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Protein Page:
APC (mouse)

Overview
APC a tumor suppressor. Defects in APC are a cause of familial adenomatous polyposis (FAP). Promotes rapid degradation of CTNNB1 and participates in Wnt signaling. Activity is correlated with its phosphorylation state. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Tumor suppressor; Motility/polarity/chemotaxis
Cellular Component: centrosome; microtubule; dendrite; beta-catenin destruction complex; kinetochore; cell-cell adherens junction; membrane; cell soma; cytoplasmic microtubule; cell projection membrane; lamellipodium; cytoplasm; synapse; lateral plasma membrane; nuclear membrane; neuron projection; protein complex; tight junction; cell cortex; cytoskeleton; growth cone; cell projection; axon; plasma membrane; nucleus; cell junction
Molecular Function: microtubule plus-end binding; protein binding; protease binding; gamma-catenin binding; microtubule binding; protein complex binding; beta-catenin binding; protein kinase regulator activity; protein kinase binding
Biological Process: skin development; negative regulation of Wnt receptor signaling pathway; positive regulation of cell adhesion; regulation of cell cycle; somatic stem cell maintenance; positive regulation of apoptosis; T cell differentiation in the thymus; Wnt receptor signaling pathway through beta-catenin; regulation of cell migration; cytoplasmic microtubule organization and biogenesis; muscle maintenance; anterior/posterior pattern formation; cytokinesis after mitosis; hair follicle development; positive regulation of epithelial cell differentiation; protein complex assembly; kidney development; cell cycle arrest; neurite development; regulation of microtubule-based process; negative regulation of odontogenesis; regulation of osteoblast differentiation; negative regulation of cyclin-dependent protein kinase activity; retina development in camera-type eye; positive regulation of cell division; regulation of epithelial cell differentiation; positive regulation of protein catabolic process; regulation of nitrogen compound metabolic process; positive regulation of cell differentiation; mitotic metaphase/anaphase transition; negative regulation of apoptosis; positive regulation of microtubule polymerization; establishment and/or maintenance of cell polarity; chromosome organization and biogenesis; negative regulation of cell proliferation; regulation of osteoclast differentiation; regulation of cell differentiation; mitotic cell cycle spindle assembly checkpoint; proximal/distal pattern formation; negative regulation of epithelial cell proliferation; cell migration; regulation of attachment of spindle microtubules to kinetochore; Wnt receptor signaling pathway; thymus development; negative regulation of MAPKKK cascade; negative regulation of microtubule depolymerization; axis specification; stem cell maintenance; pattern specification process; positive regulation of pseudopodium formation; dorsal/ventral pattern formation; axonogenesis; response to DNA damage stimulus; positive regulation of cell migration
Reference #:  Q61315 (UniProtKB)
Alt. Names/Synonyms: adenomatosis polyposis coli; Adenomatous polyposis coli protein; AI047805; Apc; AU020952; AW124434; CC1; mAPC; Min; multiple intestinal neoplasia; Protein APC
Gene Symbols: Apc
Molecular weight: 311,089 Da
Basal Isoelectric point: 7.44  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  ESC Pluripotency and Differentiation  |  Microtubule Dynamics  |  Wnt/├č-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

APC

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Source  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

