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PEA-15 (human)

Overview PEA-15 an ubiquitously expressed anti-apoptotic protein. Inhibits both Fas- and Tnfrsf1a/Tnfr1-mediated caspase-8 activity and apoptosis. Interacts with CASP8/FLICE and FADD. Regulates glucose transport by controlling both the content of GLUT1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of GLUT4 from the cell interior to the surface. Most abundant in tissues such as heart, brain, muscle and adipose tissue which utilize glucose as an energy source. Lower expression in glucose-producing tissues. Higher levels of expression are found in tissues from individuals with type 2 diabetes than in controls. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; Apoptosis Cellular Component: microtubule associated complex; cytoplasm Molecular Function: protein binding Biological Process: regulation of apoptosis; negative regulation of glucose import; apoptosis; transport; carbohydrate transport; response to morphine; negative regulation of apoptosis Reference #:  Q15121 (UniProtKB) Alt. Names/Synonyms: 15 kDa phosphoprotein enriched in astrocytes; Astrocytic phosphoprotein PEA-15; HMAT1; homolog of mouse MAT-1 oncogene; HUMMAT1H; MAT1; MAT1H; PEA-15; PEA15; PED; phosphoprotein enriched in astrocytes 15; Phosphoprotein enriched in astrocytes, 15kD; Phosphoprotein enriched in diabetes Gene Symbols: PEA15 Molecular weight: 15,040 Da Basal Isoelectric point: 4.93  Predict pI for various phosphorylation states CST Pathways:  GPCRs Signaling to MAPK/Erk  |  MAPK/Erk in Growth and Differentiation Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PEA-15 4IZ5 - A/D/C/B=8-360 (human) 4IZA - A/C=8-360 (human) 2LS7 - A=1-90 (mouse) 1N3K - A=1-130 (hamster) 4IZ7 - A/C=8-360 (hamster)

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	Sites Implicated In
apoptosis, inhibited: S116‑p autophagy, altered: S104‑p, S116‑p signaling pathway regulation: S104‑p, S116‑p protein stabilization: S116‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		Y4-p	____MAEyGtLLQDL
0	2		T6-p	__MAEyGtLLQDLTN
0	1		S25-p	EDLEQLKsACkEDIP
0	1		K28-u	EQLKsACkEDIPSEK
0	1		K54	SFLESHNKLDKDNLs
0	4		S61-p	KLDKDNLsYIEHIFE
0	3		S90-p	RTRVLKIsEEDELDT
0	2		K98-u	EEDELDTkLtRIPsA
0	21		T100-p	DELDTkLtRIPsAKK
7	314		S104-p	TkLtRIPsAKKyKDI
0	9		Y108-p	RIPsAKKyKDIIRQP
8	1081		S116-p	KDIIRQPsEEEIIKL

	mouse
Y4	____MAEYGtLLQDL
T6-p	__MAEYGtLLQDLTN
S25	EDLEQLKSACKEDIP
K28	EQLKSACKEDIPSEK
K54-u	SFLESHNkLDKDNLs
S61-p	kLDKDNLsYIEHIFE
S90-p	RTRVLKIsEEEELDT
K98-u	EEEELDTkLtRIPsA
T100-p	EELDTkLtRIPsAKK
S104-p	TkLtRIPsAKKyKDI
Y108-p	RIPsAKKyKDIIRQP
S116-p	KDIIRQPsEEEIIKL

	rat
Y4	____MAEYGTLLQDL
T6	__MAEYGTLLQDLTN
S25	EDLEQLKSACKEDIP
K28	EQLKSACKEDIPSEK
K54	SFLESHNKLDKDNLS
S61	KLDKDNLSYIEHIFE
S90	RTRVLKISEEDELDT
K98	EEDELDTKLTRIPsA
T100	DELDTKLTRIPsAKK
S104-p	TKLTRIPsAKKYKDI
Y108	RIPsAKKYKDIIRQP
S116-p	KDIIRQPsEEEIIKL

	hamster
Y4	____MAEYGTLLQDL
T6	__MAEYGTLLQDLTN
S25	EDLEQLKSACKEDIP
K28	EQLKSACKEDIPSEK
K54	SFLESHNKLDKDNLS
S61	KLDKDNLSYIEHIFE
S90	RTRVLKISEEDELDT
K98	EEDELDTKLTRIPsA
T100	DELDTKLTRIPsAKK
S104-p	TKLTRIPsAKKYKDI
Y108	RIPsAKKYKDIIRQP
S116-p	KDIIRQPsEEEIIKL

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