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Protein Page:
ICAM1 (mouse)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
ICAM1 a type I membrane protein of the immunoglobulin superfamily. Is a ligand for the leukocyte adhesion LFA-1 protein (Integrin alpha-L/beta-2) and a Rhinovirus receptor. Typically expressed on endothelial cells and cells of the immune system. ICAM1 binds to integrins of type CD11a / CD18, or CD11b / CD18. Its expression is activated by p53 in an NF-kappaB-independent manner. Induced by TNFalpha in a process that involves IKKbeta. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Cell adhesion; Immunoglobulin superfamily
Cellular Component: extracellular space; cell surface; membrane; plasma membrane; integral to membrane; immunological synapse; external side of plasma membrane
Molecular Function: integrin binding; protein complex binding
Biological Process: regulation of cell adhesion; adhesion to symbiont; virion attachment, binding of host cell surface receptor; negative regulation of calcium ion transport; positive regulation of nitric oxide biosynthetic process; T cell antigen processing and presentation; activation of NF-kappaB transcription factor; positive regulation of cellular extravasation; regulation of cell shape; leukocyte adhesion; cell-cell adhesion; positive regulation of peptidyl-tyrosine phosphorylation; sensory perception of sound; positive regulation of actin filament polymerization; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; positive regulation of vasoconstriction; cell adhesion mediated by integrin; cell adhesion; positive regulation of Rho GTPase activity; acute inflammatory response to antigenic stimulus
Reference #:  P13597 (UniProtKB)
Alt. Names/Synonyms: CD54; ICAM-1; Icam1; Intercellular adhesion molecule 1; Ly-47; MALA-2; MGC6195; MyD10
Gene Symbols: Icam1
Molecular weight: 58,844 Da
Basal Isoelectric point: 5.79  Predict pI for various phosphorylation states
Select Structure to View Below

ICAM1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
0 1 T62 DLSLGLETQWLKDEL
0 2 - gap
1 0 Y507 GLVMAASYVYNRQRK
5 2 Y518-p RQRKIRIyKLQKAQE
0 3 - gap
0 4 - gap
0 29 K529-u KAQEEAIkLKGQAPP
0 4 - gap
  human

 
T62-ga PKLLGIEtPLPKKEL
K359-u PRAQLLLkATPEDNG
Y501-p GTAGLSTyLYNRQRK
Y512-p RQRKIKKyRLQQAQk
K519-u yRLQQAQkGtPMkPN
T521-p LQQAQkGtPMkPNTQ
K524-u AQkGtPMkPNTQAtP
T530-p MkPNTQAtPP_____
  rat

 
T63 NLGLGLETNWMKDEL
- gap
Y515 FVIVASIYTYYRQRK
Y526 RQRKIRIYKLQKAQE
- gap
- gap
K537 KAQEEALKLKVQAPP
- gap
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