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Protein Page:
Caveolin-2 (human)

Overview
Caveolin-2 a scaffolding protein. A component of caveolae, small invaginations of the plasma membrane found in most cell types. Involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Caveolin-2 may function as an accessory protein in conjunction with caveolin-1. Two splice-variant isoforms have been observed. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold
Cellular Component: Golgi apparatus; cell surface; protein complex; integral to plasma membrane; lipid particle; caveola; cytosol; lipid raft; acrosomal membrane; Golgi membrane; transport vesicle; extrinsic to internal side of plasma membrane; membrane; perinuclear region of cytoplasm; plasma membrane; intracellular; cytoplasmic vesicle; nucleus
Molecular Function: protein binding; protein homodimerization activity; syntaxin binding; phosphoprotein binding; D1 dopamine receptor binding
Biological Process: endoplasmic reticulum organization and biogenesis; vesicle fusion; mitochondrion organization and biogenesis; synaptic transmission; positive regulation of dopamine receptor signaling pathway; vesicle docking; vesicle organization and biogenesis; negative regulation of endothelial cell proliferation; regulation of mitosis; skeletal muscle fiber development; positive regulation of endothelial cell proliferation; negative regulation of transforming growth factor beta receptor signaling pathway; protein oligomerization
Reference #:  P51636 (UniProtKB)
Alt. Names/Synonyms: CAV; CAV2; caveolae protein, 20-kD; caveolin 2; caveolin 2 isoform a and b; Caveolin-2; MGC12294
Gene Symbols: CAV2
Molecular weight: 18,291 Da
Basal Isoelectric point: 5.06  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  ErbB/HER Signaling  |  Insulin Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Caveolin-2

Protein Structure Not Found.


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Sites Implicated In
activity, induced: S23‑p, S36‑p, S135‑p
intracellular localization: Y19‑p, Y27‑p
molecular association, regulation: Y19‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 42 S18-p QLFMDDDsysHHsGL
8 32 Y19-p LFMDDDsysHHsGLE
1 45 S20-p FMDDDsysHHsGLEy
4 94 S23-p DDsysHHsGLEyADP
5 38 Y27-p sHHsGLEyADPEKFA
3 6 S36-p DPEKFADsDQDRDPH
0 1 T121-p ILMPFVKtCLMVLPs
0 1 S128-p tCLMVLPsVQtIWKs
0 1 T131-p MVLPsVQtIWKsVTD
1 0 S135-p sVQtIWKsVTDVIIA
0 2 S153 TSVGRCFSSVSLQLS
0 1 S154 SVGRCFSSVSLQLSQ
0 1 S156 GRCFSSVSLQLSQD_
  mouse

 
A18 QLFMADDAysHHsGV
Y19-p LFMADDAysHHsGVD
S20-p FMADDAysHHsGVDy
S23-p DDAysHHsGVDyADP
Y27-p sHHsGVDyADPEKYV
S36 DPEKYVDSSHDRDPH
T121 ILMPFVKTCLMVLPS
S128 TCLMVLPSVQTIWKS
T131 MVLPSVQTIWKSVTD
S135 SVQTIWKSVTDVVIG
S153-p TSVGRSFssVsMQLS
S154-p SVGRSFssVsMQLSH
S156-p GRSFssVsMQLSHD_
  rat

 
A18 QLFMADDAysHHSVV
Y19-p LFMADDAysHHSVVD
S20-p FMADDAysHHSVVDy
S23 DDAysHHSVVDyTDP
Y27-p sHHSVVDyTDPEKYV
S36 DPEKYVDSSQDRDPH
T121 ILMPFVKTCLMVLPS
S128 TCLMVLPSVQTIWKS
T131 MVLPSVQTIWKSVTD
S135 SVQTIWKSVTDVVIG
S153 TSVGRIFSSVSMQLS
S154 SVGRIFSSVSMQLSH
S156 GRIFSSVSMQLSHD_
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