a member of the Notch family. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. Affects the implementation of differentiation, proliferation and apoptotic programs. Cleaved in the trans-Golgi network and presented on the cell surface as a heterodimer. This protein functions as a receptor for the membrane bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Receptor, misc.
Cellular Component: cell surface; membrane; integral to plasma membrane; cell; plasma membrane; integral to membrane; nucleus; receptor complex; cilium
Molecular Function: NF-kappaB binding; protein binding; enzyme binding; calcium ion binding
Biological Process: wound healing; positive regulation of apoptosis; positive regulation of osteoclast differentiation; multicellular organismal development; cell fate determination; negative regulation of transcription from RNA polymerase II promoter; bone remodeling; negative regulation of cell proliferation; regulation of transcription, DNA-dependent; positive regulation of cell proliferation; morphogenesis of an epithelial sheet; heart looping; cell differentiation; cell cycle arrest; cell growth; positive regulation of BMP signaling pathway; embryonic limb morphogenesis; placenta development; regulation of developmental process; Notch signaling pathway; transcription, DNA-dependent; in utero embryonic development; humoral immune response; organ morphogenesis; inflammatory response to antigenic stimulus; positive regulation of Ras protein signal transduction; determination of left/right symmetry
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.