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Protein Page:
IP3R1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
IP3R1 a multi-pass endoplasmic reticulum membrane receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaMKII, eventually leading to the activation of downstream apoptosis pathways. Part of a cGMP kinase signaling complex that includes alpha-actin, calponin H1, phospholamban, PKG1 and IP3R1. Widely expressed. The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region. Phosphorylation by PKA prevents the ligand-induced opening of the calcium channels. Belongs to the ryanodine-inositol 1,4,5-triphosphate receptor ca(2+) channel (rir-cac) family. Eight alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Channel, calcium; Membrane protein, multi-pass; Membrane protein, integral; Channel, ligand-gated
Cellular Component: endoplasmic reticulum membrane; membrane; sarcoplasmic reticulum; endoplasmic reticulum; postsynaptic density; integral to membrane; nucleolus; nuclear inner membrane; platelet dense granule membrane; calcineurin complex
Molecular Function: protein binding; calcium ion transmembrane transporter activity; intracellular ligand-gated calcium channel activity; phosphoinositide binding; inositol 1,4,5-triphosphate-sensitive calcium-release channel activity
Biological Process: epidermal growth factor receptor signaling pathway; platelet activation; voluntary musculoskeletal movement; inositol phosphate-mediated signaling; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; signal transduction; post-embryonic development; endoplasmic reticulum calcium ion homeostasis; phospholipase C activation; calcium ion transport; release of sequestered calcium ion into cytosol; response to hypoxia; energy reserve metabolic process; innate immune response; blood coagulation; regulation of insulin secretion
Reference #:  Q14643 (UniProtKB)
Alt. Names/Synonyms: DKFZp313E1334; DKFZp313N1434; inositol 1,4,5-triphosphate receptor, type 1; Inositol 1,4,5-trisphosphate receptor type 1; INSP3R1; IP3 receptor; IP3 receptor isoform 1; IP3R; IP3R 1; IP3R1; ITPR1; SCA15; SCA16; Type 1 inositol 1,4,5-trisphosphate receptor; Type 1 InsP3 receptor
