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Mpl (human)

Overview Mpl a hematopoietic receptor for thrombopoietin. Thrombopoietin is the major regulator of megakaryocytopoiesis and platelet formation. Dimerizes upon binding of thrombopoietin, leading to its phosphorylation and activation of JAKs and STATs. May represent a regulatory molecule specific for TPO-R-dependent immune responses. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB. Protein type: Receptor, cytokine; Membrane protein, integral Cellular Component: integral to plasma membrane; plasma membrane Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; transmembrane receptor activity Biological Process: platelet activation; cell proliferation; cell surface receptor linked signal transduction; homeostasis of number of cells; blood coagulation; regulation of chemokine production Reference #:  P40238 (UniProtKB) Alt. Names/Synonyms: C-MPL; CD110; MPL; MPLV; Myeloproliferative leukemia protein; myeloproliferative leukemia virus oncogene; Proto-oncogene c-Mpl; Thrombopoietin receptor; TPO-R; TPOR Gene Symbols: MPL Molecular weight: 71,245 Da Basal Isoelectric point: 6.03  Predict pI for various phosphorylation states

Select Structure to View Below Mpl

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE 159530 187950 604498  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
cell growth, inhibited: K553‑u, K573‑u protein degradation: K553‑u, K573‑u

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S81-p	PRACPLSsQSMPHFG
1	0		S531	LRHALWPSLPDLHRV
1	0		S550	LRDTAALSPPkATVS
1	0		P552	DTAALSPPkATVSDT
1	0		K553-u	TAALSPPkATVSDTC
1	0		T559	PkATVSDTCEEVEPS
1	0		K573-u	SLLEILPkSSERTPL
1	0		S574	LLEILPkSSERTPLP
1	0		S575	LEILPkSSERTPLPL
1	0		R577	ILPkSSERTPLPLCS
1	0		T578	LPkSSERTPLPLCSS
1	17		Y591-p	SSQAQMDyRRLQPSC
5	2		Y626	THIANHSYLPLSyWQ
4	0		Y631-p	HSYLPLSyWQQP___

	mouse
S81	PRACPLYSQSVPTFG
S522-p	LRHALWPsLPDLHRV
S541-p	LRDTAALsPsKATVT
S543-p	DTAALsPsKATVTDs
K544	TAALsPsKATVTDsC
S550-p	sKATVTDsCEEVEPS
K564	SLLEILPKssEstPL
S565-p	LLEILPKssEstPLP
S566-p	LEILPKssEstPLPL
S568-p	ILPKssEstPLPLCP
T569-p	LPKssEstPLPLCPS
Y582-p	PSQPQMDyRGLQPCL
Y616-p	THIANHSyLPLSyWQ
Y621-p	HSyLPLSyWQQP___

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