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Protein Page:
Notch 2 (mouse)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
Notch 2 a member of the Notch family. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. Affects the implementation of differentiation, proliferation and apoptotic programs. Cleaved in the trans-Golgi network and presented on the cell surface as a heterodimer. This protein functions as a receptor for the membrane bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Receptor, misc.
Cellular Component: cell surface; membrane; cell; integral to plasma membrane; plasma membrane; integral to membrane; nucleus; receptor complex; cilium
Molecular Function: NF-kappaB binding; protein binding; enzyme binding; calcium ion binding
Biological Process: wound healing; positive regulation of osteoclast differentiation; positive regulation of apoptosis; multicellular organismal development; negative regulation of transcription from RNA polymerase II promoter; cell fate determination; bone remodeling; negative regulation of cell proliferation; regulation of transcription, DNA-dependent; positive regulation of cell proliferation; morphogenesis of an epithelial sheet; heart looping; cell growth; cell cycle arrest; cell differentiation; positive regulation of BMP signaling pathway; embryonic limb morphogenesis; regulation of developmental process; placenta development; Notch signaling pathway; transcription, DNA-dependent; in utero embryonic development; humoral immune response; organ morphogenesis; inflammatory response to antigenic stimulus; positive regulation of Ras protein signal transduction; determination of left/right symmetry
Reference #:  O35516 (UniProtKB)
Alt. Names/Synonyms: AI853703; Motch B; N2; Neurogenic locus notch homolog protein 2; NOTC2; Notch 2; Notch 2 extracellular truncation; Notch 2 intracellular domain; Notch gene homolog 2 (Drosophila); Notch2
Gene Symbols: Notch2
Molecular weight: 265,327 Da
Basal Isoelectric point: 5.04  Predict pI for various phosphorylation states
CST Pathways:  ESC Pluripotency and Differentiation  |  Notch Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Notch 2

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  Source  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
0 1 T434 HAGKCVNTDGAFHCE
0 1 K1703 GVIMAKRKQAWLPLA
0 2 - gap
0 11 T1715 PLAAGRFTLRRDSSN
0 3 S1721 FTLRRDSSNHKRREP
0 2 S1744-p KNLSVQVsEANLIGS
0 10 S1777-p AEDEALLsEDDPIDR
0 4 T1800 EAADISHTPSLALTP
0 3 S1802 ADISHTPSLALTPPQ
0 6 T1806 HTPSLALTPPQAEQE
0 3 S1840-p ASLRGGSsDLsDEDE
0 4 S1843-p RGGSsDLsDEDEDAE
0 2 S2068 DEYNVTPSPPGTVLT
1 0 S2076 PPGTVLTSALsPVLC
0 1 S2079-p TVLTSALsPVLCGPN
1 1 S2088 VLCGPNRSFLSLKHT
0 2 T2095 SFLSLKHTPMGKKAR
0 1 S2113 TKSTMPTSLPNLAKE
0 7 S2127 EAKDAKGSRRKKCLN
0 7 C2132 KGSRRKKCLNEKVQL
0 2 T2295 PEGKHMSTQREPLPP
0 1 Y2339 AGPLPSMYQIPEMPR
0 3 Y2469 PHSNMQVYA______
  human

 
T436-p HAGKCVNtDGAFHCE
K1705-u IMAKRKRkHGsLWLP
S1708-p KRKRkHGsLWLPEGF
T1716-p LWLPEGFtLRRDAsN
S1722-p FtLRRDAsNHKRREP
S1745 KNLSVQVSEANLIGT
S1778-p AEDEALLsEEDDPID
T1802-p EAADIRRtPsLALtP
S1804-p ADIRRtPsLALtPPQ
T1808-p RtPsLALtPPQAEQE
S1842 ASLRGGSSDLsDEDE
S1845-p RGGSSDLsDEDEDAE
S2070-p DEYNVTPsPPGTVLT
S2078-p PPGTVLTsALsPVIC
S2081-p TVLTsALsPVICGPN
S2090-p VICGPNRsFLSLKHt
T2097-p sFLSLKHtPMGKKSR
S2115-p AKSTMPTsLPNLAKE
S2129-p EAKDAKGsRRKKsLS
S2134-p KGsRRKKsLSEKVQL
T2296-p PEGKHITtPREPLPP
Y2340-p AGPLPTMyQIPEMAR
Y2470-p PHNNMQVyA______
  rat

 
T436 HAGKCVNTDGAFHCE
K1705 IMAKRKRKHGFLWLP
F1708 KRKRKHGFLWLPEGF
T1716 LWLPEGFTLRRDSSN
S1722 FTLRRDSSNHKRREP
S1745 KNLSVQVSEANLIGS
S1779-p EDDEALLsEDDPVDR
T1802 EAADIRRTPSLALTP
S1804 ADIRRTPSLALTPPQ
T1808 RTPSLALTPPQAEQE
S1842-p ASLRGGSsDLSDEDE
S1845 RGGSsDLSDEDEDAE
S2070 DEYNVTPSPPGTVLT
S2078-p PPGTVLTsALSPVLC
S2081 TVLTsALSPVLCGPN
S2090-p VLCGPNRsFLSLKHT
T2097 sFLSLKHTPMGKKAR
S2115 TKSTMPTSLPNLAKE
S2129 EAKDVKGSRRKKCLN
C2134 KGSRRKKCLNEKVQL
T2296 PEGKPIPTQREPLPP
Y2340 AGPLPSMYQIPEMAR
Y2470 PHSNMQVYA______
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