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Protein Page:
hnRNP I (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
hnRNP I a ubiquitously expressed heterogeneous nuclear ribonucleoprotein (hnRNP). hnRNPs are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. Binds to the polypyrimidine tract of introns. May promote the binding of U2 snRNP to pre-mRNA. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: RNA splicing; RNA binding protein
Cellular Component: nucleoplasm; membrane; nucleolus
Molecular Function: protein binding; poly-pyrimidine tract binding; RNA binding; nucleotide binding
Biological Process: alternative nuclear mRNA splicing, via spliceosome; nuclear mRNA splicing, via spliceosome; negative regulation of RNA splicing; negative regulation of nuclear mRNA splicing, via spliceosome; negative regulation of muscle cell differentiation; RNA splicing; gene expression; mRNA processing; regulation of alternative nuclear mRNA splicing, via spliceosome
Reference #:  P26599 (UniProtKB)
Alt. Names/Synonyms: 57 kDa RNA-binding protein PPTB-1; Heterogeneous nuclear ribonucleoprotein I; heterogeneous nuclear ribonucleoprotein polypeptide I; hnRNP I; HNRNP-I; HNRNPI; HNRPI; MGC10830; MGC8461; polypyrimidine tract binding protein (heterogeneous nuclear ribonucleoprotein I); polypyrimidine tract binding protein 1; Polypyrimidine tract-binding protein 1; pPTB; PTB; PTB-1; PTB-T; PTB2; PTB3; PTB4; PTBP1
Gene Symbols: PTBP1
Molecular weight: 57,221 Da
Basal Isoelectric point: 9.22  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

hnRNP I

Protein Structure Not Found.


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Sites Implicated In
intracellular localization: S16‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 D2 ______MDGIVPDIA
0 1 T12-p VPDIAVGtkRGsDEL
0 1 K13-ub PDIAVGtkRGsDELF
0 1 K13-sc PDIAVGtkRGsDELF
1 6 S16-p AVGtkRGsDELFstC
0 1 S21-p RGsDELFstCVtNGP
0 1 T22-p GsDELFstCVtNGPF
0 1 T25-gl ELFstCVtNGPFIMs
0 1 S32-p tNGPFIMsSNSASAA
0 14 K45-ac AANGNDSkkFKGDSR
0 4 K46-ac ANGNDSkkFKGDSRs
0 1 S53-p kFKGDSRsAGVPSRV
0 13 K65-ub SRVIHIRkLPIDVTE
0 2 K84-ub SLGLPFGkVTNLLML
0 2 K92-ub VTNLLMLkGkNQAFI
0 1 K94-ub NLLMLkGkNQAFIEM
0 572 Y127-p VLRGQPIyIQFsNHk
0 4 S131-p QPIyIQFsNHkELKt
0 2 K134-ac yIQFsNHkELKtDss
0 1 K137 FsNHkELKtDssPNQ
0 2 T138-p sNHkELKtDssPNQA
0 1 S140-p HkELKtDssPNQARA
0 14 S141-p kELKtDssPNQARAQ
0 1 D172 AASAAAVDAGMAMAG
0 3 Y193-p IIVENLFyPVTLDVL
0 10 K212-ub SKFGTVLkIITFTkN
0 21 K218-ub LkIITFTkNNQFQAL
0 1 S233-p LQYADPVsAQHAKLS
0 25 K259-ub TLRIDFSkLTSLNVk
0 6 K266-ac kLTSLNVkyNNDkSR
0 9 K266-ub kLTSLNVkyNNDkSR
0 1 Y267-p LTSLNVkyNNDkSRD
0 2 K271-ub NVkyNNDkSRDYTRP
0 2 S337-p GLAGAGNsVLLVsNL
0 1 S342-p GNsVLLVsNLNPERV
0 1 K368-ub YGDVQRVkILFNKKE
0 1 K368-sc YGDVQRVkILFNKKE
0 1 K374 VkILFNKKENALVQM
0 1 K398 MSHLNGHKLHGkPIR
0 1 K402-ub NGHKLHGkPIRITLS
0 1 K410-ac PIRITLSkHQNVQLP
0 5 K410-ub PIRITLSkHQNVQLP
0 2 N413 ITLSkHQNVQLPREG
0 2 T427-p GQEDQGLtkDyGNsP
0 8 K428-ub QEDQGLtkDyGNsPL
0 1 K428-sc QEDQGLtkDyGNsPL
0 19 Y430-p DQGLtkDyGNsPLHR
0 11 S433-p LtkDyGNsPLHRFKK
0 1 V472 VSEEDLKVLFSsNGG
0 1 S475 EDLKVLFSsNGGVVk
0 2 S476-p DLKVLFSsNGGVVkG
0 15 K482-ub SsNGGVVkGFkFFQk
0 1 K482-sc SsNGGVVkGFkFFQk
0 4 K485-ub GGVVkGFkFFQkDRK
0 1 K485-sc GGVVkGFkFFQkDRK
0 1 K489-ub kGFkFFQkDRKMALI
0 22 K528-ub HLRVSFSkSTI____
  mouse

