Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
RelB (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
RelB a transcription factor of the nuclear factor-kappaB (NFkB) transcription complex. Stimulates promoter activity in the presence NFkB1/NFkB-p50. Plays role in regulation of apoptosis in hepatocellular carcinoma through activation of downstream target genes. Does not associate with DNA or RelA/NFkB-p65. Note: This description may include information from UniProtKB.
Protein type: Transcription factor
Cellular Component: cytoplasm; nucleolus; microtubule organizing center; cytosol; nucleus
Molecular Function: protein binding; transcription factor activity; transcription corepressor activity
Biological Process: antigen processing and presentation; regulation of transcription, DNA-dependent; transcription, DNA-dependent; T-helper 1 cell differentiation; myeloid dendritic cell differentiation; circadian regulation of gene expression
Reference #:  Q01201 (UniProtKB)
Alt. Names/Synonyms: I-Rel; IREL; REL-B; RELB; Transcription factor RelB; v-rel avian reticuloendotheliosis viral oncogene homolog B (nuclear factor of kappa light polypeptide gene enhancer in B-cells 3); v-rel reticuloendotheliosis viral oncogene homolog B; v-rel reticuloendotheliosis viral oncogene homolog B, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3
Gene Symbols: RELB
Molecular weight: 62,134 Da
Basal Isoelectric point: 5.84  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  NF-kB Signaling  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

RelB

Protein Structure Not Found.


STRING  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 R16-m1 GPSVPTGrAMPSRRV
0 4 S37-p PELGALGsPDLSSLS
1 0 T103 GPVAPPATPPPWGCP
0 3 S116-p CPLGRLVsPAPGPGP
0 1 S161 GESSTEASKTLPAIE
0 1 Y293-p PVLSEPVyDKKSTNT
1 0 K295 LSEPVyDKKSTNTSE
1 0 K296 SEPVyDKKSTNTSEL
1 0 K327 ELYLLCDKVQKEDIS
1 0 K330 LLCDKVQKEDISVVF
1 0 S390 RLTDGVCSEPLPFTY
0 1 S425-p VLGELNSsDPHGIES
1 0 S472-p DFFSGTVsLPGLEPP
2 8 S573-p AFGGGLLsPGPEAt_
0 1 T579-p LsPGPEAt_______
4999 : Phospho-RelB (Ser552) Antibody
5025 : Phospho-RelB (Ser552) (D41B9) XP(R) Rabbit mAb
13567 : Phospho-RelB (Ser552) (D41B9) XP(R) Rabbit mAb (PE Conjugate)
  mouse

 
- gap
S19 PELGALGSSDLSSLS
T84-p AAPPPPAtPSWSCTL
S96 CTLGRLVSPGPCPRP
S139-p GESSTEAsKTLPAIE
Y271 PILSEPVYDkkSTNT
K273-ub LSEPVYDkkSTNTSE
K274-ub SEPVYDkkSTNTSEL
K305-ub ELYLLCDkVQkEDIS
K308-ub LLCDkVQkEDISVVF
S368-p RLTDGVCsEPLPFTY
S403 VLGELSSSDPHGIES
- under review  
S552-p AFGGGLLsPGPEAT_
T558 LsPGPEAT_______
4999 : Phospho-RelB (Ser552) Antibody
5025 : Phospho-RelB (Ser552) (D41B9) XP(R) Rabbit mAb
13567 : Phospho-RelB (Ser552) (D41B9) XP(R) Rabbit mAb (PE Conjugate)
  rat

 
- under review  
K19 PELGALGKQTLSLPS
- under review  
S95 CTLGRLVSPGPCPRP
S138 GESSTEASKTLPAIE
Y270 PILSEPVYDKKSTNT
K272 LSEPVYDKKSTNTSE
K273 SEPVYDKKSTNTSEL
K304 ELYLLCDKVQKEDIS
K307 LLCDKVQKEDISVVF
S367 RLTDGVCSEPLPFTY
S402 VLGELSSSDPHGIES
- under review  
S551-p AFGGGLLsPGPEAT_
T557 LsPGPEAT_______
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.