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ICAM1 (human)

Overview ICAM1 a type I membrane protein of the immunoglobulin superfamily. Is a ligand for the leukocyte adhesion LFA-1 protein (Integrin alpha-L/beta-2) and a Rhinovirus receptor. Typically expressed on endothelial cells and cells of the immune system. ICAM1 binds to integrins of type CD11a / CD18, or CD11b / CD18. Its expression is activated by p53 in an NF-kappaB-independent manner. Induced by TNFalpha in a process that involves IKKbeta. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral; Cell adhesion; Immunoglobulin superfamily Cellular Component: extracellular space; integral to plasma membrane; plasma membrane; immunological synapse; external side of plasma membrane Molecular Function: integrin binding; protein binding; transmembrane receptor activity; receptor activity; cell surface binding Biological Process: adhesion to symbiont; positive regulation of nitric oxide biosynthetic process; T cell antigen processing and presentation; response to organic cyclic substance; activation of NF-kappaB transcription factor; positive regulation of cellular extravasation; regulation of cell shape; leukocyte adhesion; cellular response to nutrient levels; ovarian follicle development; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; membrane to membrane docking; response to sulfur dioxide; cell adhesion; regulation of leukocyte mediated cytotoxicity; response to drug; regulation of cell adhesion; virion attachment, binding of host cell surface receptor; regulation of immune response; negative regulation of calcium ion transport; cytokine and chemokine mediated signaling pathway; response to amphetamine; cell aging; response to amino acid stimulus; heterophilic cell adhesion; response to ethanol; response to copper ion; positive regulation of vasoconstriction; cell adhesion mediated by integrin; response to ionizing radiation; leukocyte migration Reference #:  P05362 (UniProtKB) Alt. Names/Synonyms: BB2; CD54; cell surface glycoprotein P3.58; human rhinovirus receptor; ICAM-1; ICAM1; Intercellular adhesion molecule 1; intercellular adhesion molecule 1 (CD54), human rhinovirus receptor; Major group rhinovirus receptor; P3.58 Gene Symbols: ICAM1 Molecular weight: 57,825 Da Basal Isoelectric point: 8.31  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below ICAM1 1D3E - I=28-212 (human) 1D3I - I=28-212 (human) 1D3L - A=28-212 (human) 1IAM - A=28-212 (human) 1IC1 - A/B=28-217 (human) 1IJ4 - I=44-109 (human) 1MQ8 - A/C=28-318 (human) 1P53 - A/B=212-477 (human) 1Z7Z - I=28-477 (human) 2OZ4 - A=213-477 (human) 3TCX - S/A/O/a/W/K/Y/E/Q/M/C/I/G/U=29-112 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1D3E 1D3I 1D3L 1IAM 1IC1 1IJ4 1MQ8 1P53 1Z7Z 2OZ4 3TCX  |  Phospho3D  |  DISEASE 147840 248310 611162  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
cell adhesion, altered: Y512‑p cell motility, altered: Y512‑p molecular association, regulation: Y512‑p protein processing: Y501‑p, Y512‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		Y207-p	FENTSAPyQLQtFVL
0	1		T211-p	SAPyQLQtFVLPAtP
0	1		T217-p	QtFVLPAtPPQLVsP
0	1		S223-p	AtPPQLVsPRVLEVD
0	1		S275-p	DSFSAKAsVSVTAED
0	2		K359-u	PRAQLLLkATPEDNG
1	0		Y501-p	GTAGLSTyLYNRQRK
5	2		Y512-p	RQRKIKKyRLQQAQk
0	1		Q516	IKKyRLQQAQkGtPM
0	3		K519-u	yRLQQAQkGtPMkPN
0	3		T521-p	LQQAQkGtPMkPNTQ
0	29		K524-u	AQkGtPMkPNTQAtP
0	3		T530-p	MkPNTQAtPP_____

	mouse
R209	FSNVSEARSLRTFDL
T213	SEARSLRTFDLPATI
T219	RTFDLPATIPKLDTP
T225	ATIPKLDTPDLLEVG
L277	DSVSATALVEVTEEF
-	gap
Y507	GLVMAASYVYNRQRK
Y518-p	RQRKIRIyKLQkAQE
K522-u	IRIyKLQkAQEEAIk
E525	yKLQkAQEEAIkLKG
E526	KLQkAQEEAIkLKGQ
K529-u	kAQEEAIkLKGQAPP
P535	IkLKGQAPPP_____

	rat
R207	FKNVSEVRQLRTFDL
T211	SEVRQLRTFDLPTRV
R217	RTFDLPTRVLKLDTP
T223	TRVLKLDTPDLLEVG
S275	DFVSATASVEVTEKL
-	gap
Y515	FVIVASIYTYYRQRK
Y526	RQRKIRIYKLQKAQE
K530	IRIYKLQKAQEEALK
E533	YKLQKAQEEALKLKV
E534	KLQKAQEEALKLKVQ
K537	KAQEEALKLKVQAPP
P543	LKLKVQAPPP_____

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