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Protein Page:
ITGB4 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ITGB4 integrin alpha-6/beta-4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells. Five alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Receptor, misc.; Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion
Cellular Component: cell surface; hemidesmosome; leading edge; plasma membrane; basal plasma membrane; basement membrane; integrin complex; receptor complex
Molecular Function: protein binding; G-protein-coupled receptor binding; receptor activity
Biological Process: integrin-mediated signaling pathway; hemidesmosome assembly; extracellular matrix organization and biogenesis; filopodium formation; cell-matrix adhesion; multicellular organismal development; response to wounding; cell motility involved in cell locomotion; autophagy; cell adhesion
Reference #:  P16144 (UniProtKB)
Alt. Names/Synonyms: CD104; CD104 antigen; GP150; Integrin beta-4; integrin beta-4 subunit; integrin, beta 4; ITB4; ITGB4
Gene Symbols: ITGB4
Molecular weight: 202,167 Da
Basal Isoelectric point: 5.74  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ITGB4

Protein Structure Not Found.


STRING  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  DISEASE  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Sites Implicated In
cell motility, altered: S1356‑p, S1364‑p
cytoskeletal reorganization: S1356‑p, S1364‑p
intracellular localization: S1494‑p
molecular association, regulation: S1325‑p, S1356‑p, S1360‑p, S1364‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S7-p _MAGPRPsPWARLLL
0 1 S21-p LAALISVsLSGTLAN
0 1 Y50-p RVDKDCAyCTDEMFR
0 1 S102-p TLRRSQMsPQGLRVR
0 1 K173-ub DYTIGFGkFVDkVSV
0 1 K177-ub GFGkFVDkVSVPQTD
0 1 K191-ub DMRPEKLkEPWPNSD
0 1 K219-ub DVDEFRNkLQGERIS
0 1 S368-p EAFNRIRsNLDIRAL
0 1 S377-p LDIRALDsPRGLRtE
0 1 T383-p DsPRGLRtEVTskMF
0 1 S387-p GLRtEVTskMFQKTR
0 1 K388-ub LRtEVTskMFQKTRT
0 1 K437-ub QKGNIHLkPSFSDGL
0 1 K654 TCEECNFKVKMVDEL
0 1 K656 EECNFKVKMVDELkR
0 1 K662-ub VKMVDELkRAEEVVV
0 1 T681-p RDEDDDCtYSYTMEG
0 1 K758-ub RGHMVGFkEDHYMLR
0 1 K785-ub MLRSGNLkGRDVVRW
0 1 S821-p ELVPYGLsLRLARLC
0 1 T829-p LRLARLCtENLLkPD
0 2 K834-ub LCtENLLkPDtRECA
0 1 T837-p ENLLkPDtRECAQLR
0 32 Y855-p EENLNEVyRQISGVH
0 1 T886-p QDHTIVDtVLMAPRS
0 1 K895-ub LMAPRSAkPALLKLT
0 1 K904-ub ALLKLTEkQVEQRAF
0 3 K915-ub QRAFHDLkVAPGyyt
0 65 Y920-p DLkVAPGyytLTADQ
0 11 Y921-p LkVAPGyytLTADQD
0 2 T922-p kVAPGyytLTADQDA
0 1 K958-ub RPEDDDEkQLLVEAI
0 1 T973-p DVPAGTAtLGRRLVN
0 1 T982-p GRRLVNItIIKEQAR
0 1 S1000-p SFEQPEFsVSRGDQV
0 1 K1021-ub RRVLDGGkSQVSYRT
