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K7 (human)

Overview K7 a type II cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Phosphorylation of keratins at specific sites affects their organization, assembly dynamics, and their interaction with signaling molecules. Specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels. Note: This description may include information from UniProtKB. Protein type: Cytoskeletal protein Cellular Component: Golgi apparatus; keratin filament; cytoplasm; nucleolus; intermediate filament; nucleus Molecular Function: protein binding; structural molecule activity Biological Process: regulation of translation; virus-host interaction; interphase; cytoskeleton organization and biogenesis; DNA replication Reference #:  P08729 (UniProtKB) Alt. Names/Synonyms: CK-7; CK7; cytokeratin 7; Cytokeratin-7; K2C7; K7; keratin 7; keratin, 55K type II cytoskeletal; keratin, simple epithelial type I, K7; Keratin, type II cytoskeletal 7; Keratin-7; KRT7; MGC129731; MGC3625; Sarcolectin; SCL; type II mesothelial keratin K7; Type-II keratin Kb7 Gene Symbols: KRT7 Molecular weight: 51,386 Da Basal Isoelectric point: 5.4  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below K7

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S7-p	_MSIHFSsPVFTSRS
0	1		S14	sPVFTSRSAAFSGrG
0	16		R20-m1	RSAAFSGrGAQVrLS
0	5		R20-m2	RSAAFSGrGAQVrLS
0	6		R25-m1	SGrGAQVrLSSARPG
0	16		S36-p	ARPGGLGsssLyGLG
0	36		S37-p	RPGGLGsssLyGLGA
0	118		S38-p	PGGLGsssLyGLGAs
0	596		Y40-p	GLGsssLyGLGAsRP
0	3		S45-p	sLyGLGAsRPRVAVR
0	1		S53	RPRVAVRSAyGGPVG
0	88		Y55-p	RVAVRSAyGGPVGAG
0	2		T67-p	GAGIREVtINQSLLA
0	5		K96-u	QEESEQIkTLNNkFA
1	29		K101-a	QIkTLNNkFAsFIDk
0	9		K101-u	QIkTLNNkFAsFIDk
0	15		S104-p	TLNNkFAsFIDkVRF
0	6		K108-a	kFAsFIDkVRFLEQQ
0	10		K108-u	kFAsFIDkVRFLEQQ
0	3		K117-u	RFLEQQNkLLETkWT
0	4		K122-u	QNkLLETkWTLLQEQ
0	4		K130-u	WTLLQEQkSAKSSRL
0	1		K179-a	VVEDFKNkYEDEINH
0	1		K198-u	ENEFVVLkkDVDAAy
0	1		K199-a	NEFVVLkkDVDAAyM
0	4		K199-u	NEFVVLkkDVDAAyM
0	125		Y205-p	kkDVDAAyMSKVELE
0	2		K214-u	SKVELEAkVDALNDE
0	1		A217	ELEAkVDALNDEINF
0	1		T227-p	DEINFLRtLNETELt
0	1		T234-p	tLNETELtELQsQIS
0	3		S238-p	TELtELQsQISDTSV
0	3		S254-p	LSMDNSRsLDLDGII
0	2		K265-u	DGIIAEVkAQyEEMA
0	2		Y268-p	IAEVkAQyEEMAkCS
0	3		K273-u	AQyEEMAkCSRAEAE
0	10		Y283-p	RAEAEAWyQTkFETL
0	3		K286-u	AEAWyQTkFETLQAQ
0	2		K296-a	TLQAQAGkHGDDLRN
0	2		K296-u	TLQAQAGkHGDDLRN
0	5		K326-u	QAEIDNIkNQRAkLE
0	1		K331-u	NIkNQRAkLEAAIAE
0	10		K348-u	ERGELALkDARAkQE
0	1		K353-u	ALkDARAkQEELEAA
0	2		Y375-p	MARQLREyQELMsVK
0	1		S380-p	REyQELMsVKLALDI
0	1		Y392-p	LDIEIATyRkLLEGE
0	59		K394-u	IEIATyRkLLEGEES
0	2		S456-p	PGLLKAYsIRtASAs
0	1		T459-p	LKAYsIRtASAsRRs
0	1		S463-p	sIRtASAsRRsARD_
0	1		S466-p	tASAsRRsARD____

