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Protein Page:
DRPLA (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
DRPLA a protein that interacts with the E3 ubiquitin-protein ligase WWP1 and WWP2. May be involved in the third step of ubiquitin conjugation. Relatively high levels in the brain, ovary, testis and prostate. Lower levels in the liver, thymus and leukocytes. Defects are the cause of the neurodegenerative disorders dentatorubral-pallidoluysian atrophy (DRPLA) and Haw River syndrome (HRS). Note: This description may include information from UniProtKB.
Protein type: Ubiquitin conjugating system
Cellular Component: nuclear matrix; perinuclear region of cytoplasm; cytoplasm; nucleolus; nucleus; cell junction
Molecular Function: protein domain specific binding; protein binding; toxin receptor binding; transcription corepressor activity
Biological Process: cell migration; neuron apoptosis; central nervous system development; transcription, DNA-dependent; toxin metabolic process; negative regulation of transcription from RNA polymerase II promoter; maintenance of cell polarity
Reference #:  P54259 (UniProtKB)
Alt. Names/Synonyms: ATN1; atrophin 1; Atrophin-1; B37; D12S755E; Dentatorubral-pallidoluysian atrophy protein; DRPLA; HRS; NOD
Gene Symbols: ATN1
Molecular weight: 125,414 Da
Basal Isoelectric point: 9.01  Predict pI for various phosphorylation states
Select Structure to View Below

DRPLA

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K2-ac ______MkTRQNkDs
0 1 K7-ac _MkTRQNkDsMsMRS
0 1 S9-p kTRQNkDsMsMRSGR
0 1 S11-p RQNkDsMsMRSGRKK
0 15 S34-p LRSRGRAsPGGVsTS
0 2 S39-p RAsPGGVsTSSSDGk
0 1 K46-ac sTSSSDGkAEKSRQT
0 16 T64-p ARVEEAStPKVNKQG
0 15 S77-p QGRSEEIsEsEsEET
0 8 S79-p RSEEIsEsEsEETNA
0 1 S81-p EEIsEsEsEETNAPK
0 1 T92 NAPKKTKTEQELPRP
0 16 S101-p QELPRPQsPsDLDsL
0 7 S103-p LPRPQsPsDLDsLDG
0 22 S107-p QsPsDLDsLDGRsLN
0 3 S112-p LDsLDGRsLNDDGSs
0 1 S119-p sLNDDGSsDPRDIDQ
0 64 S168-p PPPLFPPsPQPPDST
0 1 S355-p KGPTLAPsPHSLPPA
0 5 S632-p PAGYKTAsPPGPPPY
0 4 K641-ac PGPPPYGkRAPsPGA
0 22 S645-p PYGkRAPsPGAYKtA
0 1 T651-p PsPGAYKtAtPPGyK
0 13 T653-p PGAYKtAtPPGyKPG
0 2 Y657-p KtAtPPGyKPGsPPs
0 14 S661-p PPGyKPGsPPsFRTG
0 1 S664-p yKPGsPPsFRTGtPP
0 9 T669-p PPsFRTGtPPGYRGT
0 1 S677-p PPGYRGTsPPAGPGT
0 1 S689 PGTFKPGSPTVGPGP
0 1 T691 TFKPGSPTVGPGPLP
0 1 Y734-p KQEPAEEyETPEsPV
1 6 S739-p EEyETPEsPVPPARs
0 9 S746-p sPVPPARsPsPPPKV
0 9 S748-p VPPARsPsPPPKVVD
0 1 S758 PKVVDVPSHASQSAR
0 1 S790 YFVPLEGSkLAKKRA
0 2 K791-ac FVPLEGSkLAKKRAD
0 6 S896-p YARPHVMsPGNRNHP
0 2 Y905-p GNRNHPFyVPLGAVD
0 1 K947-ub RDLRDRLkPGFEVKP
0 6 R1115-m2 LHENEVLrHQLFAAP
0 1 R1115-m1 LHENEVLrHQLFAAP
  mouse

