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Protein Page:
Notch 2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Notch 2 a member of the Notch family. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. Affects the implementation of differentiation, proliferation and apoptotic programs. Cleaved in the trans-Golgi network and presented on the cell surface as a heterodimer. This protein functions as a receptor for the membrane bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.; Motility/polarity/chemotaxis
Cellular Component: nucleoplasm; Golgi membrane; endoplasmic reticulum membrane; cell surface; membrane; integral to plasma membrane; plasma membrane; extracellular region; nucleus; receptor complex
Molecular Function: protein binding; receptor activity; calcium ion binding
Biological Process: apoptosis; positive regulation of apoptosis; multicellular organismal development; cell fate determination; bone remodeling; negative regulation of cell proliferation; regulation of transcription, DNA-dependent; morphogenesis of an epithelial sheet; hemopoiesis; cell growth; cell cycle arrest; embryonic limb morphogenesis; nervous system development; transcription initiation from RNA polymerase II promoter; Notch signaling pathway; intracellular receptor-mediated signaling pathway; in utero embryonic development; stem cell maintenance; Notch receptor processing; humoral immune response; organ morphogenesis; inflammatory response to antigenic stimulus; gene expression; positive regulation of Ras protein signal transduction; determination of left/right symmetry; negative regulation of apoptosis
Reference #:  Q04721 (UniProtKB)
Alt. Names/Synonyms: AGS2; hN2; Neurogenic locus notch homolog protein 2; NOTC2; Notch 2; Notch 2 extracellular truncation; Notch 2 intracellular domain; Notch homolog 2 (Drosophila); NOTCH2
Gene Symbols: NOTCH2
Molecular weight: 265,405 Da
Basal Isoelectric point: 4.95  Predict pI for various phosphorylation states
CST Pathways:  ESC Pluripotency and Differentiation  |  Notch Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Notch 2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S359-p TCIDRVAsFSCMCPE
0 1 T436-p HAGKCVNtDGAFHCE
0 1 K1580-ac LHTNLRIkRDSQGEL
0 1 K1596-ac VYPYYGEkSAAMKkQ
0 1 K1601 GEkSAAMKkQRMTRR
0 1 K1602 EkSAAMKKQRMTRRS
0 1 K1602-ub EkSAAMKkQRMTRRS
0 1 S1609 kQRMTRRSLPGEQEQ
0 1 K1622-ub EQEVAGSkVFLEIDN
0 1 S1670-p LVSVVSEsLTPERTQ
0 1 K1705-ub IMAKRKRkHGsLWLP
0 3 S1708-p KRKRkHGsLWLPEGF
0 19 T1716-p LWLPEGFtLRRDAsN
0 3 S1722-p FtLRRDAsNHKRREP
0 2 S1745 KNLSVQVSEANLIGT
0 13 S1778-p AEDEALLsEEDDPID
0 4 T1802-p EAADIRRtPsLALtP
