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RelB (human)

Overview RelB a transcription factor of the nuclear factor-kappaB (NFkB) transcription complex. Stimulates promoter activity in the presence NFkB1/NFkB-p50. Plays role in regulation of apoptosis in hepatocellular carcinoma through activation of downstream target genes. Does not associate with DNA or RelA/NFkB-p65. Note: This description may include information from UniProtKB. Protein type: Transcription factor Cellular Component: microtubule organizing center; cytosol; nucleus Molecular Function: protein binding; DNA binding; transcription factor activity; transcription corepressor activity Biological Process: antigen processing and presentation; transcription, DNA-dependent; T-helper 1 cell differentiation; myeloid dendritic cell differentiation Reference #:  Q01201 (UniProtKB) Alt. Names/Synonyms: I-Rel; IREL; REL-B; RELB; Transcription factor RelB; v-rel avian reticuloendotheliosis viral oncogene homolog B (nuclear factor of kappa light polypeptide gene enhancer in B-cells 3); v-rel reticuloendotheliosis viral oncogene homolog B; v-rel reticuloendotheliosis viral oncogene homolog B, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 Gene Symbols: RELB Molecular weight: 62,134 Da Basal Isoelectric point: 5.84  Predict pI for various phosphorylation states CST Pathways:  Apoptosis  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  NF-kB Signaling  |  T Cell Receptor Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below RelB 1ZK9 - A=277-378 (mouse) 1ZKA - A=277-378 (mouse) 2V2T - A=91-378 (mouse) 3JSS - A=278-378 (mouse) 3JUZ - A=278-378 (mouse) 3JV0 - A=278-378 (mouse) 3JV4 - A/C/E=278-378 (mouse) 3JV6 - A/C/E=278-378 (mouse)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		R16-m1	GPSVPTGrAMPSRRV
0	2		S37-p	PELGALGsPDLSSLS
1	0		T103	GPVAPPATPPPWGCP
0	1		S116-p	CPLGRLVsPAPGPGP
0	1		S161	GESSTEASKTLPAIE
0	1		Y293-p	PVLSEPVyDKKSTNT
1	0		K295	LSEPVyDKKSTNTSE
1	0		K296	SEPVyDKKSTNTSEL
1	0		K327	ELYLLCDKVQKEDIS
1	0		K330	LLCDKVQKEDISVVF
1	0		S390	RLTDGVCSEPLPFTY
2	6		S573-p	AFGGGLLsPGPEAt_
0	1		T579-p	LsPGPEAt_______

	mouse
-	gap
S19	PELGALGSSDLSSLS
T84-p	AAPPPPAtPSWSCTL
S96	CTLGRLVSPGPCPRP
S139-p	GESSTEAsKTLPAIE
Y271	PILSEPVYDkkSTNT
K273-u	LSEPVYDkkSTNTSE
K274-u	SEPVYDkkSTNTSEL
K305-u	ELYLLCDkVQkEDIS
K308-u	LLCDkVQkEDISVVF
S368-p	RLTDGVCsEPLPFTY
S552-p	AFGGGLLsPGPEAT_
T558	LsPGPEAT_______

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