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Protein Page:
GADD45A (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
GADD45A In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity. Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase. Interacts with MAPK14. Interacts with GADD45GIP1. Interacts with PCNA. By UV irradiation, X-rays, growth arrest and alkylating agents. The induction is mediate by some kinase(s) other than PKC. Belongs to the GADD45 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Cell cycle regulation; DNA repair, damage
Cellular Component: cytoplasm; nucleus
Molecular Function: protein binding
Biological Process: positive regulation of apoptosis; apoptosis; centrosome cycle; activation of MAPKKK activity; DNA damage response, signal transduction; positive regulation of JNK cascade; negative regulation of protein kinase activity; regulation of cyclin-dependent protein kinase activity; cell cycle arrest; DNA repair
Reference #:  P24522 (UniProtKB)
Alt. Names/Synonyms: DDIT-1; DDIT1; DNA damage-inducible transcript 1 protein; DNA damage-inducible transcript-1; DNA-damage-inducible transcript 1; GA45A; GADD45; GADD45A; Growth arrest and DNA damage-inducible protein GADD45 alpha; growth arrest and DNA-damage-inducible 45 alpha; growth arrest and DNA-damage-inducible, alpha
Gene Symbols: GADD45A
Molecular weight: 18,336 Da
Basal Isoelectric point: 4.36  Predict pI for various phosphorylation states
CST Pathways:  G2/M DNA Damage Checkpoint  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

GADD45A

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T2-p ______MtLEEFSAG
0 4 K12-ub EFSAGEQkTERMDkV
0 4 K18-ub QkTERMDkVGDALEE
0 26 K29-ub ALEEVLSkALsQRTI
0 1 S32-p EVLSkALsQRTITVG
0 1 Y41-p RTITVGVyEAAKLLN
  mouse

 
T2 ______MTLEEFSAA
K12 EFSAAEQKTERMDTV
T18 QKTERMDTVGDALEE
K29 ALEEVLSKARSQRTI
S32 EVLSKARSQRTITVG
Y41 RTITVGVYEAAKLLN
  rat

 
T2 ______MTLEEFSAA
K12 EFSAAEQKIERMDTV
T18 QKIERMDTVGDALEE
K29 ALEEVLSKARSQRTI
S32 EVLSKARSQRTITVG
Y41 RTITVGVYEAAKLLN
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