Home

caveolin-2 (human)

Overview caveolin-2 a scaffolding protein. A component of caveolae, small invaginations of the plasma membrane found in most cell types. Involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Caveolin-2 may function as an accessory protein in conjunction with caveolin-1. Two splice-variant isoforms have been observed. Note: This description may include information from UniProtKB. Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis Cellular Component: Golgi apparatus; cell surface; protein complex; integral to plasma membrane; lipid particle; caveola; cytosol; lipid raft; acrosomal membrane; Golgi membrane; transport vesicle; extrinsic to internal side of plasma membrane; membrane; perinuclear region of cytoplasm; plasma membrane; intracellular; nucleus Molecular Function: protein binding; protein homodimerization activity; syntaxin binding; phosphoprotein binding; D1 dopamine receptor binding Biological Process: endoplasmic reticulum organization and biogenesis; vesicle fusion; mitochondrion organization and biogenesis; positive regulation of dopamine receptor signaling pathway; synaptic transmission; vesicle docking; vesicle organization and biogenesis; negative regulation of endothelial cell proliferation; skeletal muscle fiber development; regulation of mitosis; protein oligomerization Reference #:  P51636 (UniProtKB) Alt. Names/Synonyms: CAV; CAV2; caveolae protein, 20-kD; caveolin 2; caveolin 2 isoform a and b; Caveolin-2; MGC12294 Gene Symbols: CAV2 Molecular weight: 18,291 Da Basal Isoelectric point: 5.06  Predict pI for various phosphorylation states CST Pathways:  Adherens Junction Dynamics  |  ErbB/HER Signaling  |  Insulin Receptor Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below caveolin-2

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
activation: S23‑p, S36‑p, S135‑p intracellular localization: Y19‑p, Y27‑p molecular association, regulation: Y19‑p

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	40		S18-p	QLFMDDDsysHHsGL
7	28		Y19-p	LFMDDDsysHHsGLE
1	40		S20-p	FMDDDsysHHsGLEy
3	87		S23-p	DDsysHHsGLEyADP
5	34		Y27-p	sHHsGLEyADPEKFA
3	5		S36-p	DPEKFADsDQDRDPH
0	1		T121-p	ILMPFVKtCLMVLPs
0	1		S128-p	tCLMVLPsVQtIWKs
0	1		T131-p	MVLPsVQtIWKsVTD
1	0		S135-p	sVQtIWKsVTDVIIA
0	1		S153	TSVGRCFSSVSLQLS
0	1		S154	SVGRCFSSVSLQLSQ
0	1		S156	GRCFSSVSLQLSQD_

	mouse
A18	QLFMADDAysHHsGV
Y19-p	LFMADDAysHHsGVD
S20-p	FMADDAysHHsGVDy
S23-p	DDAysHHsGVDyADP
Y27-p	sHHsGVDyADPEKYV
S36	DPEKYVDSSHDRDPH
T121	ILMPFVKTCLMVLPS
S128	TCLMVLPSVQTIWKS
T131	MVLPSVQTIWKSVTD
S135	SVQTIWKSVTDVVIG
S153-p	TSVGRSFssVsMQLS
S154-p	SVGRSFssVsMQLSH
S156-p	GRSFssVsMQLSHD_

	rat
A18	QLFMADDAysHHSVV
Y19-p	LFMADDAysHHSVVD
S20-p	FMADDAysHHSVVDy
S23	DDAysHHSVVDyTDP
Y27-p	sHHSVVDyTDPEKYV
S36	DPEKYVDSSQDRDPH
T121	ILMPFVKTCLMVLPS
S128	TCLMVLPSVQTIWKS
T131	MVLPSVQTIWKSVTD
S135	SVQTIWKSVTDVVIG
S153	TSVGRIFSSVSMQLS
S154	SVGRIFSSVSMQLSH
S156	GRIFSSVSMQLSHD_

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.