0 1 Y1039-p TAQGNRDyIPVEGEL
0 1 K1060-ub AWKELQVkLLELQEV
0 3 S1069-p LELQEVDsLLRGRQV
0 1 S1084-p RRFHVQLsNPKFGAH
0 1 S1097-p AHLGQPHsttIIIRD
0 1 T1098-p HLGQPHsttIIIRDP
0 1 T1099-p LGQPHsttIIIRDPD
0 1 S1140-p PNAKAAGsRKIHFNW
0 24 Y1187-p SVELTNLyPyCDYEM
0 55 Y1189-p ELTNLyPyCDYEMKV
0 1 Y1199-p YEMKVCAyGAQGEGP
0 595 Y1207-p GAQGEGPyssLVSCR
0 41 S1208-p AQGEGPyssLVSCRT
0 87 S1209-p QGEGPyssLVSCRTH
0 2 T1246-p SWAEPAEtNGEITAY
1 0 Y1257-p ITAYEVCyGLVNDDN
0 1 Y1294 NLRESQPYRYtVKAR
0 1 T1297-p ESQPYRYtVKARNGA
0 1 T1318-p EAIINLAtQPKRPMs
1 0 S1325-p tQPKRPMsIPIIPDI
0 15 Y1343-p DAQSGEDyDsFLMys
0 4 S1345-p QSGEDyDsFLMysDD
0 7 Y1349-p DyDsFLMysDDVLRs
0 1 S1350-p yDsFLMysDDVLRsP
5 2 S1356-p ysDDVLRsPSGsQRP
4 4 S1360-p VLRsPSGsQRPsVSD
4 3 S1364-p PSGsQRPsVSDDTGC
0 1 S1403-p LIPRLSAsSGRSSDA
0 1 S1428-p GAGGKGGsLPRSAtP
0 1 T1434-p GsLPRSAtPGPPGEH
0 2 S1454-p MDFAFPGstNsLHRM
0 1 T1455-p DFAFPGstNsLHRMT
0 5 S1457-p AFPGstNsLHRMTTT
0 1 S1465-p LHRMTTTsAAAyGtH
0 67 Y1469-p TTTsAAAyGtHLsPH
0 22 T1471-p TsAAAyGtHLsPHVP
0 69 S1474-p AAyGtHLsPHVPHRV
0 21 S1483-p HVPHRVLstsstLtR
0 4 T1484-p VPHRVLstsstLtRD
0 10 S1485-p PHRVLstsstLtRDy
0 9 S1486-p HRVLstsstLtRDyN
0 10 T1487-p RVLstsstLtRDyNs
0 3 T1489-p LstsstLtRDyNsLt
1 61 Y1492-p sstLtRDyNsLtRsE
3 33 S1494-p tLtRDyNsLtRsEHs
0 8 T1496-p tRDyNsLtRsEHsHs
0 8 S1498-p DyNsLtRsEHsHstt
0 2 S1501-p sLtRsEHsHsttLPR
0 1 S1503-p tRsEHsHsttLPRDy
0 6 T1504-p RsEHsHsttLPRDys
0 4 T1505-p sEHsHsttLPRDyst
2 161 Y1510-p sttLPRDystLtsVs
0 5 S1511-p ttLPRDystLtsVss
0 9 T1512-p tLPRDystLtsVssH
0 4 T1514-p PRDystLtsVssHDS
0 8 S1515-p RDystLtsVssHDSR
0 7 S1517-p ystLtsVssHDSRLt
0 25 S1518-p stLtsVssHDSRLtA
0 1 - gap
0 1 T1524-p ssHDSRLtAGVPDtP
0 10 T1530-p LtAGVPDtPTRLVFS
3 1 Y1564-p LQGYSVEyQLLNGGE
0 4 S1595-p EDLLPNHsyVFRVRA
1 7 Y1596-p DLLPNHsyVFRVRAQ
0 12 S1604-p VFRVRAQsQEGWGRE
0 1 S1653-p PLVFTALsPDSLQLS
0 2 Y1674-p PNGDIVGyLVTCEMA
0 1 T1688-p AQGGGPAtAFRVDGD
0 1 S1707-p RLTVPGLsENVPYKF
1 0 Y1712 GLsENVPYKFKVQAR
0 1 T1720-p KFKVQARttEGFGPE
0 1 T1721-p FKVQARttEGFGPER
0 8 S1758-p LFQHPLQsEyssItt
0 40 Y1760-p QHPLQsEyssItttH
0 3 S1761-p HPLQsEyssItttHT
0 2 S1762-p PLQsEyssItttHTS
0 1 T1764-p QsEyssItttHTSAt
0 2 T1765-p sEyssItttHTSAtE
0 2 T1766-p EyssItttHTSAtEP
0 1 T1771-p tttHTSAtEPFLVDG
0 8 S1791-p QHLEAGGsLtRHVtQ
0 4 T1793-p LEAGGsLtRHVtQEF
1 16 T1797-p GsLtRHVtQEFVSRt
0 1 T1804-p tQEFVSRtLttSGTL
1 5 T1806-p EFVSRtLttSGTLST
0 3 T1807-p FVSRtLttSGTLSTH
  ITGB4 iso2  
S7 _MAGPRPSPWARLLL
S21 LAALISVSLSGTLAN
Y50 RVDKDCAYCTDEMFR
S102 TLRRSQMSPQGLRVR
K173 DYTIGFGKFVDKVSV
K177 GFGKFVDKVSVPQTD
K191 DMRPEKLKEPWPNSD
K219 DVDEFRNKLQGERIS
S368 EAFNRIRSNLDIRAL
S377 LDIRALDSPRGLRTE
