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eIF6 (human)

Overview eIF6 eukaryotic translation initiation factor 6. Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex. Note: This description may include information from UniProtKB. Protein type: Translation; Translation initiation Cellular Component: cytoplasm; lamin filament; nucleolus; nucleus Molecular Function: protein binding; translation initiation factor activity; ribosome binding Biological Process: mature ribosome assembly Reference #:  P56537 (UniProtKB) Alt. Names/Synonyms: 2; b; b(2)gcn; B(2)GCN homolog; B4 integrin interactor; CAB; eIF-6; EIF3A; EIF6; eukaryotic translation initiation factor 3A; Eukaryotic translation initiation factor 6; gcn; IF6; integrin beta 4 binding protein; ITGB4BP; p27 beta-4 integrin-binding protein; p27(BBP); p27BBP Gene Symbols: EIF6 Molecular weight: 26,599 Da Basal Isoelectric point: 4.56  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below eIF6

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	Sites Implicated In
translation, altered: S235‑p intracellular localization: S174‑p, S175‑p molecular association, regulation: S235‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	11		Y113-p	NVTTCNDyVALVHPD
1	0		S174-p	IEDQDELssLLQVPL
1	0		S175-p	EDQDELssLLQVPLV
0	1		K223-a	SVVESVFkLNEAQPS
0	1		Q228	VFkLNEAQPSTIATs
3	3		S235-p	QPSTIATsMRDsLID
0	3		S239-p	IATsMRDsLIDsLt_
0	4		S243-p	MRDsLIDsLt_____
0	1		T245-p	DsLIDsLt_______

	mouse
Y113	NVTTCNDYVALVHPD
S174	IEDQDELSSLLQVPL
S175	EDQDELSSLLQVPLV
K223	SVVESVFKLNEAkPS
K228-u	VFKLNEAkPSTIATS
S235	kPSTIATSMRDsLID
S239-p	IATSMRDsLIDsLt_
S243-p	MRDsLIDsLt_____
T245-p	DsLIDsLt_______

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