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Protein Page:
FAF1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
FAF1 a pro-apoptotic protein that binds to FAS antigen. Potentiates but cannot initiate FAS-induced apoptosis. Its pro-apoptotic activity requires a ubiquitin-like domain but not the FAS-binding domain. Phosphorylation by protein kinase CK2 influences transport into nucleus. Two transcript variants encoding different protein isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Apoptosis
Cellular Component: perinuclear region of cytoplasm; CD95 death-inducing signaling complex; nuclear envelope; cytosol; nucleus
Molecular Function: NF-kappaB binding; protein domain specific binding; ubiquitin binding; protein binding; heat shock protein binding; ubiquitin protein ligase binding; protein kinase regulator activity; protein kinase binding
Biological Process: cell death; regulation of cell adhesion; proteasomal ubiquitin-dependent protein catabolic process; cytoplasmic sequestering of NF-kappaB; positive regulation of protein complex assembly; positive regulation of apoptosis; apoptosis; regulation of protein catabolic process; regulation of protein kinase activity
Reference #:  Q9UNN5 (UniProtKB)
Alt. Names/Synonyms: CGI-03; FAF1; Fas (TNFRSF6) associated factor 1; FAS-associated factor 1; FLJ37524; hFAF1; HFAF1s; TNFRSF6-associated factor 1; UBX domain protein 3A; UBX domain-containing protein 12; UBX domain-containing protein 3A; UBXD12; UBXN3A
Gene Symbols: FAF1
Molecular weight: 73,954 Da
Basal Isoelectric point: 4.81  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

FAF1

Protein Structure Not Found.


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Sites Implicated In
cell cycle regulation: S289‑p, S291‑p
intracellular localization: S289‑p, S291‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 17 K139-u ELQIPVSkMLLkGWk
0 11 K143-u PVSkMLLkGWkTGDV
0 86 K146-u kMLLkGWkTGDVEDS
0 49 K157-u VEDSTVLkSLHLPkN
0 7 K163-u LkSLHLPkNNSLYVL
0 1 Y207 HREVQREYNLNFSGS
0 1 S212 REYNLNFSGSSTIQE
0 1 S215 NLNFSGSSTIQEVkR
0 1 T216 LNFSGSSTIQEVkRN
0 19 K221-u SSTIQEVkRNVyDLT
0 15 Y225-p QEVkRNVyDLTSIPV
0 1 S269-p RLTVGRRssPAQtRE
0 17 S270-p LTVGRRssPAQtREQ
0 5 T274-p RRssPAQtREQSEEQ
2 1 S289-p ITDVHMVsDsDGDDF
2 1 S291-p DVHMVsDsDGDDFED
0 10 S320-p ASSALRKsPMMPENA
0 16 K444-u AQTIRTQkTDQFPLF
0 3 K457-u LFLIIMGkRSSNEVL
0 1 S556 EREAIRLSLEQALPP
0 18 T580-p VSKLRIRtPsGEFLE
0 200 S582-p KLRIRtPsGEFLERR
0 2 K637-u NKSLLEVkLFPQETL
  FAF1 iso2  
K139 ELQIPVSKMLLKGWK
K143 PVSKMLLKGWKTGDV
K146 KMLLKGWKTGDVEDS
K157 VEDSTVLKSLHLPKN
K163 LKSLHLPKNNSLYVL
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K292 AQTIRTQKTDQFPLF
K305 LFLIIMGKRSSNEVL
S404 EREAIRLSLEQALPP
T428-p VSKLRIRtPsGEFLE
S430-p KLRIRtPsGEFLERR
K485 NKSLLEVKLFPQETL
  mouse

 
K138-u ELQIPVPkMLLkGWk
K142-u PVPkMLLkGWkTGDV
K145-u kMLLkGWkTGDVEDS
K156-u VEDSTVLkSLHLPKN
K162 LkSLHLPKNNSLYVL
Y206-p HREVQREyNLNFsGS
S211-p REyNLNFsGSstVQE
S214-p NLNFsGSstVQEVkR
T215-p LNFsGSstVQEVkRN
K220-u SstVQEVkRNVyDLT
Y224-p QEVkRNVyDLTSIPV
T268-p RLTVGRRtsPVQtRE
S269-p LTVGRRtsPVQtREQ
T273-p RRtsPVQtREQSEEQ
S288 STDVHMVSDSDGDDF
S290 DVHMVSDSDGDDFED
S319-p ASSTLRKsPMMPENA
K443-u AQTIRTQkTDQFPLF
K456 LFLIIMGKRSSNEVL
S555-p EREAIRLsLEQALPP
T579-p VSKLRIRtPsGEFLE
S581-p KLRIRtPsGEFLERR
N636 NKSLLEVNLFPQETL
  rat

 
K138 ELQIPVPKMLLKGWK
K142 PVPKMLLKGWKTGDV
K145 KMLLKGWKTGDVEDS
K156 VEDSTVLKSLHLPKN
K162 LKSLHLPKNNSLYVL
Y206 HREVQREYNLNFSGS
S211 REYNLNFSGSSTVQE
S214 NLNFSGSSTVQEVKR
T215 LNFSGSSTVQEVKRN
K220 SSTVQEVKRNVYDLT
Y224 QEVKRNVYDLTSIPV
T268 RLTVGRRTSPVQTRE
S269 LTVGRRTSPVQTREQ
T273 RRTSPVQTREQSEEQ
S288 STVVHMVSDSDGDDF
S290 VVHMVSDSDGDDFED
S319 ASSTMRKSPMMPENA
K443 AQTIRTQKTDQFPLF
K456 LFLIIMGKRSSNEVL
S555 EREAIRLSLEQALPP
T579 VSKLRIRTPsGEFLE
S581-p KLRIRTPsGEFLERR
N636 NKSLLEVNLFPQETL
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