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IP3R1 (human)

Overview IP3R1 receptor for inositol 1,4,5-trisphosphate, mediating the release of intracellular calcium especially from the endoplasmic reticulum. Contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region. Phosphorylation can inhibit the ligand-induced opening of the calcium channel. Eight alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB. Protein type: Channel, ligand-gated; Membrane protein, integral; Receptor, misc.; Channel, calcium Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane; platelet dense granule membrane Molecular Function: protein binding; calcium ion transmembrane transporter activity; intracellular ligand-gated calcium channel activity; phosphoinositide binding; inositol 1,4,5-triphosphate-sensitive calcium-release channel activity Biological Process: epidermal growth factor receptor signaling pathway; platelet activation; inositol phosphate-mediated signaling; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; signal transduction; phospholipase C activation; calcium ion transport; release of sequestered calcium ion into cytosol; response to hypoxia; energy reserve metabolic process; blood coagulation; regulation of insulin secretion Reference #:  Q14643 (UniProtKB) Alt. Names/Synonyms: DKFZp313E1334; DKFZp313N1434; inositol 1,4,5-triphosphate receptor, type 1; Inositol 1,4,5-trisphosphate receptor type 1; INSP3R1; IP3 receptor; IP3 receptor isoform 1; IP3R; IP3R 1; IP3R1; ITPR1; SCA15; SCA16; Type 1 inositol 1,4,5-trisphosphate receptor; Type 1 InsP3 receptor Gene Symbols: ITPR1 Molecular weight: 313,945 Da Basal Isoelectric point: 5.71  Predict pI for various phosphorylation states CST Pathways:  B Cell Receptor Signaling  |  Phospholipase Signaling  |  T Cell Receptor Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below IP3R1 1N4K - A=224-604 (mouse) 1XZZ - A=2-223 (mouse) 3UJ0 - A/B=1-604 (rat) 3UJ4 - A/B=1-604 (rat)

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	Sites Implicated In
transcription, altered: Y353‑p activation: Y353‑p molecular association, regulation: T800‑p, S1598‑p receptor desensitization, altered: Y353‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	1		K77	KQFWKAAKPGANSTT
0	1		K225	WKIVLFMKWSDNKDD
0	1		K258-a	LTCDEHRkKQHVFLR
0	1		K279	ATSATSSKALWEVEV
0	1		Y298-p	PCRGGAGyWNSLFRF
0	1		K306	WNSLFRFKHLATGHY
3	0		Y353-p	NAQEKMVySLVSVPE
0	1		T420-p	PVMLKIGtsPVKEDK
2	1		S421-p	VMLKIGtsPVKEDKE
0	1		K427	tsPVKEDKEAFAIVP
2	0		S436	AFAIVPVSPAEVRDL
0	1		K451	DFANDASKVLGSIAG
0	1		K462	SIAGKLEKGTITQNE
0	1		K517	MREQNILKQIFKLLQ
0	4		K569-a	HSQQDYRkNQEYIAk
0	1		K576-a	kNQEYIAkQFGFMQK
0	1		S704-p	VWLFWRDsNKEIRSK
2	0		T800-p	RDPQEQVtPVKYARL
0	1		K862	FSDKEKNKLTFEVVN
0	1		K917	MAKGEENKGNNDVEK
1	9		T955-p	GGGFLPMtPMAAAPE
0	1		K972	VKQAEPEKEDIMVMD
0	1		K981	DIMVMDTKLKIIEIL
0	1		K1138	QLRSIVEKSELWVyK
0	3		Y1144-p	EKSELWVyKGQGPDE
0	1		Y1183-p	ESTSSYNyRVVKEIL
0	1		T1238-p	PYEKAEDtKMQEIMR
0	1		K1320	GRNVQYIKFLQTIVK
0	1		K1327	KFLQTIVKAEGKFIK
0	1		K1581	KSHSIVQKTAMNWRL
0	1		S1589	TAMNWRLSARNAARR
8	18		S1598-p	RNAARRDsVLAASRD
0	1		K1664	ESGGFICKLIKHTKQ
0	1		K1670	CKLIKHTKQLLEENE
0	1		K1683	NEEKLCIKVLQtLRE
0	1		T1687-p	LCIKVLQtLREMMTK
8	15		S1764-p	RPSGRREsLtsFGNG
0	3		T1766-p	SGRREsLtsFGNGPL
0	2		S1767-p	GRREsLtsFGNGPLs
1	1		S1774-p	sFGNGPLsAGGPGKP
0	1		K1780	LsAGGPGKPGGGGGG
0	1		K1866	KKSEKFFKVFYDRMK
0	1		K1893	NTSDLGNKKKDDEVD
0	1		K1894	TSDLGNKKKDDEVDR
0	1		K1895	SDLGNKKKDDEVDRD
0	1		K1910	APSRKKAKEPTTQIT
0	1		K1933	EASAATRKAFTTFRR
0	1		T2065	ENQNCIATHESNGID
0	2		K2127	ILYNMRPKELVEVIK
0	1		K2176	HQLARHNKELQSMLK
0	1		K2247	ERDEQGSKINDFFLR
0	2		K2266	FNEMNWQKKLRAQPV
0	1		Y2275-p	LRAQPVLyWCARNMS
0	1		Y2649-p	EEHNMWHyLCFIVLV
1	2		S2690-p	FPRMRAMsLVssDsE
0	1		S2693-p	MRAMsLVssDsEGEQ
0	1		S2694-p	RAMsLVssDsEGEQN
0	3		S2696-p	MsLVssDsEGEQNEL
0	1		K2709	ELRNLQEKLESTMKL
0	1		K2715	EKLESTMKLVTNLSG
0	1		S2721	MKLVTNLSGQLSELK

