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Protein Page:
Catalase (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Catalase Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells. Homotetramer. Belongs to the catalase family. Note: This description may include information from UniProtKB.
Protein type: Oxidoreductase; Apoptosis; EC 1.11.1.6; Hydrolase; Mitochondrial; Energy Metabolism - methane; Amino Acid Metabolism - tryptophan; Endoplasmic reticulum
Cellular Component: peroxisomal membrane; Golgi apparatus; peroxisomal matrix; intracellular membrane-bound organelle; membrane; lysosome; endoplasmic reticulum; plasma membrane; mitochondrial intermembrane space; peroxisome; cytosol
Molecular Function: antioxidant activity; oxidoreductase activity, acting on peroxide as acceptor; protein homodimerization activity; enzyme binding; catalase activity; metal ion binding; heme binding; NADP binding; aminoacylase activity; receptor binding
Biological Process: cholesterol metabolic process; nucleobase, nucleoside and nucleotide metabolic process; hemoglobin metabolic process; menopause; purine base metabolic process; protein homotetramerization; activation of NF-kappaB transcription factor; positive regulation of phosphoinositide 3-kinase cascade; osteoblast differentiation; response to reactive oxygen species; response to vitamin E; response to hyperoxia; triacylglycerol metabolic process; UV protection; inhibition of NF-kappaB transcription factor; hydrogen peroxide catabolic process; ureteric bud development; positive regulation of cell division; aerobic respiration; response to hypoxia; purine nucleotide catabolic process; kidney development; protein tetramerization; negative regulation of apoptosis
Reference #:  P04040 (UniProtKB)
Alt. Names/Synonyms: CAT; CATA; Catalase; MGC138422; MGC138424
Gene Symbols: CAT
Molecular weight: 59,756 Da
Basal Isoelectric point: 6.9  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Catalase

Protein Structure Not Found.


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Sites Implicated In
enzymatic activity, induced: S167‑p, Y231‑p, Y386‑p
protein conformation: S167‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S9-p ADSRDPAsDQMQHWK
0 1 Q13 DPAsDQMQHWKEQRA
0 1 Q13 DPAsDQMQHWKEQRA
0 1 Q13 DPAsDQMQHWKEQRA
0 4 A21 HWKEQRAAQkADVLT
0 1 K23-ub KEQRAAQkADVLTTG
0 1 K38-ac AGNPVGDkLNVITVG
0 1 K38 AGNPVGDKLNVITVG
0 1 K38 AGNPVGDKLNVITVG
0 125 Y84-p KGAGAFGyFEVTHDI
