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Protein Page:
ICAM1 (mouse)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ICAM1 a type I membrane protein of the immunoglobulin superfamily. Is a ligand for the leukocyte adhesion LFA-1 protein (Integrin alpha-L/beta-2) and a Rhinovirus receptor. Typically expressed on endothelial cells and cells of the immune system. ICAM1 binds to integrins of type CD11a / CD18, or CD11b / CD18. Its expression is activated by p53 in an NF-kappaB-independent manner. Induced by TNFalpha in a process that involves IKKbeta. Note: This description may include information from UniProtKB.
Protein type: Immunoglobulin superfamily; Membrane protein, integral; Cell adhesion
Cellular Component: extracellular space; cell surface; membrane; integral to membrane; plasma membrane; immunological synapse; external side of plasma membrane
Molecular Function: integrin binding; protein complex binding
Biological Process: regulation of cell adhesion; virion attachment, binding of host cell surface receptor; negative regulation of calcium ion transport; positive regulation of nitric oxide biosynthetic process; T cell antigen processing and presentation; activation of NF-kappaB transcription factor; positive regulation of cellular extravasation; regulation of cell shape; cell-cell adhesion; positive regulation of peptidyl-tyrosine phosphorylation; leukocyte adhesion; sensory perception of sound; positive regulation of actin filament polymerization; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; positive regulation of vasoconstriction; cell adhesion mediated by integrin; adhesion to host; cell adhesion; positive regulation of Rho GTPase activity; acute inflammatory response to antigenic stimulus
Reference #:  P13597 (UniProtKB)
Alt. Names/Synonyms: CD54; ICAM-1; Icam1; Intercellular adhesion molecule 1; Ly-47; MALA-2; MGC6195; MyD10
Gene Symbols: Icam1
Molecular weight: 58,844 Da
Basal Isoelectric point: 5.79  Predict pI for various phosphorylation states
Select Structure to View Below

ICAM1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
0 1 S43 AFLPQGGSVQVNCSS
0 1 T62 DLSLGLETQWLKDEL
0 1 R209 FSNVSEARSLRTFDL
0 1 T213 SEARSLRTFDLPATI
0 1 T219 RTFDLPATIPKLDTP
0 1 T225 ATIPKLDTPDLLEVG
0 1 L277 DSVSATALVEVTEEF
0 2 - gap
1 0 Y507 GLVMAASYVYNRQRK
5 2 Y518-p RQRKIRIyKLQkAQE
0 1 K522-ub IRIyKLQkAQEEAIk
0 3 - gap
0 6 - gap
0 29 K529-ub kAQEEAIkLKGQAPP
0 1 - gap
0 7 - gap
  human

 
S43-p VILPRGGsVLVTCST
T62-ga PKLLGIEtPLPKKEL
Y207-p FENTSAPyQLQtFVL
T211-p SAPyQLQtFVLPAtP
T217-p QtFVLPAtPPQLVsP
S223-p AtPPQLVsPRVLEVD
S275-p DSFSAKAsVSVTAED
K359-ub PRAQLLLkATPEDNG
Y501-p GTAGLSTyLYNRQRK
Y512-p RQRKIKKyRLQQAQk
Q516 IKKyRLQQAQkGtPM
K519-ub yRLQQAQkGtPMkPN
T521-p LQQAQkGtPMkPNtQ
K524-ub AQkGtPMkPNtQAtP
T527-p GtPMkPNtQAtPP__
T530-p MkPNtQAtPP_____
  rat

 
S43 AFLPRGGSVQVNCSS
T63 NLGLGLETNWMKDEL
R207 FKNVSEVRQLRTFDL
T211 SEVRQLRTFDLPTRV
- gap
T223 TRVLKLDTPDLLEVG
S275 DFVSATASVEVTEKL
- gap
Y515 FVIVASIYTYYRQRK
Y526 RQRKIRIYKLQKAQE
K530 IRIYKLQKAQEEALK
- gap
- gap
K537 KAQEEALKLKVQAPP
- gap
- gap
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