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Protein Page:
SOCS3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SOCS3 SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo. Probable substrate recognition component of a SCF-like ECS (Elongin BC- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST. Interacts with multiple activated proteins of the tyrosine kinase signaling pathway including IGF1 receptor, insulin receptor and JAK2. Binding to JAK2 is mediated through the KIR and SH2 domains to a phosphorylated tyrosine residue within the JAK2 JH1 domain. Binds specific activated tyrosine residues of the leptin, EPO, IL12, GSCF and gp130 receptors. Interaction with CSNK1E stabilizes SOCS3 protein. Component of the probable ECS(SOCS3) E3 ubiquitin-protein ligase complex which contains CUL5, RNF7/RBX2, Elongin BC complex and SOCS3. Interacts with CUL5, RNF7, TCEB1 and TCEB2. Interacts with CUL2. Interacts with FGFR3. Interacts with INSR. Widely expressed with high expression in heart, placenta, skeletal muscle, peripheral blood leukocytes, fetal and adult lung, and fetal liver and kidney. Lower levels in thymus. Note: This description may include information from UniProtKB.
Protein type: Inhibitor protein
Cellular Component: cytosol
Molecular Function: protein binding; protein kinase inhibitor activity
Biological Process: cytokine and chemokine mediated signaling pathway; regulation of growth; protein ubiquitination; negative regulation of protein kinase activity; negative regulation of insulin receptor signaling pathway; positive regulation of cell differentiation; JAK-STAT cascade; negative regulation of apoptosis
Reference #:  O14543 (UniProtKB)
Alt. Names/Synonyms: ATOD4; CIS-3; CIS3; Cish3; cytokine-induced SH2 protein 3; Cytokine-inducible SH2 protein 3; MGC71791; SOCS-3; SOCS3; SSI-3; SSI3; STAT-induced STAT inhibitor 3; Suppressor of cytokine signaling 3
Gene Symbols: SOCS3
Molecular weight: 24,770 Da
Basal Isoelectric point: 8.97  Predict pI for various phosphorylation states
CST Pathways:  IL6 Signaling  |  Insulin Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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SOCS3

Protein Structure Not Found.


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Sites Implicated In
transcription, altered: Y204‑p, Y221‑p
molecular association, regulation: Y204‑p, Y221‑p
protein degradation: Y204‑p, Y221‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 K6-ub __MVTHSkFPAAGMS
0 1 T86-p FFTLSVKtQSGTKNL
0 1 Y165-p GSPPRRAyyIYSGGE
0 1 Y166-p SPPRRAyyIYSGGEK
4 14 Y204-p VNGHLDSyEKVTQLP
3 0 Y221-p IREFLDQyDAPL___
  mouse

 
K6 __MVTHSKFPAAGMS
T86 FFTLSVKTQSGTKNL
Y165 GSTPKRAYYIYSGGE
Y166 STPKRAYYIYSGGEK
Y204-p VNGHLDSyEKVTQLP
Y221 IREFLDQYDAPL___
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