a member of the Notch family. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. Affects the implementation of differentiation, proliferation and apoptotic programs. Cleaved in the trans-Golgi network and presented on the cell surface as a heterodimer. This protein functions as a receptor for the membrane bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Receptor, misc.; Membrane protein, integral
Cellular Component: nucleoplasm; Golgi membrane; endoplasmic reticulum membrane; cell surface; integral to plasma membrane; plasma membrane; extracellular region; nucleus
Molecular Function: protein binding; calcium ion binding; receptor activity
Biological Process: nervous system development; transcription initiation from RNA polymerase II promoter; Notch signaling pathway; apoptosis; multicellular organismal development; stem cell maintenance; Notch receptor processing; cell fate determination; bone remodeling; negative regulation of cell proliferation; organ morphogenesis; regulation of transcription, DNA-dependent; hemopoiesis; gene expression; positive regulation of Ras protein signal transduction; cell growth; cell cycle arrest; negative regulation of apoptosis
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.