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Protein Page:
ACTN1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
ACTN1 a cytoskeletal protein of the spectrin superfamily. An actin-binding protein with multiple roles in different cell types. A nonmuscle isoform structurally similar to the erythroid beta spectrin gene. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Cytoskeletal protein
Cellular Component: focal adhesion; dendritic spine; extracellular region; fascia adherens; pseudopodium; Z disc; cytosol; ruffle; cell projection; cytoskeleton; cytoplasm; plasma membrane; nucleus
Molecular Function: actin filament binding; integrin binding; protein domain specific binding; protein binding; double-stranded RNA binding; calcium ion binding; vinculin binding
Biological Process: regulation of apoptosis; focal adhesion formation; platelet activation; actin filament bundle formation; extracellular matrix organization and biogenesis; platelet degranulation; negative regulation of cell motility; blood coagulation
Reference #:  P12814 (UniProtKB)
Alt. Names/Synonyms: actinin 1 smooth muscle; actinin, alpha 1; ACTN1; alpha-actinin 1; Alpha-actinin cytoskeletal isoform; Alpha-actinin-1; FLJ40884; FLJ54432; Non-muscle alpha-actinin-1
Gene Symbols: ACTN1
Molecular weight: 103,058 Da
Basal Isoelectric point: 5.25  Predict pI for various phosphorylation states
CST Pathways:  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ACTN1

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Source  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Sites Implicated In
cell motility, altered: Y12‑p
cytoskeletal reorganization: Y12‑p
molecular association, regulation: Y12‑p
phosphorylation: Y12‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y4-p ____MDHyDsQQTND
0 2 S6-p __MDHyDsQQTNDyM
4 4 Y12-p DsQQTNDyMQPEEDW
0 3 K35-u AWEKQQRkTFTAWCN
0 3 T50-p SHLRKAGtQIENIEE
0 1 K95-a HKISNVNkALDFIAS
0 14 S140-p RFAIQDIsVEETSAK
0 380 Y193-p HRPELIDyGkLRKDD
0 1 K195-a PELIDyGkLRKDDPL
0 1 K195 PELIDyGKLRKDDPL
0 1 K198 IDyGkLRKDDPLTNL
0 26 Y215-p AFDVAEKyLDIPKML
0 3 Y241-p DEKAIMTyVssFyHA
0 2 S243-p KAIMTyVssFyHAFs
0 29 S244-p AIMTyVssFyHAFsG
0 517 Y246-p MTyVssFyHAFsGAQ
0 3 S250-p ssFyHAFsGAQKAET
0 47 K331-u KPPKVQEkCQLEINF
0 1 S362-p PSEGRMVsDINNAWG
0 2 K398-a RLDHLAEkFRQkASI
0 2 K398-u RLDHLAEkFRQkASI
0 2 K402-u LAEkFRQkASIHEAW
1 1 S404 EkFRQkASIHEAWTD
0 1 K420 KEAMLRQKDYETATL
0 1 T490 WDNLGALTQkRREAL
0 2 K492-a NLGALTQkRREALER
0 3 K516 QLYLEYAKRAAPFNN
0 2 K633-u QHNERLRkQFGAQAN
0 6 Y674-p QLSHLRQyEksIVNy
0 1 K676-a SHLRQyEksIVNyKP
0 1 S677-p HLRQyEksIVNyKPK
0 19 Y681-p yEksIVNyKPKIDQL
0 1 T737-p EVENQILtRDAKGIS
0 1 K741 QILtRDAKGISQEQM
0 1 H762 FNHFDRDHSGTLGPE
0 1 T820-p IDFMSREtADTDTAD
0 2 S832-p TADQVMAsFKILAGD
0 3 Y842-p ILAGDKNyITMDELR
  mouse

