GABRB1 (human)

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Protein Page:

GABRB1 (human)

p	Phosphorylation
a	Acetylation
m	Methylation
m1	Mono-methylation
m2	Di-methylation
m3	Tri-methylation
u	Ubiquitination
s	Sumoylation
n	Neddylation
gl	O-GlcNAc
ga	O-GalNAc
h	Palmitoylation
ad	Adenylylation
sn	S-Nitrosylation
ca	Caspase cleavage

Overview

GABRB1 GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRB1 sub-subfamily. Note: This description may include information from UniProtKB.

Protein type: Channel, ligand-gated; Membrane protein, integral; Channel, chloride

Cellular Component: postsynaptic membrane; integral to plasma membrane; plasma membrane; cell junction

Molecular Function: chloride channel activity; GABA-A receptor activity; extracellular ligand-gated ion channel activity

Biological Process: synaptic transmission; transport; signal transduction; transmembrane transport

Reference #: P18505 (UniProtKB)

Alt. Names/Synonyms: GABA(A) receptor subunit beta-1; GABRB1; gamma-aminobutyric acid (GABA) A receptor, beta 1; Gamma-aminobutyric acid receptor subunit beta-1; GBRB1

Gene Symbols: GABRB1

Molecular weight: 54,235 Da

Basal Isoelectric point: 8.88 Predict pI for various phosphorylation states

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	GABRB1

Modification Sites and Domains

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Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend

Show Multiple Sequence Alignment

SS SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.		human

1	2	K46-u	ETVDRLLkGYDIRLR
0	1	Y82-p	VSEVNMDyTLtMYFQ
0	1	T85-p	VNMDyTLtMYFQQSW
1	0	T227	SKKVEFTTGAYPRLS
1	0	Y230	VEFTTGAYPRLSLSF
1	0	T287	ITTVLTMTTISTHLR
1	0	T288	TTVLTMTTISTHLRE
1	0	S290	VLTMTTISTHLRETL
1	0	T291	LTMTTISTHLRETLP
0	1	Y309-p	YVKAIDIyLMGCFVF
0	1	Y324-p	VFLALLEyAFVNYIF
1	0	S396	DPKATMYSYDSASIQ
1	0	S399	ATMYSYDSASIQYRK
1	1	S401	MYSYDSASIQYRKPL
1	0	Y404	YDSASIQYRKPLSSR
3	0	S409	IQYRKPLSSREAYGR
1	0	S410	QYRKPLSSREAYGRA
6	0	S434	GRIRRRASQLKVKIP

	mouse

K46-u	ETVDRLLkGYDIRLR
Y82	VSEVNMDYTLTMYFQ
T85	VNMDYTLTMYFQQSW
T227-p	SKKVEFTtGAyPRLS
Y230-p	VEFTtGAyPRLSLSF
T287-p	ITTVLTMttIstHLR
T288-p	TTVLTMttIstHLRE
S290-p	VLTMttIstHLRETL
T291-p	LTMttIstHLRETLP
Y309	YVKAIDIYLMGCFVF
Y324	VFLALLEYAFVNYIF
S396-p	DPKATMYsYDsAsIQ
S399-p	ATMYsYDsAsIQyRK
S401-p	MYsYDsAsIQyRKPL
Y404-p	YDsAsIQyRKPLssR
S409-p	IQyRKPLssREGFGR
S410-p	QyRKPLssREGFGRG
S434-p	GRIRRRAsQLKVKIP

	rat

K46	ETVDRLLKGYDIRLR
Y82	VSEVNMDYTLTMYFQ
T85	VNMDYTLTMYFQQSW
T227	SKKVEFTTGAYPRLS
Y230	VEFTTGAYPRLSLSF
T287	ITTVLTMTTISTHLR
T288	TTVLTMTTISTHLRE
S290	VLTMTTISTHLRETL
T291	LTMTTISTHLRETLP
Y309	YVKAIDIYLMGCFVF
Y324	VFLALLEYAFVNYIF
S396	DPKATMYSYDSASIQ
S399	ATMYSYDSASIQYRK
S401	MYSYDSASIQYRKPL
Y404	YDSASIQYRKPLSSR
S409	IQYRKPLSSREGFGR
S410	QYRKPLSSREGFGRG
S434-p	GRIRRRAsQLKVKIP

	cow

K46	ETVDRLLKGYDIRLR
Y82	VSEVNMDYTLTMYFQ
T85	VNMDYTLTMYFQQSW
T227	SKKVEFTTGAYPRLS
Y230	VEFTTGAYPRLSLSF
T287	ITTVLTMTTISTHLR
T288	TTVLTMTTISTHLRE
S290	VLTMTTISTHLRETL
T291	LTMTTISTHLRETLP
Y309	YVKAIDIYLMGCFVF
Y324	VFLALLEYAFVNYIF
S396	DPKTTMYSYDSASIQ
S399	TTMYSYDSASIQYRK
S401	MYSYDSASIQYRKPM
Y404	YDSASIQYRKPMSSR
S409	IQYRKPMSSREGYGR
S410	QYRKPMSSREGYGRA
S434	GRIRRRASQLKVKIP

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