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RAIG1 (human)

Overview RAIG1 a type 3 G protein-coupling receptor. May be involved in modulating differentiation and maintaining homeostasis of epithelial cells. This retinoic acid-inducible GPCR provides evidence for a possible interaction between retinoid and G-protein signaling pathways. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral; GPCR, family 3; Receptor, GPCR Cellular Component: Golgi apparatus; cytoplasmic vesicle membrane; intracellular membrane-bound organelle; integral to plasma membrane; plasma membrane Molecular Function: G-protein coupled receptor activity Biological Process: signal transduction Reference #:  Q8NFJ5 (UniProtKB) Alt. Names/Synonyms: G protein-coupled receptor, family C, group 5, member A; G-protein coupled receptor family C group 5 member A; GPCR5A; GPRC5A; Orphan G-protein-coupling receptor PEIG-1; RAI3; RAIG-1; RAIG1; retinoic acid induced 3; retinoic acid responsive; Retinoic acid-induced gene 1 protein; Retinoic acid-induced protein 3 Gene Symbols: GPRC5A Molecular weight: 40,251 Da Basal Isoelectric point: 8.39  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below RAIG1

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	3		K285-u	PVEDAFCkPQLVkks
0	2		K290-u	FCkPQLVkksyGVEN
0	2		K291-u	CkPQLVkksyGVENR
0	1		S292-p	kPQLVkksyGVENRA
0	18		Y293-p	PQLVkksyGVENRAy
0	45		Y300-p	yGVENRAysQEEItQ
0	20		S301-p	GVENRAysQEEItQG
0	5		T306-p	AysQEEItQGFEEtG
0	7		T312-p	ItQGFEEtGDtLyAP
0	14		T315-p	GFEEtGDtLyAPyst
0	286		Y317-p	EEtGDtLyAPystHF
0	164		Y320-p	GDtLyAPystHFQLQ
0	21		S321-p	DtLyAPystHFQLQN
0	22		T322-p	tLyAPystHFQLQNQ
0	1		K333-u	LQNQPPQkEFsIPRA
0	11		S336-p	QPPQkEFsIPRAHAW
0	208		S345-p	PRAHAWPsPykDyEV
0	818		Y347-p	AHAWPsPykDyEVkK
0	5		K348-u	HAWPsPykDyEVkKE
0	801		Y350-p	WPsPykDyEVkKEGs
0	1		K353-u	PykDyEVkKEGs___
0	52		S357-p	yEVkKEGs_______

	mouse
K287-u	PVEDAFCkPQLMKQS
K292	FCkPQLMKQSYGVEN
Q293	CkPQLMKQSYGVENR
S294	kPQLMKQSYGVENRA
Y295	PQLMKQSYGVENRAy
Y302-p	YGVENRAysQEEITQ
S303-p	GVENRAysQEEITQG
T308	AysQEEITQGLEMGD
M313	EITQGLEMGDTLyAP
T316	QGLEMGDTLyAPySt
Y318-p	LEMGDTLyAPyStHF
Y321-p	GDTLyAPyStHFQLQ
S322	DTLyAPyStHFQLQN
T323-p	TLyAPyStHFQLQNH
K332	FQLQNHQKDFsIPRA
S335-p	QNHQKDFsIPRAQAP
S344-p	PRAQAPAsPyNDyEG
Y346-p	AQAPAsPyNDyEGRK
N347	QAPAsPyNDyEGRKG
Y349-p	PAsPyNDyEGRKGDs
R352	PyNDyEGRKGDs___
S356-p	yEGRKGDs_______

	rat
K118	PVEDAFCKPQLMKQS
K123	FCKPQLMKQSYGVEN
Q124	CKPQLMKQSYGVENR
S125	KPQLMKQSYGVENRA
Y126	PQLMKQSYGVENRAY
Y133	YGVENRAYSQEEITQ
S134	GVENRAYSQEEITQG
T139	AYSQEEITQGLEEMG
M145	ITQGLEEMGDTLYAP
T148	GLEEMGDTLYAPYST
Y150	EEMGDTLYAPYSTHF
Y153	GDTLYAPYSTHFQMQ
S154	DTLYAPYSTHFQMQN
T155	TLYAPYSTHFQMQNR
K164	FQMQNRQKDFSIPRA
S167	QNRQKDFSIPRAHTP
S176	PRAHTPASPYNDYEG
Y178	AHTPASPYNDYEGRK
N179	HTPASPYNDYEGRKG
Y181	PASPYNDYEGRKGDS
R184	PYNDYEGRKGDS___
S188	YEGRKGDS_______

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