T383 DSPRGLRTEVTSKMF
S387 GLRTEVTSKMFQKTR
K388 LRTEVTSKMFQKTRT
K437 QKGNIHLKPSFSDGL
K654 TCEECNFKVKMVDEL
K656 EECNFKVKMVDELKR
K662 VKMVDELKRAEEVVV
T681 RDEDDDCTYSYTMEG
K758 RGHMVGFKEDHYMLR
K785 MLRSGNLKGRDVVRW
S821 ELVPYGLSLRLARLC
T829 LRLARLCTENLLKPD
K834 LCTENLLKPDTRECA
T837 ENLLKPDTRECAQLR
Y855-p EENLNEVyRQISGVH
T886 QDHTIVDTVLMAPRS
K895 LMAPRSAKPALLKLT
K904 ALLKLTEKQVEQRAF
K915 QRAFHDLKVAPGyYT
Y920-p DLKVAPGyYTLTADQ
Y921 LKVAPGyYTLTADQD
T922 KVAPGyYTLTADQDA
K958 RPEDDDEKQLLVEAI
T973 DVPAGTATLGRRLVN
T982 GRRLVNITIIKEQAR
S1000 SFEQPEFSVSRGDQV
K1021 RRVLDGGKSQVSYRT
Y1039 TAQGNRDYIPVEGEL
K1060 AWKELQVKLLELQEV
S1069 LELQEVDSLLRGRQV
S1084 RRFHVQLSNPKFGAH
S1097 AHLGQPHSTTIIIRD
T1098 HLGQPHSTTIIIRDP
T1099 LGQPHSTTIIIRDPD
S1140 PNAKAAGSRKIHFNW
Y1187 SVELTNLYPyCDYEM
Y1189-p ELTNLYPyCDYEMKV
Y1199 YEMKVCAYGAQGEGP
Y1207-p GAQGEGPySSLVSCR
S1208 AQGEGPySSLVSCRT
S1209 QGEGPySSLVSCRTH
T1246 SWAEPAETNGEITAY
Y1257 ITAYEVCYGLVNDDN
Y1294 NLRESQPYRYTVKAR
T1297 ESQPYRYTVKARNGA
T1318 EAIINLATQPKRPMS
S1325 TQPKRPMSIPIIPDI
Y1343-p DAQSGEDyDSFLMyS
S1345 QSGEDyDSFLMySDD
Y1349-p DyDSFLMySDDVLRs
S1350 yDSFLMySDDVLRsP
S1356-p ySDDVLRsPSGsQRP
S1360-p VLRsPSGsQRPsVSD
S1364-p PSGsQRPsVSDDTEH
- gap
- gap
- gap
S1384 MDFAFPGSTNSLHRM
T1385 DFAFPGSTNSLHRMT
S1387 AFPGSTNSLHRMTTT
S1395 LHRMTTTSAAAyGTH
Y1399-p TTTSAAAyGTHLsPH
T1401 TSAAAyGTHLsPHVP
S1404-p AAyGTHLsPHVPHRV
S1413-p HVPHRVLsTsstLTR
T1414 VPHRVLsTsstLTRD
S1415-p PHRVLsTsstLTRDy
S1416-p HRVLsTsstLTRDyN
T1417-p RVLsTsstLTRDyNs
T1419 LsTsstLTRDyNsLT
Y1422-p sstLTRDyNsLTRSE
S1424-p tLTRDyNsLTRSEHS
T1426 TRDyNsLTRSEHSHS
S1428 DyNsLTRSEHSHSTT
S1431 sLTRSEHSHSTTLPR
S1433 TRSEHSHSTTLPRDy
T1434 RSEHSHSTTLPRDyS
T1435 SEHSHSTTLPRDyST
Y1440-p STTLPRDySTLTSVS
S1441 TTLPRDySTLTSVSS
T1442 TLPRDySTLTSVSSH
T1444 PRDySTLTSVSSHDS
S1445 RDySTLTSVSSHDSR
S1447 ySTLTSVSSHDSRLT
S1448 STLTSVSSHDSRLTA
- gap
T1454 SSHDSRLTAGVPDTP
T1460 LTAGVPDTPTRLVFS
Y1494-p LQGYSVEyQLLNGGE
S1525 EDLLPNHSyVFRVRA
Y1526-p DLLPNHSyVFRVRAQ
S1534-p VFRVRAQsQEGWGRE
S1583 PLVFTALSPDSLQLS
Y1604 PNGDIVGYLVTCEMA
T1618 AQGGGPATAFRVDGD
S1637 RLTVPGLSENVPyKF
Y1642-p GLSENVPyKFKVQAR
T1650 KFKVQARTTEGFGPE
T1651 FKVQARTTEGFGPER
S1688 LFQHPLQSEySSITT
Y1690-p QHPLQSEySSITTTH
S1691 HPLQSEySSITTTHT
S1692 PLQSEySSITTTHTS
T1694 QSEySSITTTHTSAT
T1695 SEySSITTTHTSATE
T1696 EySSITTTHTSATEP
T1701 TTTHTSATEPFLVDG
S1721 QHLEAGGSLTRHVtQ
T1723 LEAGGSLTRHVtQEF
T1727-p GSLTRHVtQEFVSRT
T1734 tQEFVSRTLttSGTL
T1736-p EFVSRTLttSGTLST
T1737-p FVSRTLttSGTLSTH
  ITGB4 iso3  
S7 _MAGPRPSPWARLLL
S21 LAALISVSLSGTLAN
Y50 RVDKDCAYCTDEMFR
S102 TLRRSQMSPQGLRVR
K173 DYTIGFGKFVDKVSV
K177 GFGKFVDKVSVPQTD
K191 DMRPEKLKEPWPNSD
K219 DVDEFRNKLQGERIS