► Hide Isoforms
 
D2-ca ______MdGIVPDIA
T12 VPDIAVGTKRGsDEL
K13 PDIAVGTKRGsDELF
K13 PDIAVGTKRGsDELF
S16-p AVGTKRGsDELFSTC
S21 RGsDELFSTCVSNGP
T22 GsDELFSTCVSNGPF
S25 ELFSTCVSNGPFIMS
S32 SNGPFIMSSSASAAN
K44-ac AANGNDSkkFKGDNR
K45-ac ANGNDSkkFKGDNRS
S52 kFKGDNRSAGVPSRV
K64-ub SRVIHVRkLPSDVTE
K83-ub SLGLPFGkVTNLLML
K91-ub VTNLLMLkGKNQAFI
K93 NLLMLkGKNQAFIEM
Y126-p VLRGQPIyIQFSNHK
S130 QPIyIQFSNHKELKT
K133 yIQFSNHKELKTDSS
K136 FSNHKELKTDSSPNQ
T137 SNHKELKTDSSPNQV
S139 HKELKTDSSPNQVRA
S140 KELKTDSSPNQVRAQ
D171-ca AASAAAVdAGMAMAG
Y192 IIVENLFYPVTLDVL
K211-ub SKFGTVLkIITFTkN
K217-ub LkIITFTkNNQFQAL
S232 LQYADPVSAQHAKLS
K258-ub TLRIDFSkLTSLNVk
K265-ac kLTSLNVkYNNDKSR
K265-ub kLTSLNVkYNNDKSR
Y266 LTSLNVkYNNDKSRD
K270 NVkYNNDKSRDYTRP
S335-p GLAGAGNsVLLVSNL
S340 GNsVLLVSNLNPERV
K366 YGDVQRVKILFNKKE
K366 YGDVQRVKILFNKKE
K372 VKILFNKKENALVQM
- gap
- gap
- under review  
- gap
- gap
T424 GQEDQGLTKDYGSSP
K425 QEDQGLTKDYGSSPL
K425 QEDQGLTKDYGSSPL
Y427 DQGLTKDYGSSPLRF
S430 LTKDYGSSPLRFKKP
S468-p VSEDDLKsLFssNGG
S471-p DDLKsLFssNGGVVk
S472-p DLKsLFssNGGVVkG
K478-ub ssNGGVVkGFkFFQK
K478 ssNGGVVKGFkFFQK
K481-ub GGVVkGFkFFQKDRK
K481 GGVVkGFKFFQKDRK
K485 kGFkFFQKDRKMALI
K524 HLRVSFSKSTI____
  hnRNP I iso2  
D2 ______MDGIVPDIA
T12 VPDIAVGTKRGSDEL
K13 PDIAVGTKRGSDELF
K13 PDIAVGTKRGSDELF
S16 AVGTKRGSDELFSTC
S21 RGSDELFSTCVSNGP
T22 GSDELFSTCVSNGPF
S25 ELFSTCVSNGPFIMS
S32 SNGPFIMSSSASAAN
K44 AANGNDSKKFKGDNR
K45 ANGNDSKKFKGDNRS
S52 KFKGDNRSAGVPSRV
K64 SRVIHVRKLPSDVTE
K83 SLGLPFGKVTNLLML
K91 VTNLLMLKGKNQAFI
K93 NLLMLKGKNQAFIEM
Y126 VLRGQPIYIQFSNHK
S130 QPIYIQFSNHKELkt
K133 YIQFSNHKELktDss
K136-ub FSNHKELktDssPNQ
T137-p SNHKELktDssPNQA
S139-p HKELktDssPNQARA
S140-p KELktDssPNQARAQ
D171 AASAAAVDAGMAMAG
Y192 IIVENLFYPVTLDVL
K211 SKFGTVLKIITFTKN
K217 LKIITFTKNNQFQAL
S232 LQYADPVSAQHAKLS
K258 TLRIDFSKLTSLNVK
K265 KLTSLNVKYNNDKSR
K265 KLTSLNVKYNNDKSR
Y266 LTSLNVKYNNDKSRD
K270 NVKYNNDKSRDYTRP
S336 GLAGAGNSVLLVSNL
S341 GNSVLLVSNLNPERV
K367 YGDVQRVKILFNKkE
K367 YGDVQRVKILFNKkE
K373-ub VKILFNKkENALVQM
K397-ub MSHLNGHkLHGKSVR
K401 NGHkLHGKSVRITLS
K409 SVRITLSKHQsVQLP
K409-ub SVRITLSkHQsVQLP
S412-p ITLSkHQsVQLPREG
T426 GQEDQGLTkDyGSsP
K427-ub QEDQGLTkDyGSsPL
K427 QEDQGLTKDyGSsPL
Y429-p DQGLTkDyGSsPLHR
S432-p LTkDyGSsPLHRFKK
S471 VSEDDLKSLFSSNGG
S474 DDLKSLFSSNGGVVK
S475 DLKSLFSSNGGVVKG
K481 SSNGGVVKGFKFFQK
K481 SSNGGVVKGFKFFQK
K484 GGVVKGFKFFQKDRK
K484 GGVVKGFKFFQKDRK
K488 KGFKFFQKDRKMALI
K527 HLRVSFSKSTI____
  rat

