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Protein Page:
GRP58 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
GRP58 a protein disulfide isomerase found in the endoplasmic reticulum lumen. Catalyzes the rearrangement of both intrachain and interchain disulfide bonds in proteins to form the native structures. An essential component of the peptide-loading complex of the major histocompatibility complex class I pathway. Note: This description may include information from UniProtKB.
Protein type: Chaperone; Endoplasmic reticulum; EC 5.3.4.1; Phospholipase; Protease; Isomerase; Apoptosis
Cellular Component: cell surface; endoplasmic reticulum; endoplasmic reticulum lumen; melanosome; nucleus
Molecular Function: protein binding; cysteine-type endopeptidase activity; protein disulfide isomerase activity; phospholipase C activity
Biological Process: antigen processing and presentation of peptide antigen via MHC class I; cellular protein metabolic process; protein folding; protein import into nucleus; cell redox homeostasis; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of exogenous peptide antigen via MHC class I; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification; proteolysis; signal transduction; protein retention in ER
Reference #:  P30101 (UniProtKB)
Alt. Names/Synonyms: 58 kDa glucose-regulated protein; 58 kDa microsomal protein; Disulfide isomerase ER-60; endoplasmic reticulum P58; Endoplasmic reticulum resident protein 57; Endoplasmic reticulum resident protein 60; ER protein 57; ER protein 60; ER60; ERP57; ERP60; ERp61; glucose regulated protein, 58kDa; GRP57; GRP58; HsT17083; p58; PDIA3; phospholipase C-alpha; PI-PLC; protein disulfide isomerase family A, member 3; protein disulfide isomerase-associated 3; Protein disulfide-isomerase A3
Gene Symbols: PDIA3
Molecular weight: 56,782 Da
Basal Isoelectric point: 5.98  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

GRP58

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S37-p LTDDNFEsRISDTGS
0 2 K61-m1 APWCGHCkRLAPEyE
0 14 Y67-p CkRLAPEyEAAATRL
0 1 T91 DCTANTNTCNkYGVs
0 3 K94-ac ANTNTCNkYGVsGyP
0 1 K94-ub ANTNTCNkYGVsGyP
0 1 S98-p TCNkYGVsGyPtLkI
0 1 Y100-p NkYGVsGyPtLkIFR
0 1 T102-ga YGVsGyPtLkIFRDG
0 20 K104-ac VsGyPtLkIFRDGEE