► Hide Isoforms
 
0 3 Y94-p SKMSLRSyGsREGSV
0 3 S96-p MSLRSyGsREGSVSS
0 1 S105-p EGSVSSRsGECsPVP
0 2 S109-p SSRsGECsPVPMGSF
0 4 Y314 GTKVEMVYSLLSMLG
0 3 S742-p YKDANIMsPGSsLPS
0 1 S746-p NIMsPGSsLPSLHVR
0 8 S778-p FDNIDNLsPKASHRS
0 3 - gap
0 5 Y794 QRHKQNLYGDYAFDA
0 11 Y797 KQNLYGDYAFDANRH
0 36 Y861 RGIGLSAYHPTTENA
0 2 T865 LSAYHPTTENAGTSS
0 1 S893 AKVMEEVSAIHTSQD
0 1 T897 EEVSAIHTSQDDRSS
0 1 S906 QDDRSSASTTEFHCV
0 2 Y933 SHTHSNTYNFTKSEN
0 28 Y949 NRTCSMPYAKVEYKR
0 2 S961-p YKRSSNDsLNSVTSS
0 1 S983-p QMKPSVEsYSEDDES
0 1 S1030 INYSLKYSDEQLNsG
0 4 S1036-p YSDEQLNsGRQsPSQ
0 7 S1040-p QLNsGRQsPSQNERW
0 10 Y1076 QNTSYPVYSENTDDK
0 11 S1098-p FGQQECVsPYRSRGT
0 8 Y1100 QQECVsPYRSRGTSG
0 1 S1179 VDQPIDYSLKYATDI
0 1 Y1182 PIDYSLKYATDISSS
0 2 S1193-p ISSSQKPsFSFSKNS
0 2 S1211-p STKPEHLsPSSENTA
0 7 - gap
1 0 S1277 SRCSSLSSLSSADDE
1 6 S1359-p EFSSGAKsPSKsGAQ
0 1 S1361 SSGAKsPSKsGAQTP
0 2 S1363-p GAKsPSKsGAQTPKs
0 5 S1370-p sGAQTPKsPPEHYVQ
0 2 T1379-p PEHYVQEtPLVFsRC
0 3 S1384-p QEtPLVFsRCTsVSs
0 1 S1388-p LVFsRCTsVSsLDSF
1 1 S1391-p sRCTsVSsLDSFESR
0 6 T1437-p MPPSRSKtPPPPPQT
1 0 S1500 ESTPDGFSCSSSLSA
1 0 S1502 TPDGFSCSSSLSALS
1 0 S1503 PDGFSCSSSLSALSL
2 0 S1504 DGFSCSSSLSALSLD
2 0 S1506 FSCSSSLSALSLDEP
1 0 S1509 SSSLSALSLDEPFIQ
0 1 - gap
0 1 S1557-p KEVEKPDsEKDLLDD
0 9 S1608-p PPVARKPsQLPVYKL
0 4 Y1613 KPsQLPVYKLLPAQN
0 1 T1631 AQKHVSFTPGDDVPR
0 1 S1662-p LSDLTIEsPPNELAT
0 1 T1695 IPTEGRSTDDAQRGK
0 1 T1708-p GKISSIVtPDLDDNK
0 1 N1714 VtPDLDDNKAEEGDI
0 1 T1771-p DTKKKKPtSPVKPMP
0 3 S1772 TKKKKPtSPVKPMPQ
0 2 Y1844 ALDSPHHYTPIEGTP
0 5 Y1852 TPIEGTPYCFSRNDs
0 4 S1859-p YCFSRNDsLssLDFD
0 3 S1861-p FSRNDsLssLDFDDD
0 4 S1862-p SRNDsLssLDFDDDD
0 1 T1930-p PVLQKQPtFPQSSKD
0 1 S1994-p KEAEPANsQGEPSKP
0 2 S2021 EDTPVCFSRNSSLSS
1 0 S2033 LSSLSIDSEDDLLQE
2 0 S2053 MPKKKRPSRLKsESE
0 2 S2057-p KRPSRLKsESEKQSP
0 3 S2087 KDLQRPDSEHAFsPG
0 5 S2092-p PDSEHAFsPGSENFD
0 2 S2095 EHAFsPGSENFDWKA
0 5 S2125-p AAAAACLsRQAssDs
0 29 S2129-p ACLsRQAssDsDSIL
0 4 S2130-p CLsRQAssDsDSILS
0 2 S2132-p sRQAssDsDSILSLK
0 2 S2140-p DSILSLKsGISLGsP
