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Protein Page:
PEA-15 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PEA-15 an ubiquitously expressed anti-apoptotic protein. Inhibits both Fas- and Tnfrsf1a/Tnfr1-mediated caspase-8 activity and apoptosis. Interacts with CASP8/FLICE and FADD. Regulates glucose transport by controlling both the content of GLUT1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of GLUT4 from the cell interior to the surface. Most abundant in tissues such as heart, brain, muscle and adipose tissue which utilize glucose as an energy source. Lower expression in glucose-producing tissues. Higher levels of expression are found in tissues from individuals with type 2 diabetes than in controls. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Apoptosis
Chromosomal Location of Human Ortholog: 1q21.1
Cellular Component: microtubule associated complex; cytoplasm
Molecular Function: protein binding
Biological Process: negative regulation of glucose import; apoptosis; transport; carbohydrate transport; response to morphine
Reference #:  Q15121 (UniProtKB)
Alt. Names/Synonyms: 15 kDa phosphoprotein enriched in astrocytes; Astrocytic phosphoprotein PEA-15; HMAT1; homolog of mouse MAT-1 oncogene; HUMMAT1H; MAT1; MAT1H; PEA-15; PEA15; PED; phosphoprotein enriched in astrocytes 15; Phosphoprotein enriched in astrocytes, 15kD; Phosphoprotein enriched in diabetes
Gene Symbols: PEA15
Molecular weight: 15,040 Da
Basal Isoelectric point: 4.93  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PEA-15

Protein Structure Not Found.


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Sites Implicated In
apoptosis, inhibited: S104‑p, S116‑p
autophagy, altered: S104‑p, S116‑p
signaling pathway regulation: S104‑p, S116‑p
protein stabilization: S116‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y4-p ____MAEyGtLLQDL
0 2 T6-p __MAEyGtLLQDLTN
0 1 S25-p EDLEQLKsACkEDIP
0 1 K28-ub EQLKsACkEDIPSEK
0 1 K54 SFLESHNKLDKDNLs
0 5 S61-p KLDKDNLsYIEHIFE
0 3 S90-p RTRVLKIsEEDELDt
0 1 T97-p sEEDELDtkLtRIPs
0 2 K98-ub EEDELDtkLtRIPsA
0 22 T100-p DELDtkLtRIPsAKK
7 321 S104-p tkLtRIPsAKKyKDI
0 9 Y108-p RIPsAKKyKDIIRQP
8 1118 S116-p KDIIRQPsEEEIIKL
2776 : Phospho-PEA-15 (Ser104) Antibody
  mouse

 
Y4 ____MAEYGtLLQDL
T6-p __MAEYGtLLQDLTN
S25 EDLEQLKSACKEDIP
K28 EQLKSACKEDIPSEK
K54-ub SFLESHNkLDKDNLs
S61-p kLDKDNLsYIEHIFE
S90-p RTRVLKIsEEEELDT
T97 sEEEELDTkLtRIPs
K98-ub EEEELDTkLtRIPsA
T100-p EELDTkLtRIPsAKK
S104-p TkLtRIPsAKKyKDI
Y108-p RIPsAKKyKDIIRQP
S116-p KDIIRQPsEEEIIKL
2776 : Phospho-PEA-15 (Ser104) Antibody
  rat

 
Y4 ____MAEYGTLLQDL
T6 __MAEYGTLLQDLTN
S25 EDLEQLKSACKEDIP
K28 EQLKSACKEDIPSEK
K54 SFLESHNKLDKDNLs
S61-p KLDKDNLsYIEHIFE
S90-p RTRVLKIsEEDELDT
T97 sEEDELDTKLTRIPs
K98 EEDELDTKLTRIPsA
T100 DELDTKLTRIPsAKK
S104-p TKLTRIPsAKKYKDI
Y108 RIPsAKKYKDIIRQP
S116-p KDIIRQPsEEEIIKL
2776 : Phospho-PEA-15 (Ser104) Antibody
  hamster

 
Y4 ____MAEYGTLLQDL
T6 __MAEYGTLLQDLTN
S25 EDLEQLKSACKEDIP
K28 EQLKSACKEDIPSEK
K54 SFLESHNKLDKDNLS
S61 KLDKDNLSYIEHIFE
S90 RTRVLKISEEDELDT
T97 SEEDELDTKLTRIPs
K98 EEDELDTKLTRIPsA
T100 DELDTKLTRIPsAKK
S104-p TKLTRIPsAKKYKDI
Y108 RIPsAKKYKDIIRQP
S116-p KDIIRQPsEEEIIKL
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