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Protein Page:
Mpl (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Mpl a hematopoietic receptor for thrombopoietin. Thrombopoietin is the major regulator of megakaryocytopoiesis and platelet formation. Dimerizes upon binding of thrombopoietin, leading to its phosphorylation and activation of JAKs and STATs. May represent a regulatory molecule specific for TPO-R-dependent immune responses. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Receptor, cytokine; Membrane protein, integral
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; transmembrane receptor activity
Biological Process: platelet activation; cell proliferation; cell surface receptor linked signal transduction; cytokine and chemokine mediated signaling pathway; homeostasis of number of cells; blood coagulation; regulation of chemokine production
Reference #:  P40238 (UniProtKB)
Alt. Names/Synonyms: C-MPL; CD110; MPL; MPLV; Myeloproliferative leukemia protein; myeloproliferative leukemia virus oncogene; Proto-oncogene c-Mpl; Thrombopoietin receptor; TPO-R; TPOR
Gene Symbols: MPL
Molecular weight: 71,245 Da
Basal Isoelectric point: 6.03  Predict pI for various phosphorylation states
Select Structure to View Below

Mpl

Protein Structure Not Found.


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Sites Implicated In
cell growth, inhibited: K553‑ub, K573‑ub
protein degradation: K553‑ub, K573‑ub

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S81-p PRACPLSsQSMPHFG
1 0 S531 LRHALWPSLPDLHRV
0 1 T546-p LGQYLRDtAALSPPk
1 0 S550 LRDtAALSPPkATVS
1 0 P552 DtAALSPPkATVSDT
1 0 K553-ub tAALSPPkATVSDTC
1 0 T559 PkATVSDTCEEVEPS
1 0 K573-ub SLLEILPkSSERTPL
1 0 S574 LLEILPkSSERTPLP
1 0 S575 LEILPkSSERTPLPL
1 0 R577 ILPkSSERTPLPLCS
1 0 T578 LPkSSERTPLPLCSS
2 17 Y591-p SSQAQMDyRRLQPSC
6 2 Y626-p THIANHSyLPLSyWQ
5 0 Y631-p HSyLPLSyWQQP___
12712 : Phospho-TPOR (Tyr626) (D3H7B) Rabbit mAb
  mouse

 
S81 PRACPLYSQSVPTFG
S522-p LRHALWPsLPDLHRV
T537 LGQYLRDTAALsPsK
S541-p LRDTAALsPsKATVT
S543-p DTAALsPsKATVTDs
K544 TAALsPsKATVTDsC
S550-p sKATVTDsCEEVEPS
K564 SLLEILPKssEstPL
S565-p LLEILPKssEstPLP
S566-p LEILPKssEstPLPL
S568-p ILPKssEstPLPLCP
T569-p LPKssEstPLPLCPS
Y582-p PSQPQMDyRGLQPCL
Y616-p THIANHSyLPLSyWQ
Y621-p HSyLPLSyWQQP___
12712 : Phospho-TPOR (Tyr626) (D3H7B) Rabbit mAb
  rat

 
S81 PRPCPLHSQSVPTFG
S541 LRHALWPSLPDLHRV
T556 LGQYLRDTAALSPSK
S560 LRDTAALSPSKATVT
S562 DTAALSPSKATVTDS
K563 TAALSPSKATVTDSC
S569 SKATVTDSCEEVEPS
K583 SLLEILPKSPERTPL
S584 LLEILPKSPERTPLP
P585 LEILPKSPERTPLPL
R587 ILPKSPERTPLPLCP
T588 LPKSPERTPLPLCPS
Y601 PSQPQMDYRGLQPCL
Y635 THIANHSYLPLSYWQ
Y640 HSYLPLSYWQQP___
12712 : Phospho-TPOR (Tyr626) (D3H7B) Rabbit mAb
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