S368 EAFNRIRSNLDIRAL
S377 LDIRALDSPRGLRTE
T383 DSPRGLRTEVTSKMF
S387 GLRTEVTSKMFQKTR
K388 LRTEVTSKMFQKTRT
K437 QKGNIHLKPSFSDGL
K654 TCEECNFKVKMVDEL
K656 EECNFKVKMVDELKR
K662 VKMVDELKRAEEVVV
T681 RDEDDDCTYSYTMEG
K758 RGHMVGFKEDHYMLR
K785 MLRSGNLKGRDVVRW
S821 ELVPYGLSLRLARLC
T829 LRLARLCTENLLKPD
K834 LCTENLLKPDTRECA
T837 ENLLKPDTRECAQLR
Y855 EENLNEVYRQISGVH
T886 QDHTIVDTVLMAPRS
K895 LMAPRSAKPALLKLT
K904 ALLKLTEKQVEQRAF
K915 QRAFHDLKVAPGYYT
Y920 DLKVAPGYYTLTADQ
Y921 LKVAPGYYTLTADQD
T922 KVAPGYYTLTADQDA
K958 RPEDDDEKQLLVEAI
T973 DVPAGTATLGRRLVN
T982 GRRLVNITIIKEQAR
S1000 SFEQPEFSVSRGDQV
K1021 RRVLDGGKSQVSYRT
Y1039 TAQGNRDYIPVEGEL
K1060 AWKELQVKLLELQEV
S1069 LELQEVDSLLRGRQV
S1084 RRFHVQLSNPKFGAH
S1097 AHLGQPHSTTIIIRD
T1098 HLGQPHSTTIIIRDP
T1099 LGQPHSTTIIIRDPD
S1140 PNAKAAGSRKIHFNW
Y1187 SVELTNLYPYCDYEM
Y1189 ELTNLYPYCDYEMKV
Y1199 YEMKVCAYGAQGEGP
Y1207 GAQGEGPYSSLVSCR
S1208 AQGEGPYSSLVSCRT
S1209 QGEGPYSSLVSCRTH
T1246 SWAEPAETNGEITAY
Y1257 ITAYEVCYGLVNDDN
Y1294 NLRESQPYRYTVKAR
T1297 ESQPYRYTVKARNGA
T1318 EAIINLATQPKRPMS
S1325 TQPKRPMSIPIIPDI
Y1343 DAQSGEDYDSFLMYS
S1345 QSGEDYDSFLMYSDD
Y1349 DYDSFLMYSDDVLRs
S1350 YDSFLMYSDDVLRsP
S1356-p YSDDVLRsPSGsQRP
S1360-p VLRsPSGsQRPsVSD
S1364-p PSGsQRPsVSDDTEH
- gap
- gap
- gap
S1384 MDFAFPGSTNSLHRM
T1385 DFAFPGSTNSLHRMT
S1387 AFPGSTNSLHRMTTT
S1395 LHRMTTTSAAAYGTH
Y1399 TTTSAAAYGTHLSPH
T1401 TSAAAYGTHLSPHVP
S1404 AAYGTHLSPHVPHRV
S1413 HVPHRVLSTSSTLTR
T1414 VPHRVLSTSSTLTRD
S1415 PHRVLSTSSTLTRDY
S1416 HRVLSTSSTLTRDYN
T1417 RVLSTSSTLTRDYNS
T1419 LSTSSTLTRDYNSLT
Y1422 SSTLTRDYNSLTRSE
S1424 TLTRDYNSLTRSEHS
T1426 TRDYNSLTRSEHSHS
S1428 DYNSLTRSEHSHSTT
S1431 SLTRSEHSHSTTLPR
S1433 TRSEHSHSTTLPRDy
T1434 RSEHSHSTTLPRDys
T1435 SEHSHSTTLPRDysT
Y1440-p STTLPRDysTLTSVS
S1441-p TTLPRDysTLTSVSS
T1442 TLPRDysTLTSVSSH
T1444 PRDysTLTSVSSHGL
S1445 RDysTLTSVSSHGLP
S1447 ysTLTSVSSHGLPPI
S1448 sTLTSVSSHGLPPIW
S1482 QMKGFPPSRGPRDSI
T1507 WGPDSRLTAGVPDTP
T1513 LTAGVPDTPTRLVFS
Y1547 LQGYSVEYQLLNGGE
S1578 EDLLPNHSYVFRVRA
Y1579 DLLPNHSYVFRVRAQ
S1587 VFRVRAQSQEGWGRE
S1636 PLVFTALSPDSLQLS
Y1657 PNGDIVGYLVTCEMA
T1671 AQGGGPATAFRVDGD
S1690 RLTVPGLSENVPYKF
Y1695 GLSENVPYKFKVQAR
T1703 KFKVQARTTEGFGPE
T1704 FKVQARTTEGFGPER
S1741 LFQHPLQSEYSSITT
Y1743 QHPLQSEYSSITTTH
S1744 HPLQSEYSSITTTHT
S1745 PLQSEYSSITTTHTS
T1747 QSEYSSITTTHTSAT
T1748 SEYSSITTTHTSATE
T1749 EYSSITTTHTSATEP
T1754 TTTHTSATEPFLVDG
S1774 QHLEAGGSLTRHVTQ
T1776 LEAGGSLTRHVTQEF
T1780 GSLTRHVTQEFVSRT
T1787 TQEFVSRTLTTSGTL
T1789 EFVSRTLTTSGTLST
T1790 FVSRTLTTSGTLSTH
  mouse

► Hide Isoforms
 
S7 _MAGPCCSPWVKLLL
S22 LAAMLSASLPGDLAN
Y51 RVDKSCAYCTDELFK
S103 SLHRSQVSPQGLQVR
K174 DYTIGFGKFVDKVSV
K178 GFGKFVDKVSVPQTD
