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XIAP (human)

Overview XIAP an apoptotic suppressor protein. Inhibist apoptosis through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2. Inhibits apoptosis induced by menadione, a potent inducer of free radicals, and ICE. Inhibits cell-death proteases, caspase-3, caspase-7, and perhaps caspase-9. Note: This description may include information from UniProtKB. Protein type: EC 6.3.2.-; Ubiquitin ligase; Apoptosis; Ubiquitin conjugating system; Ligase Cellular Component: cytoplasm; nucleus; cytosol Molecular Function: protein binding; zinc ion binding; caspase inhibitor activity; ubiquitin-protein ligase activity Biological Process: Wnt receptor signaling pathway; apoptosis; regulation of inflammatory response; regulation of BMP signaling pathway; negative regulation of caspase activity; response to DNA damage stimulus; copper ion homeostasis; regulation of innate immune response; negative regulation of apoptosis; regulation of cell proliferation Reference #:  P98170 (UniProtKB) Alt. Names/Synonyms: API3; apoptosis inhibitor 3; baculoviral IAP repeat-containing 4; Baculoviral IAP repeat-containing protein 4; BIRC4; E3 ubiquitin-protein ligase XIAP; hIAP-3; hIAP3; hILP; IAP-3; IAP-like protein; IAP3; ILP; ILP1; Inhibitor of apoptosis protein 3; MIHA; X-linked IAP; X-linked inhibitor of apoptosis; X-linked inhibitor of apoptosis protein; XIAP; XLP2 Gene Symbols: XIAP Molecular weight: 56,685 Da Basal Isoelectric point: 6.22  Predict pI for various phosphorylation states CST Pathways:  Apoptosis  |  Death Receptor Signaling  |  ErbB/HER Signaling  |  Inhibition of Apoptosis  |  Mitochondrial Control of Apoptosis  |  PI3K/Akt Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below XIAP 1C9Q - A=124-240 (human) 1F9X - A=241-356 (human) 1G3F - A=241-356 (human) 1G73 - C/D=238-358 (human) 1I3O - E/F=124-240 (human) 1I4O - C/D=120-260 (human) 1I51 - E/F=124-240 (human) 1KMC - C/D=124-242 (human) 1NW9 - A=253-350 (human) 1TFQ - A=241-356 (human) 1TFT - A=241-356 (human) 2ECG - A=430-497 (human) 2JK7 - A=241-356 (human) 2KNA - A=357-449 (human) 2OPY - A=249-354 (human) 2OPZ - A/B/C/D=249-357 (human) 2POI - A=10-99 (human) 2POP - B/D=10-100 (human) 2QRA - A/B/C/D=10-99 (human) 2VSL - A=250-345 (human) 3CLX - A/C/D/B=241-356 (human) 3CM2 - F/A/J/E/B/H/D/C/I/G=241-356 (human) 3CM7 - A/D/C/B=241-356 (human) 3EYL - A/B=241-356 (human) 3G76 - F/A/E/B/H/C/D/G=241-356 (human) 3HL5 - A/B=256-346 (human) 3UW4 - A=338-348 (human) 3UW5 - A/B=336-348 (human) 4EC4 - F/A/J/K/E/B/C/D/G/L=241-356 (human) 4HY0 - F/A/E/B/H/C/D/G=238-357 (human) 4IC2 - A/B=429-497 (human) 4IC3 - A/B=429-497 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1C9Q 1F9X 1G3F 1G73 1I3O 1I4O 1I51 1KMC 1NW9 1TFQ 1TFT 2ECG 2JK7 2KNA 2OPY 2OPZ 2POI 2POP 2QRA 2VSL 3CLX 3CM2 3CM7 3EYL 3G76 3HL5 3UW4 3UW5 4EC4 4HY0 4IC2 4IC3  |  ENZYME  |  Phospho3D  |  DISEASE 300079 300635  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
apoptosis, altered: S87‑p apoptosis, inhibited: S87‑p protein stabilization: S87‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K10-u	FNSFEGSkTCVPADI
0	1		K19	CVPADINKEEEFVEE
0	4		K31-u	VEEFNRLktFANFPS
0	2		T32-p	EEFNRLktFANFPSG
0	2		S45-p	SGSPVSAstLARAGF
0	2		T46-p	GSPVSAstLARAGFL
2	0		S87-p	VGRHRKVsPNCRFIN
0	2		K116-u	GIQNGQYkVENyLGs
0	1		Y120-p	GQYkVENyLGsRDHF
0	1		S123-p	kVENyLGsRDHFALD
1	1		Y139-p	PSETHADyLLRTGQV
0	4		K168-u	YSEEARLkSFQNWPD
0	1		S169	SEEARLkSFQNWPDY
0	1		T180-p	WPDYAHLtPRELASA
1	0		K322-u	DPWEQHAkWYPGCkY
1	1		K328-u	AkWYPGCkYLLEQKG
0	2		K358-u	CLVRTTEkTPSLTRR
0	1		S400-p	MEEKIQIsGSNykSL
0	2		Y404-p	IQIsGSNykSLEVLV
0	3		K405-u	QIsGSNykSLEVLVA
0	1		T429-p	MQDESSQtsLQkEIS
1	0		S430-p	QDESSQtsLQkEIST
0	1		K433-u	SSQtsLQkEISTEEQ

	mouse
R10	FNSFEGTRTFVLADT
K19-u	FVLADTNkDEEFVEE
K31-u	VEEFNRLkTFANFPS
T32	EEFNRLkTFANFPSS
S45	SSSPVSASTLARAGF
T46	SSPVSASTLARAGFL
S87	VGRHRRISPNCRFIN
K116	GIQNGQYKSENCVGN
C120	GQYKSENCVGNRNPF
N123	KSENCVGNRNPFAPD
Y139	PPETHADYLLRTGQV
K168-u	CSEEARLksFQNWPD
S169-p	SEEARLksFQNWPDY
T180	WPDYAHLTPRELASA
K321	DPWEQHAKWYPGCKY
K327	AKWYPGCKYLLDEKG
K357	SLGRTAEKTPSLTKK
S399	MEEKIQTSGSSYLSL
Y403	IQTSGSSYLSLEVLI
L404	QTSGSSYLSLEVLIA
T428	TEDESSQTSLQKDIS
S429	EDESSQTSLQKDIST
K432	SSQTSLQKDISTEEQ

	rat
R10	FNSFEGSRTVVPADT
K19	VVPADTNKDEEFVEE
K31	VEEFNRLKTFANFPS
T32	EEFNRLKTFANFPSS
S45	SSSPVSASTLARAGF
T46	SSPVSASTLARAGFL
S87	VGRHRRISPNCRFIN
K116	GIQNGQYKSENCVGN
C120	GQYKSENCVGNRNHF
N123	KSENCVGNRNHFALD
Y139-p	PSETHADyLLRTGQV
K168	CSEEARLKTFQNWPD
T169	SEEARLKTFQNWPDY
S180	WPDYAHLSPRELASA
K321	DPWEQHAKWYPGCKY
K327	AKWYPGCKYLLDEKG
K357	SVVRTAEKTPSVTKK
S399	MEEKLQTSGSNYLSL
Y403	LQTSGSNYLSLEVLI
L404	QTSGSNYLSLEVLIA
T428	SQDESSQTSLQKDIS
S429	QDESSQTSLQKDIST
K432	SSQTSLQKDISTEEQ

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