Gene Symbols: ITPR1
Molecular weight: 313,929 Da
Basal Isoelectric point: 5.71  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  Phospholipase Signaling  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

IP3R1

Protein Structure Not Found.


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Sites Implicated In
transcription, altered: Y353‑p
activity, induced: Y353‑p
molecular association, regulation: T800‑p, S1598‑p
receptor desensitization, altered: Y353‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 K77 KQFWKAAKPGANSTT
0 1 K225 WKIVLFMKWSDNKDD
0 1 K258-ac LTCDEHRkKQHVFLR
0 1 K279 ATSATSSKALWEVEV
0 1 K306 WNSLFRFKHLATGHY
3 0 Y353-p NAQEKMVySLVSVPE
0 2 T420-p PVMLKIGtsPVKEDK
2 1 S421-p VMLKIGtsPVKEDKE
0 1 K427 tsPVKEDKEAFAIVP
2 1 S436-p AFAIVPVsPAEVRDL
0 1 K451 DFANDASKVLGSIAG
0 1 K462 SIAGKLEKGTITQNE
0 1 K517 MREQNILKQIFKLLQ
0 4 K569-ac HSQQDYRkNQEYIAk
0 1 K576-ac kNQEYIAkQFGFMQK
0 1 S704-p VWLFWRDsNKEIRSK
2 0 T800-p RDPQEQVtPVKYARL
0 1 S826-p DYDSSGAsKDEIKER
0 1 K862 FSDKEKNKLTFEVVN
0 1 K917 MAKGEENKGNNDVEK
1 9 T955-p GGGFLPMtPMAAAPE
0 1 K972 VKQAEPEKEDIMVMD
0 1 K981 DIMVMDTKLKIIEIL
0 1 K1138 QLRSIVEKSELWVyK
0 3 Y1144-p EKSELWVyKGQGPDE
0 1 T1238-p PYEKAEDtKMQEIMR
0 1 K1320 GRNVQYIKFLQTIVK
0 1 K1327 KFLQTIVKAEGKFIK
0 1 K1581 KSHSIVQKTAMNWRL
0 1 S1589 TAMNWRLSARNAARR
8 29 S1598-p RNAARRDsVLAAsRD
0 3 S1603-p RDsVLAAsRDyRNII
0 1 Y1606-p VLAAsRDyRNIIERL
0 1 K1664 ESGGFICKLIKHTKQ
0 1 K1670 CKLIKHTKQLLEENE
0 1 K1683 NEEKLCIKVLQtLRE
0 1 T1687-p LCIKVLQtLREMMTK
10 26 S1764-p RPSGRREsLtsFGNG
0 3 T1766-p SGRREsLtsFGNGPL
0 2 S1767-p GRREsLtsFGNGPLs
1 1 S1774-p sFGNGPLsAGGPGKP
0 1 K1780 LsAGGPGKPGGGGGG
0 1 K1866 KKSEKFFKVFYDRMK
0 1 T1882-p AQQEIKAtVTVNTSD
0 1 K1893 NTSDLGNKKKDDEVD
0 1 K1894 TSDLGNKKKDDEVDR
0 1 K1895 SDLGNKKKDDEVDRD
0 1 K1910 APSRKKAKEPTTQIT
0 1 K1933 EASAATRKAFTTFRR
0 1 T2065 ENQNCIATHESNGID
0 2 K2127 ILYNMRPKELVEVIK
0 1 K2176 HQLARHNKELQSMLK
0 1 K2247 ERDEQGSKINDFFLR
0 2 K2266 FNEMNWQKKLRAQPV
0 1 Y2275-p LRAQPVLyWCARNMS
0 1 Y2649-p EEHNMWHyLCFIVLV
0 1 S2661-p VLVKVKDstEYTGPE
0 1 T2662-p LVKVKDstEYTGPES
1 2 S2690-p FPRMRAMsLVssDsE
