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Protein Page:
Neu3 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
Neu3 Plays a role in modulating the ganglioside content of the lipid bilayer at the level of membrane-bound sialyl glycoconjugates. Belongs to the glycosyl hydrolase 33 family. Note: This description may include information from UniProtKB.
Protein type: Glycan Metabolism - other glycan degradation; Hydrolase; EC 3.2.1.18; Lipid Metabolism - sphingolipid
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: alpha-sialidase activity; exo-alpha-sialidase activity
Biological Process: oligosaccharide catabolic process; sphingolipid metabolic process; ganglioside catabolic process; carbohydrate metabolic process; glycosphingolipid metabolic process
Reference #:  Q9UQ49 (UniProtKB)
Alt. Names/Synonyms: FLJ12388; Ganglioside sialidase; Membrane sialidase; N-acetyl-alpha-neuraminidase 3; NEU3; NEUR3; neuraminidase 3; SIAL3; sialidase 3 (membrane sialidase); Sialidase-3
Gene Symbols: NEU3
Molecular weight: 48,252 Da
Basal Isoelectric point: 6.78  Predict pI for various phosphorylation states
Select Structure to View Below

Neu3

Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: Y346‑p
phosphorylation: Y346‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 7 K154-u EVIGSELkHWATFAV
0 32 Y241-p RAGHPVLyCsARTPN
0 2 S243-p GHPVLyCsARTPNRC
0 2 C295 PLEIPHRCQDSSSKD
0 1 S310-p APTIQQSsPGSSLRL
0 1 S313 IQQSsPGSSLRLEEE
0 4 Y331-p PSESWLLySHPTSRK
1 0 Y346-p QRVDLGIyLNQTPLE
0 1 S417-p HLQGDCTsPGRNPsQ
0 16 S423-p TsPGRNPsQFKSN__
  mouse

 
K154-u EVIGSEVkRWATFAV
Y239 TAGNPVLYCSARTPS
S241 GNPVLYCSARTPSRF
Y293-p PLKMPNTyQDSIGKG
P308 APATQKCPLLDsPLE
S312-p QKCPLLDsPLEVEKG
Y330 PSATWLLYSHPTSKR
Y345 KRINLGIYYNRNPLE
S414 LSCEDCTSPSSD___
- gap
  rat

 
K154 EVVGSEMKHWATFAV
Y239 KAGNLVLYCSARTPN
S241 GNLVLYCSARTPNKF
C293 PLKMPYTCQDSSGKD
P308 VPSTQKCPLMDRSLE
R312 QKCPLMDRSLEVEEG
Y330 PSGTWLLYSHPTNKK
Y345 KRMNLGIYYNQNPLE
S414 LSCDDCTSPSSN___
- gap
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