0 4 K98-ub ITKYSKAkVFEHIGK
0 14 K105 kVFEHIGKKtPIAVR
0 1 K105 kVFEHIGKKtPIAVR
0 1 K105 kVFEHIGKKtPIAVR
0 1 T107-p FEHIGKKtPIAVRFs
0 1 S114-gl tPIAVRFstVAGESG
0 1 T115-p PIAVRFstVAGESGS
1 0 S167-p LFPSFIHsQKRNPQT
0 3 K169 PSFIHsQKRNPQTHL
0 1 K169 PSFIHsQKRNPQTHL
0 2 K169 PSFIHsQKRNPQTHL
0 1 K221 GYGSHTFKLVNANGE
0 1 K221 GYGSHTFKLVNANGE
2 315 Y231-p NANGEAVyCKFHYkT
0 1 K233 NGEAVyCKFHYkTDQ
0 2 K237-ac VyCKFHYkTDQGIkN
0 1 K237 VyCKFHYKTDQGIkN
0 2 K237 VyCKFHYKTDQGIkN
0 5 K243-ub YkTDQGIkNLSVEDA
0 2 K243 YkTDQGIKNLSVEDA
0 2 K243 YkTDQGIKNLSVEDA
0 1 S254-gl VEDAARLsQEDPDyG
0 1 Y260-p LsQEDPDyGIRDLFN
0 1 K301 FNPFDLTKVWPHKDy
0 5 K306 LTKVWPHKDyPLIPV
0 1 K306 LTKVWPHKDyPLIPV
0 2 K306 LTKVWPHKDyPLIPV
0 1 Y308-p KVWPHKDyPLIPVGK
0 1 K315 yPLIPVGKLVLNRNP
0 1 K315 yPLIPVGKLVLNRNP
0 1 K349 GIEASPDKMLQGRLF
0 3 Y358-p LQGRLFAyPDTHRHR
0 1 Y370-p RHRLGPNyLHIPVNC
0 11 Y379-p HIPVNCPyRARVANy
2 0 Y386-p yRARVANyQRDGPMC
0 1 Y405 QGGAPNYYPNSFGAP
0 1 S417 GAPEQQPSALEHsIQ
0 3 S422-p QPSALEHsIQySGEV
0 1 Y425-p ALEHsIQySGEVRRF
0 32 R430 IQySGEVRRFNTAND
0 1 R430 IQySGEVRRFNTAND
0 1 R430 IQySGEVRRFNTAND
0 3 T434 GEVRRFNTANDDNVT
0 1 T441 TANDDNVTQVRAFYV
0 1 V448 TQVRAFYVNVLNEEQ
0 3 N449 QVRAFYVNVLNEEQR
0 1 N449 QVRAFYVNVLNEEQR
0 2 N449 QVRAFYVNVLNEEQR
0 9 K457 VLNEEQRKRLCENIA
0 1 K457 VLNEEQRKRLCENIA
0 1 K468-ac ENIAGHLkDAQIFIQ
0 1 K468 ENIAGHLKDAQIFIQ
0 1 K468 ENIAGHLKDAQIFIQ
0 23 K476-ac DAQIFIQkKAVkNFT
0 1 K476 DAQIFIQKKAVkNFT
0 2 K476 DAQIFIQKKAVkNFT
0 5 K477 AQIFIQkKAVkNFTE
0 1 K477 AQIFIQkKAVkNFTE
0 3 K480-ac FIQkKAVkNFTEVHP
0 2 K480-ub FIQkKAVkNFTEVHP
0 2 K480 FIQkKAVKNFTEVHP
0 3 K499 HIQALLDKYNAEKPK
0 1 K499 HIQALLDKYNAEKPK
0 2 K499 HIQALLDKYNAEKPK
0 1 Y500 IQALLDKYNAEKPKN
0 1 K504 LDKYNAEKPKNAIHt
0 8 T511-p KPKNAIHtFVQsGsH
0 5 F512 PKNAIHtFVQsGsHL
0 1 V513 KNAIHtFVQsGsHLA
0 5 S515-p AIHtFVQsGsHLAAR
0 8 S517-p HtFVQsGsHLAAREK
0 5 R522 sGsHLAAREKANL__
0 1 R522 sGsHLAAREKANL__
  mouse

 
S9 SDSRDPASDQMkQWK
K13-ac DPASDQMkQWKEQRA
K13-ub DPASDQMkQWKEQRA
K13-sc DPASDQMkQWKEQRA
S21-p QWKEQRAsQRPDVLT
R23 KEQRAsQRPDVLTTG
K38-ac GGNPIGDkLNIMTAG
K38-ub GGNPIGDkLNIMTAG
K38-sc GGNPIGDkLNIMTAG
Y84-p KGAGAFGyFEVTHDI
K98-ub ITRYSKAkVFEHIGk
K105-ac kVFEHIGkRTPIAVR
K105-ub kVFEHIGkRTPIAVR
K105-sc kVFEHIGkRTPIAVR
T107 FEHIGkRTPIAVRFS
S114 TPIAVRFSTVTGESG
T115 PIAVRFSTVTGESGS
S167 LFPSFIHSQkRNPQT
K169-ac PSFIHSQkRNPQTHL
K169-ub PSFIHSQkRNPQTHL
K169-sc PSFIHSQkRNPQTHL
K221-ac GYGSHTFkLVNADGE
K221-ub GYGSHTFkLVNADGE
Y231-p NADGEAVyCkFHYkT