	IP3R1 iso3
K77	KQFWKAAKPGANSTT
K225	WKIVLFMKWSDNKDD
K258	LTCDEHRKKQHVFLR
K279	ATSATSSKALWEVEV
Y298	PCRGGAGYWNSLFRF
K306	WNSLFRFKHLATGHY
Y353	NAQEKMVYSLVSVPE
T420	PVMLKIGTSPVKEDK
S421	VMLKIGTSPVKEDKE
K427	TSPVKEDKEAFAIVP
S436	AFAIVPVSPAEVRDL
K451	DFANDASKVLGSIAG
K462	SIAGKLEKGTITQNE
K517	MREQNILKQIFKLLQ
K569	HSQQDYRKNQEYIAK
K576	KNQEYIAKQFGFMQK
S704	VWLFWRDSNKEIRSK
T800	RDPQEQVTPVKYARL
K862	FSDKEKNKLTFEVVN
K917	MAKGEENKGSNVMRS
T946	GGGFLPMTPMAAAPE
K963	VKQAEPEKEDIMVMD
K972	DIMVMDTKLKIIEIL
K1129	QLRSIVEKSELWVYK
Y1135	EKSELWVYKGQGPDE
Y1174	ESTSSYNYRVVKEIL
T1229	PYEKAEDTKMQEIMR
K1311	GRNVQYIKFLQTIVK
K1318	KFLQTIVKAEGKFIK
K1572	KSHSIVQKTAMNWRL
S1580	TAMNWRLSARNAARR
S1589	RNAARRDSVLAASRD
K1655	ESGGFICKLIKHTKQ
K1661	CKLIKHTKQLLEENE
K1674	NEEKLCIKVLQTLRE
T1678	LCIKVLQTLREMMTK
S1716	RPSGRRESLTSFGNG
T1718	SGRRESLTSFGNGPL
S1719	GRRESLTSFGNGPLS
S1726	SFGNGPLSAGGPGKP
K1732	LSAGGPGKPGGGGGG
K1818	KKSEKFFKVFYDRMK
K1845	NTSDLGNKKKDDEVD
K1846	TSDLGNKKKDDEVDR
K1847	SDLGNKKKDDEVDRD
K1862	APSRKKAKEPTTQIT
K1885	EASAATRKAFTTFRR
T2017	ENQNCIATHESNGID
K2079	ILYNMRPKELVEVIK
K2128	HQLARHNKELQSMLK
K2199	ERDEQGSKINDFFLR
K2218	FNEMNWQKKLRAQPV
Y2227	LRAQPVLYWCARNMS
Y2601	EEHNMWHYLCFIVLV
S2642	FPRMRAMSLVSSDSE
S2645	MRAMSLVSSDSEGEQ
S2646	RAMSLVSSDSEGEQN
S2648	MSLVSSDSEGEQNEL
K2661	ELRNLQEKLESTMKL
K2667	EKLESTMKLVTNLSG
S2673	MKLVTNLSGQLSELK

