Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells. Homotetramer. Belongs to the catalase family. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - tryptophan; Endoplasmic reticulum; Hydrolase; Energy Metabolism - methane; Apoptosis; Mitochondrial; EC 184.108.40.206; Oxidoreductase
Molecular Function: antioxidant activity; oxidoreductase activity, acting on peroxide as acceptor; protein homodimerization activity; enzyme binding; catalase activity; metal ion binding; heme binding; NADP binding; receptor binding; aminoacylase activity
Biological Process: response to toxin; response to L-ascorbic acid; response to estradiol stimulus; response to insulin stimulus; protein homotetramerization; response to vitamin A; activation of NF-kappaB transcription factor; response to vitamin E; UV protection; ureteric bud development; hydrogen peroxide catabolic process; protein tetramerization; aging; response to drug; response to inactivity; cholesterol metabolic process; nucleobase, nucleoside and nucleotide metabolic process; hemoglobin metabolic process; response to light intensity; purine base metabolic process; osteoblast differentiation; positive regulation of phosphoinositide 3-kinase cascade; response to reactive oxygen species; response to ethanol; response to hyperoxia; triacylglycerol metabolic process; response to cadmium ion; response to hydrogen peroxide; inhibition of NF-kappaB transcription factor; positive regulation of cell division; response to ozone; response to lead ion; aerobic respiration; response to hypoxia; purine nucleotide catabolic process; response to activity; negative regulation of apoptosis
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.