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Protein Page:
PSMA2 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
PSMA2 a proteasomal protein of the T1A peptidase family. The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. The component C3 may have a potential regulatory effect on another component(s) of the proteasome complex through tyrosine phosphorylation. Note: This description may include information from UniProtKB.
Protein type: Proteasome complex; Protease; EC 3.4.25.1
Cellular Component: proteasome complex; nucleoplasm; proteasome core complex; cytosol; nucleus
Molecular Function: threonine endopeptidase activity; protein binding
Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; protein polyubiquitination; viral reproduction; apoptosis; response to virus; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; mRNA metabolic process; regulation of apoptosis; antigen processing and presentation of peptide antigen via MHC class I; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; RNA metabolic process; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; gene expression; mitotic cell cycle; regulation of amino acid metabolic process; G1/S transition of mitotic cell cycle; negative regulation of apoptosis
Reference #:  P25787 (UniProtKB)
Alt. Names/Synonyms: HC3; Macropain subunit C3; MU; Multicatalytic endopeptidase complex subunit C3; PMSA2; proteasome (prosome, macropain) subunit, alpha type, 2; Proteasome component C3; Proteasome subunit alpha type-2; proteasome subunit HC3; PSA2; PSC2; PSC3; PSMA2
Gene Symbols: PSMA2
Molecular weight: 25,899 Da
Basal Isoelectric point: 6.91  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PSMA2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 8 Y6-p __MAERGysFSLTTF
0 11 S7-p _MAERGysFSLTTFs
0 1 S14-p sFSLTTFsPsGKLVQ
0 1 S16-p SLTTFsPsGKLVQIE
0 131 Y24-p GKLVQIEyALAAVAG
0 7 K39-u GAPSVGIkAANGVVL
0 23 K50-u GVVLATEkkQkSILy
0 6 K51-u VVLATEkkQkSILyD
0 9 K53-u LATEkkQkSILyDER
0 128 Y57-p kkQkSILyDERSVHk
0 32 K64-u yDERSVHkVEPITkH
0 104 K70-u HkVEPITkHIGLVys
0 1 K70-a HkVEPITkHIGLVys
0 830 Y76-p TkHIGLVysGMGPDY
0 14 S77-p kHIGLVysGMGPDYR
0 70 K92-u VLVHRARkLAQQyyL
0 1 K92-a VLVHRARkLAQQyyL
0 15 Y97-p ARkLAQQyyLVyQEP
0 42 Y98-p RkLAQQyyLVyQEPI
0 354 Y101-p AQQyyLVyQEPIPTA
1 0 Y121 VASVMQEYTQSGGVR
0 27 K165-u WKATAMGkNyVNGkT
0 4 Y167-p ATAMGkNyVNGkTFL
0 9 K171-a GkNyVNGkTFLEkRY
0 26 K171-u GkNyVNGkTFLEkRY
0 12 K176-u NGkTFLEkRYNEDLE
0 18 K227-u RLTPTEVkDYLAAIA
  mouse

 
Y6-p __MAERGysFSLTTF
S7-p _MAERGysFSLTTFS
S14 sFSLTTFSPSGKLVQ
S16 SLTTFSPSGKLVQIE
Y24-p GKLVQIEyALAAVAG
K39 GAPSVGIKAANGVVL
K50-u GVVLATEkKQkSILy
K51 VVLATEkKQkSILyD
K53-u LATEkKQkSILyDER
Y57-p kKQkSILyDERSVHK
K64 yDERSVHKVEPITkH
K70-u HKVEPITkHIGLVys
K70 HKVEPITKHIGLVys
Y76-p TkHIGLVysGMGPDY
S77-p kHIGLVysGMGPDYR
K92-u VLVHRARkLAQQyyL
K92 VLVHRARKLAQQyyL
Y97-p ARkLAQQyyLVyQEP
Y98-p RkLAQQyyLVyQEPI
Y101-p AQQyyLVyQEPIPTA
Y121 VASVMQEYTQSGGVR
K165-u WKATAMGkNyVNGkT
Y167-p ATAMGkNyVNGkTFL
K171 GkNyVNGKTFLEKRY
K171-u GkNyVNGkTFLEKRY
K176 NGkTFLEKRYNEDLE
R227 RLTPTEVRDYLAAIA
  rat

 
Y6 __MAERGYSFSLTTF
S7 _MAERGYSFSLTTFS
S14 SFSLTTFSPSGKLVQ
S16 SLTTFSPSGKLVQIE
Y24-p GKLVQIEyALAAVAG
K39 GAPSVGIKAANGVVL
K50 GVVLATEKKQKSILY
K51 VVLATEKKQKSILYD
K53 LATEKKQKSILYDER
Y57 KKQKSILYDERSVHK
K64 YDERSVHKVEPITkH
K70-u HKVEPITkHIGLVyS
K70 HKVEPITKHIGLVyS
Y76-p TkHIGLVySGMGPDY
S77 kHIGLVySGMGPDYR
K92 VLVHRARKLAQQYyL
K92 VLVHRARKLAQQYyL
Y97 ARKLAQQYyLVyQEP
Y98-p RKLAQQYyLVyQEPI
Y101-p AQQYyLVyQEPIPTA
Y121-p VASVMQEyTQSGGVR
K165 WKATAMGKNyVNGKT
Y167-p ATAMGKNyVNGKTFL
K171 GKNyVNGKTFLEKRY
K171 GKNyVNGKTFLEKRY
K176 NGKTFLEKRYNEDLE
R227 RLTPTEVRDYLAAIA
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