	mouse ► Hide Isoforms
K77-u	KQFWKAAkPGANSTT
K225-a	WKIVLFMkWSDNKDD
K258	LTCDEHRKKQHVFLR
K279-u	ATSATSSkALWEVEV
Y298	PCRGGAGYWNSLFRF
K306	WNSLFRFKHLATGHY
Y353-p	NAQEKMVySLVSVPE
T420	PVMLKIGTsPLKEDk
S421-p	VMLKIGTsPLKEDkE
K427-u	TsPLKEDkEAFAIVP
S436-p	AFAIVPVsPAEVRDL
K451-u	DFANDASkVLGSIAG
K462-u	SIAGKLEkGTITQNE
K517-u	MREQNILkQIFKLLQ
K569	HSQQDYRKNQEYIAK
K576	KNQEYIAKQFGFMQK
S703	VWLFWRDSNKEIRSK
T799-p	RDPQEQVtPVKYARL
K861-u	FSDKEKNkLTFEVVN
K916-u	MTKGEENkGSNVMRS
T945	GGGFLPMTPMAAAPE
K962-u	VKQAEPEkEDIMVMD
K971-u	DIMVMDTkLKIIEIL
K1128-u	QLRSIVEkSELWVYK
Y1134	EkSELWVYKGQGPDE
Y1173	ESTSSYNYRVVKEIL
T1228	PYEKAEDTKMQEIMR
K1310-u	GRNVQYIkFLQTIVk
K1317-u	kFLQTIVkAEGKFIK
K1571-u	KSHNIVQkTALNWRL
S1579-p	TALNWRLsARNAARR
S1588-p	RNAARRDsVLAASRD
K1654-u	ESGGFICkLIKHTkQ
K1660-u	CkLIKHTkQLLEENE
K1673-u	NEEKLCIkVLQTLRE
T1677	LCIkVLQTLREMMTK
S1755-p	RPSGRREsLtsFGNG
T1757-p	SGRREsLtsFGNGPL
S1758-p	GRREsLtsFGNGPLs
S1765-p	sFGNGPLsPGGPSkP
K1771-u	LsPGGPSkPGGGGGG
K1857-u	KKSEKFFkVFYDRMK
K1884-u	NTSDLGNkkkDDEVD
K1885-u	TSDLGNkkkDDEVDR
K1886-u	SDLGNkkkDDEVDRD
K1901-u	APSRKKAkEPTTQIT
K1924-u	EASAATRkAFTTFRR
T2056-p	ENQNCIAtHESNGID
K2118-u	ILYNMRPkELVEVIK
K2167-u	HQLARHNkELQTMLK
K2238-u	ERDEQGSkINDFFLR
K2257-u	FNEMNWQkKLRAQPV
Y2266	LRAQPVLYWCARNMS
Y2640	EEHNMWHYLCFIVLV
S2681-p	FPRMRAMsLVSSDsE
S2684	MRAMsLVSSDsEGEQ
S2685	RAMsLVSSDsEGEQN
S2687-p	MsLVSSDsEGEQNEL
K2700-u	ELRNLQEkLESTMkL
K2706-u	EkLESTMkLVTNLsG
S2712-p	MkLVTNLsGQLSELK

