a protein disulfide isomerase found in the endoplasmic reticulum lumen. Catalyzes the rearrangement of both intrachain and interchain disulfide bonds in proteins to form the native structures. An essential component of the peptide-loading complex of the major histocompatibility complex class I pathway. Note: This description may include information from UniProtKB.
Molecular Function: protein binding; electron carrier activity; cysteine-type endopeptidase activity; protein disulfide oxidoreductase activity; protein disulfide isomerase activity; phospholipase C activity
Biological Process: protein folding; positive regulation of apoptosis; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; post-translational protein modification; signal transduction; glycerol ether metabolic process; antigen processing and presentation of peptide antigen via MHC class I; cellular protein metabolic process; cell redox homeostasis; protein import into nucleus; antigen processing and presentation of exogenous peptide antigen via MHC class I; protein amino acid N-linked glycosylation via asparagine; protein retention in ER
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.