K192 DMRPEKLKEPWPNSD
K220 NVEEFWNKLQGERIS
S369 EAFYRIRSNLDIRAL
S378 LDIRALDSPRGLRTE
T384 DSPRGLRTEVTSDTL
S388 GLRTEVTSDTLQKTE
D389 LRTEVTSDTLQKTET
K439 QGGNIHLKPSFSDGL
K656 ACDDCPFKVKMVDEL
K658 DDCPFKVKMVDELKK
K664 VKMVDELKKAEEVVE
T683 RDEDDDCTYSYNVEG
K760 RGHMVGFKEDHYMLR
K787 MLRSGNLKGRDTVRW
S823 ELVPYGLSLRLGRLC
T831 LRLGRLCTENLMKPG
K836 LCTENLMKPGTRECD
T839 ENLMKPGTRECDQLR
Y857 EENLNEVYRQVSGAH
T888 QDHTIVDTVLLAPRS
K897 LLAPRSAKQMLLKLT
K906 MLLKLTEKQVEQGSF
K917 QGSFHELKVAPGYYT
Y922 ELKVAPGYYTVTAEQ
Y923 LKVAPGYYTVTAEQD
T924 KVAPGYYTVTAEQDA
K960 RPEDDDEKQLLVEAI
T975 DVPVGTATLGRRLVN
T984 GRRLVNITIIKEQAS
S1002 SFEQPEYSVSRGDQV
K1023 RHILDNGKSQVSYST
Y1041 TAHGHRDYVPVEGEL
K1062 TWKELQVKLLELQEV
S1071 LELQEVDSLLRGRQV
S1086 RRFQVQLSNPKFGAR
T1099 ARLGQPSTTTVILGE
T1100 RLGQPSTTTVILGEH
T1101 LGQPSTTTVILGEHD
S1142 PNAKAAGSRKIHFNW
Y1189 SVELTNLYPYCDYEM
Y1191 ELTNLYPYCDYEMKV
Y1201 YEMKVCAYGAQGEGP
Y1209-p GAQGEGPySsLVSCR
S1210 AQGEGPySsLVSCRT
S1211-p QGEGPySsLVSCRTH
T1248-p SWAEPAEtNGEITAY
Y1259 ITAYEVCYGLVNEDN
Y1296 NLRESQPYRYTVKAR
T1299 ESQPYRYTVKARNGA
T1320 EAIINLATQPKRPMS
S1327 TQPKRPMSIPIIPDI
Y1345 DAQGGEDYENFLMYS
N1347 QGGEDYENFLMYSDD
Y1351 DYENFLMYSDDVLRS
S1352 YENFLMYSDDVLRSP
S1358 YSDDVLRSPASSQRP
S1362 VLRSPASSQRPSVSD
S1366 PASSQRPSVSDDTGC
S1405 LIPRLSASSGRSDED
S1424 GGVEGEGSGWIRGAT
T1431 SGWIRGATPRPPGEH
S1451 MDFAYPGSANSLHRM
A1452 DFAYPGSANSLHRMT
S1454 AYPGSANSLHRMTAA
N1462 LHRMTAANVAYGTHL
Y1465 MTAANVAYGTHLSPH
T1467 AANVAYGTHLSPHLS
S1470 VAYGTHLSPHLSHRV
S1479 HLSHRVLSTSSTLTR
T1480 LSHRVLSTSSTLTRD
S1481 SHRVLSTSSTLTRDY
S1482 HRVLSTSSTLTRDYH
T1483 RVLSTSSTLTRDYHS
T1485 LSTSSTLTRDYHSLT
Y1488 SSTLTRDYHSLTRTE
S1490 TLTRDYHSLTRTEHS
T1492 TRDYHSLTRTEHSHS
T1494 DYHSLTRTEHSHSGT
S1497 SLTRTEHSHSGTLPR
S1499 TRTEHSHSGTLPRDY
G1500 RTEHSHSGTLPRDYs
T1501 TEHSHSGTLPRDYsT
Y1506 SGTLPRDYsTLTSLS
S1507-p GTLPRDYsTLTSLSS
T1508 TLPRDYsTLTSLSSQ
T1510 PRDYsTLTSLSSQDS
S1511 RDYsTLTSLSSQDSR
S1513 YsTLTSLSSQDSRGA
S1514 sTLTSLSSQDSRGAV
- gap
A1520 SSQDSRGAVGVPDTP
T1526 GAVGVPDTPTRLVFS
Y1560 LLGYSVEYQLLNGGE
S1591 EDLLPNHSYVFRVRA
Y1592 DLLPNHSYVFRVRAQ
S1600 VFRVRAQSQEGWGRE
S1649 PLVFTALSPDSLQLS
Y1670 PNGDILGYLVTCEMA
R1684 AQGGAPARTFRVDGD
S1703 RLTVPGLSENVPYKF
Y1708 GLSENVPYKFKVQAR
T1716 KFKVQARTTEGFGPE
T1717 FKVQARTTEGFGPER
S1754 LFQNPVQSEFSSVTS
F1756 QNPVQSEFSSVTSTH
S1757 NPVQSEFSSVTSTHS
S1758 PVQSEFSSVTSTHST
T1760 QSEFSSVTSTHSTTT
S1761 SEFSSVTSTHSTTTE
T1762 EFSSVTSTHSTTTEP
T1767 TSTHSTTTEPFLMDG
S1787 QRLEAGGSLTRHVTQ
T1789 LEAGGSLTRHVTQEF
T1793 GSLTRHVTQEFVTRT
T1800 TQEFVTRTLTASGSL
T1802 EFVTRTLTASGSLST
A1803 FVTRTLTASGSLSTH
  ITGB4 iso2  
S7 _MAGPCCSPWVKLLL
S22 LAAMLSASLPGDLAN
Y51 RVDKSCAYCTDELFK
S103 SLHRSQVSPQGLQVR