K233-sc DGEAVyCkFHYkTDQ
K237-ac VyCkFHYkTDQGIkN
K237-ub VyCkFHYkTDQGIkN
K237-sc VyCkFHYkTDQGIkN
K243-ub YkTDQGIkNLPVGEA
K243-sc YkTDQGIkNLPVGEA
K243-ac YkTDQGIkNLPVGEA
A254 VGEAGRLAQEDPDYG
Y260 LAQEDPDYGLRDLFN
K301-ub FNPFDLTkVWPHkDY
K306-ac LTkVWPHkDYPLIPV
K306-ub LTkVWPHkDYPLIPV
K306-sc LTkVWPHkDYPLIPV
Y308 kVWPHkDYPLIPVGk
K315-ub YPLIPVGkLVLNKNP
K315-sc YPLIPVGkLVLNKNP
K349-ub GIEPSPDkMLQGRLF
Y358-p LQGRLFAyPDTHRHR
Y370 RHRLGPNYLQIPVNC
Y379-p QIPVNCPyRARVANy
Y386-p yRARVANyQRDGPMC
Y405-p QGGAPNYyPNSFSAP
S417-p SAPEQQRsALEHsVQ
S422-p QRsALEHsVQCAVDV
C425 ALEHsVQCAVDVkRF
K430-ac VQCAVDVkRFNsANE
K430-ub VQCAVDVkRFNsANE
K430-sc VQCAVDVkRFNsANE
S434-p VDVkRFNsANEDNVt
T441-p sANEDNVtQVRTFYt
T448-p tQVRTFYtkVLNEEE
K449-ac QVRTFYtkVLNEEER
K449-ub QVRTFYtkVLNEEER
K449-sc QVRTFYtkVLNEEER
K457-ac VLNEEERkRLCENIA
K457-sc VLNEEERkRLCENIA
K468 ENIAGHLKDAQLFIQ
K468-ub ENIAGHLkDAQLFIQ
K468-sc ENIAGHLkDAQLFIQ
K476-ac DAQLFIQkkAVkNFT
K476-ub DAQLFIQkkAVkNFT
K476-sc DAQLFIQkkAVkNFT
K477-ac AQLFIQkkAVkNFTD
K477-sc AQLFIQkkAVkNFTD
K480-ac FIQkkAVkNFTDVHP
K480-ub FIQkkAVkNFTDVHP
K480-sc FIQkkAVkNFTDVHP
K499-ac RIQALLDkyNAEkPK
K499-ub RIQALLDkyNAEkPK
K499-sc RIQALLDkyNAEkPK
Y500-p IQALLDkyNAEkPKN
K504-sc LDkyNAEkPKNAIHt
T511-p kPKNAIHtytQAGsH
Y512-p PKNAIHtytQAGsHM
T513-p KNAIHtytQAGsHMA
A515 AIHtytQAGsHMAAk
S517-p HtytQAGsHMAAkGK
K522-ac AGsHMAAkGKANL__
K522-sc AGsHMAAkGKANL__
  rat

 
S9 ADSRDPASDQMKQWK
K13 DPASDQMKQWKEQRA
K13 DPASDQMKQWKEQRA
K13 DPASDQMKQWKEQRA
P21 QWKEQRAPQKPDVLT
K23 KEQRAPQKPDVLTTG
K38 GGNPIGDKLNIMTAG
K38 GGNPIGDKLNIMTAG
K38 GGNPIGDKLNIMTAG
Y84-p KGAGAFGyFEVTHDI
K98 ITRYSKAKVFEHIGK
K105 KVFEHIGKRTPIAVR
K105 KVFEHIGKRTPIAVR
K105 KVFEHIGKRTPIAVR
T107 FEHIGKRTPIAVRFS
S114 TPIAVRFSTVAGESG
T115 PIAVRFSTVAGESGS
S167 LFPSFIHSQKRNPQT
K169 PSFIHSQKRNPQTHL
K169 PSFIHSQKRNPQTHL
K169 PSFIHSQKRNPQTHL
K221 GYGSHTFKLVNANGE
K221 GYGSHTFKLVNANGE
Y231-p NANGEAVyCKFHYKT
K233 NGEAVyCKFHYKTDQ
K237 VyCKFHYKTDQGIKN
K237 VyCKFHYKTDQGIKN
K237 VyCKFHYKTDQGIKN
K243 YKTDQGIKNLPVEEA
K243 YKTDQGIKNLPVEEA
K243 YKTDQGIKNLPVEEA
A254 VEEAGRLAQEDPDYG
Y260 LAQEDPDYGLRDLFN
K301 FNPFDLTKVWPHKDY
K306 LTKVWPHKDYPLIPV
K306 LTKVWPHKDYPLIPV
K306 LTKVWPHKDYPLIPV
Y308 KVWPHKDYPLIPVGK
K315 YPLIPVGKLVLNRNP
K315 YPLIPVGKLVLNRNP
K349 GIEPSPDKMLQGRLF
Y358 LQGRLFAYPDTHRHR
Y370 RHRLGPNYLQIPVNC
Y379 QIPVNCPYRARVANY
Y386 YRARVANYQRDGPMC
Y405 QGGAPNYYPNSFSAP
S417 SAPEQQGSALEHHSQ
S423 GSALEHHSQCSADVK
C425 ALEHHSQCSADVKRF
K430 SQCSADVKRFNsANE
K430 SQCSADVKRFNsANE
