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ICAM1 (mouse)

Overview ICAM1 a type I membrane protein of the immunoglobulin superfamily. Is a ligand for the leukocyte adhesion LFA-1 protein (Integrin alpha-L/beta-2) and a Rhinovirus receptor. Typically expressed on endothelial cells and cells of the immune system. ICAM1 binds to integrins of type CD11a / CD18, or CD11b / CD18. Its expression is activated by p53 in an NF-kappaB-independent manner. Induced by TNFalpha in a process that involves IKKbeta. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral; Cell adhesion; Immunoglobulin superfamily Cellular Component: extracellular space; cell surface; membrane; integral to membrane; plasma membrane; immunological synapse; external side of plasma membrane Molecular Function: integrin binding; protein complex binding; cell surface binding Biological Process: adhesion to symbiont; regulation of cell adhesion; virion attachment, binding of host cell surface receptor; negative regulation of calcium ion transport; positive regulation of nitric oxide biosynthetic process; T cell antigen processing and presentation; activation of NF-kappaB transcription factor; positive regulation of cellular extravasation; regulation of cell shape; leukocyte adhesion; cell-cell adhesion; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; positive regulation of vasoconstriction; cell adhesion mediated by integrin; cell adhesion Reference #:  P13597 (UniProtKB) Alt. Names/Synonyms: CD54; ICAM-1; Icam1; Intercellular adhesion molecule 1; Ly-47; MALA-2; MGC6195; MyD10 Gene Symbols: Icam1 Molecular weight: 58,844 Da Basal Isoelectric point: 5.79  Predict pI for various phosphorylation states

Select Structure to View Below ICAM1 1D3E - I=28-212 (human) 1D3I - I=28-212 (human) 1D3L - A=28-212 (human) 1IAM - A=28-212 (human) 1IC1 - A/B=28-217 (human) 1IJ4 - I=44-109 (human) 1MQ8 - A/C=28-318 (human) 1P53 - A/B=212-477 (human) 1Z7Z - I=28-477 (human) 2OZ4 - A=213-477 (human) 3TCX - S/A/O/a/W/K/Y/E/Q/M/C/I/G/U=29-112 (human)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			mouse
0	1		R209	FSNVSEARSLRTFDL
0	1		T213	SEARSLRTFDLPATI
0	1		T219	RTFDLPATIPKLDTP
0	1		T225	ATIPKLDTPDLLEVG
0	1		L277	DSVSATALVEVTEEF
0	2		-	gap
1	0		Y507	GLVMAASYVYNRQRK
5	2		Y518-p	RQRKIRIyKLQkAQE
0	1		K522-u	IRIyKLQkAQEEAIk
0	3		E525	yKLQkAQEEAIkLKG
0	3		E526	KLQkAQEEAIkLKGQ
0	29		K529-u	kAQEEAIkLKGQAPP
0	3		P535	IkLKGQAPPP_____

	human
Y207-p	FENTSAPyQLQtFVL
T211-p	SAPyQLQtFVLPAtP
T217-p	QtFVLPAtPPQLVsP
S223-p	AtPPQLVsPRVLEVD
S275-p	DSFSAKAsVSVTAED
K359-u	PRAQLLLkATPEDNG
Y501-p	GTAGLSTyLYNRQRK
Y512-p	RQRKIKKyRLQQAQk
Q516	IKKyRLQQAQkGtPM
K519-u	yRLQQAQkGtPMkPN
T521-p	LQQAQkGtPMkPNTQ
K524-u	AQkGtPMkPNTQAtP
T530-p	MkPNTQAtPP_____

	rat
R207	FKNVSEVRQLRTFDL
T211	SEVRQLRTFDLPTRV
R217	RTFDLPTRVLKLDTP
T223	TRVLKLDTPDLLEVG
S275	DFVSATASVEVTEKL
-	gap
Y515	FVIVASIYTYYRQRK
Y526	RQRKIRIYKLQKAQE
K530	IRIYKLQKAQEEALK
E533	YKLQKAQEEALKLKV
E534	KLQKAQEEALKLKVQ
K537	KAQEEALKLKVQAPP
P543	LKLKVQAPPP_____

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