K174 DYTIGFGKFVDKVSV
K178 GFGKFVDKVSVPQTD
K192 DMRPEKLKEPWPNSD
K220 NVEEFWNKLQGERIS
S369 EAFYRIRSNLDIRAL
S378 LDIRALDSPRGLRTE
T384 DSPRGLRTEVTSDTL
S388 GLRTEVTSDTLQKTE
D389 LRTEVTSDTLQKTET
K439 QGGNIHLKPSFSDGL
K656-ac ACDDCPFkVkMVDEL
K658-ac DDCPFkVkMVDELKK
K664 VkMVDELKKAEEVVE
T683 RDEDDDCTYSYNVEG
K760 RGHMVGFKEDHYMLR
K787 MLRSGNLKGRDTVRW
S823 ELVPYGLSLRLGRLC
T831 LRLGRLCTENLMKPG
K836 LCTENLMKPGTRECD
T839 ENLMKPGTRECDQLR
Y857 EENLNEVYRQVSGAH
T888 QDHTIVDTVLLAPRS
K897 LLAPRSAKQMLLKLT
K906 MLLKLTEKQVEQGSF
K917 QGSFHELKVAPGYYT
Y922 ELKVAPGYYTVTAEQ
Y923 LKVAPGYYTVTAEQD
T924 KVAPGYYTVTAEQDA
K960 RPEDDDEKQLLVEAI
T975 DVPVGTATLGRRLVN
T984 GRRLVNITIIKEQAS
S1002 SFEQPEYSVSRGDQV
K1023 RHILDNGKSQVSYST
Y1041 TAHGHRDYVPVEGEL
K1062 TWKELQVKLLELQEV
S1071-p LELQEVDsLLRGRQV
S1086 RRFQVQLSNPKFGAR
T1099 ARLGQPSTTTVILGE
T1100 RLGQPSTTTVILGEH
T1101 LGQPSTTTVILGEHD
S1142 PNAKAAGSRKIHFNW
Y1189 SVELTNLYPYCDYEM
Y1191 ELTNLYPYCDYEMKV
Y1201 YEMKVCAYGAQGEGP
Y1209 GAQGEGPYSSLVSCR
S1210 AQGEGPYSSLVSCRT
S1211 QGEGPYSSLVSCRTH
T1248 SWAEPAETNGEITAY
Y1259 ITAYEVCYGLVNEDN
Y1296-p NLRESQPyRYTVKAR
T1299 ESQPyRYTVKARNGA
T1320 EAIINLATQPKRPMS
S1327 TQPKRPMSIPIIPDI
Y1345 DAQGGEDYENFLMYS
N1347 QGGEDYENFLMYSDD
Y1351 DYENFLMYSDDVLRS
S1352 YENFLMYSDDVLRSP
S1358 YSDDVLRSPASSQRP
S1362 VLRSPASSQRPsVSD
S1366-p PASSQRPsVSDDTEH
- gap
- gap
- gap
S1386-p MDFAYPGsANsLHRM
A1387 DFAYPGsANsLHRMT
S1389-p AYPGsANsLHRMTAA
N1397 LHRMTAANVAYGtHL
Y1400 MTAANVAYGtHLsPH
T1402-p AANVAYGtHLsPHLS
S1405-p VAYGtHLsPHLSHRV
S1414 HLSHRVLSTSStLtR
T1415 LSHRVLSTSStLtRD
S1416 SHRVLSTSStLtRDY
S1417 HRVLSTSStLtRDYH
T1418-p RVLSTSStLtRDYHS
T1420-p LSTSStLtRDYHSLT
Y1423 SStLtRDYHSLTRTE
S1425 tLtRDYHSLTRTEHS
T1427 tRDYHSLTRTEHSHS
T1429 DYHSLTRTEHSHSGT
S1432 SLTRTEHSHSGTLPR
S1434 TRTEHSHSGTLPRDY
G1435 RTEHSHSGTLPRDYs
T1436 TEHSHSGTLPRDYsT
Y1441 SGTLPRDYsTLTsLS
S1442-p GTLPRDYsTLTsLSS
T1443 TLPRDYsTLTsLSSQ
T1445 PRDYsTLTsLSSQDS
S1446-p RDYsTLTsLSSQDSR
S1448 YsTLTsLSSQDSRGA
S1449 sTLTsLSSQDSRGAV
- gap
A1455 SSQDSRGAVGVPDTP
T1461 GAVGVPDTPTRLVFS
Y1495 LLGYSVEYQLLNGGE
S1526 EDLLPNHSYVFRVRA
Y1527 DLLPNHSYVFRVRAQ
S1535 VFRVRAQSQEGWGRE
S1584 PLVFTALSPDSLQLS
Y1605 PNGDILGYLVTCEMA
R1619 AQGGAPARTFRVDGD
S1638 RLTVPGLSENVPYKF
Y1643 GLSENVPYKFKVQAR
T1651 KFKVQARTTEGFGPE
T1652 FKVQARTTEGFGPER
S1689 LFQNPVQSEFSSVTS
F1691 QNPVQSEFSSVTSTH
S1692 NPVQSEFSSVTSTHS
S1693 PVQSEFSSVTSTHST
T1695 QSEFSSVTSTHSTTT
S1696 SEFSSVTSTHSTTTE
T1697 EFSSVTSTHSTTTEP
T1702 TSTHSTTTEPFLMDG
S1722-p QRLEAGGsLTRHVTQ
T1724 LEAGGsLTRHVTQEF
T1728 GsLTRHVTQEFVTRT
T1735 TQEFVTRTLTASGSL
T1737 EFVTRTLTASGSLST
A1738 FVTRTLTASGSLSTH
  ITGB4 iso3  
S7 _MAGPCCSPWVKLLL
S22 LAAMLSASLPGDLAN
Y51 RVDKSCAYCTDELFK
