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Protein Page:
RelB (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
RelB a transcription factor of the nuclear factor-kappaB (NFkB) transcription complex. Stimulates promoter activity in the presence NFkB1/NFkB-p50. Plays role in regulation of apoptosis in hepatocellular carcinoma through activation of downstream target genes. Does not associate with DNA or RelA/NFkB-p65. Note: This description may include information from UniProtKB.
Protein type: Transcription factor
Cellular Component: microtubule organizing center; cytosol
Molecular Function: protein binding; DNA binding; transcription corepressor activity; transcription factor activity
Biological Process: antigen processing and presentation; transcription, DNA-dependent; T-helper 1 cell differentiation; myeloid dendritic cell differentiation
Reference #:  Q01201 (UniProtKB)
Alt. Names/Synonyms: I-Rel; IREL; REL-B; RELB; Transcription factor RelB; v-rel avian reticuloendotheliosis viral oncogene homolog B (nuclear factor of kappa light polypeptide gene enhancer in B-cells 3); v-rel reticuloendotheliosis viral oncogene homolog B; v-rel reticuloendotheliosis viral oncogene homolog B, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3
Gene Symbols: RELB
Molecular weight: 62,134 Da
Basal Isoelectric point: 5.84  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  NF-kB Signaling  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

RelB

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 R16-m1 GPSVPTGrAMPSRRV
0 2 S37-p PELGALGsPDLSSLS
1 0 T103 GPVAPPATPPPWGCP
0 1 S116-p CPLGRLVsPAPGPGP
1 0 K295 LSEPVYDKKSTNTSE
1 0 K296 SEPVYDKKSTNTSEL
1 0 K327 ELYLLCDKVQKEDIS
1 0 K330 LLCDKVQKEDISVVF
1 0 S390 RLTDGVCSEPLPFTY
2 6 S573-p AFGGGLLsPGPEAT_
4999 : Phospho-RelB (Ser552) Antibody
5025 : Phospho-RelB (Ser552) (D41B9) XP(R) Rabbit mAb
13567 : Phospho-RelB (Ser552) (D41B9) XP(R) Rabbit mAb (PE Conjugate)
  mouse

 
- gap
S19 PELGALGSSDLSSLS
T84-p AAPPPPAtPSWSCTL
S96 CTLGRLVSPGPCPRP
K273-u LSEPVYDkkSTNTSE
K274-u SEPVYDkkSTNTSEL
K305-u ELYLLCDkVQkEDIS
K308-u LLCDkVQkEDISVVF
S368-p RLTDGVCsEPLPFTY
S552-p AFGGGLLsPGPEAT_
4999 : Phospho-RelB (Ser552) Antibody
5025 : Phospho-RelB (Ser552) (D41B9) XP(R) Rabbit mAb
13567 : Phospho-RelB (Ser552) (D41B9) XP(R) Rabbit mAb (PE Conjugate)
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