0 2 K104-ub VsGyPtLkIFRDGEE
0 2 Y115-p DGEEAGAyDGPRTAD
0 12 K129 DGIVSHLKKQAGPAS
0 1 K129-sc DGIVSHLkKQAGPAS
0 1 S136 kKQAGPASVPLRtEE
0 2 T141-p PASVPLRtEEEFKKF
0 4 K146 LRtEEEFKKFISDKD
0 1 K146 LRtEEEFKKFISDKD
1 1 S150 EEFKKFISDKDASIV
0 1 K152 FKKFISDKDASIVGF
0 1 K152 FKKFISDKDASIVGF
0 1 S163-p IVGFFDDsFSEAHSE
0 1 K173 EAHSEFLKAASNLRD
0 1 K173 EAHSEFLKAASNLRD
0 1 K214 RPSHLTNKFEDkTVA
0 1 K218 LTNKFEDKTVAYtEQ
0 1 K218-sc LTNKFEDkTVAYtEQ
0 1 T223-p EDkTVAYtEQkMTSG
0 1 Q225 kTVAYtEQkMTSGKI
0 1 K226-ac TVAYtEQkMTSGKIK
0 1 K226-sc TVAYtEQkMTSGKIK
0 1 K271 YYDVDYEKNAkGSNY
0 1 K274 VDYEKNAKGSNYWRN
0 1 K274-sc VDYEKNAkGSNYWRN
0 1 K296-ub KFLDAGHkLNFAVAs
0 1 K296-sc KFLDAGHkLNFAVAs
0 1 S303-p kLNFAVAsRkTFSHE
0 2 K305-ub NFAVAsRkTFSHELS
0 1 T306 FAVAsRkTFSHELSD
0 1 T319-p SDFGLEStAGEIPVV
0 1 R329 EIPVVAIRTAKGEkF
0 1 T330 IPVVAIRTAKGEkFV
0 2 K335-ub IRTAKGEkFVMQEEF
1 2 S343-p FVMQEEFsRDGKALE
0 1 Y356-p LERFLQDyFDGNLkR
0 32 K362-ac DyFDGNLkRYLksEP
0 2 K362-ub DyFDGNLkRYLksEP
0 1 K362-sc DyFDGNLkRYLksEP
0 1 R363 yFDGNLkRYLksEPI
0 1 K366-sc GNLkRYLksEPIPEs
0 1 S367-p NLkRYLksEPIPEsN
0 1 S373-p ksEPIPEsNDGPVKV
0 2 K425-ub ELGEKLSkDPNIVIA
0 1 K433 DPNIVIAKMDATAND
1 1 Y445-p ANDVPSPyEVRGFPt
0 1 T452-ga yEVRGFPtIyFsPAN
1 0 Y454-p VRGFPtIyFsPANKK
1 3 S456-p GFPtIyFsPANKKLN
0 1 S456-ga GFPtIyFsPANKKLN
0 1 K460 IyFsPANKKLNPKKY
0 1 K460 IyFsPANKKLNPKKY
1 0 Y467 KKLNPKKYEGGRELs
0 1 S474-p YEGGRELsDFIsyLQ
0 2 S478-p RELsDFIsyLQREAt
0 1 Y479-p ELsDFIsyLQREAtN
0 1 T485-ga syLQREAtNPPVIQE
0 1 K494 PPVIQEEKPKKKKKA
  mouse

 
S37 LTDENFESRVSDTGS
K61 APWCGHCKRLAPEYE
Y67 CKRLAPEYEAAATRL
T91-p DCTANTNtCNKYGVS
K94 ANTNtCNKYGVSGYP
K94 ANTNtCNKYGVSGYP
S98 tCNKYGVSGYPTLkI
Y100 NKYGVSGYPTLkIFR
T102 YGVSGYPTLkIFRDG
K104-ac VSGYPTLkIFRDGEE
K104-ub VSGYPTLkIFRDGEE
Y115 DGEEAGAYDGPRTAD
K129-ac DGIVSHLkKQAGPAs
K129-sc DGIVSHLkKQAGPAs
S136-p kKQAGPAsVPLRTEE
T141 PAsVPLRTEEEFkKF
K146-ac LRTEEEFkKFISDkD
K146-sc LRTEEEFkKFISDkD
S150 EEFkKFISDkDASVV
K152-ac FkKFISDkDASVVGF
K152-ub FkKFISDkDASVVGF
L163 VVGFFRDLFSDGHSE
K173-ac DGHSEFLkAASNLRD
K173-ub DGHSEFLkAASNLRD
K214-ac RPLHLANkFEDkTVA
K218-ac LANkFEDkTVAYTEk
K218-sc LANkFEDkTVAYTEk
T223 EDkTVAYTEkKMTSG
K225-sc kTVAYTEkKMTSGKI
K226 TVAYTEkKMTSGKIK
K226 TVAYTEkKMTSGKIK
K271-ac YYDVDYEkNAkGSNY
K274-ub VDYEkNAkGSNYWRN
