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Notch 2 (human)

Overview Notch 2 a member of the Notch family. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. Affects the implementation of differentiation, proliferation and apoptotic programs. Cleaved in the trans-Golgi network and presented on the cell surface as a heterodimer. This protein functions as a receptor for the membrane bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. Note: This description may include information from UniProtKB. Protein type: Receptor, misc.; Membrane protein, integral; Motility/polarity/chemotaxis Cellular Component: nucleoplasm; Golgi membrane; endoplasmic reticulum membrane; cell surface; integral to plasma membrane; plasma membrane; extracellular region; nucleus Molecular Function: protein binding; calcium ion binding; receptor activity Biological Process: nervous system development; transcription initiation from RNA polymerase II promoter; Notch signaling pathway; multicellular organismal development; stem cell maintenance; Notch receptor processing; cell fate determination; bone remodeling; humoral immune response; negative regulation of cell proliferation; organ morphogenesis; inflammatory response to antigenic stimulus; regulation of transcription, DNA-dependent; tissue regeneration; induction of apoptosis; morphogenesis of an epithelial sheet; gene expression; hemopoiesis; positive regulation of Ras protein signal transduction; determination of left/right symmetry; cell cycle arrest; cell growth; negative regulation of apoptosis; embryonic limb morphogenesis Reference #:  Q04721 (UniProtKB) Alt. Names/Synonyms: AGS2; hN2; Neurogenic locus notch homolog protein 2; NOTC2; Notch 2; Notch 2 extracellular truncation; Notch 2 intracellular domain; Notch homolog 2 (Drosophila); NOTCH2 Gene Symbols: NOTCH2 Molecular weight: 265,405 Da Basal Isoelectric point: 4.95  Predict pI for various phosphorylation states CST Pathways:  ESC Pluripotency and Differentiation  |  Notch Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Notch 2 2OO4 - A/B=1426-1677 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  Phospho3D  |  DISEASE 600275 610205  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T436-p	HAGKCVNtDGAFHCE
0	1		K1580-a	LHTNLRIkRDSQGEL
0	1		K1596-a	VYPYYGEkSAAMKkQ
0	1		K1601	GEkSAAMKkQRMTRR
0	1		K1602	EkSAAMKKQRMTRRS
0	1		K1602-u	EkSAAMKkQRMTRRS
0	1		S1609	kQRMTRRSLPGEQEQ
0	1		K1622-u	EQEVAGSkVFLEIDN
0	1		S1670-p	LVSVVSEsLTPERTQ
0	1		K1705-u	IMAKRKRkHGsLWLP
0	2		S1708-p	KRKRkHGsLWLPEGF
0	11		T1716-p	LWLPEGFtLRRDAsN
0	3		S1722-p	FtLRRDAsNHKRREP
0	2		S1745	KNLSVQVSEANLIGT
0	8		S1778-p	AEDEALLsEEDDPID
0	4		T1802-p	EAADIRRtPsLALtP
0	3		S1804-p	ADIRRtPsLALtPPQ
0	6		T1808-p	RtPsLALtPPQAEQE
0	2		S1842	ASLRGGSSDLsDEDE
0	4		S1845-p	RGGSSDLsDEDEDAE
0	2		S2070-p	DEYNVTPsPPGTVLT
1	0		S2078	PPGTVLTSALsPVIC
0	1		S2081-p	TVLTSALsPVICGPN
1	0		S2090	VICGPNRSFLSLKHt
0	1		T2097-p	SFLSLKHtPMGkkSR
0	1		K2101-u	LKHtPMGkkSRRPSA
0	1		K2102-u	KHtPMGkkSRRPSAK
0	7		S2129-p	EAKDAKGsRRKKsLs
0	7		S2134-p	KGsRRKKsLsEKVQL
0	1		S2136-p	sRRKKsLsEKVQLSE
0	2		T2296-p	PEGKHITtPREPLPP
0	1		Y2373-p	AQTILPAyHPFPASV
0	2		Y2470-p	PHNNMQVyA______

	mouse
T434	HAGKCVNTDGAFHCE
K1578	LHTNLRIKQDSQGAL
K1594	VYPYFGEKSAAMkkQ
K1599-a	GEKSAAMkkQKMTRR
K1600-a	EKSAAMkkQKMTRRs
K1600	EKSAAMkKQKMTRRs
S1607-p	kQKMTRRsLPEEQEQ
K1622	EQEVIGSKIFLEIDN
L1670	LVSVFSELESPRNAQ
A1705	IMAKRKQAWLPLAAG
-	gap
T1715	PLAAGRFTLRRDSSN
S1721	FTLRRDSSNHKRREP
S1744-p	KNLSVQVsEANLIGS
S1777-p	AEDEALLsEDDPIDR
T1800	EAADISHTPSLALTP
S1802	ADISHTPSLALTPPQ
T1806	HTPSLALTPPQAEQE
S1840-p	ASLRGGSsDLsDEDE
S1843-p	RGGSsDLsDEDEDAE
S2068	DEYNVTPSPPGTVLT
S2076	PPGTVLTSALSPVLC
S2079	TVLTSALSPVLCGPN
S2088	VLCGPNRSFLSLKHT
T2095	SFLSLKHTPMGKKAR
K2099	LKHTPMGKKARRPNT
K2100	KHTPMGKKARRPNTK
S2127	EAKDAKGSRRKKCLN
C2132	KGSRRKKCLNEKVQL
N2134	SRRKKCLNEKVQLSE
T2295	PEGKHMSTQREPLPP
Y2372	AQTIVPTYHPFPASV
Y2469	PHSNMQVYA______

	rat
T436	HAGKCVNTDGAFHCE
K1580	LHTNLRIKQDSQGAL
K1596	VYPYYGEKSAAMKKQ
K1601	GEKSAAMKKQKVARR
K1602	EKSAAMKKQKVARRS
K1602	EKSAAMKKQKVARRS
S1609	KQKVARRSLPDEQEQ
K1622	EQEIIGSKVFLEIDN
S1670	LVSVVSESEDPRNTP
K1705	IMAKRKRKHGFLWLP
F1708	KRKRKHGFLWLPEGF
T1716	LWLPEGFTLRRDSSN
S1722	FTLRRDSSNHKRREP
S1745	KNLSVQVSEANLIGS
L1778	AEDDEALLSEDDPVD
T1802	EAADIRRTPSLALTP
S1804	ADIRRTPSLALTPPQ
T1808	RTPSLALTPPQAEQE
S1842	ASLRGGSSDLSDEDE
S1845	RGGSSDLSDEDEDAE
S2070	DEYNVTPSPPGTVLT
S2078-p	PPGTVLTsALSPVLC
S2081	TVLTsALSPVLCGPN
S2090-p	VLCGPNRsFLSLKHT
T2097	sFLSLKHTPMGKKAR
K2101	LKHTPMGKKARRPNT
K2102	KHTPMGKKARRPNTK
S2129	EAKDVKGSRRKKCLN
C2134	KGSRRKKCLNEKVQL
N2136	SRRKKCLNEKVQLSE
T2296	PEGKPIPTQREPLPP
Y2373	AQTIVPTYHPFPASV
Y2470	PHSNMQVYA______

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