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BATF (human)

Overview BATF a nuclear basic leucine zipper protein that belongs to the AP-1/ATF superfamily of transcription factors. Functions as a negative regulator of AP-1 mediated transcription by binding to Jun proteins. Jun/B-ATF heterodimers bind DNA preferentially at the 12-O-tetradecanoylphorbol-13- acetate response element (TRE) and weaker at the cAMP responsive region (CRE), but are transcriptionally inert. Note: This description may include information from UniProtKB. Protein type: DNA binding protein; Transcription factor Cellular Component: cytoplasm; nucleus Molecular Function: protein binding; sequence-specific DNA binding; transcription factor activity Biological Process: transcription, DNA-dependent; DNA damage response, signal transduction by p53 class mediator; isotype switching; cytokine production; myeloid dendritic cell differentiation; lymphoid progenitor cell differentiation; T-helper 2 cell differentiation; defense response to protozoan; response to DNA damage stimulus Reference #:  Q16520 (UniProtKB) Alt. Names/Synonyms: activating transcription factor B; B-ATF; B-cell-activating transcription factor; basic leucine zipper transcription factor, ATF-like; Basic leucine zipper transcriptional factor ATF-like; BATF; BATF1; SF-HT-activated gene 2 protein; SFA-2; SFA2 Gene Symbols: BATF Molecular weight: 14,120 Da Basal Isoelectric point: 8.82  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below BATF

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	Sites Implicated In
transcription, altered: S43‑p

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S13	DSSDSSFSRSPPPGK
0	1		S15	SDSSFSRSPPPGKQD
1	0		S43-p	NRIAAQKsRQRQtQK
1	0		T48-p	QKsRQRQtQKADTLH
0	1		T76-p	RKEIKQLtEELKYFT

	mouse
S13-p	DSSDSSFsRsPPPGK
S15-p	SDSSFsRsPPPGKQD
S43	NRIAAQKSRQRQTQK
T48	QKSRQRQTQKADTLH
T76	RKEIKQLTEELKYFT

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