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NFkB-p100
a transcription factor of the nuclear factor-kappaB ( NFkB) group. Precursor of the p52 subunit of the nuclear factor NF-kappa-B, which binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. The precursor protein itself does not bind to DNA. LT-beta receptor agonists and LPS induce NF-kappaB/p100 processing to p52 at the level of the ribosome. There are five NFkB proteins in mammals (RelA/NFkB-p65, RelB, c-Rel, NF-_B1/NFkB-p105, and NF-_B2/NFkB-p100). They form a variety of homodimers and heterodimers, each of which activates its own characteristic set of genes. Two spliced isoforms have been identified. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65. Note: This description may include information from UniProtKB.
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| Protein type: Transcription factor; DNA binding protein |
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Cellular Component: Bcl3/NF-kappaB2 complex; nucleoplasm; cytoplasm; nucleolus; cytosol; nucleus
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Molecular Function: protein binding; DNA binding; transcription coactivator activity; transcription factor activity
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Biological Process: spleen development; extracellular matrix organization and biogenesis; transcription, DNA-dependent; MyD88-independent toll-like receptor signaling pathway; follicular dendritic cell differentiation; toll-like receptor 3 signaling pathway; Toll signaling pathway; toll-like receptor 1 signaling pathway; activation of NF-kappaB transcription factor; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; regulation of transcription, DNA-dependent; positive regulation of interferon type I production; germinal center formation; toll-like receptor signaling pathway; innate immune response; toll-like receptor 4 signaling pathway
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Reference #:
Q00653 (UniProtKB)
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| Alt. Names/Synonyms: DNA-binding factor KBF2; H2TF1; Lymphocyte translocation chromosome 10 protein; LYT-10; LYT10; NFKB2; Nuclear factor NF-kappa-B p100 subunit; Nuclear factor NF-kappa-B p52 subunit; nuclear factor of kappa light chain gene enhancer in B-cells 2; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100); Oncogene Lyt-10; p52 |
| Gene Symbols: NFKB2 |
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Molecular weight: 96,749 Da
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Basal Isoelectric point: 5.84
Predict pI for various phosphorylation states
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CST Pathways:
Apoptosis
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B Cell Receptor Signaling
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Death Receptor Signaling
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Inhibition of Apoptosis
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NF-kB Signaling
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T Cell Receptor Signaling
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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