K430 SQCSADVKRFNsANE
S434-p ADVKRFNsANEDNVT
T441 sANEDNVTQVRTFYT
T448 TQVRTFYTKVLNEEE
K449 QVRTFYTKVLNEEER
K449 QVRTFYTKVLNEEER
K449 QVRTFYTKVLNEEER
K457 VLNEEERKRLCENIA
K457 VLNEEERKRLCENIA
K468 ENIANHLKDAQLFIQ
K468 ENIANHLKDAQLFIQ
K468 ENIANHLKDAQLFIQ
R476 DAQLFIQRKAVKNFT
R476 DAQLFIQRKAVKNFT
R476 DAQLFIQRKAVKNFT
K477 AQLFIQRKAVKNFTD
K477 AQLFIQRKAVKNFTD
K480 FIQRKAVKNFTDVHP
K480 FIQRKAVKNFTDVHP
K480 FIQRKAVKNFTDVHP
Q499 RVQALLDQYNSQKPK
Q499 RVQALLDQYNSQKPK
Q499 RVQALLDQYNSQKPK
Y500 VQALLDQYNSQKPKN
K504 LDQYNSQKPKNAIHT
T511 KPKNAIHTYVQAGsH
Y512 PKNAIHTYVQAGsHI
V513 KNAIHTYVQAGsHIA
A515 AIHTYVQAGsHIAAK
S517-p HTYVQAGsHIAAKGK
K522 AGsHIAAKGKANL__
K522 AGsHIAAKGKANL__
  pig

 
S9 ADNRDPASDQMKHWK
K13 DPASDQMKHWKEQRA
K13 DPASDQMKHWKEQRA
K13 DPASDQMKHWKEQRA
A21 HWKEQRAAQKPDILT
K23 KEQRAAQKPDILTTG
K38 SGNPIGDKLNILTAG
K38 SGNPIGDKLNILTAG
K38 SGNPIGDKLNILTAG
Y84 KGAGAFGYFEVTHDI
K98 ITRFSKAKVFEHVGK
K105 KVFEHVGKRTPIAVR
K105 KVFEHVGKRTPIAVR
K105 KVFEHVGKRTPIAVR
T107 FEHVGKRTPIAVRFS
S114 TPIAVRFSTVAGESG
T115 PIAVRFSTVAGESGS
S167 LFPSFIHSQKRNPQT
K169 PSFIHSQKRNPQTHL
K169 PSFIHSQKRNPQTHL
K169 PSFIHSQKRNPQTHL
K221 GYGSHTFKLVNEKGE
K221 GYGSHTFKLVNEKGE
Y231 NEKGEAVYCKFHYKT
K233 KGEAVYCKFHYKTDQ
K237 VYCKFHYKTDQGIKN
K237 VYCKFHYKTDQGIKN
K237 VYCKFHYKTDQGIKN
K243 YKTDQGIKNLSVEDA
K243 YKTDQGIKNLSVEDA
K243 YKTDQGIKNLSVEDA
P254 VEDAARLPQEDPDYG
Y260 LPQEDPDYGIRDLFN
K301 FNPFDLTKVWPHSEY
S306 LTKVWPHSEYPLIPV
S306 LTKVWPHSEYPLIPV
S306 LTKVWPHSEYPLIPV
Y308 KVWPHSEYPLIPVGK
K315 YPLIPVGKLVLNRNP
K315 YPLIPVGKLVLNRNP
K349 GIEPSPDKMLQGRLF
Y358 LQGRLFGYPDTHRHR
Y370 RHRLGANYLQIPVNC
F379 QIPVNCPFRARVANY
Y386 FRARVANYQRDGPMC
Y405 QGGAPNYYPNSFSAP
S417 SAPEQTHSALEHCTR
T423 HSALEHCTRYSGDVQ
Y425 ALEHCTRYSGDVQRF
Q430 TRYSGDVQRFNSANE
Q430 TRYSGDVQRFNSANE
Q430 TRYSGDVQRFNSANE
S434 GDVQRFNSANEDNVT
T441 SANEDNVTQVRTFYL
L448 TQVRTFYLNVLNEEE
N449 QVRTFYLNVLNEEER
N449 QVRTFYLNVLNEEER
N449 QVRTFYLNVLNEEER
K457 VLNEEERKRLCENIA
K457 VLNEEERKRLCENIA
K468 ENIAGHLKDAQLFIQ
K468 ENIAGHLKDAQLFIQ
K468 ENIAGHLKDAQLFIQ
K476 DAQLFIQKKAVKNFS
K476 DAQLFIQKKAVKNFS
K476 DAQLFIQKKAVKNFS
K477 AQLFIQKKAVKNFSD
K477 AQLFIQKKAVKNFSD
K480 FIQKKAVKNFSDVHP
K480 FIQKKAVKNFSDVHP
K480 FIQKKAVKNFSDVHP
K499 RIQALLDKYNAEXPE
K499 RIQALLDKYNAEXPE
K499 RIQALLDKYNAEXPE
Y500 IQALLDKYNAEXPEN
- gap
T511 XPENAVHTYVQAGSH
Y512 PENAVHTYVQAGSHL
V513 ENAVHTYVQAGSHLA
A515 AVHTYVQAGSHLAAR
S517 HTYVQAGSHLAAREK
R522 AGSHLAAREKANL__
R522 AGSHLAAREKANL__
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