 
D2 ______MDGIVPDIA
T12 VPDIAVGTKRGSDEL
K13 PDIAVGTKRGSDELF
K13 PDIAVGTKRGSDELF
S16 AVGTKRGSDELFSTC
S21 RGSDELFSTCVSNGP
T22 GSDELFSTCVSNGPF
S25 ELFSTCVSNGPFIMS
S32 SNGPFIMSSSASAAN
K44 AANGNDSKKFKGDNR
K45 ANGNDSKKFKGDNRS
S52 KFKGDNRSTGVPSRV
K64 SRVIHVRKLPSDVTE
K83 SLGLPFGKVTNLLML
K91 VTNLLMLKGKNQAFI
K93 NLLMLKGKNQAFIEM
Y126-p VLRGQPIyIQFSNHK
S130 QPIyIQFSNHKELKT
K133 yIQFSNHKELKTDSS
K136 FSNHKELKTDSSPNQ
T137 SNHKELKTDSSPNQA
S139 HKELKTDSSPNQARA
S140 KELKTDSSPNQARAQ
D171 AASAAAVDAGMAMAG
Y192 IIVENLFYPVTLDVL
K211 SKFGTVLKIITFTKN
K217 LKIITFTKNNQFQAL
S232 LQYADPVSAQHAKLS
K258 TLRIDFSKLTSLNVK
K265 KLTSLNVKYNNDKSR
K265 KLTSLNVKYNNDKSR
Y266 LTSLNVKYNNDKSRD
K270 NVKYNNDKSRDYTRP
S361 GLAGAGNSVLLVSNL
S366 GNSVLLVSNLNPERV
K392 YGDVQRVKILFNKKE
K392 YGDVQRVKILFNKKE
K398 VKILFNKKENALVEM
K422 MSHLNGHKLHGKSVR
K426 NGHKLHGKSVRITLS
K434 SVRITLSKHQsVQLP
K434 SVRITLSKHQsVQLP
S437-p ITLSKHQsVQLPREG
T451 GQEDQGLTKDYGSSP
K452 QEDQGLTKDYGSSPL
K452 QEDQGLTKDYGSSPL
Y454 DQGLTKDYGSSPLHR
S457 LTKDYGSSPLHRFKK
S496 VSEDDLKSLFSSNGG
S499 DDLKSLFSSNGGVVK
S500 DLKSLFSSNGGVVKG
K506 SSNGGVVKGFKFFQK
K506 SSNGGVVKGFKFFQK
K509 GGVVKGFKFFQKDRK
K509 GGVVKGFKFFQKDRK
K513 KGFKFFQKDRKMALI
K552 HLRVSFSKSTI____
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