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Notch 2 (mouse)

Overview Notch 2 a member of the Notch family. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. Affects the implementation of differentiation, proliferation and apoptotic programs. Cleaved in the trans-Golgi network and presented on the cell surface as a heterodimer. This protein functions as a receptor for the membrane bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. Cellular Component: cell surface; membrane; integral to plasma membrane; plasma membrane; integral to membrane; nucleus Molecular Function: NF-kappaB binding; protein binding; enzyme binding; calcium ion binding Biological Process: Notch signaling pathway; transcription, DNA-dependent; wound healing; positive regulation of apoptosis; positive regulation of osteoclast differentiation; in utero embryonic development; multicellular organismal development; cell fate determination; bone remodeling; humoral immune response; negative regulation of cell proliferation; organ morphogenesis; inflammatory response to antigenic stimulus; regulation of transcription, DNA-dependent; morphogenesis of an epithelial sheet; heart looping; positive regulation of Ras protein signal transduction; cell differentiation; cell cycle arrest; determination of left/right symmetry; cell growth; placenta development; regulation of developmental process; embryonic limb morphogenesis Reference #:  O35516 (UniProtKB) Alt. Names/Synonyms: AI853703; Motch B; N2; Neurogenic locus notch homolog protein 2; NOTC2; Notch 2; Notch 2 extracellular truncation; Notch 2 intracellular domain; Notch gene homolog 2 (Drosophila); Notch2 Gene Symbols: Notch2 Molecular weight: 265,327 Da Basal Isoelectric point: 5.04  Predict pI for various phosphorylation states CST Pathways:  ESC Pluripotency and Differentiation  |  Notch Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Notch 2 2OO4 - A/B=1426-1677 (human)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			mouse
0	1		T434	HAGKCVNTDGAFHCE
0	1		K1578	LHTNLRIKQDSQGAL
0	1		K1594	VYPYFGEKSAAMkkQ
0	1		K1599-a	GEKSAAMkkQKMTRR
0	1		K1600-a	EKSAAMkkQKMTRRs
0	1		K1600	EKSAAMkKQKMTRRs
0	1		S1607-p	kQKMTRRsLPEEQEQ
0	1		K1622	EQEVIGSKIFLEIDN
0	1		L1670	LVSVFSELESPRNAQ
0	1		A1705	IMAKRKQAWLPLAAG
0	2		-	gap
0	11		T1715	PLAAGRFTLRRDSSN
0	3		S1721	FTLRRDSSNHKRREP
0	2		S1744-p	KNLSVQVsEANLIGS
0	8		S1777-p	AEDEALLsEDDPIDR
0	4		T1800	EAADISHTPSLALTP
0	3		S1802	ADISHTPSLALTPPQ
0	6		T1806	HTPSLALTPPQAEQE
0	2		S1840-p	ASLRGGSsDLsDEDE
0	4		S1843-p	RGGSsDLsDEDEDAE
0	2		S2068	DEYNVTPSPPGTVLT
1	0		S2076	PPGTVLTSALSPVLC
0	1		S2079	TVLTSALSPVLCGPN
1	0		S2088	VLCGPNRSFLSLKHT
0	1		T2095	SFLSLKHTPMGKKAR
0	1		K2099	LKHTPMGKKARRPNT
0	1		K2100	KHTPMGKKARRPNTK
0	7		S2127	EAKDAKGSRRKKCLN
0	7		C2132	KGSRRKKCLNEKVQL
0	1		N2134	SRRKKCLNEKVQLSE
0	2		T2295	PEGKHMSTQREPLPP
0	1		Y2372	AQTIVPTYHPFPASV
0	2		Y2469	PHSNMQVYA______

	human
T436-p	HAGKCVNtDGAFHCE
K1580-a	LHTNLRIkRDSQGEL
K1596-a	VYPYYGEkSAAMKkQ
K1601	GEkSAAMKkQRMTRR
K1602	EkSAAMKKQRMTRRS
K1602-u	EkSAAMKkQRMTRRS
S1609	kQRMTRRSLPGEQEQ
K1622-u	EQEVAGSkVFLEIDN
S1670-p	LVSVVSEsLTPERTQ
K1705-u	IMAKRKRkHGsLWLP
S1708-p	KRKRkHGsLWLPEGF
T1716-p	LWLPEGFtLRRDAsN
S1722-p	FtLRRDAsNHKRREP
S1745	KNLSVQVSEANLIGT
S1778-p	AEDEALLsEEDDPID
T1802-p	EAADIRRtPsLALtP
S1804-p	ADIRRtPsLALtPPQ
T1808-p	RtPsLALtPPQAEQE
S1842	ASLRGGSSDLsDEDE
S1845-p	RGGSSDLsDEDEDAE
S2070-p	DEYNVTPsPPGTVLT
S2078	PPGTVLTSALsPVIC
S2081-p	TVLTSALsPVICGPN
S2090	VICGPNRSFLSLKHt
T2097-p	SFLSLKHtPMGkkSR
K2101-u	LKHtPMGkkSRRPSA
K2102-u	KHtPMGkkSRRPSAK
S2129-p	EAKDAKGsRRKKsLs
S2134-p	KGsRRKKsLsEKVQL
S2136-p	sRRKKsLsEKVQLSE
T2296-p	PEGKHITtPREPLPP
Y2373-p	AQTILPAyHPFPASV
Y2470-p	PHNNMQVyA______

	rat
T436	HAGKCVNTDGAFHCE
K1580	LHTNLRIKQDSQGAL
K1596	VYPYYGEKSAAMKKQ
K1601	GEKSAAMKKQKVARR
K1602	EKSAAMKKQKVARRS
K1602	EKSAAMKKQKVARRS
S1609	KQKVARRSLPDEQEQ
K1622	EQEIIGSKVFLEIDN
S1670	LVSVVSESEDPRNTP
K1705	IMAKRKRKHGFLWLP
F1708	KRKRKHGFLWLPEGF
T1716	LWLPEGFTLRRDSSN
S1722	FTLRRDSSNHKRREP
S1745	KNLSVQVSEANLIGS
L1778	AEDDEALLSEDDPVD
T1802	EAADIRRTPSLALTP
S1804	ADIRRTPSLALTPPQ
T1808	RTPSLALTPPQAEQE
S1842	ASLRGGSSDLSDEDE
S1845	RGGSSDLSDEDEDAE
S2070	DEYNVTPSPPGTVLT
S2078-p	PPGTVLTsALSPVLC
S2081	TVLTsALSPVLCGPN
S2090-p	VLCGPNRsFLSLKHT
T2097	sFLSLKHTPMGKKAR
K2101	LKHTPMGKKARRPNT
K2102	KHTPMGKKARRPNTK
S2129	EAKDVKGSRRKKCLN
C2134	KGSRRKKCLNEKVQL
N2136	SRRKKCLNEKVQLSE
T2296	PEGKPIPTQREPLPP
Y2373	AQTIVPTYHPFPASV
Y2470	PHSNMQVYA______

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