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Protein Page:
RAIG1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
RAIG1 a G protein coupled receptor that is induced by all-trans retinoic acid (ATRA). Retinoic acids (RA) are a group of pleiotropic signaling molecules that regulate a broad range of physiologic and developmental processes. RAIG1 is expressed in lung tissue and in several lung cancer cell lines. This retinoic acid-inducible GPCR provides evidence for an interaction between retinoid and G-protein signaling pathways. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 3; Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral
Cellular Component: cytoplasmic vesicle membrane; intracellular membrane-bound organelle; integral to plasma membrane; plasma membrane
Molecular Function: G-protein coupled receptor activity
Biological Process: G-protein coupled receptor protein signaling pathway; signal transduction
Reference #:  Q8NFJ5 (UniProtKB)
Alt. Names/Synonyms: G protein-coupled receptor, family C, group 5, member A; G-protein coupled receptor family C group 5 member A; GPCR5A; GPRC5A; Orphan G-protein-coupling receptor PEIG-1; RAI3; RAIG-1; RAIG1; retinoic acid induced 3; retinoic acid responsive; Retinoic acid-induced gene 1 protein; Retinoic acid-induced protein 3
Gene Symbols: GPRC5A
Molecular weight: 40,251 Da
Basal Isoelectric point: 8.39  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

RAIG1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 K285-ub PVEDAFCkPQLVkks
0 2 K290-ub FCkPQLVkksyGVEN
0 2 K291-ub CkPQLVkksyGVENR
0 1 S292-p kPQLVkksyGVENRA
0 25 Y293-p PQLVkksyGVENRAy
0 49 Y300-p yGVENRAysQEEItQ
0 20 S301-p GVENRAysQEEItQG
0 5 T306-p AysQEEItQGFEEtG
0 9 T312-p ItQGFEEtGDtLyAP
0 13 T315-p GFEEtGDtLyAPyst
0 298 Y317-p EEtGDtLyAPystHF
0 179 Y320-p GDtLyAPystHFQLQ
0 20 S321-p DtLyAPystHFQLQN
0 24 T322-p tLyAPystHFQLQNQ
0 1 K333-ub LQNQPPQkEFsIPRA
0 13 S336-p QPPQkEFsIPRAHAW
0 209 S345-p PRAHAWPsPykDyEV
1 829 Y347-p AHAWPsPykDyEVkK
0 5 K348-ub HAWPsPykDyEVkKE
0 806 Y350-p WPsPykDyEVkKEGs
0 1 K353-ub PykDyEVkKEGs___
0 51 S357-p yEVkKEGs_______
  mouse

 
K287-ub PVEDAFCkPQLMKQS
K292 FCkPQLMKQSYGVEN
Q293 CkPQLMKQSYGVENR
S294 kPQLMKQSYGVENRA
Y295 PQLMKQSYGVENRAy
Y302-p YGVENRAysQEEITQ
S303-p GVENRAysQEEITQG
T308 AysQEEITQGLEMGD
M313 EITQGLEMGDTLyAP
T316 QGLEMGDTLyAPySt
Y318-p LEMGDTLyAPyStHF
Y321-p GDTLyAPyStHFQLQ
S322 DTLyAPyStHFQLQN
T323-p TLyAPyStHFQLQNH
K332 FQLQNHQKDFsIPRA
S335-p QNHQKDFsIPRAQAP
S344-p PRAQAPAsPyNDyEG
Y346-p AQAPAsPyNDyEGRK
N347 QAPAsPyNDyEGRKG
Y349-p PAsPyNDyEGRKGDs
R352 PyNDyEGRKGDs___
S356-p yEGRKGDs_______
  rat

 
K118 PVEDAFCKPQLMKQS
K123 FCKPQLMKQSYGVEN
Q124 CKPQLMKQSYGVENR
S125 KPQLMKQSYGVENRA
Y126 PQLMKQSYGVENRAY
Y133 YGVENRAYSQEEITQ
S134 GVENRAYSQEEITQG
T139 AYSQEEITQGLEEMG
M145 ITQGLEEMGDTLYAP
T148 GLEEMGDTLYAPYST
Y150 EEMGDTLYAPYSTHF
Y153 GDTLYAPYSTHFQMQ
S154 DTLYAPYSTHFQMQN
T155 TLYAPYSTHFQMQNR
K164 FQMQNRQKDFSIPRA
S167 QNRQKDFSIPRAHTP
S176-p PRAHTPAsPYNDYEG
Y178 AHTPAsPYNDYEGRK
N179 HTPAsPYNDYEGRKG
Y181 PAsPYNDYEGRKGDS
R184 PYNDYEGRKGDS___
S188 YEGRKGDS_______
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