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GADD45A (human)

Overview GADD45A In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity. Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase. Interacts with MAPK14. Interacts with GADD45GIP1. Interacts with PCNA. By UV irradiation, X-rays, growth arrest and alkylating agents. The induction is mediate by some kinase(s) other than PKC. Belongs to the GADD45 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Apoptosis; Cell cycle regulation; DNA repair Cellular Component: nucleus Molecular Function: protein binding Biological Process: apoptosis; DNA damage response, signal transduction; centrosome cycle; negative regulation of protein kinase activity; regulation of cyclin-dependent protein kinase activity; G2/M transition of mitotic cell cycle; DNA repair; cell cycle arrest Reference #:  P24522 (UniProtKB) Alt. Names/Synonyms: DDIT-1; DDIT1; DNA damage-inducible transcript 1 protein; DNA damage-inducible transcript-1; DNA-damage-inducible transcript 1; GA45A; GADD45; GADD45A; Growth arrest and DNA damage-inducible protein GADD45 alpha; growth arrest and DNA-damage-inducible 45 alpha; growth arrest and DNA-damage-inducible, alpha Gene Symbols: GADD45A Molecular weight: 18,336 Da Basal Isoelectric point: 4.36  Predict pI for various phosphorylation states CST Pathways:  Cell Cycle: G2/M DNA Damage Checkpoint  |  T Cell Receptor Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below GADD45A 2KG4 - A=1-165 (human)

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  RCSB PDB  |  Phospho3D  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	4		K12-u	EFSAGEQkTERMDkV
0	4		K18-u	QkTERMDkVGDALEE
0	26		K29-u	ALEEVLSkALsQRTI
0	1		S32-p	EVLSkALsQRTITVG
0	1		Y41-p	RTITVGVyEAAKLLN

	mouse
K12	EFSAAEQKTERMDTV
T18	QKTERMDTVGDALEE
K29	ALEEVLSKARSQRTI
S32	EVLSKARSQRTITVG
Y41	RTITVGVYEAAKLLN

	rat
K12	EFSAAEQKIERMDTV
T18	QKIERMDTVGDALEE
K29	ALEEVLSKARSQRTI
S32	EVLSKARSQRTITVG
Y41	RTITVGVYEAAKLLN

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