	IP3R1 iso2
K77	KQFWKAAKPGANSTT
K225	WKIVLFMKWSDNKDD
K258	LTCDEHRKKQHVFLR
K279	ATSATSSKALWEVEV
Y298	PCRGGAGYWNSLFRF
K306-u	WNSLFRFkHLATGHY
Y338	NAQEKMVYSLVSVPE
T405	PVMLKIGTSPLKEDK
S406	VMLKIGTSPLKEDKE
K412	TSPLKEDKEAFAIVP
S421	AFAIVPVSPAEVRDL
K436	DFANDASKVLGSIAG
K447	SIAGKLEKGTITQNE
K502	MREQNILKQIFKLLQ
K554	HSQQDYRKNQEYIAK
K561	KNQEYIAKQFGFMQK
S688	VWLFWRDSNKEIRSK
T784	RDPQEQVTPVKYARL
K846	FSDKEKNKLTFEVVN
K901	MTKGEENKGSNVMRS
T930	GGGFLPMTPMAAAPE
K947	VKQAEPEKEDIMVMD
K956	DIMVMDTKLKIIEIL
K1113	QLRSIVEKSELWVYK
Y1119	EKSELWVYKGQGPDE
Y1158	ESTSSYNYRVVKEIL
T1213	PYEKAEDTKMQEIMR
K1295	GRNVQYIKFLQTIVK
K1302	KFLQTIVKAEGKFIK
K1556	KSHNIVQKTALNWRL
S1564	TALNWRLSARNAARR
S1573	RNAARRDSVLAASRD
K1639	ESGGFICKLIKHTKQ
K1645	CKLIKHTKQLLEENE
K1658	NEEKLCIKVLQTLRE
T1662	LCIKVLQTLREMMTK
S1740	RPSGRRESLTSFGNG
T1742	SGRRESLTSFGNGPL
S1743	GRRESLTSFGNGPLS
S1750	SFGNGPLSPGGPSKP
K1756	LSPGGPSKPGGGGGG
K1842	KKSEKFFKVFYDRMK
K1869	NTSDLGNKKKDDEVD
K1870	TSDLGNKKKDDEVDR
K1871	SDLGNKKKDDEVDRD
K1886	APSRKKAKEPTTQIT
K1909	EASAATRKAFTTFRR
T2041	ENQNCIATHESNGID
K2103	ILYNMRPKELVEVIK
K2152	HQLARHNKELQTMLK
K2223	ERDEQGSKINDFFLR
K2242	FNEMNWQKKLRAQPV
Y2251	LRAQPVLYWCARNMS
Y2625	EEHNMWHYLCFIVLV
S2666	FPRMRAMSLVSSDSE
S2669	MRAMSLVSSDSEGEQ
S2670	RAMSLVSSDSEGEQN
S2672	MSLVSSDSEGEQNEL
K2685	ELRNLQEKLESTMKL
K2691	EKLESTMKLVTNLSG
S2697	MKLVTNLSGQLSELK

	rat
K77	KQFWKAAKPGANSTT
K225	WKIVLFMKWSDNKDD
K258	LTCDEHRKKQHVFLR
K279	ATSATSSKALWEVEV
Y298	PCRGGAGYWNSLFRF
K306	WNSLFRFKHLATGHY
Y353	NAQEKMVYSLVSVPE
T420	PVMLKIGTsPLKEDK
S421-p	VMLKIGTsPLKEDKE
K427	TsPLKEDKEAFAIVP
S436	AFAIVPVSPAEVRDL
K451	DFANDASKVLGSIAG
K462	SIAGKLEKGTITQNE
K517	MREQNILKQIFKLLQ
K569	HSQQDYRKNQEYIAK
K576	KNQEYIAKQFGFMQK
S703	VWLFWRDSNKEIRSK
T799-p	RDPQEQVtPVKYARL
K861	FSDKEKNKLTFEVVN
K916	MTKGEENKGSNVMRS
T945-p	GGGFLPMtPMAAAPE
K962	VKQAEPEKEDIMVMD
K971	DIMVMDTKLKIIEIL
K1128	QLRSIVEKSELWVYK
Y1134	EKSELWVYKGQGPDE
Y1173	ESTSSYNYRVVKEIL
T1228	PYEKAEDTKMQEIMR
K1310	GRNVQYIKFLQTIVK
K1317	KFLQTIVKAEGKFIK
K1572	KSHNIVQKTAMNWRL
S1580	TAMNWRLSARNAARR
S1589-p	RNAARRDsVLAASRD
K1655	ESGGFICKLIKHTKQ
K1661	CKLIKHTKQLLEENE
K1674	NEEKLCIKVLQTLRE
T1678	LCIKVLQTLREMMTK
S1756-p	RPSGRREsLTSFGNG
T1758	SGRREsLTSFGNGPL
S1759	GRREsLTSFGNGPLS
S1766	SFGNGPLSPGGPSKP
K1772	LSPGGPSKPGGGGGG
K1858	KKSEKFFKVFYDRMK
K1885	NTSDLGNKKKDDEVD
K1886	TSDLGNKKKDDEVDR
K1887	SDLGNKKKDDEVDRD
K1902	APSRKKAKEPTTQIT
K1925	EASAATRKAFTTFRR
T2057	ENQNCIATHESNGID
K2119	ILYNMRPKELVEVIK
K2168	HQLARHNKELQTMLK
K2239	ERDEQGSKINDFFLR
K2258	FNEMNWQKKLRAQPV
Y2267	LRAQPVLYWCARNMS
Y2641	EEHNMWHYLCFIVLV
S2682-p	FPRMRAMsLVSSDSE
S2685	MRAMsLVSSDSEGEQ
S2686	RAMsLVSSDSEGEQN
S2688	MsLVSSDSEGEQNEL
K2701	ELRNLQEKLESTMKL
K2707	EKLESTMKLVTNLSG
S2713	MKLVTNLSGQLSELK

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