a pro-apoptotic protein that binds to FAS antigen. Potentiates but cannot initiate FAS-induced apoptosis. Its pro-apoptotic activity requires a ubiquitin-like domain but not the FAS-binding domain. Phosphorylation by protein kinase CK2 influences transport into nucleus. Two transcript variants encoding different protein isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 1p33
Cellular Component: perinuclear region of cytoplasm; CD95 death-inducing signaling complex; nuclear envelope; cytosol; nucleus
Molecular Function: NF-kappaB binding; protein domain specific binding; ubiquitin binding; protein binding; heat shock protein binding; ubiquitin protein ligase binding; protein kinase regulator activity; protein kinase binding
Biological Process: cell death; regulation of cell adhesion; proteasomal ubiquitin-dependent protein catabolic process; cytoplasmic sequestering of NF-kappaB; positive regulation of protein complex assembly; apoptosis; positive regulation of apoptosis; regulation of protein catabolic process; regulation of protein kinase activity
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.