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); regulation of synaptic transmission, glutamatergic; activation of MAPKK activity; activation of MAPK activity; protein kinase C activation; metabotropic glutamate receptor signaling pathway; locomotory behavior; regulation of sensory perception of pain; sensory perception of pain
Reference #:  Q13255 (UniProtKB)
Alt. Names/Synonyms: glutamate receptor, metabotropic 1; GPRC1A; GRM1; GRM1A; Metabotropic glutamate receptor 1; mGlu1; MGLUR1; MGLUR1A
Gene Symbols: GRM1
Molecular weight: 132,357 Da
Basal Isoelectric point: 6.27  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

mGluR1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 T188-p PQIAYSAtSIDLSDK
0 2 Y672-p GLSSAMCysALVtKT
0 1 S673-p LSSAMCysALVtKTN
0 1 T677-p MCysALVtKTNRIAR
1 0 T695 GSKKKICTRKPRFMS
0 1 K740-m1 ILSYPSIkEVYLICN
0 1 K841 KMYIIIAKPERNVRS
0 2 S853 VRSAFTTSDVVRMHV
0 1 S869-p DGKLPCRsNtFLNIF
1 5 T871-p KLPCRsNtFLNIFRR
0 1 K891-ub GNANSNGkSVSWSEP
0 2 S894 NSNGkSVSWSEPGGG
0 1 K942 KSYQGSGKSLTFSDT
0 1 A963 NVEEEEDAQPIRFSP
0 4 S969 DAQPIRFSPPGSPSM
0 1 G972 PIRFSPPGSPSMVVH
0 2 S973 IRFSPPGSPSMVVHR
0 4 S1091 TFGEELVSPPADDDD
0 1 S1100 PADDDDDSERFKLLQ
0 1 - gap
0 1 Y1109-p RFKLLQEyVyEHERE
0 1 Y1111-p KLLQEyVyEHEREGN
0 1 T1138 LQAASKLTPDDSPAL
0 3 S1142 SKLTPDDSPALTPPS
0 1 T1146 PDDSPALTPPSPFRD
0 3 S1149 SPALTPPSPFRDSVA
0 1 S1163 ASGSSVPSSPVSESV
0 1 S1164 SGSSVPSSPVSESVL
0 1 T1173 VSESVLCTPPNVSYA
  mouse

 
T188 PQIAYSATSIDLSDK
Y672 GLSSAMCYSALVTKT
S673 LSSAMCYSALVTKTN
T677 MCYSALVTKTNRIAR
T695 GSKKKICTRKPRFMS
K740 ILSYPSIKEVYLICN
K841-ub KMYIIIAkPERNVRS
S853-p VRSAFTTsDVVRMHV
S869 DGKLPCRSNtFLNIF
T871-p KLPCRSNtFLNIFRR
K891 GNANSNGKSVsWSEP
S894-p NSNGKSVsWSEPGGR
K942 KSYQGSGKSLTFSDA
T963-p NVEEEDNtPSTHFsP
S969-p NtPSTHFsPPssPSM
S972-p STHFsPPssPSMVVH
S973-p THFsPPssPSMVVHR
S1097-p TFREEPIsPPGEDDD
S1107-p GEDDDDDssERFKLL
S1108-p EDDDDDssERFKLLQ
F1117 RFKLLQEFVYEREGN
Y1119 KLLQEFVYEREGNTE
T1143-p LPAASKLtPEDsPAL
S1147-p SKLtPEDsPALtPPs
T1151-p PEDsPALtPPsPFRD
S1154-p sPALtPPsPFRDSVA
S1168-p ASGSSVPssPVSESV
S1169-p SGSSVPssPVSESVL
T1178-p VSESVLCtPPNVTYA
  rat

 
T188 PQIAYSATSIDLSDK
Y672 GLSSAMCYSALVTKT
S673 LSSAMCYSALVTKTN
T677 MCYSALVTKTNRIAR
T695-p GSKKKICtRKPRFMS
K740 ILSYPSIKEVYLICN
K841 KMYIIIAKPERNVRS
S853 VRSAFTTSDVVRMHV
S869 DGKLPCRSNtFLNIF
T871-p KLPCRSNtFLNIFRR
K891 GNANSNGKSVsWSEP
S894-p NSNGKSVsWSEPGGR
K942-ub KSYQGSGkSLTFSDA
T963 NVEEEDNTPSAHFSP
S969 NTPSAHFSPPSSPSM
S972 SAHFSPPSSPSMVVH
S973 AHFSPPSSPSMVVHR
S1098 TFQEESISPPGEDID
S1108 GEDIDDDSERFKLLQ
- gap
F1117 RFKLLQEFVYEREGN
Y1119 KLLQEFVYEREGNTE
T1143 LPTASKLTPEDsPAL
S1147-p SKLTPEDsPALtPPS
T1151-p PEDsPALtPPSPFRD
S1154 sPALtPPSPFRDSVA
S1168 ASGSSVPSSPVSESV
S1169 SGSSVPSSPVSESVL
T1178 VSESVLCTPPNVTYA
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