0 1 S2693-p MRAMsLVssDsEGEQ
0 1 S2694-p RAMsLVssDsEGEQN
0 3 S2696-p MsLVssDsEGEQNEL
0 1 K2709 ELRNLQEKLESTMKL
0 1 K2715 EKLESTMKLVTNLSG
0 1 S2721 MKLVTNLSGQLSELK
3760 : Phospho-IP3 Receptor (Ser1756) Antibody
8548 : Phospho-IP3 Receptor (Ser1756) (D10E3) Rabbit mAb
  IP3R1 iso3  
K77 KQFWKAAKPGANSTT
K225 WKIVLFMKWSDNKDD
K258 LTCDEHRKKQHVFLR
K279 ATSATSSKALWEVEV
K306 WNSLFRFKHLATGHY
Y353 NAQEKMVYSLVSVPE
T420 PVMLKIGTSPVKEDK
S421 VMLKIGTSPVKEDKE
K427 TSPVKEDKEAFAIVP
S436 AFAIVPVSPAEVRDL
K451 DFANDASKVLGSIAG
K462 SIAGKLEKGTITQNE
K517 MREQNILKQIFKLLQ
K569 HSQQDYRKNQEYIAK
K576 KNQEYIAKQFGFMQK
S704 VWLFWRDSNKEIRSK
T800 RDPQEQVTPVKYARL
S826 DYDSSGASKDEIKER
K862 FSDKEKNKLTFEVVN
K917 MAKGEENKGSNVMRS
T946 GGGFLPMTPMAAAPE
K963 VKQAEPEKEDIMVMD
K972 DIMVMDTKLKIIEIL
K1129 QLRSIVEKSELWVYK
Y1135 EKSELWVYKGQGPDE
T1229 PYEKAEDTKMQEIMR
K1311 GRNVQYIKFLQTIVK
K1318 KFLQTIVKAEGKFIK
K1572 KSHSIVQKTAMNWRL
S1580 TAMNWRLSARNAARR
S1589 RNAARRDSVLAASRD
S1594 RDSVLAASRDYRNII
Y1597 VLAASRDYRNIIERL
K1655 ESGGFICKLIKHTKQ
K1661 CKLIKHTKQLLEENE
K1674 NEEKLCIKVLQTLRE
T1678 LCIKVLQTLREMMTK
S1716 RPSGRRESLTSFGNG
T1718 SGRRESLTSFGNGPL
S1719 GRRESLTSFGNGPLS
S1726 SFGNGPLSAGGPGKP
K1732 LSAGGPGKPGGGGGG
K1818 KKSEKFFKVFYDRMK
T1834 AQQEIKATVTVNTSD
K1845 NTSDLGNKKKDDEVD
K1846 TSDLGNKKKDDEVDR
K1847 SDLGNKKKDDEVDRD
K1862 APSRKKAKEPTTQIT
K1885 EASAATRKAFTTFRR
T2017 ENQNCIATHESNGID
K2079 ILYNMRPKELVEVIK
K2128 HQLARHNKELQSMLK
K2199 ERDEQGSKINDFFLR
K2218 FNEMNWQKKLRAQPV
Y2227 LRAQPVLYWCARNMS
Y2601 EEHNMWHYLCFIVLV
S2613 VLVKVKDSTEYTGPE
T2614 LVKVKDSTEYTGPES
S2642 FPRMRAMSLVSSDSE
S2645 MRAMSLVSSDSEGEQ
S2646 RAMSLVSSDSEGEQN
S2648 MSLVSSDSEGEQNEL
K2661 ELRNLQEKLESTMKL
K2667 EKLESTMKLVTNLSG
S2673 MKLVTNLSGQLSELK
3760 : Phospho-IP3 Receptor (Ser1756) Antibody
8548 : Phospho-IP3 Receptor (Ser1756) (D10E3) Rabbit mAb
  mouse

► Hide Isoforms
 
K77-ub KQFWKAAkPGANSTT
K225-ac WKIVLFMkWSDNKDD
K258 LTCDEHRKKQHVFLR
K279-ub ATSATSSkALWEVEV
K306 WNSLFRFKHLATGHY
Y353-p NAQEKMVySLVSVPE
T420 PVMLKIGTsPLKEDk
S421-p VMLKIGTsPLKEDkE
K427-ub TsPLKEDkEAFAIVP
S436-p AFAIVPVsPAEVRDL
K451-ub DFANDASkVLGSIAG
K462-ub SIAGKLEkGTITQNE
K517-ub MREQNILkQIFKLLQ
K569 HSQQDYRKNQEYIAK
K576 KNQEYIAKQFGFMQK