0 5 S1804-p ADIRRtPsLALtPPQ
0 8 T1808-p RtPsLALtPPQAEQE
0 2 T1830-p VRGPDGCtPLMLAsL
0 1 S1836-p CtPLMLAsLRGGSSD
0 3 S1842 AsLRGGSSDLsDEDE
0 4 S1845-p RGGSSDLsDEDEDAE
0 3 S2070-p DEYNVTPsPPGtVLT
0 1 T2074-p VTPsPPGtVLTsALs
1 1 S2078-p PPGtVLTsALsPVIC
0 3 S2081-p tVLTsALsPVICGPN
1 1 S2090-p VICGPNRsFLsLKHt
0 1 S2093-p GPNRsFLsLKHtPMG
0 3 T2097-p sFLsLKHtPMGkkSR
0 1 K2101-ub LKHtPMGkkSRRPSA
0 1 K2102-ub KHtPMGkkSRRPSAK
0 3 S2115-p AKSTMPTsLPNLAKE
0 7 S2129-p EAKDAKGsRRKKsLs
0 7 S2134-p KGsRRKKsLsEKVQL
0 1 S2136-p sRRKKsLsEKVQLSE
0 3 T2296-p PEGKHITtPREPLPP
0 1 Y2340-p AGPLPTMyQIPEMAR
0 1 Y2373-p AQTILPAyHPFPASV
0 1 T2385-p ASVGKYPtPPsQHSY
0 1 S2388-p GKYPtPPsQHSYASS
0 4 Y2470-p PHNNMQVyA______
  mouse

 
S357 TCIDRVASFSCLCPE
T434 HAGKCVNTDGAFHCE
K1578 LHTNLRIKQDSQGAL
K1594 VYPYFGEKSAAMkkQ
K1599-ac GEKSAAMkkQKMTRR
K1600-ac EKSAAMkkQKMTRRs
K1600 EKSAAMkKQKMTRRs
S1607-p kQKMTRRsLPEEQEQ
K1622 EQEVIGSKIFLEIDN
L1670 LVSVFSELESPRNAQ
K1703 GVIMAKRKQAWLPLA
- gap
T1715 PLAAGRFTLRRDSSN
S1721 FTLRRDSSNHKRREP
S1744-p KNLSVQVsEANLIGS
S1777-p AEDEALLsEDDPIDR
T1800 EAADISHTPSLALTP
S1802 ADISHTPSLALTPPQ
T1806 HTPSLALTPPQAEQE
T1828 VRGPDGCTPLMLASL
S1834 CTPLMLASLRGGSsD
S1840-p ASLRGGSsDLsDEDE
S1843-p RGGSsDLsDEDEDAE
S2068 DEYNVTPSPPGTVLT
T2072 VTPSPPGTVLTSALs
S2076 PPGTVLTSALsPVLC
S2079-p TVLTSALsPVLCGPN
S2088 VLCGPNRSFLSLKHT
S2091 GPNRSFLSLKHTPMG
T2095 SFLSLKHTPMGKKAR
K2099 LKHTPMGKKARRPNT
K2100 KHTPMGKKARRPNTK
S2113 TKSTMPTSLPNLAKE
S2127 EAKDAKGSRRKKCLN
C2132 KGSRRKKCLNEKVQL
N2134 SRRKKCLNEKVQLSE
T2295 PEGKHMSTQREPLPP
Y2339 AGPLPSMYQIPEMPR
Y2372 AQTIVPTYHPFPASV
T2384 ASVGKYPTPPSQHSY
S2387 GKYPTPPSQHSYASS
Y2469 PHSNMQVYA______
  rat

 
S359 TCIDRVASFSCLCPE
T436 HAGKCVNTDGAFHCE
K1580 LHTNLRIKQDSQGAL
K1596 VYPYYGEKSAAMKKQ
K1601 GEKSAAMKKQKVARR
K1602 EKSAAMKKQKVARRS
K1602 EKSAAMKKQKVARRS
S1609 KQKVARRSLPDEQEQ
K1622 EQEIIGSKVFLEIDN
S1670 LVSVVSESEDPRNTP
K1705 IMAKRKRKHGFLWLP
F1708 KRKRKHGFLWLPEGF
T1716 LWLPEGFTLRRDSSN
S1722 FTLRRDSSNHKRREP
S1745 KNLSVQVSEANLIGS
S1779-p EDDEALLsEDDPVDR
T1802 EAADIRRTPSLALTP
S1804 ADIRRTPSLALTPPQ
T1808 RTPSLALTPPQAEQE
T1830 VRGPDGCTPLMLASL
S1836 CTPLMLASLRGGSsD
S1842-p ASLRGGSsDLsDEDE
S1845-p RGGSsDLsDEDEDAE
S2070 DEYNVTPSPPGTVLT
T2074 VTPSPPGTVLTsALS
S2078-p PPGTVLTsALSPVLC
S2081 TVLTsALSPVLCGPN
S2090-p VLCGPNRsFLSLKHT
S2093 GPNRsFLSLKHTPMG
T2097 sFLSLKHTPMGKKAR
K2101 LKHTPMGKKARRPNT
K2102 KHTPMGKKARRPNTK
S2115 TKSTMPTSLPNLAKE
S2129 EAKDVKGSRRKKCLN
C2134 KGSRRKKCLNEKVQL
N2136 SRRKKCLNEKVQLSE
T2296 PEGKPIPTQREPLPP
Y2340 AGPLPSMYQIPEMAR
Y2373 AQTIVPTYHPFPASV
T2385 ASVGKYPTPPSQHSY
S2388 GKYPTPPSQHSYASS
Y2470 PHSNMQVYA______
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