Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
XIAP (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
XIAP an apoptotic suppressor protein. Inhibist apoptosis through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2. Inhibits apoptosis induced by menadione, a potent inducer of free radicals, and ICE. Inhibits cell-death proteases, caspase-3, caspase-7, and perhaps caspase-9. Note: This description may include information from UniProtKB.
Protein type: Ligase; Apoptosis; Ubiquitin ligase; Ubiquitin conjugating system; EC 6.3.2.-
Cellular Component: cytoplasm; nucleus; cytosol
Molecular Function: protein binding; zinc ion binding; caspase inhibitor activity; ubiquitin-protein ligase activity
Biological Process: Wnt receptor signaling pathway; positive regulation of protein ubiquitination; apoptosis; regulation of BMP signaling pathway; regulation of inflammatory response; protein ubiquitination; negative regulation of caspase activity; response to DNA damage stimulus; copper ion homeostasis; regulation of cell proliferation; regulation of innate immune response; negative regulation of apoptosis
Reference #:  P98170 (UniProtKB)
Alt. Names/Synonyms: API3; apoptosis inhibitor 3; baculoviral IAP repeat-containing 4; Baculoviral IAP repeat-containing protein 4; BIRC4; E3 ubiquitin-protein ligase XIAP; hIAP-3; hIAP3; hILP; IAP-3; IAP-like protein; IAP3; ILP; ILP1; Inhibitor of apoptosis protein 3; MIHA; X-linked IAP; X-linked inhibitor of apoptosis; X-linked inhibitor of apoptosis protein; XIAP; XLP2
Gene Symbols: XIAP
Molecular weight: 56,685 Da
Basal Isoelectric point: 6.22  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Death Receptor Signaling  |  ErbB/HER Signaling  |  Inhibition of Apoptosis  |  Mitochondrial Control of Apoptosis  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

XIAP

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Sites Implicated In
apoptosis, altered: S87‑p
apoptosis, inhibited: S87‑p
protein stabilization: S87‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K10-u FNSFEGSkTCVPADI
0 1 K19 CVPADINKEEEFVEE
0 4 K31-u VEEFNRLktFANFPS
0 2 T32-p EEFNRLktFANFPSG
0 2 S45-p SGSPVSAstLARAGF
0 2 T46-p GSPVSAstLARAGFL
3 0 S87-p VGRHRKVsPNCRFIN
0 2 K116-u GIQNGQYkVENYLGs
0 1 S123-p kVENYLGsRDHFALD
1 1 Y139-p PSETHADyLLRTGQV
0 4 K168-u YSEEARLkSFQNWPD
1 0 K322-u DPWEQHAkWYPGCkY
1 1 K328-u AkWYPGCkYLLEQKG
0 2 K358-u CLVRTTEkTPSLTRR
0 2 Y404-p IQISGSNykSLEVLV
0 3 K405-u QISGSNykSLEVLVA
1 0 S430-p QDESSQTsLQkEIST
0 1 K433-u SSQTsLQkEISTEEQ
  mouse

 
R10 FNSFEGTRTFVLADT
K19-u FVLADTNkDEEFVEE
K31-u VEEFNRLkTFANFPS
T32 EEFNRLkTFANFPSS
S45 SSSPVSASTLARAGF
T46 SSPVSASTLARAGFL
S87 VGRHRRISPNCRFIN
K116 GIQNGQYKSENCVGN
N123 KSENCVGNRNPFAPD
Y139 PPETHADYLLRTGQV
K168-u CSEEARLkSFQNWPD
K321 DPWEQHAKWYPGCKY
K327 AKWYPGCKYLLDEKG
K357 SLGRTAEKTPSLTKK
Y403 IQTSGSSYLSLEVLI
L404 QTSGSSYLSLEVLIA
S429 EDESSQTSLQKDIST
K432 SSQTSLQKDISTEEQ
  rat

 
R10 FNSFEGSRTVVPADT
K19 VVPADTNKDEEFVEE
K31 VEEFNRLKTFANFPS
T32 EEFNRLKTFANFPSS
S45 SSSPVSASTLARAGF
T46 SSPVSASTLARAGFL
S87 VGRHRRISPNCRFIN
K116 GIQNGQYKSENCVGN
N123 KSENCVGNRNHFALD
Y139-p PSETHADyLLRTGQV
K168 CSEEARLKTFQNWPD
K321 DPWEQHAKWYPGCKY
K327 AKWYPGCKYLLDEKG
K357 SVVRTAEKTPSVTKK
Y403 LQTSGSNYLSLEVLI
L404 QTSGSNYLSLEVLIA
S429 QDESSQTSLQKDIST
K432 SSQTSLQKDISTEEQ
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.