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Protein Page:
BACE (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
BACE an integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Cleaves APP at the amino terminus of the A-beta peptide sequence, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated carboxy-terminal fragment which is later release by gamma-secretase. Four splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; EC 3.4.23.46; Protease
Cellular Component: Golgi apparatus; cytoplasmic vesicle membrane; cell surface; integral to plasma membrane; axon; endoplasmic reticulum; integral to membrane; trans-Golgi network; endosome
Molecular Function: enzyme binding; beta-aspartyl-peptidase activity; aspartic-type endopeptidase activity
Biological Process: beta-amyloid metabolic process; membrane protein ectodomain proteolysis; proteolysis
Reference #:  P56817 (UniProtKB)
Alt. Names/Synonyms: APP beta-secretase; Asp 2; ASP2; Aspartyl protease 2; BACE; BACE1; Beta-secretase 1; beta-site amyloid beta A4 precursor protein-cleaving enzyme; Beta-site amyloid precursor protein cleaving enzyme 1; Beta-site APP cleaving enzyme 1; beta-site APP-cleaving enzyme 1; FLJ90568; HSPC104; KIAA1149; Memapsin-2; Membrane-associated aspartic protease 2; transmembrane aspartic proteinase Asp2
Gene Symbols: BACE1
Molecular weight: 55,711 Da
Basal Isoelectric point: 5.24  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

BACE

Protein Structure Not Found.


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Sites Implicated In
intracellular localization: S498‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 1 K126-a STYRDLRkGVYVPYT
1 0 K275-a EINGQDLkMDCkEYN
1 0 K279-a QDLkMDCkEYNYDkS
1 0 K285-a CkEYNYDkSIVDSGT
1 0 K299-a TTNLRLPkkVFEAAV
1 0 K300-a TNLRLPkkVFEAAVk
1 0 K307-a kVFEAAVkSIKAASS
4 2 S498-p DDFADDIsLLk____
2 0 K501-u ADDIsLLk_______
  mouse

 
K126 STYRDLRKGVYVPYT
K275 EINGQDLKMDCKEYN
K279 QDLKMDCKEYNYDKS
K285 CKEYNYDKSIVDSGT
K299 TTNLRLPKKVFEAAV
K300 TNLRLPKKVFEAAVK
K307 KVFEAAVKSIKAASS
S498-p DDFADDIsLLK____
K501 ADDIsLLK_______
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