► Hide Isoforms
 
Y4 ____MDHYDSQQTND
S6 __MDHYDSQQTNDYM
Y12 DSQQTNDYMQPEEDW
K35-u AWEKQQRkTFTAWCN
T50 SHLRKAGTQIENIEE
K95 HKISNVNKALDFIAS
S140-p RFAIQDIsVEETSAK
Y193-p HRPELIDyGkLRkDD
K195 PELIDyGKLRkDDPL
K195-u PELIDyGkLRkDDPL
K198-u IDyGkLRkDDPLTNL
F215 AFDVAERFLDIPKML
Y241 DEKAIMTYVSsFyHA
S243 KAIMTYVSsFyHAFS
S244-p AIMTYVSsFyHAFSG
Y246-p MTYVSsFyHAFSGAQ
S250 SsFyHAFSGAQKAET
K331-u KPPKVQEkCQLEINF
S362-p PSEGRMVsDINNAWG
K398 RLDHLAEKFRQkASI
K398-u RLDHLAEkFRQkASI
K402-u LAEkFRQkASIHEAW
S404 EkFRQkASIHEAWTD
K420-a KEAMLRQkDYETATL
T490-p WDNLGALtQkRREAL
K492-a NLGALtQkRREALER
K516-a QLYLEYAkRAAPFNN
K633-u QHNERLRkQFGAQAN
Y674 QLSHLRQYEKsIVNy
K676 SHLRQYEKsIVNyKP
S677-p HLRQYEKsIVNyKPK
Y681-p YEKsIVNyKPKIDQL
T737 EVENQILTRDAkGIS
K741-u QILTRDAkGISQEQM
H762 FNHFDRDHSGTLGPE
T820 IDFMSRETADTDTAD
S832 TADQVMASFKILAGD
Y842 ILAGDKNYITEDELR
  ACTN1 iso3  
Y4 ____MDHYDSQQTND
S6 __MDHYDSQQTNDYM
Y12 DSQQTNDYMQPEEDW
K35 AWEKQQRKTFTAWCN
T50 SHLRKAGTQIENIEE
K95 HKISNVNKALDFIAS
S140 RFAIQDISVEETSAK
Y193 HRPELIDYGKLRKDD
K195 PELIDYGKLRKDDPL
K195 PELIDYGKLRKDDPL
K198 IDYGKLRKDDPLTNL
F215 AFDVAERFLDIPKML
Y241 DEKAIMTYVSSFYHA
S243 KAIMTYVSSFYHAFS
S244 AIMTYVSSFYHAFSG
Y246 MTYVSSFYHAFSGAQ
S250 SSFYHAFSGAQKAET
K331 KPPKVQEKCQLEINF
S362 PSEGRMVSDINNAWG
K398 RLDHLAEKFRQKASI
K398 RLDHLAEKFRQKASI
K402 LAEKFRQKASIHEAW
S404 EKFRQKASIHEAWTD
K420 KEAMLRQKDYETATL
T490 WDNLGALTQKRREAL
K492 NLGALTQKRREALER
K516 QLYLEYAKRAAPFNN
K633 QHNERLRKQFGAQAN
Y674 QLSHLRQYEKSIVNY
K676 SHLRQYEKSIVNYKP
S677 HLRQYEKSIVNYKPK
Y681 YEKSIVNYKPKIDQL
T737 EVENQILTRDAKGIS
K741 QILTRDAKGISQEQM
K762-u FNHFDRKkTGMMDTD
T815 IDFMSRETADTDTAD
S827 TADQVMASFKILAGD
Y837 ILAGDKNYITEDELR
  rat

 
Y4 ____MDHYDSQQTND
S6 __MDHYDSQQTNDYM
Y12 DSQQTNDYMQPEEDW
K35 AWEKQQRKTFTAWCN
T50 SHLRKAGTQIENIEE
K95 HKISNVNKALDFIAS
S140-p RFAIQDIsVEETSAK
Y193 HRPELIDYGKLRKDD
K195 PELIDYGKLRKDDPL
K195 PELIDYGKLRKDDPL
K198 IDYGKLRKDDPLTNL
Y215 AFDVAERYLDIPKML
Y241 DEKAIMTYVSSFyHA
S243 KAIMTYVSSFyHAFS
S244 AIMTYVSSFyHAFSG
Y246-p MTYVSSFyHAFSGAQ
S250 SSFyHAFSGAQKAET
K331-u KPPKVQEkCQLEINF
S362 PSEGRMVSDINNAWG
K398-a RLDHLAEkFRQKAsI
K398 RLDHLAEKFRQKAsI
K402 LAEkFRQKAsIHEAW
S404-p EkFRQKAsIHEAWTD
K420 KEAMLRQKDYETATL
T490 WDNLGALTQKRREAL
K492 NLGALTQKRREALER
K516 QLYLEYAKRAAPFNN
K633 QHNERLRKQFGAQAN
Y674 QLSHLRQYEKSIVNY
K676 SHLRQYEKSIVNYKP
S677 HLRQYEKSIVNYKPK
Y681 YEKSIVNYKPKIDQL
T737 EVENQILTRDAKGIS
K741 QILTRDAKGISQEQM
H762 FNHFDRDHSGTLGPE
T820 IDFMSRETADTDTAD
S832 TADQVMASFKILAGD
Y842 ILAGDKNYITGDELR
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