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StAR (human)

Overview StAR Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. May interact with TSPO. Expressed in gonads, adrenal cortex and kidney. Note: This description may include information from UniProtKB. Protein type: Lipid binding protein; Mitochondrial; Carrier protein Cellular Component: mitochondrial intermembrane space Molecular Function: cholesterol transporter activity; cholesterol binding Biological Process: steroid metabolic process; glucocorticoid metabolic process; cholesterol metabolic process; C21-steroid hormone biosynthetic process; regulation of steroid biosynthetic process; cellular lipid metabolic process; steroid biosynthetic process Reference #:  P49675 (UniProtKB) Alt. Names/Synonyms: cholesterol trafficker; mitochondrial steroid acute regulatory protein; STAR; StAR-related lipid transfer (START) domain containing 1; STARD1; START domain containing 1; START domain-containing protein 1; steroid acute regulatory protein; steroidogenic acute regulator; steroidogenic acute regulatory protein; Steroidogenic acute regulatory protein, mitochondrial Gene Symbols: STAR Molecular weight: 31,914 Da Basal Isoelectric point: 9.17  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below StAR 1IMG - A=67-280 (human) 2I93 - A=67-280 (human) 3P0L - A/D/C/B=66-284 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1IMG 2I93 3P0L  |  Phospho3D  |  DISEASE 201710 600617  |  Source  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
activation: S195‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		R15	LCAGSSYRHMRNMKG
3	0		S56	INQVRRRSsLLGsRL
4	1		S57-p	NQVRRRSsLLGsRLE
0	1		S61-p	RRSsLLGsRLEETLY
1	0		S100	QEGWKKESQQDNGDK
7	0		S195-p	RCAKRRGsTCVLAGM
0	1		T204-p	CVLAGMAtDFGNMPE
2	0		S233	VLHPLAGSPSKTKLT
0	1		K273-a	DFANHLRkRLESHPA
1	0		S277	HLRkRLESHPASEAR

	mouse
R15-m1	LCAGSSYrHMRNMKG
S55	MGQVRRRSSLLGSQL
S56	GQVRRRSSLLGSQLE
S60	RRSSLLGSQLEATLY
S99	QEGWKKESQQENGDE
S194-p	RCTKRRGsTCVLAGM
T203	CVLAGMATHFGEMPE
S232-p	VLHPLAGsPSKTKLT
K272	EFANHLRKRLEASPA
S277	LRKRLEASPASEAQC

	rat
R15	LCAGSSYRHMRNMKG
S55-p	MGQVRRRssLLGSQL
S56-p	GQVRRRssLLGSQLE
S60	RRssLLGSQLEATLY
S99-p	QEGWKKEsQQENGDE
S194-p	RCTKRRGsTCVLAGM
T203	CVLAGMATHFGEMPE
S232	VLHPLAGSPSKTKLT
K272	EFASHLRKRLEsSPA
S276-p	HLRKRLEsSPASEAQ

	hamster
R15	LCAGSSYRHLRNMKG
S55-p	ISQVRRRssLLGSQL
S56-p	SQVRRRssLLGSQLE
S60	RRssLLGSQLEAALY
N99	QEGWKKENQQENGDE
S194-p	RCAKRRGsTCVLAGI
T203	CVLAGIATHFGEMPE
S232	VLHPLAGSPSKTKFT
K272	EFANHLRKRLESSSA
S276	HLRKRLESSSASEAR

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