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Protein Page:
ICAM1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
ICAM1 a type I membrane protein of the immunoglobulin superfamily. Is a ligand for the leukocyte adhesion LFA-1 protein (Integrin alpha-L/beta-2) and a Rhinovirus receptor. Typically expressed on endothelial cells and cells of the immune system. ICAM1 binds to integrins of type CD11a / CD18, or CD11b / CD18. Its expression is activated by p53 in an NF-kappaB-independent manner. Induced by TNFalpha in a process that involves IKKbeta. Note: This description may include information from UniProtKB.
Protein type: Immunoglobulin superfamily; Cell adhesion; Membrane protein, integral
Cellular Component: extracellular space; integral to plasma membrane; plasma membrane; immunological synapse; external side of plasma membrane
Molecular Function: integrin binding; viral receptor activity; protein binding; transmembrane receptor activity; receptor activity
Biological Process: adhesion to symbiont; extracellular matrix organization and biogenesis; positive regulation of nitric oxide biosynthetic process; T cell antigen processing and presentation; response to organic cyclic substance; activation of NF-kappaB transcription factor; positive regulation of cellular extravasation; regulation of cell shape; leukocyte adhesion; cellular response to nutrient levels; ovarian follicle development; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; membrane to membrane docking; response to sulfur dioxide; cell adhesion; regulation of leukocyte mediated cytotoxicity; response to drug; regulation of cell adhesion; virion attachment, binding of host cell surface receptor; negative regulation of calcium ion transport; regulation of immune response; cytokine and chemokine mediated signaling pathway; response to amphetamine; cell aging; response to amino acid stimulus; heterophilic cell adhesion; positive regulation of peptidyl-tyrosine phosphorylation; response to ethanol; positive regulation of actin filament polymerization; response to copper ion; positive regulation of vasoconstriction; cell adhesion mediated by integrin; response to ionizing radiation; leukocyte migration; positive regulation of Rho GTPase activity
Reference #:  P05362 (UniProtKB)
Alt. Names/Synonyms: BB2; CD54; cell surface glycoprotein P3.58; human rhinovirus receptor; ICAM-1; ICAM1; Intercellular adhesion molecule 1; intercellular adhesion molecule 1 (CD54), human rhinovirus receptor; Major group rhinovirus receptor; P3.58
Gene Symbols: ICAM1
Molecular weight: 57,825 Da
Basal Isoelectric point: 8.31  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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ICAM1

Protein Structure Not Found.


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Sites Implicated In
cell adhesion, altered: Y512‑p
cell motility, altered: Y512‑p
molecular association, regulation: Y512‑p
protein processing: Y501‑p, Y512‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T62-ga PKLLGIEtPLPKKEL
0 2 K359-u PRAQLLLkATPEDNG
1 0 Y501-p GTAGLSTyLYNRQRK
5 2 Y512-p RQRKIKKyRLQQAQk
0 3 K519-u yRLQQAQkGtPMkPN
0 4 T521-p LQQAQkGtPMkPNTQ
0 29 K524-u AQkGtPMkPNTQAtP
0 4 T530-p MkPNTQAtPP_____
  mouse

 
T62 DLSLGLETQWLKDEL
- gap
Y507 GLVMAASYVYNRQRK
Y518-p RQRKIRIyKLQKAQE
- gap
- gap
K529-u KAQEEAIkLKGQAPP
- gap
  rat

 
T63 NLGLGLETNWMKDEL
- gap
Y515 FVIVASIYTYYRQRK
Y526 RQRKIRIYKLQKAQE
- gap
- gap
K537 KAQEEALKLKVQAPP
- gap
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