	mouse
S7	_MSIHFSSRsTAYPG
S9-p	SIHFSSRsTAYPGrG
R15-m1	RsTAYPGrGAQVrLS
R15	RsTAYPGRGAQVrLS
R20-m1	PGrGAQVrLSSGRAS
S30	SGRASFGSRsLyGLG
R31	GRASFGSRsLyGLGS
S32-p	RASFGSRsLyGLGSs
Y34-p	SFGSRsLyGLGSsRP
S39-p	sLyGLGSsRPRVAVR
S47-p	RPRVAVRsAyGGPVG
Y49-p	RVAVRsAyGGPVGAG
T61	GAGIREITINQSLLA
K90	QEEREQIKTLNNkFA
K95	QIKTLNNKFAsFIDk
K95-u	QIKTLNNkFAsFIDk
S98-p	TLNNkFAsFIDkVRF
K102	kFAsFIDKVRFLEQQ
K102-u	kFAsFIDkVRFLEQQ
K111-u	RFLEQQNkMLETKWA
K116	QNkMLETKWALLQEQ
K124	WALLQEQKSAKSSQL
K173	VVEDFKNKYEEEINR
K192	ENEFVLLKKDVDAAy
K193	NEFVLLKKDVDAAyT
K193	NEFVLLKKDVDAAyT
Y199-p	KKDVDAAyTNKVELE
K208	NKVELEAKADsLQDE
S211-p	ELEAKADsLQDEINF
T221	DEINFLKTLHETELA
A228	TLHETELAELQSQIS
S232	TELAELQSQISDTSV
S248-p	LSMDNSRsLDLDGII
K259	DGIIADVKAQYEEMA
Y262	IADVKAQYEEMANHS
N267	AQYEEMANHSRAEAE
Y277	RAEAEAWYQTKFETL
K280	AEAWYQTKFETLQAQ
K290	TLQAQAGKHGDDLRN
K290	TLQAQAGKHGDDLRN
K320-u	QAEIDTLkNQRAKLE
K325	TLkNQRAKLESSIAE
K342	EQGELAIKDAHAKQG
K347	AIKDAHAKQGELEAA
Y369	VARQLREYQELLNTK
N374	REYQELLNTKLALDI
Y386	LDIEIATYRkLLEGE
K388-u	IEIATYRkLLEGEES
S444	PGALRAYSIKTTSTT
T447	LRAYSIKTTSTTRRG
T451	SIKTTSTTRRGTHN_
G454	TTSTTRRGTHN____

	rat
S7	_MSIHFSSRSTAYPG
S9	SIHFSSRSTAYPGrG
R15-m1	RSTAYPGrGAQVrLS
R15	RSTAYPGRGAQVrLS
R20-m1	PGrGAQVrLSSGRAG
S30	SGRAGFGSRSLYGLG
R31	GRAGFGSRSLYGLGT
S32	RAGFGSRSLYGLGTS
Y34	GFGSRSLYGLGTSRP
S39	SLYGLGTSRPRVAVR
S47	RPRVAVRSAYGGPVG
Y49	RVAVRSAYGGPVGAG
T61	GAGIREITINQNLLA
K90	QEEREQIKTLNNKFA
K95	QIKTLNNKFASFIDK
K95	QIKTLNNKFASFIDK
S98	TLNNKFASFIDKVRF
K102	KFASFIDKVRFLEQQ
K102	KFASFIDKVRFLEQQ
K111	RFLEQQNKMLETKWA
K116	QNKMLETKWALLQDQ
K124	WALLQDQKSAKSSQL
K173	VVEDFKNKYEEEINR
K192	ENEFVLLKKDVDAAY
K193	NEFVLLKKDVDAAYT
K193	NEFVLLKKDVDAAYT
Y199	KKDVDAAYTNKVELE
K208	NKVELEAKADSLQDK
S211	ELEAKADSLQDKINF
T221	DKINFLKTLHETELA
A228	TLHETELAELQSQIS
S232	TELAELQSQISDTCV
S248	LSMDNSRSLDLDGII
K259	DGIIADVKAQYEEMA
Y262	IADVKAQYEEMANHS
N267	AQYEEMANHSQAEAE
Y277	QAEAEAWYQTKFETL
K280	AEAWYQTKFETLQAQ
K290	TLQAQAGKHGDDLRN
K290	TLQAQAGKHGDDLRN
K320	QAEIDTVKNQRAKLE
K325	TVKNQRAKLESSIAE
K342-u	EQGELALkDARAKLA
K347	ALkDARAKLAEVEEA
Y369	LARLLREYQELMNVK
N374	REYQELMNVKLGLDI
Y386	LDIEIATYRKLLEGE
K388	IEIATYRKLLEGEES
S444-p	PGVLRTYsIKTTSTA
T447	LRTYsIKTTSTARRG
A451	sIKTTSTARRGTHH_
G454	TTSTARRGTHH____

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