Home

BACE (human)

Overview BACE an integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Cleaves APP at the amino terminus of the A-beta peptide sequence, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated carboxy-terminal fragment which is later release by gamma-secretase. Four splice-variant isoforms have been described. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral; Protease; EC 3.4.23.46 Cellular Component: Golgi apparatus; cytoplasmic vesicle membrane; cell surface; endoplasmic reticulum; integral to plasma membrane; integral to membrane; trans-Golgi network; endosome Molecular Function: enzyme binding; beta-aspartyl-peptidase activity; aspartic-type endopeptidase activity Biological Process: beta-amyloid metabolic process; membrane protein ectodomain proteolysis; proteolysis Reference #:  P56817 (UniProtKB) Alt. Names/Synonyms: APP beta-secretase; Asp 2; ASP2; Aspartyl protease 2; BACE; BACE1; Beta-secretase 1; beta-site amyloid beta A4 precursor protein-cleaving enzyme; Beta-site amyloid precursor protein cleaving enzyme 1; Beta-site APP cleaving enzyme 1; beta-site APP-cleaving enzyme 1; FLJ90568; HSPC104; KIAA1149; Memapsin-2; Membrane-associated aspartic protease 2; transmembrane aspartic proteinase Asp2 Gene Symbols: BACE1 Molecular weight: 55,711 Da Basal Isoelectric point: 5.24  Predict pI for various phosphorylation states CST Pathways:  Alzheimer's Disease Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below BACE 1FKN - A/B=56-446 (human) 1M4H - A/B=56-446 (human) 1PY1 - E/F/G/H=494-501, E/F/G/H=494-501 (human) 1SGZ - A/B/C/D=58-446 (human) 1TQF - A=43-446 (human) 1UJJ - C=490-501 (human) 1UJK - C/D=490-501 (human) 1W50 - A=43-453 (human) 1W51 - A=43-453 (human) 1XN2 - A/B/C/D=58-446 (human) 1XN3 - A/B/C/D=58-446 (human) 1XS7 - D=58-446 (human) 1YM2 - A/B/C=48-447 (human) 1YM4 - A/B/C=48-453 (human) 2B8L - A=43-446 (human) 2B8V - A=43-446 (human) 2F3E - A/B/C=48-447 (human) 2F3F - A/B/C=48-447 (human) 2FDP - A/B/C=59-377 (human) 2G94 - A/B/C/D=58-446 (human) 2HIZ - A/B/C=14-453 (human) 2HM1 - A=57-453 (human) 2IQG - A=57-453 (human) 2IRZ - A=43-446 (human) 2IS0 - A=43-446 (human) 2NTR - A=43-446 (human) 2OAH - A=43-446 (human) 2OF0 - A=45-446 (human) 2OHK - A=45-446 (human) 2OHL - A=45-446 (human) 2OHM - A=45-446 (human) 2OHN - A=45-446 (human) 2OHP - A=45-446 (human) 2OHQ - A=45-446 (human) 2OHR - A=45-446 (human) 2OHS - A=45-446 (human) 2OHT - A=45-446 (human) 2OHU - A=45-446 (human) 2P4J - A/B/C/D=58-446 (human) 2P83 - A/B/C=14-453 (human) 2P8H - A=43-446 (human) 2PH6 - A=43-446 (human) 2PH8 - A=43-446 (human) 2Q11 - A/B/C=59-446 (human) 