S103 SLHRSQVSPQGLQVR
K174 DYTIGFGKFVDKVSV
K178 GFGKFVDKVSVPQTD
K192 DMRPEKLKEPWPNSD
K220 NVEEFWNKLQGERIS
S369 EAFYRIRSNLDIRAL
S378 LDIRALDSPRGLRTE
T384 DSPRGLRTEVTSDTL
S388 GLRTEVTSDTLQKTE
D389 LRTEVTSDTLQKTET
K439 QGGNIHLKPSFSDGL
K656 ACDDCPFKVKMVDEL
K658 DDCPFKVKMVDELKK
K664 VKMVDELKKAEEVVE
T683 RDEDDDCTYSYNVEG
K760 RGHMVGFKEDHYMLR
K787 MLRSGNLKGRDTVRW
S823 ELVPYGLSLRLGRLC
T831 LRLGRLCTENLMKPG
K836 LCTENLMKPGTRECD
T839 ENLMKPGTRECDQLR
Y857 EENLNEVYRQVSGAH
T888 QDHTIVDTVLLAPRS
K897 LLAPRSAKQMLLKLT
K906 MLLKLTEKQVEQGSF
K917 QGSFHELKVAPGYYT
Y922 ELKVAPGYYTVTAEQ
Y923 LKVAPGYYTVTAEQD
T924 KVAPGYYTVTAEQDA
K960 RPEDDDEKQLLVEAI
T975 DVPVGTATLGRRLVN
T984 GRRLVNITIIKEQAS
S1002 SFEQPEYSVSRGDQV
K1023 RHILDNGKSQVSYST
Y1041 TAHGHRDYVPVEGEL
K1062 TWKELQVKLLELQEV
S1071 LELQEVDSLLRGRQV
S1086 RRFQVQLSNPKFGAR
T1099 ARLGQPSTTTVILGE
T1100 RLGQPSTTTVILGEH
T1101 LGQPSTTTVILGEHD
S1142 PNAKAAGSRKIHFNW
Y1189 SVELTNLYPYCDYEM
Y1191 ELTNLYPYCDYEMKV
Y1201 YEMKVCAYGAQGEGP
Y1209 GAQGEGPYSSLVSCR
S1210 AQGEGPYSSLVSCRT
S1211 QGEGPYSSLVSCRTH
T1248 SWAEPAETNGEITAY
Y1259 ITAYEVCYGLVNEDN
Y1296 NLRESQPYRYTVKAR
T1299 ESQPYRYTVKARNGA
T1320 EAIINLATQPKRPMS
S1327 TQPKRPMSIPIIPDI
Y1345 DAQGGEDYENFLMYS
N1347 QGGEDYENFLMYSDD
Y1351 DYENFLMYSDDVLRS
S1352 YENFLMYSDDVLRSP
S1358 YSDDVLRSPASSQRP
S1362 VLRSPASSQRPSVSD
S1366 PASSQRPSVSDDTEH
- gap
- gap
- gap
S1386 MDFAYPGSANSLHRM
A1387 DFAYPGSANSLHRMT
S1389 AYPGSANSLHRMTAA
N1397 LHRMTAANVAYGTHL
Y1400 MTAANVAYGTHLSPH
T1402 AANVAYGTHLSPHLS
S1405 VAYGTHLSPHLSHRV
S1414 HLSHRVLSTSSTLTR
T1415 LSHRVLSTSSTLTRD
S1416 SHRVLSTSSTLTRDY
S1417 HRVLSTSSTLTRDYH
T1418 RVLSTSSTLTRDYHS
T1420 LSTSSTLTRDYHSLT
Y1423 SSTLTRDYHSLTRTE
S1425 TLTRDYHSLTRTEHS
T1427 TRDYHSLTRTEHSHS
T1429 DYHSLTRTEHSHSGT
S1432 SLTRTEHSHSGTLPR
S1434 TRTEHSHSGTLPRDY
G1435 RTEHSHSGTLPRDYS
T1436 TEHSHSGTLPRDYST
Y1441 SGTLPRDYSTLTSLS
S1442 GTLPRDYSTLTSLSS
T1443 TLPRDYSTLTSLSSQ
T1445 PRDYSTLTSLSSQGL
S1446 RDYSTLTSLSSQGLP
S1448 YSTLTSLSSQGLPPI
S1449 STLTSLSSQGLPPIW
S1483-p HMKGVPAsRGSPDSI
A1508 WGTDSRGAVGVPDTP
T1514 GAVGVPDTPTRLVFS
Y1548 LLGYSVEYQLLNGGE
S1579 EDLLPNHSYVFRVRA
Y1580 DLLPNHSYVFRVRAQ
S1588 VFRVRAQSQEGWGRE
S1637 PLVFTALSPDSLQLS
Y1658 PNGDILGYLVTCEMA
R1672 AQGGAPARTFRVDGD
S1691 RLTVPGLSENVPYKF
Y1696 GLSENVPYKFKVQAR
T1704 KFKVQARTTEGFGPE
T1705 FKVQARTTEGFGPER
S1742 LFQNPVQSEFSSVTS
F1744 QNPVQSEFSSVTSTH
S1745 NPVQSEFSSVTSTHS
S1746 PVQSEFSSVTSTHST
T1748 QSEFSSVTSTHSTTT
S1749 SEFSSVTSTHSTTTE
T1750 EFSSVTSTHSTTTEP
T1755 TSTHSTTTEPFLMDG
S1775 QRLEAGGSLTRHVTQ
T1777 LEAGGSLTRHVTQEF
T1781 GSLTRHVTQEFVTRT
T1788 TQEFVTRTLTASGSL
T1790 EFVTRTLTASGSLST
A1791 FVTRTLTASGSLSTH
  rat

 
S7 _MAGLCSSPWVKLLL
G21 LAVVLSAGLPGNMAN
