Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
Notch 2 (mouse)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Notch 2 a member of the Notch family. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. Affects the implementation of differentiation, proliferation and apoptotic programs. Cleaved in the trans-Golgi network and presented on the cell surface as a heterodimer. This protein functions as a receptor for the membrane bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. Note: This description may include information from UniProtKB.
Protein type: Receptor, misc.; Membrane protein, integral; Motility/polarity/chemotaxis
Cellular Component: cell surface; membrane; cell; integral to plasma membrane; plasma membrane; integral to membrane; nucleus; receptor complex; cilium
Molecular Function: NF-kappaB binding; protein binding; enzyme binding; calcium ion binding
Biological Process: wound healing; positive regulation of osteoclast differentiation; positive regulation of apoptosis; multicellular organismal development; cell fate determination; negative regulation of transcription from RNA polymerase II promoter; bone remodeling; negative regulation of cell proliferation; regulation of transcription, DNA-dependent; positive regulation of cell proliferation; morphogenesis of an epithelial sheet; heart looping; cell growth; cell cycle arrest; cell differentiation; positive regulation of BMP signaling pathway; regulation of developmental process; embryonic limb morphogenesis; placenta development; Notch signaling pathway; transcription, DNA-dependent; in utero embryonic development; humoral immune response; organ morphogenesis; inflammatory response to antigenic stimulus; positive regulation of Ras protein signal transduction; determination of left/right symmetry
Reference #:  O35516 (UniProtKB)
Alt. Names/Synonyms: AI853703; Motch B; N2; Neurogenic locus notch homolog protein 2; NOTC2; Notch 2; Notch 2 extracellular truncation; Notch 2 intracellular domain; Notch gene homolog 2 (Drosophila); Notch2
Gene Symbols: Notch2
Molecular weight: 265,327 Da
Basal Isoelectric point: 5.04  Predict pI for various phosphorylation states
CST Pathways:  ESC Pluripotency and Differentiation  |  Notch Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Notch 2

Protein Structure Not Found.


STRING  |  Reactome  |  BioGPS  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  Source  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
0 1 T434 HAGKCVNTDGAFHCE
0 1 K1578 LHTNLRIKQDSQGAL
0 1 K1594 VYPYFGEKSAAMkkQ
0 1 K1599-ac GEKSAAMkkQKMTRR
0 1 K1600-ac EKSAAMkkQKMTRRs
0 1 K1600 EKSAAMkKQKMTRRs
0 1 S1607-p kQKMTRRsLPEEQEQ
0 1 K1622 EQEVIGSKIFLEIDN
0 1 L1670 LVSVFSELESPRNAQ
0 1 K1703 GVIMAKRKQAWLPLA
0 2 - gap
0 16 T1715 PLAAGRFTLRRDSSN
0 3 S1721 FTLRRDSSNHKRREP
0 2 S1744-p KNLSVQVsEANLIGS
0 12 S1777-p AEDEALLsEDDPIDR
0 4 T1800 EAADISHTPSLALTP
0 5 S1802 ADISHTPSLALTPPQ
0 8 T1806 HTPSLALTPPQAEQE
0 1 T1828 VRGPDGCTPLMLASL
0 1 S1834 CTPLMLASLRGGSsD
0 3 S1840-p ASLRGGSsDLsDEDE
0 4 S1843-p RGGSsDLsDEDEDAE
0 3 S2068 DEYNVTPSPPGTVLT
0 1 T2072 VTPSPPGTVLTSALs
1 1 S2076 PPGTVLTSALsPVLC
0 3 S2079-p TVLTSALsPVLCGPN
1 1 S2088 VLCGPNRSFLSLKHT
0 1 S2091 GPNRSFLSLKHTPMG
0 3 T2095 SFLSLKHTPMGKKAR
0 1 K2099 LKHTPMGKKARRPNT
0 1 K2100 KHTPMGKKARRPNTK
0 2 S2113 TKSTMPTSLPNLAKE
0 7 S2127 EAKDAKGSRRKKCLN
0 7 C2132 KGSRRKKCLNEKVQL
0 1 N2134 SRRKKCLNEKVQLSE
0 2 T2295 PEGKHMSTQREPLPP
0 1 Y2339 AGPLPSMYQIPEMPR
0 1 Y2372 AQTIVPTYHPFPASV
0 3 Y2469 PHSNMQVYA______
  human

