Home

mGluR1 (human)

Overview mGluR1 Receptor for glutamate. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol- calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum. Homodimer; disulfide-linked. The PPXXF motif binds HOMER1, HOMER2 and HOMER3. Interacts with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3 and GRASP. Belongs to the G-protein coupled receptor 3 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: GPCR, family 3; Receptor, GPCR; Membrane protein, integral Cellular Component: presynaptic membrane; integral to plasma membrane; axon; postsynaptic density; plasma membrane; nucleus Molecular Function: G-protein coupled receptor activity; estrogen receptor binding; glutamate receptor activity Biological Process: synaptic transmission; G-protein coupled receptor protein signaling pathway; regulation of synaptic transmission, glutamatergic; activation of MAPKK activity; activation of MAPK activity; calcium-mediated signaling; locomotory behavior; regulation of sensory perception of pain; sensory perception of pain Reference #:  Q13255 (UniProtKB) Alt. Names/Synonyms: glutamate receptor, metabotropic 1; GPRC1A; GRM1; GRM1A; Metabotropic glutamate receptor 1; mGlu1; MGLUR1; MGLUR1A Gene Symbols: GRM1 Molecular weight: 132,357 Da Basal Isoelectric point: 6.27  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below mGluR1 3KS9 - A/B=28-518 (human) 1EWK - A/B=33-522 (rat) 1EWT - A/B=33-522 (rat) 1EWV - A/B=33-522 (rat) 1ISR - A=33-522 (rat) 1ISS - A/B=33-522 (rat)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	0		T188-p	PQIAYSAtSIDLSDK
0	1		Y672-p	GLSSAMCySALVtKt
0	1		T677-p	MCySALVtKtNRIAR
0	1		T679-p	ySALVtKtNRIARIL
1	0		T695	GSKKKICTRKPRFMS
0	1		K740-m1	ILSYPSIkEVYLICN
0	1		K841	KMYIIIAKPERNVRS
0	2		S853	VRSAFTTSDVVRMHV
0	1		S869-p	DGKLPCRsNtFLNIF
1	5		T871-p	KLPCRsNtFLNIFRR
0	1		K891-u	GNANSNGkSVSWSEP
0	2		S894	NSNGkSVSWSEPGGG
0	1		K942	KSYQGSGKSLTFSDT
0	1		A963	NVEEEEDAQPIRFSP
0	3		S969	DAQPIRFSPPGSPSM
0	1		S973	IRFSPPGSPSMVVHR
0	4		S1091	TFGEELVSPPADDDD
0	1		S1100	PADDDDDSERFKLLQ
0	1		-	gap
0	1		Y1109-p	RFKLLQEyVyEHERE
0	1		Y1111-p	KLLQEyVyEHEREGN
0	1		T1138	LQAASKLTPDDSPAL
0	3		S1142	SKLTPDDSPALTPPS
0	1		T1146	PDDSPALTPPSPFRD
0	3		S1149	SPALTPPSPFRDSVA
0	1		S1163	ASGSSVPSSPVSESV
0	1		S1164	SGSSVPSSPVSESVL
0	1		T1173	VSESVLCTPPNVSYA

	mouse
T188	PQIAYSATSIDLSDK
Y672	GLSSAMCYSALVTKT
T677	MCYSALVTKTNRIAR
T679	YSALVTKTNRIARIL
T695	GSKKKICTRKPRFMS
K740	ILSYPSIKEVYLICN
K841-u	KMYIIIAkPERNVRS
S853-p	VRSAFTTsDVVRMHV
S869	DGKLPCRSNtFLNIF
T871-p	KLPCRSNtFLNIFRR
K891	GNANSNGKSVsWSEP
S894-p	NSNGKSVsWSEPGGR
K942	KSYQGSGKSLTFSDA
T963-p	NVEEEDNtPSTHFsP
S969-p	NtPSTHFsPPSsPSM
S973-p	THFsPPSsPSMVVHR
S1097-p	TFREEPIsPPGEDDD
S1107-p	GEDDDDDssERFKLL
S1108-p	EDDDDDssERFKLLQ
F1117	RFKLLQEFVYEREGN
Y1119	KLLQEFVYEREGNTE
T1143-p	LPAASKLtPEDsPAL
S1147-p	SKLtPEDsPALtPPs
T1151-p	PEDsPALtPPsPFRD
S1154-p	sPALtPPsPFRDSVA
S1168-p	ASGSSVPssPVSESV
S1169-p	SGSSVPssPVSESVL
T1178-p	VSESVLCtPPNVTYA

	rat
T188	PQIAYSATSIDLSDK
Y672	GLSSAMCYSALVTKT
T677	MCYSALVTKTNRIAR
T679	YSALVTKTNRIARIL
T695-p	GSKKKICtRKPRFMS
K740	ILSYPSIKEVYLICN
K841	KMYIIIAKPERNVRS
S853	VRSAFTTSDVVRMHV
S869	DGKLPCRSNtFLNIF
T871-p	KLPCRSNtFLNIFRR
K891	GNANSNGKSVSWSEP
S894	NSNGKSVSWSEPGGR
K942-u	KSYQGSGkSLTFSDA
T963	NVEEEDNTPSAHFSP
S969	NTPSAHFSPPSSPSM
S973	AHFSPPSSPSMVVHR
S1098	TFQEESISPPGEDID
S1108	GEDIDDDSERFKLLQ
-	gap
F1117	RFKLLQEFVYEREGN
Y1119	KLLQEFVYEREGNTE
T1143	LPTASKLTPEDSPAL
S1147	SKLTPEDSPALTPPS
T1151	PEDSPALTPPSPFRD
S1154	SPALTPPSPFRDSVA
S1168	ASGSSVPSSPVSESV
S1169	SGSSVPSSPVSESVL
T1178	VSESVLCTPPNVTYA

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.