S703 VWLFWRDSNKEIRSK
T799-p RDPQEQVtPVKYARL
S825 DYDSSGTSKDEIKER
K861-ub FSDKEKNkLTFEVVN
K916-ub MTKGEENkGSNVMRS
T945 GGGFLPMTPMAAAPE
K962-ub VKQAEPEkEDIMVMD
K971-ub DIMVMDTkLKIIEIL
K1128-ub QLRSIVEkSELWVYK
Y1134 EkSELWVYKGQGPDE
T1228 PYEKAEDTKMQEIMR
K1310-ub GRNVQYIkFLQTIVk
K1317-ub kFLQTIVkAEGKFIK
K1571-ub KSHNIVQkTALNWRL
S1579-p TALNWRLsARNAARR
S1588-p RNAARRDsVLAAsRD
S1593-p RDsVLAAsRDYRNII
Y1596 VLAAsRDYRNIIERL
K1654-ub ESGGFICkLIKHTkQ
K1660-ub CkLIKHTkQLLEENE
K1673-ub NEEKLCIkVLQTLRE
T1677 LCIkVLQTLREMMTK
S1755-p RPSGRREsLtsFGNG
T1757-p SGRREsLtsFGNGPL
S1758-p GRREsLtsFGNGPLs
S1765-p sFGNGPLsPGGPSkP
K1771-ub LsPGGPSkPGGGGGG
K1857-ub KKSEKFFkVFYDRMK
T1873 AQQEIKATVTVNTSD
K1884-ub NTSDLGNkkkDDEVD
K1885-ub TSDLGNkkkDDEVDR
K1886-ub SDLGNkkkDDEVDRD
K1901-ub APSRKKAkEPTTQIT
K1924-ub EASAATRkAFTTFRR
T2056-p ENQNCIAtHESNGID
K2118-ub ILYNMRPkELVEVIK
K2167-ub HQLARHNkELQTMLK
K2238-ub ERDEQGSkINDFFLR
K2257-ub FNEMNWQkKLRAQPV
Y2266 LRAQPVLYWCARNMS
Y2640 EEHNMWHYLCFIVLV
S2652 VLVKVKDSTEYTGPE
T2653 LVKVKDSTEYTGPES
S2681-p FPRMRAMsLVSSDsE
S2684 MRAMsLVSSDsEGEQ
S2685 RAMsLVSSDsEGEQN
S2687-p MsLVSSDsEGEQNEL
K2700-ub ELRNLQEkLESTMkL
K2706-ub EkLESTMkLVTNLsG
S2712-p MkLVTNLsGQLSELK
3760 : Phospho-IP3 Receptor (Ser1756) Antibody
8548 : Phospho-IP3 Receptor (Ser1756) (D10E3) Rabbit mAb
  IP3R1 iso2  
K77 KQFWKAAKPGANSTT
K225 WKIVLFMKWSDNKDD
K258 LTCDEHRKKQHVFLR
K279 ATSATSSKALWEVEV
K306-ub WNSLFRFkHLATGHY
Y338 NAQEKMVYSLVSVPE
T405 PVMLKIGTSPLKEDK
S406 VMLKIGTSPLKEDKE
K412 TSPLKEDKEAFAIVP
S421 AFAIVPVSPAEVRDL
K436 DFANDASKVLGSIAG
K447 SIAGKLEKGTITQNE
K502 MREQNILKQIFKLLQ
K554 HSQQDYRKNQEYIAK
K561 KNQEYIAKQFGFMQK
S688 VWLFWRDSNKEIRSK
T784 RDPQEQVTPVKYARL
S810 DYDSSGTSKDEIKER
K846 FSDKEKNKLTFEVVN
K901 MTKGEENKGSNVMRS
T930 GGGFLPMTPMAAAPE
K947 VKQAEPEKEDIMVMD
K956 DIMVMDTKLKIIEIL
K1113 QLRSIVEKSELWVYK
Y1119 EKSELWVYKGQGPDE
T1213 PYEKAEDTKMQEIMR
K1295 GRNVQYIKFLQTIVK
K1302 KFLQTIVKAEGKFIK
K1556 KSHNIVQKTALNWRL
S1564 TALNWRLSARNAARR
S1573 RNAARRDSVLAASRD
S1578 RDSVLAASRDYRNII
Y1581 VLAASRDYRNIIERL
K1639 ESGGFICKLIKHTKQ
K1645 CKLIKHTKQLLEENE
K1658 NEEKLCIKVLQTLRE
T1662 LCIKVLQTLREMMTK
S1740 RPSGRRESLTSFGNG
T1742 SGRRESLTSFGNGPL