Y50 RVDKSCAYCTDELFK
S102 SLHRSQVSPQGLQVR
K173 DYTIGFGKFVDKVSV
K177 GFGKFVDKVSVPQTD
K191 DMRPEKLKEPWPNSD
K219 NVEEFWDKLQGERIS
S368 EAFYRIRSNLDIRAL
S377 LDIRALDSPRGLRTE
T383 DSPRGLRTEVTSDTL
S387 GLRTEVTSDTLQKTE
D388 LRTEVTSDTLQKTET
K438 QRGNIHLKPSFSDGL
K656 TCEECNFKVKMVDEL
K658 EECNFKVKMVDELKK
K664 VKMVDELKKAEEVVE
T683 RDEDDDCTYSYTVEG
K760 QGHMVGFKEDHYMLR
K787 MLRSGNLKGRDTVRW
S823 ELVPYGLSLRLGRLC
T831 LRLGRLCTENLMKPG
K836 LCTENLMKPGTRECD
T839 ENLMKPGTRECDQLR
Y857 EENLNEVYRQVNGVH
T888 QDHTIVDTVLLAPRS
K897 LLAPRSAKQSLLKLT
K906 SLLKLTEKQVEQGSF
K917 QGSFHELKVAPGYYT
Y922 ELKVAPGYYTLTAEQ
Y923 LKVAPGYYTLTAEQD
T924 KVAPGYYTLTAEQDA
K960 RPEDDDEKQLLVEAI
T975 DVPVGTATLGRRLVN
T984 GRRLVNITIIKEQAS
S1002 SFEQPEYSVSRGDQV
K1023 RHILDNGKSQVSYST
Y1041 TAHGHRDYVPVEGEL
K1062 TWKELQVKLLELQEV
S1071 LELQEVDSLLRGRQV
S1086 RRFQVQLSNPKFGAR
T1099 ARLGQPNTATVIIGE
A1100 RLGQPNTATVIIGEQ
T1101 LGQPNTATVIIGEQD
S1142 PNAKAAGSRKIHFNW
Y1189 SVELTNLYPYCDYEM
Y1191 ELTNLYPYCDYEMKV
Y1201 YEMKVCAYGAHGEGP
Y1209 GAHGEGPYSSLVSCR
S1210 AHGEGPYSSLVSCRT
S1211 HGEGPYSSLVSCRTH
T1248 SWAEPAETNGEITAY
Y1259 ITAYEVCYGLVNEDN
Y1296 NLRESQPYRYTVKAR
T1299 ESQPYRYTVKARNGA
T1320 EAIINLATQPKRPMS
S1327 TQPKRPMSIPIIPDI
Y1345 DAQGGEDYENFLMYS
N1347 QGGEDYENFLMYSDD
Y1351 DYENFLMYSDDVLRS
S1352 YENFLMYSDDVLRSP
S1358 YSDDVLRSPASSQRP
S1362 VLRSPASSQRPSVSD
S1366 PASSQRPSVSDDTEH
- gap
- gap
- gap
S1386 MDFAYPGSANSLHRM
A1387 DFAYPGSANSLHRMT
S1389 AYPGSANSLHRMTAA
N1397 LHRMTAANVAYGTHL
Y1400 MTAANVAYGTHLSPH
T1402 AANVAYGTHLSPHQT
S1405 VAYGTHLSPHQTHRM
S1414 HQTHRMLSTSSTLTR
T1415 QTHRMLSTSSTLTRD
S1416 THRMLSTSSTLTRDY
S1417 HRMLSTSSTLTRDYH
T1418 RMLSTSSTLTRDYHS
T1420 LSTSSTLTRDYHSLT
Y1423 SSTLTRDYHSLTRTD
S1425 TLTRDYHSLTRTDHS
T1427 TRDYHSLTRTDHSQS
T1429 DYHSLTRTDHSQSGT
S1432 SLTRTDHSQSGTLPR
S1434 TRTDHSQSGTLPRDY
G1435 RTDHSQSGTLPRDYS
T1436 TDHSQSGTLPRDYST
Y1441 SGTLPRDYSTLTSLS
S1442 GTLPRDYSTLTSLSS
T1443 TLPRDYSTLTSLSSQ
T1445 PRDYSTLTSLSSQGL
S1446 RDYSTLTSLSSQGLP
S1448 YSTLTSLSSQGLPPI
S1449 STLTSLSSQGLPPIW
S1483 QMKGVPASRGSPDSI
A1508 WGTDSRGAMGVPDTP
T1514 GAMGVPDTPTRLVFS
Y1548 LLGYSVEYQLLNGGE
S1579 EDLLPNHSYVFRVRA
Y1580 DLLPNHSYVFRVRAQ
S1588 VFRVRAQSQEGWGRE
S1637 PLVFTALSPDSLQLS
Y1658 PNGDILGYLVTCEMA
R1672 AQGGGPARTFRVDGD
S1691 RLTVPGLSENVPYKF
Y1696 GLSENVPYKFKVQAR
T1704 KFKVQARTTEGFGPE
T1705 FKVQARTTEGFGPER
S1742 LFQNPLQSEYSTVTS
Y1744 QNPLQSEYSTVTSTH
S1745 NPLQSEYSTVTSTHS
T1746 PLQSEYSTVTSTHST
T1748 QSEYSTVTSTHSTTT
S1749 SEYSTVTSTHSTTTT
T1750 EYSTVTSTHSTTTTE
T1756 STHSTTTTEPFLIDG
S1776 QRLEAGGSLTRHVTQ
T1778 LEAGGSLTRHVTQEF
T1782 GSLTRHVTQEFVSRT
T1789 TQEFVSRTLTTSGSL
T1791 EFVSRTLTTSGSLST
T1792 FVSRTLTTSGSLSTH
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