 
K2 ______MKTRQNKDS
K7 _MKTRQNKDSMSMRS
S9 KTRQNKDSMSMRSGR
S11 RQNKDSMSMRSGRKK
S34-p LRSRGRAsPGGVSTS
S39 RAsPGGVSTSSSDGK
K46 STSSSDGKAEKSRQT
A64 ARIEEPSAPKASKQG
S77-p QGRSEEIsEsEsEET
S79-p RSEEIsEsEsEETSA
S81-p EEIsEsEsEETSAPK
T92-p SAPKKTKtEQELPRP
S101-p QELPRPQsPsDLDsL
S103-p LPRPQsPsDLDsLDG
S107-p QsPsDLDsLDGRsIN
S112-p LDsLDGRsINDDGSS
S119 sINDDGSSDPRDIDQ
S168 PPPLFPPSPPPPDST
S357 KGPTLAPSPHPLPPA
S617-p PAGYKTAsPPGPPQY
K626 PGPPQYSKRAPsPGS
S630-p QYSKRAPsPGSYKTA
T636 PsPGSYKTAtPPGYK
T638-p PGSYKTAtPPGYKPG
Y642 KTAtPPGYKPGsPPS
S646-p PPGYKPGsPPSFRTG
S649 YKPGsPPSFRTGtPP
T654-p PPSFRTGtPPGYRGT
S662 PPGYRGTSPPAGPGT
S674-p PGTFKPGsPtVGPGP
T676-p TFKPGsPtVGPGPLP
Y719-p KQEPAEEyEPPEsPV
S724-p EEyEPPEsPVPPARs
S731-p sPVPPARsPsPPPKV
S733-p VPPARsPsPPPKVVD
S743-p PKVVDVPsHASQSAR
S775-p YFVPLEGsKLAKKRA
K776 FVPLEGsKLAKKRAD
S881-p YARPHVMsPGNRNHP
Y890 GNRNHPFYVPLGAVD
K932 RDLRDRLKPGFEVKP
R1100-m2 LHENEVLrHQLFAAP
R1100 LHENEVLRHQLFAAP
  rat

 
K2 ______MKTRQNKDS
K7 _MKTRQNKDSMSMRS
S9 KTRQNKDSMSMRSGR
S11 RQNKDSMSMRSGRKK
S34-p LRSRGRAsPGGVSTS
S39 RAsPGGVSTSSSDGK
K46 STSSSDGKAEKSRQT
T64 ARVEETSTPKANKQG
S77-p QGRSEEIsEsESEET
S79-p RSEEIsEsESEETSA
S81 EEIsEsESEETSAPK
T92 SAPKKTKTEELPRPQ
S100-p EELPRPQsPSDLDsL
S102 LPRPQsPSDLDsLDG
S106-p QsPSDLDsLDGRSIN
S111 LDsLDGRSINDDGSS
S118 SINDDGSSDPRDIDQ
S167 PPPLFPPSPPPPDSI
S356 KGPTLAPSPHPLPPA
S625-p PAGYKTAsPPGPPQY
K634 PGPPQYSKRAPSPGS
S638 QYSKRAPSPGSYKTA
T644 PSPGSYKTAtPPGYK
T646-p PGSYKTAtPPGYKPG
Y650 KTAtPPGYKPGSPPS
S654 PPGYKPGSPPSFRTG
S657 YKPGSPPSFRTGtPP
T662-p PPSFRTGtPPGYRGT
S670 PPGYRGTSPPAGPGT
S682 PGTFKPGSPTVGPGP
T684 TFKPGSPTVGPGPLP
Y727 KQEPAEEYETPEsPV
S732-p EEYETPEsPVPPARs
S739-p sPVPPARsPsPPPKV
S741-p VPPARsPsPPPKVVD
S751 PKVVDVPSHASQSAR
S783 YFVPLEGSkLAKKRA
K784-ac FVPLEGSkLAKKRAD
S889 YARPHVMSPGNRNHP
Y898 GNRNHPFYVPLGAVD
K940 RDLRDRLKPGFEVKP
R1108 LHENEVLRHQLFAAP
R1108 LHENEVLRHQLFAAP
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