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Protein Page:
Neu3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Neu3 Plays a role in modulating the ganglioside content of the lipid bilayer at the level of membrane-bound sialyl glycoconjugates. Belongs to the glycosyl hydrolase 33 family. Note: This description may include information from UniProtKB.
Protein type: EC 3.2.1.18; Hydrolase; Lipid Metabolism - sphingolipid; Glycan Metabolism - other glycan degradation
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: alpha-sialidase activity; exo-alpha-sialidase activity
Biological Process: oligosaccharide catabolic process; sphingolipid metabolic process; ganglioside catabolic process; carbohydrate metabolic process; glycosphingolipid metabolic process
Reference #:  Q9UQ49 (UniProtKB)
Alt. Names/Synonyms: FLJ12388; Ganglioside sialidase; Membrane sialidase; N-acetyl-alpha-neuraminidase 3; NEU3; NEUR3; neuraminidase 3; SIAL3; sialidase 3 (membrane sialidase); Sialidase-3
Gene Symbols: NEU3
Molecular weight: 48,252 Da
Basal Isoelectric point: 6.78  Predict pI for various phosphorylation states
Select Structure to View Below

Neu3

Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: Y346‑p
phosphorylation: Y346‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T23-p QEDDRGItyRIPALL
0 1 Y24-p EDDRGItyRIPALLy
0 1 Y31-p yRIPALLyIPPtHTF
0 1 T35-p ALLyIPPtHTFLAFA
0 1 K44-ub TFLAFAEkRSTRRDE
0 7 K154-ub EVIGSELkHWATFAV
0 35 Y241-p RAGHPVLyCsARTPN
0 2 S243-p GHPVLyCsARTPNRC
0 2 C295 PLEIPHRCQDSSSkD
0 1 K301-ub RCQDSSSkDAPTIQQ
0 2 S310-p APTIQQSsPGSsLRL
0 1 S313 IQQSsPGSsLRLEEE
0 1 S314-p QQSsPGSsLRLEEEA
0 4 Y331-p PSESWLLysHPtSRK
0 1 S332-p SESWLLysHPtSRKQ
0 1 T335-p WLLysHPtSRKQRVD
1 0 Y346-p QRVDLGIyLNQTPLE
0 1 S417-p HLQGDCTsPGRNPsQ
0 17 S423-p TsPGRNPsQFKSN__
  mouse

 
T23 QEEQSGVTYRIPALL
Y24 EEQSGVTYRIPALLY
Y31 YRIPALLYLPPTHTF
T35 ALLYLPPTHTFLAFA
K44 TFLAFAEKRTSVRDE
K154-ub EVIGSEVkRWATFAV
Y239 TAGNPVLYCSARTPS
S241 GNPVLYCSARTPSRF
Y293-p PLKMPNTyQDSIGKG
K299 TyQDSIGKGAPATQK
P308 APATQKCPLLDsPLE
S312-p QKCPLLDsPLEVEKG
P313 KCPLLDsPLEVEKGA
Y330 PSATWLLYSHPTSKR
S331 SATWLLYSHPTSKRK
T334 WLLYSHPTSKRKRIN
Y345 KRINLGIYYNRNPLE
S414 LSCEDCTSPSSD___
- gap
  rat

 
T23 QEEQNRITYRIPALL
Y24 EEQNRITYRIPALLY
Y31 YRIPALLYIPPTHTF
T35 ALLYIPPTHTFLAFA
M44 TFLAFAEMRTSSRDE
K154 EVVGSEMKHWATFAV
Y239 KAGNLVLYCSARTPN
S241 GNLVLYCSARTPNKF
C293 PLKMPYTCQDSSGKD
K299 TCQDSSGKDVPSTQK
P308 VPSTQKCPLMDRSLE
R312 QKCPLMDRSLEVEEG
S313 KCPLMDRSLEVEEGA
Y330 PSGTWLLYSHPTNKK
S331 SGTWLLYSHPTNKKK
T334 WLLYSHPTNKKKRMN
Y345 KRMNLGIYYNQNPLE
S414 LSCDDCTSPSSN___
- gap
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