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5-LO (human)

Overview 5-LO arachidonate 5-lipoxygenase. Arachidonic acid promotes its phosphorylation by p38 MAPK-regulated MAPKAP kinases. Upregulated in glioblastoma multiforme and colon, pancreatic and bladder cancer. Note: This description may include information from UniProtKB. Protein type: Nuclear envelope; Oxidoreductase; Lipid Metabolism - linoleic acid; Lipid Metabolism - arachidonic acid; EC 1.13.11.34 Cellular Component: nuclear membrane; nuclear matrix; nuclear envelope lumen; dendrite; nuclear envelope; cytosol; sarcolemma Molecular Function: protein binding; lipoxygenase activity; iron ion binding; arachidonate 5-lipoxygenase activity Biological Process: leukotriene biosynthetic process; response to hyperoxia; leukotriene production during acute inflammatory response; lipoxygenase pathway; positive regulation of vasoconstriction; arachidonic acid metabolic process; leukotriene metabolic process; sensory perception of pain; response to nutrient; acute inflammatory response Reference #:  P09917 (UniProtKB) Alt. Names/Synonyms: 5-lipoxygenase; 5-LO; 5-LOX; 5LPG; ALOX5; Arachidonate 5-lipoxygenase; arachidonic acid 5-lipoxygenase; leukotriene A4 synthase; LOG5; LOX5; MGC163204 Gene Symbols: ALOX5 Molecular weight: 77,983 Da Basal Isoelectric point: 5.51  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below 5-LO 2ABV - A=2-674 (human) 3O8Y - A/B=1-674 (human) 3V92 - A/B=1-674 (human) 3V98 - A/B=1-674 (human) 3V99 - A/B=1-674 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2ABV 3O8Y 3V92 3V98 3V99  |  ENZYME  |  Phospho3D  |  DISEASE 152390 600807  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
enzymatic activity, induced: S272‑p, S664‑p enzymatic activity, inhibited: S524‑p intracellular localization: S272‑p, S524‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		Y75-p	VRIEKRKyWLNDDWY
0	1		T87-p	DWYLKYItLKTPHGD
0	1		Y95	LKTPHGDYIEFPCyR
0	1		Y101-p	DYIEFPCyRWItGDV
0	1		T105-p	FPCyRWItGDVEVVL
0	1		Y182-p	GVDFVLNysKAMENL
0	1		S183-p	VDFVLNysKAMENLF
6	2		S272-p	CSLERQLsLEQEVQQ
0	1		T298	DGIDANKTDPCTLQF
0	1		T302	ANKTDPCTLQFLAAP
0	1		K456	LCFPEAIKARGMESK
3	0		S524-p	GMRGRKSsGFPkSVK
0	1		K528-a	RKSsGFPkSVKsREQ
0	1		S532-p	GFPkSVKsREQLSEY
2	0		S664-p	QLPYYYLsPDRIPNS

	mouse
Y75	VKIEKRKYWLHDDWY
T87	DWYLKYITLKTPHGD
Y95	LKTPHGDYIEFPCYR
Y101	DYIEFPCYRWITGEG
T105	FPCYRWITGEGEIVL
Y182	GVDFVLNYSKAMENL
S183	VDFVLNYSKAMENLF
S272-p	CSLERQLsLEQEVQE
T298-p	DGIDANKtDPCtHQF
T302-p	ANKtDPCtHQFLAAP
K456-u	LCFPEAIkARGMDST
S524	GMRGKKASGFPKSIK
K528	KKASGFPKSIKSREK
S532	GFPKSIKSREKLSEY
S664	KLPYYYLSPDRIPNS

	rat
Y75	VKIEKRKYRLHDDWY
T87	DWYLKYITLKTPHDy
Y94-p	TLKTPHDyIEFPCyR
Y100-p	DyIEFPCyRWITGEG
T104	FPCyRWITGEGEIVL
Y181	GVDFVLNYSKAMENL
S182	VDFVLNYSKAMENLF
S271	CSLERQLSLEQEVQE
T297	DGIDANKTDPCTHQF
T301	ANKTDPCTHQFLAAP
K455	LCFPEAIKARGMDNT
S523-p	GMRGRKAsGFPKSIK
K527	RKAsGFPKSIKSREK
S531	GFPKSIKSREKLSEY
S663	KLPYYYLSPDRIPNS

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