 
T436-p HAGKCVNtDGAFHCE
K1580-ac LHTNLRIkRDSQGEL
K1596-ac VYPYYGEkSAAMKkQ
K1601 GEkSAAMKkQRMTRR
K1602 EkSAAMKKQRMTRRS
K1602-ub EkSAAMKkQRMTRRS
S1609 kQRMTRRSLPGEQEQ
K1622-ub EQEVAGSkVFLEIDN
S1670-p LVSVVSEsLTPERTQ
K1705-ub IMAKRKRkHGsLWLP
S1708-p KRKRkHGsLWLPEGF
T1716-p LWLPEGFtLRRDAsN
S1722-p FtLRRDAsNHKRREP
S1745 KNLSVQVSEANLIGT
S1778-p AEDEALLsEEDDPID
T1802-p EAADIRRtPsLALtP
S1804-p ADIRRtPsLALtPPQ
T1808-p RtPsLALtPPQAEQE
T1830-p VRGPDGCtPLMLAsL
S1836-p CtPLMLAsLRGGSSD
S1842 AsLRGGSSDLsDEDE
S1845-p RGGSSDLsDEDEDAE
S2070-p DEYNVTPsPPGtVLT
T2074-p VTPsPPGtVLTsALs
S2078-p PPGtVLTsALsPVIC
S2081-p tVLTsALsPVICGPN
S2090-p VICGPNRsFLsLKHt
S2093-p GPNRsFLsLKHtPMG
T2097-p sFLsLKHtPMGkkSR
K2101-ub LKHtPMGkkSRRPSA
K2102-ub KHtPMGkkSRRPSAK
S2115-p AKSTMPTsLPNLAKE
S2129-p EAKDAKGsRRKKsLs
S2134-p KGsRRKKsLsEKVQL
S2136-p sRRKKsLsEKVQLSE
T2296-p PEGKHITtPREPLPP
Y2340-p AGPLPTMyQIPEMAR
Y2373-p AQTILPAyHPFPASV
Y2470-p PHNNMQVyA______
  rat

 
T436 HAGKCVNTDGAFHCE
K1580 LHTNLRIKQDSQGAL
K1596 VYPYYGEKSAAMKKQ
K1601 GEKSAAMKKQKVARR
K1602 EKSAAMKKQKVARRS
K1602 EKSAAMKKQKVARRS
S1609 KQKVARRSLPDEQEQ
K1622 EQEIIGSKVFLEIDN
S1670 LVSVVSESEDPRNTP
K1705 IMAKRKRKHGFLWLP
F1708 KRKRKHGFLWLPEGF
T1716 LWLPEGFTLRRDSSN
S1722 FTLRRDSSNHKRREP
S1745 KNLSVQVSEANLIGS
S1779-p EDDEALLsEDDPVDR
T1802 EAADIRRTPSLALTP
S1804 ADIRRTPSLALTPPQ
T1808 RTPSLALTPPQAEQE
T1830 VRGPDGCTPLMLASL
S1836 CTPLMLASLRGGSsD
S1842-p ASLRGGSsDLSDEDE
S1845 RGGSsDLSDEDEDAE
S2070 DEYNVTPSPPGTVLT
T2074 VTPSPPGTVLTsALS
S2078-p PPGTVLTsALSPVLC
S2081 TVLTsALSPVLCGPN
S2090-p VLCGPNRsFLSLKHT
S2093 GPNRsFLSLKHTPMG
T2097 sFLSLKHTPMGKKAR
K2101 LKHTPMGKKARRPNT
K2102 KHTPMGKKARRPNTK
S2115 TKSTMPTSLPNLAKE
S2129 EAKDVKGSRRKKCLN
C2134 KGSRRKKCLNEKVQL
N2136 SRRKKCLNEKVQLSE
T2296 PEGKPIPTQREPLPP
Y2340 AGPLPSMYQIPEMAR
Y2373 AQTIVPTYHPFPASV
Y2470 PHSNMQVYA______
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.