S1743 GRRESLTSFGNGPLS
S1750 SFGNGPLSPGGPSKP
K1756 LSPGGPSKPGGGGGG
K1842 KKSEKFFKVFYDRMK
T1858 AQQEIKATVTVNTSD
K1869 NTSDLGNKKKDDEVD
K1870 TSDLGNKKKDDEVDR
K1871 SDLGNKKKDDEVDRD
K1886 APSRKKAKEPTTQIT
K1909 EASAATRKAFTTFRR
T2041 ENQNCIATHESNGID
K2103 ILYNMRPKELVEVIK
K2152 HQLARHNKELQTMLK
K2223 ERDEQGSKINDFFLR
K2242 FNEMNWQKKLRAQPV
Y2251 LRAQPVLYWCARNMS
Y2625 EEHNMWHYLCFIVLV
S2637 VLVKVKDSTEYTGPE
T2638 LVKVKDSTEYTGPES
S2666 FPRMRAMSLVSSDSE
S2669 MRAMSLVSSDSEGEQ
S2670 RAMSLVSSDSEGEQN
S2672 MSLVSSDSEGEQNEL
K2685 ELRNLQEKLESTMKL
K2691 EKLESTMKLVTNLSG
S2697 MKLVTNLSGQLSELK
  rat

 
K77 KQFWKAAKPGANSTT
K225 WKIVLFMKWSDNKDD
K258 LTCDEHRKKQHVFLR
K279 ATSATSSKALWEVEV
K306 WNSLFRFKHLATGHY
Y353 NAQEKMVYSLVSVPE
T420 PVMLKIGTsPLKEDK
S421-p VMLKIGTsPLKEDKE
K427 TsPLKEDKEAFAIVP
S436 AFAIVPVSPAEVRDL
K451 DFANDASKVLGSIAG
K462 SIAGKLEKGTITQNE
K517 MREQNILKQIFKLLQ
K569 HSQQDYRKNQEYIAK
K576 KNQEYIAKQFGFMQK
S703 VWLFWRDSNKEIRSK
T799-p RDPQEQVtPVKYARL
S825 DYDSSGASKDEIKER
K861 FSDKEKNKLTFEVVN
K916 MTKGEENKGSNVMRS
T945-p GGGFLPMtPMAAAPE
K962 VKQAEPEKEDIMVMD
K971 DIMVMDTKLKIIEIL
K1128 QLRSIVEKSELWVYK
Y1134 EKSELWVYKGQGPDE
T1228 PYEKAEDTKMQEIMR
K1310 GRNVQYIKFLQTIVK
K1317 KFLQTIVKAEGKFIK
K1572 KSHNIVQKTAMNWRL
S1580 TAMNWRLSARNAARR
S1589-p RNAARRDsVLAASRD
S1594 RDsVLAASRDYRNII
Y1597 VLAASRDYRNIIERL
K1655 ESGGFICKLIKHTKQ
K1661 CKLIKHTKQLLEENE
K1674 NEEKLCIKVLQTLRE
T1678 LCIKVLQTLREMMTK
S1756-p RPSGRREsLTSFGNG
T1758 SGRREsLTSFGNGPL
S1759 GRREsLTSFGNGPLS
S1766 SFGNGPLSPGGPSKP
K1772 LSPGGPSKPGGGGGG
K1858 KKSEKFFKVFYDRMK
T1874 AQQEIKATVTVNTSD
K1885 NTSDLGNKKKDDEVD
K1886 TSDLGNKKKDDEVDR
K1887 SDLGNKKKDDEVDRD
K1902 APSRKKAKEPTTQIT
K1925 EASAATRKAFTTFRR
T2057 ENQNCIATHESNGID
K2119 ILYNMRPKELVEVIK
K2168 HQLARHNKELQTMLK
K2239 ERDEQGSKINDFFLR
K2258 FNEMNWQKKLRAQPV
Y2267 LRAQPVLYWCARNMS
Y2641 EEHNMWHYLCFIVLV
S2653 VLVKVKDSTEYTGPE
T2654 LVKVKDSTEYTGPES
S2682-p FPRMRAMsLVSSDSE
S2685 MRAMsLVSSDSEGEQ
S2686 RAMsLVSSDSEGEQN
S2688 MsLVSSDSEGEQNEL
K2701 ELRNLQEKLESTMKL
K2707 EKLESTMKLVTNLSG
S2713 MKLVTNLSGQLSELK
3760 : Phospho-IP3 Receptor (Ser1756) Antibody
8548 : Phospho-IP3 Receptor (Ser1756) (D10E3) Rabbit mAb
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