2Q15 - A=62-446 (human) 2QK5 - A/B=55-447 (human) 2QMD - A/B=55-447 (human) 2QMF - A/B=55-447 (human) 2QMG - A/B=55-447 (human) 2QP8 - A/B=55-447 (human) 2QU2 - A=46-454 (human) 2QU3 - A=46-454 (human) 2QZK - A=43-446 (human) 2QZL - A=43-446 (human) 2VA5 - A=14-453 (human) 2VA6 - A=14-453 (human) 2VA7 - A=14-453 (human) 2VIE - A=61-452 (human) 2VIJ - A=61-452 (human) 2VIY - A=61-452 (human) 2VIZ - A=61-452 (human) 2VJ6 - A=61-452 (human) 2VJ7 - A=61-452 (human) 2VJ9 - A=61-452 (human) 2VKM - A/D/C/B=58-446 (human) 2VNM - A=61-452 (human) 2VNN - A=61-452 (human) 2WEZ - A=61-452 (human) 2WF0 - A=61-452 (human) 2WF1 - A=61-452 (human) 2WF2 - A=61-452 (human) 2WF3 - A=61-452 (human) 2WF4 - A=61-452 (human) 2WJO - A=58-460 (human) 2XFI - A=61-452 (human) 2XFJ - A=61-452 (human) 2XFK - A=61-452 (human) 2ZDZ - A=46-454 (human) 2ZE1 - A=46-454 (human) 2ZHR - A/B=45-454 (human) 2ZHS - A=45-454 (human) 2ZHT - A=45-454 (human) 2ZHU - A=45-454 (human) 2ZHV - A=45-454 (human) 2ZJH - A=43-446 (human) 2ZJI - A=43-446 (human) 2ZJJ - A=43-446 (human) 2ZJK - A/C/B=43-446 (human) 2ZJL - A=43-446 (human) 2ZJM - A=43-446 (human) 2ZJN - A=43-446 (human) 3BRA - A=46-454 (human) 3BUF - A=46-454 (human) 3BUG - A=46-454 (human) 3BUH - A=46-454 (human) 3CIB - A/B=58-447 (human) 3CIC - A/B=58-447 (human) 3CID - A/B=58-447 (human) 3CKP - A/C/B=43-454 (human) 3CKR - A/C/B=43-454 (human) 3DM6 - A/C/B=42-446 (human) 3DUY - A/C/B=48-447 (human) 3DV1 - A/C/B=48-447 (human) 3DV5 - A/C/B=48-447 (human) 3EXO - A=43-454 (human) 3FKT - A=43-446 (human) 3H0B - A/C/B=43-446 (human) 3HVG - A/C/B=46-453 (human) 3HW1 - A/C/B=46-453 (human) 3I25 - A/C/B=42-446 (human) 3IGB - A=46-454 (human) 3IN3 - A=46-454 (human) 3IN4 - A=46-454 (human) 3IND - A=46-454 (human) 3INE - A=46-454 (human) 3INF - A=46-454 (human) 3INH - A=46-454 (human) 3IVH - A=57-453 (human) 3IVI - A/C/B=57-453 (human) 3IXJ - A/C/B=59-446 (human) 3IXK - A/C/B=42-446 (human) 3K5C - A/C/B=48-447 (human) 3K5D - A/C/B=48-453 (human) 3K5F - A/C/B=48-447 (human) 3K5G - A/C/B=48-447 (human) 3KMX - A/B=53-447 (human) 3KMY - A/B=53-447 (human) 3KN0 - A/B=53-447 (human) 3KYR - A/C/B=42-446 (human) 3L38 - A=46-454 (human) 3L3A - A=46-454 (human) 3L58 - A/B=41-454 (human) 3L59 - A/B=41-454 (human) 3L5B - A/B=41-454 (human) 3L5C - A/B=41-454 (human) 3L5D - A/B=41-454 (human) 3L5E - A/B=41-454 (human) 3L5F - A/B=41-454 (human) 3LHG - A=46-454 (human) 3LNK - A/B=53-447 (human) 3LPI - A/B=14-454 (human) 3LPJ - A/B=14-454 (human) 3LPK - A/B=14-454 (human) 3MSJ - A/C/B=43-453 (human) 3MSK - A=48-453 (human) 3MSL - A=48-453 (human) 3MSM - A=48-453 (human) 3N4L - A/C/B=57-453 (human) 3NSH - A/C/B=57-453 (human) 3OHF - A/B=14-454 (human) 3OHH - A/B=14-454 (human) 3OOZ - A=46-454 (human) 3PI5 - A/C/B=48-447 (human) 3QBH - A/C/B=48-447 (human) 3QI1 - A=57-453 (human) 3R1G - B=57-453 (human) 3R2F - A/D/E/B=14-454 (human) 3RSV - A=43-453 (human) 3RSX - A=43-453 (human) 3RTH - A=43-453 (human) 3RTM - A=43-453 (human) 3RTN - A=43-453 (human) 3RU1 - A=43-453 (human) 3RVI - A=43-453 (human) 3S2O - A=48-453 (human) 3S7L - A=46-454 (human) 3S7M - A=46-454 (human) 3SKF - A/B=14-454 (human) 3SKG - A/D/E/B=14-454 (human) 3TPJ - A=43-454 (human) 3TPL - A/C/B=43-454 (human) 3TPP - A=43-454 (human) 3TPR - A=43-454 (human) 3U6A - A/C/B=58-446 (human) 3UDH - A=58-453 (human) 3UDJ - A=58-453 (human) 3UDK - A=58-453 (human) 3UDM - A=58-453 (human) 3UDN - A=58-453 (human) 3UDP - A=58-453 (human) 3UDQ - A=58-453 (human) 3UDR - A=58-453 (human) 3UDY - A=58-453 (human) 3UFL - A=58-446 (human) 3UQP - A=43-454 (human) 3UQR - A/C/B=43-454 (human) 3UQU - A=43-454 (human) 3UQW - A=43-454 (human) 3UQX - A=43-454 (human) 3VEU - A=48-447 (human) 3VF3 - A=48-447 (human) 3VG1 - A=48-447 (human) 3VV6 - A=43-454 (human) 3VV7 - A=43-454 (human) 3VV8 - A=43-454 (human) 3ZMG - A=46-454 (human) 4ACU - A=62-453 (human) 4ACX - A=62-453 (human) 4AZY - A=62-453 (human) 4B00 - A=62-453 (human) 4B05 - A=62-453 (human) 4B1C - A=62-445 (human) 4B1D - A=62-445 (human) 4B1E - A=62-445 (human) 4D83 - A/C/B=48-447 (human) 4D85 - A=48-453 (human) 4D88 - A=48-447 (human) 4D89 - A=48-447 (human) 4D8C - A/C/B=48-447 (human) 4DH6 - A=43-453 (human) 4DI2 - A/C/B=43-453 (human) 4DJU - A/B=41-454 (human) 4DJV - A/B=41-454 (human) 4DJW - A/B=41-454 (human) 4DJX - A/B=41-454 (human) 4DJY - A/B=41-454 (human) 4DPF - A=57-446 (human) 4DPI - A=57-446 (human) 4DUS - A=43-453 (human) 4DV9 - A=43-454 (human) 4DVF - A/B=43-454 (human) 4EWO - A=61-446 (human) 4EXG - A=61-446 (human) 4FGX - A=43-454 (human) 4FM7 - A=58-453 (human) 4FM8 - A=58-453 (human) 4FRI - A=43-453 (human) 4FRJ - A=43-453 (human) 4FRK - A=43-453 (human) 4FRS - A/B=53-447 (human) 4FS4 - A/B=58-447 (human) 4FSE - A/D/E/B=14-454 (human) 4FSL - A/D/E/B=43-453 (human) 4GID - A/D/C/B=59-446 (human) 4H1E - A/B=41-454 (human) 4H3F - A/B=41-454 (human) 4H3G - A/B=41-454 (human) 4H3I - A/B=41-454 (human) 4H3J - A/B=41-454 (human) 4HA5 - A/B=41-454 (human) 4HZT - A=57-453 (human) 4I0E - A=57-453 (human) 4I0F - A=57-453 (human) 4I0G - A=57-453 (human) 4I0H - A/C/B=57-453 (human) 4I0J - A=57-453 (human) 4I0Z - A=57-453 (human) 4I10 - A=57-453 (human) 4I11 - A=57-453 (human) 4I12 - A=57-453 (human) 4I1C - A=57-453 (human) 4J0T - A=46-454 (human) 4J0V - A=46-454 (human) 4J0Y - A=46-454 (human) 4J0Z - A=46-454 (human) 4J17 - A=46-454 (human) 4J1C - A=46-454 (human) 4J1E - A=46-454 (human) 4J1F - A=46-454 (human) 4J1H - A=46-454 (human) 4J1I - A=46-454 (human) 4J1K - A=46-454 (human) 4JOO - A=57-453 (human) 4JP9 - A=57-453 (human) 4JPC - A=57-453 (human) 4JPE - A=57-453 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1FKN 1M4H 1PY1 1SGZ 1TQF 1UJJ 1UJK 1W50 1W51 1XN2 1XN3 1XS7 1YM2 1YM4 2B8L 2B8V 2F3E 2F3F 2FDP 2G94 2HIZ 2HM1 2IQG 2IRZ 2IS0 2NTR 2OAH 2OF0 2OHK 2OHL 2OHM 2OHN 2OHP 2OHQ 2OHR 2OHS 2OHT 2OHU 2P4J 2P83 2P8H 2PH6 2PH8 2Q11 2Q15 2QK5 2QMD 2QMF 2QMG 2QP8 2QU2 2QU3 2QZK 2QZL 2VA5 2VA6 2VA7 2VIE 2VIJ 2VIY 2VIZ 2VJ6 2VJ7 2VJ9 2VKM 2VNM 2VNN 2WEZ 2WF0 2WF1 2WF2 2WF3 2WF4 2WJO 2XFI 2XFJ 2XFK 2ZDZ 2ZE1 2ZHR 2ZHS 2ZHT 2ZHU 2ZHV 2ZJH 2ZJI 2ZJJ 2ZJK 2ZJL 2ZJM 2ZJN 3BRA 3BUF 3BUG 3BUH 3CIB 3CIC 3CID 3CKP 3CKR 3DM6 3DUY 3DV1 3DV5 3EXO 3FKT 3H0B 3HVG 3HW1 3I25 3IGB 3IN3 3IN4 3IND 3INE 3INF 3INH 3IVH 3IVI 3IXJ 3IXK 3K5C 3K5D 3K5F 3K5G 3KMX 3KMY 3KN0 3KYR 3L38 3L3A 3L58 3L59 3L5B 3L5C 3L5D 3L5E 3L5F 3LHG 3LNK 3LPI 3LPJ 3LPK 3MSJ 3MSK 3MSL 3MSM 3N4L 3NSH 3OHF 3OHH 3OOZ 3PI5 3QBH 3QI1 3R1G 3R2F 3RSV 3RSX 3RTH 3RTM 3RTN 3RU1 3RVI 3S2O 3S7L 3S7M 3SKF 3SKG 3TPJ 3TPL 3TPP 3TPR 3U6A 3UDH 3UDJ 3UDK 3UDM 3UDN 3UDP 3UDQ 3UDR 3UDY 3UFL 3UQP 3UQR 3UQU 3UQW 3UQX 3VEU 3VF3 3VG1 3VV6 3VV7 3VV8 3ZMG 4ACU 4ACX 4AZY 4B00 4B05 4B1C 4B1D 4B1E 4D83 4D85 4D88 4D89 4D8C 4DH6 4DI2 4DJU 4DJV 4DJW 4DJX 4DJY 4DPF 4DPI 4DUS 4DV9 4DVF 4EWO 4EXG 4FGX 4FM7 4FM8 4FRI 4FRJ 4FRK 4FRS 4FS4 4FSE 4FSL 4GID 4H1E 4H3F 4H3G 4H3I 4H3J 4HA5 4HZT 4I0E 4I0F 4I0G 4I0H 4I0J 4I0Z 4I10 4I11 4I12 4I1C 4J0T 4J0V 4J0Y 4J0Z 4J17 4J1C 4J1E 4J1F 4J1H 4J1I 4J1K 4JOO 4JP9 4JPC 4JPE  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
intracellular localization: S498‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S71-p	VDNLRGKsGQGYYVE
1	1		K126-a	STYRDLRkGVYVPYT
0	1		K136-a	YVPYTQGkWEGELGT
0	1		S243	IIGGIDHSLYTGSLW
0	1		Y245	GGIDHSLYTGSLWYT
0	1		Y260-p	PIRREWYyEVIIVRV
1	0		K275-a	EINGQDLkMDCkEYN
1	0		K279-a	QDLkMDCkEYNYDkS
1	0		K285-a	CkEYNYDkSIVDSGT
1	0		K299-a	TTNLRLPkkVFEAAV
1	0		K300-a	TNLRLPkkVFEAAVk
1	0		K307-a	kVFEAAVksIKAASS
0	1		S308-p	VFEAAVksIKAASST
3	2		S498-p	DDFADDIsLLk____
2	0		K501-u	ADDIsLLk_______

	mouse
S71	VDNLRGKSGQGYYVE
K126	STYRDLRKGVYVPYT
K136	YVPYTQGKWEGELGT
S243-p	IIGGIDHsLyTGSLW
Y245-p	GGIDHsLyTGSLWYT
Y260	PIRREWYYEVIIVRV
K275	EINGQDLKMDCKEYN
K279	QDLKMDCKEYNYDKS
K285	CKEYNYDKSIVDSGT
K299	TTNLRLPKKVFEAAV
K300	TNLRLPKKVFEAAVK
K307	KVFEAAVKSIKAASS
S308	VFEAAVKSIKAASST
S498-p	DDFADDIsLLK____
K501	ADDIsLLK_______

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.