K274-sc VDYEkNAkGSNYWRN
K296 KFLDAGHKLNFAVAS
K296-sc KFLDAGHkLNFAVAS
S303 kLNFAVASRktFSHE
K305-ub NFAVASRktFSHELS
T306-p FAVASRktFSHELSD
T319 SDFGLESTTGEVPVV
R329 EVPVVAIRtAKGEkF
T330-p VPVVAIRtAKGEkFV
K335-ub IRtAKGEkFVMQEEF
S343 FVMQEEFSRDGKALE
Y356 LEQFLQEYFDGNLkR
K362-ac EYFDGNLkRYLKSEP
K362-ub EYFDGNLkRYLKSEP
K362 EYFDGNLKRYLKSEP
R363 YFDGNLkRYLKSEPI
K366 GNLkRYLKSEPIPES
S367 NLkRYLKSEPIPESN
S373 KSEPIPESNEGPVKV
K425-ub ELGEKLSkDPNIVIA
K433-sc DPNIVIAkMDATAND
Y445 ANDVPSPYEVKGFPT
T452 YEVKGFPTIYFSPAN
Y454 VKGFPTIYFSPANkK
S456 GFPTIYFSPANkKLT
S456 GFPTIYFSPANkKLT
K460-ac IYFSPANkKLTPKKY
K460-ub IYFSPANkKLTPKKY
Y467 kKLTPKKYEGGRELN
N474 YEGGRELNDFISYLQ
S478 RELNDFISYLQREAT
Y479 ELNDFISYLQREATN
T485 SYLQREATNPPIIQE
K494-ac PPIIQEEkPKKKKKA
  rat

 
S37 LTDENFESRVSDTGS
K61 APWCGHCKRLAPEYE
Y67 CKRLAPEYEAAATRL
T91 DCTANTNTCNKYGVS
K94 ANTNTCNKYGVSGYP
K94 ANTNTCNKYGVSGYP
S98 TCNKYGVSGYPTLKI
Y100 NKYGVSGYPTLKIFR
T102 YGVSGYPTLKIFRDG
K104 VSGYPTLKIFRDGEE
K104 VSGYPTLKIFRDGEE
Y115 DGEEAGAYDGPRTAD
K129-ac DGIVSHLkKQAGPAS
K129 DGIVSHLKKQAGPAS
S136 kKQAGPASVPLRTED
T141 PASVPLRTEDEFKKF
K146 LRTEDEFKKFIsDkD
K146 LRTEDEFKKFIsDkD
S150-p DEFKKFIsDkDASVV
K152-ac FKKFIsDkDASVVGF
K152 FKKFIsDKDASVVGF
L163 VVGFFRDLFSDGHSE
K173-ac DGHSEFLkAASNLRD
K173 DGHSEFLKAASNLRD
K214 RPLHLANKFEDkIVA
K218-ac LANKFEDkIVAYTEK
K218 LANKFEDKIVAYTEK
T223 EDkIVAYTEKKMTSG
K225 kIVAYTEKKMTSGKI
K226 IVAYTEKKMTSGKIK
K226 IVAYTEKKMTSGKIK
K271 YYDVDYEKNTKGSNY
K274 VDYEKNTKGSNYWRN
K274 VDYEKNTKGSNYWRN
K296 TFLDAGHKLNFAVAS
K296 TFLDAGHKLNFAVAS
S303 KLNFAVASRKTFSHE
K305 NFAVASRKTFSHELS
T306 FAVASRKTFSHELSD
T319 SDFGLESTTGEIPVV
R329-m2 EIPVVAIrTAKGEKF
T330 IPVVAIrTAKGEKFV
K335 IrTAKGEKFVMQEEF
S343-p FVMQEEFsRDGKALE
Y356 LERFLQEYFDGNLkr
K362-ac EYFDGNLkrYLKSEP
K362 EYFDGNLKrYLKSEP
K362 EYFDGNLKrYLKSEP
R363-m2 YFDGNLkrYLKSEPI
K366 GNLkrYLKSEPIPET
S367 NLkrYLKSEPIPETN
T373 KSEPIPETNEGPVKV
K425 ELGEKLSKDPNIVIA
K433 DPNIVIAKMDATAND
Y445-p ANDVPSPyEVKGFPT
T452 yEVKGFPTIyFsPAN
Y454-p VKGFPTIyFsPANKK
S456-p GFPTIyFsPANKKLT
S456 GFPTIyFSPANKKLT
K460 IyFsPANKKLTPKKy
K460 IyFsPANKKLTPKKy
Y467-p KKLTPKKyEGGRELN
N474 yEGGRELNDFISYLQ
S478 RELNDFISYLQREAT
Y479 ELNDFISYLQREATN
T485 SYLQREATNPPIIQE
K494-ac PPIIQEEkPKKKKKA
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