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FAF1 (human)

Overview FAF1 a pro-apoptotic protein that binds to FAS antigen. Potentiates but cannot initiate FAS-induced apoptosis. Its pro-apoptotic activity requires a ubiquitin-like domain but not the FAS-binding domain. Phosphorylation by protein kinase CK2 influences transport into nucleus. Two transcript variants encoding different protein isoforms have been described. Note: This description may include information from UniProtKB. Protein type: Apoptosis; Nuclear receptor co-regulator Cellular Component: perinuclear region of cytoplasm; CD95 death-inducing signaling complex; nuclear envelope; cytosol; nucleus Molecular Function: protein domain specific binding; NF-kappaB binding; ubiquitin binding; protein binding; ubiquitin protein ligase binding; heat shock protein binding; protein kinase regulator activity; protein kinase binding Biological Process: regulation of cell adhesion; cell death; proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein complex assembly; cytoplasmic sequestering of NF-kappaB; positive regulation of apoptosis; apoptosis; regulation of protein catabolic process; regulation of protein kinase activity Reference #:  Q9UNN5 (UniProtKB) Alt. Names/Synonyms: CGI-03; FAF1; Fas (TNFRSF6) associated factor 1; FAS-associated factor 1; FLJ37524; hFAF1; HFAF1s; TNFRSF6-associated factor 1; UBX domain protein 3A; UBX domain-containing protein 12; UBX domain-containing protein 3A; UBXD12; UBXN3A Gene Symbols: FAF1 Molecular weight: 73,954 Da Basal Isoelectric point: 4.81  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below FAF1 1H8C - A=569-650 (human) 2DZM - A=99-191 (human) 2EC4 - A=325-495 (human) 3E21 - A=5-47 (human) 3QC8 - B=571-650 (human) 3QCA - A/D/C/B=571-650 (human) 3QQ8 - B=568-650 (human) 3QWZ - B=571-650 (human) 3QX1 - A/B=571-650 (human) 3R3M - A/D/C/B=568-650 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1H8C 2DZM 2EC4 3E21 3QC8 3QCA 3QQ8 3QWZ 3QX1 3R3M  |  Phospho3D  |  DISEASE  |  Source  |  NURSA  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
cell cycle regulation: S289‑p, S291‑p intracellular localization: S289‑p, S291‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	17		K139-u	ELQIPVSkMLLkGWk
0	11		K143-u	PVSkMLLkGWkTGDV
0	1		K146-a	kMLLkGWkTGDVEDS
0	86		K146-u	kMLLkGWkTGDVEDS
0	1		K157-a	VEDSTVLkSLHLPkN
0	49		K157-u	VEDSTVLkSLHLPkN
0	7		K163-u	LkSLHLPkNNSLYVL
0	1		Y207	HREVQREYNLNFSGS
0	1		S212	REYNLNFSGSSTIQE
0	1		S215	NLNFSGSSTIQEVkR
0	1		T216	LNFSGSSTIQEVkRN
0	19		K221-u	SSTIQEVkRNVyDLT
0	15		Y225-p	QEVkRNVyDLTSIPV
0	1		S269-p	RLTVGRRssPAQtRE
0	16		S270-p	LTVGRRssPAQtREQ
0	5		T274-p	RRssPAQtREQSEEQ
2	1		S289-p	ITDVHMVsDsDGDDF
2	1		S291-p	DVHMVsDsDGDDFED
0	1		K319-u	MASSALRksPMMPEN
0	10		S320-p	ASSALRksPMMPENA
0	1		S342-p	LQFTAEFssRYGDCH
0	1		S343-p	QFTAEFssRYGDCHP
0	16		K444-u	AQTIRTQkTDQFPLF
0	3		K457-u	LFLIIMGkRSSNEVL
0	17		T580-p	VSKLRIRtPsGEFLE
0	198		S582-p	KLRIRtPsGEFLERR
0	2		K637-u	NKSLLEVkLFPQETL

	FAF1 iso2
K139	ELQIPVSKMLLKGWK
K143	PVSKMLLKGWKTGDV
K146	KMLLKGWKTGDVEDS
K146	KMLLKGWKTGDVEDS
K157	VEDSTVLKSLHLPKN
K157	VEDSTVLKSLHLPKN
K163	LKSLHLPKNNSLYVL
-	gap
-	gap
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-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
S190	AGALQEFSSRYGDCH
S191	GALQEFSSRYGDCHP
K292	AQTIRTQKTDQFPLF
K305	LFLIIMGKRSSNEVL
T428-p	VSKLRIRtPsGEFLE
S430-p	KLRIRtPsGEFLERR
K485	NKSLLEVKLFPQETL

	mouse
K138-u	ELQIPVPkMLLkGWk
K142-u	PVPkMLLkGWkTGDV
K145	kMLLkGWKTGDVEDS
K145-u	kMLLkGWkTGDVEDS
K156	VEDSTVLKSLHLPKN
K156-u	VEDSTVLkSLHLPKN
K162	LkSLHLPKNNSLYVL
Y206-p	HREVQREyNLNFsGS
S211-p	REyNLNFsGSstVQE
S214-p	NLNFsGSstVQEVkR
T215-p	LNFsGSstVQEVkRN
K220-u	SstVQEVkRNVyDLT
Y224-p	QEVkRNVyDLTSIPV
T268-p	RLTVGRRtsPVQtRE
S269-p	LTVGRRtsPVQtREQ
T273-p	RRtsPVQtREQSEEQ
S288	STDVHMVSDSDGDDF
S290	DVHMVSDSDGDDFED
K318	MASSTLRKsPMMPEN
S319-p	ASSTLRKsPMMPENA
S341	LQFTAEFSSRYGDCH
S342	QFTAEFSSRYGDCHP
K443-u	AQTIRTQkTDQFPLF
K456	LFLIIMGKRSSNEVL
T579-p	VSKLRIRtPsGEFLE
S581-p	KLRIRtPsGEFLERR
N636	NKSLLEVNLFPQETL

	rat
K138	ELQIPVPKMLLKGWK
K142	PVPKMLLKGWKTGDV
K145	KMLLKGWKTGDVEDS
K145	KMLLKGWKTGDVEDS
K156	VEDSTVLKSLHLPKN
K156	VEDSTVLKSLHLPKN
K162	LKSLHLPKNNSLYVL
Y206	HREVQREYNLNFSGS
S211	REYNLNFSGSSTVQE
S214	NLNFSGSSTVQEVKR
T215	LNFSGSSTVQEVKRN
K220	SSTVQEVKRNVYDLT
Y224	QEVKRNVYDLTSIPV
T268	RLTVGRRTSPVQTRE
S269	LTVGRRTSPVQTREQ
T273	RRTSPVQTREQSEEQ
S288	STVVHMVSDSDGDDF
S290	VVHMVSDSDGDDFED
K318	MASSTMRKSPMMPEN
S319	ASSTMRKSPMMPENA
S341	LQFTAEFSSRYGDCH
S342	QFTAEFSSRYGDCHP
K443	AQTIRTQKTDQFPLF
K456	LFLIIMGKRSSNEVL
T579	VSKLRIRTPsGEFLE
S581-p	KLRIRTPsGEFLERR
N636	NKSLLEVNLFPQETL

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