0 9 S2146-p KsGISLGsPFHLtPD
0 7 T2151-p LGsPFHLtPDQEEKP
0 4 S2260-p LKTPASKsPsEGPGA
0 3 S2262-p TPASKsPsEGPGATT
0 3 S2270-p EGPGATTsPRGTKPA
0 4 S2283-p PAGKSELsPITRQTs
0 11 S2290-p sPITRQTsQISGSNK
0 1 S2330 SPGRNSISPGRNGIS
0 1 S2337 SPGRNGISPPNKLSQ
0 3 S2349-p LSQLPRTsSPSTAST
0 18 Y2366 SGSGKMSYTsPGRQL
0 2 S2368-p SGKMSYTsPGRQLsQ
0 11 S2374-p TsPGRQLsQQNLTKQ
0 10 S2421-p VELSRMSsTKSSGSE
0 3 S2441 RPALVRQSTFIKEAP
0 17 T2442 PALVRQSTFIKEAPs
0 17 S2449-p TFIKEAPsPtLRRKL
0 2 T2451-p IKEAPsPtLRRKLEE
0 1 S2461-p RKLEESAsFESLSPS
0 1 S2464 EESAsFESLSPSSRP
0 2 S2473-p SPSSRPDsPtRSQAQ
0 1 T2475-p SSRPDsPtRSQAQTP
0 3 S2512-p RKLPPNLsPTIEYND
0 4 S2533 HDIARSHSESPSRLP
0 4 S2535 IARSHSESPSRLPIN
0 1 S2569 STWRRTGSSSSILSA
0 3 P2607 QMKENQVPTKGTWRK
0 5 T2611 NQVPTKGTWRKIKES
0 153 Y2645 AESKPLIYQMAPPVS
0 4 S2671-p CPINNPRsGRSPtGN
0 4 S2674 NNPRsGRSPtGNtPP
0 4 T2676-p PRsGRSPtGNtPPVI
0 4 T2679-p GRSPtGNtPPVIDSV
0 5 S2713-p KQSVGSGsPVQTVGL
0 10 S2726 GLETRLNSFVQVEAP
0 1 S2766 AERTPFSSSSSSKHS
0 1 S2770 PFSSSSSSKHSsPSG
0 3 S2774-p SSSSKHSsPSGTVAA
2 4 S2791 TPFNYNPSPRKSSAD
1 0 S2795 YNPSPRKSSADSTSA
0 1 T2822-p TKKRDSKtDItESSG
0 1 T2825-p RDSKtDItESSGAQS
0 1 - gap
0 4 S2837 AQSPKRHSGSYLVTS
0 1 S2839 SPKRHSGSYLVTSV_
0 2 Y2840 PKRHSGSYLVTSV__
  APC iso5  
Y94 SKMSLRSYGSREGSV
S96 MSLRSYGSREGSVSS
S105 EGSVSSRSGECSPVP
S109 SSRSGECSPVPMGSF
Y314 GTKVEMVYSLLSMLG
S742 YKDANIMSPGSSLPS
S746 NIMSPGSSLPSLHVR
S778 FDNIDNLSPKASHRS
- gap
Y794 QRHKQNLYGDYAFDA
Y797 KQNLYGDYAFDANRH
Y861 RGIGLSAYHPTTENA
T865 LSAYHPTTENAGTSS
S893 AKVMEEVSAIHTSQD
T897 EEVSAIHTSQDDRSS
S906 QDDRSSASTTEFHCV
Y933 SHTHSNTYNFTKSEN
Y949 NRTCSMPYAKVEYKR
S961 YKRSSNDSLNSVTSS
S983 QMKPSVESYSEDDES
S1030 INYSLKYSDEQLNSG
S1036 YSDEQLNSGRQSPSQ
S1040 QLNSGRQSPSQNERW
Y1076 QNTSYPVYSENTDDK
S1098 FGQQECVSPYRSRGT
Y1100 QQECVSPYRSRGTSG
S1179 VDQPIDYSLKYATDI
Y1182 PIDYSLKYATDISSS
S1193 ISSSQKPSFSFSKNS
S1211 STKPEHLSPSSENTA
- gap
S1277 SRCSSLSSLSSADDE
S1359 EFSSGAKSPSKSGAQ
S1361 SSGAKSPSKSGAQTP
S1363 GAKSPSKSGAQTPKS
S1370 SGAQTPKSPPEHYVQ
T1379 PEHYVQETPLVFSRC
S1384 QETPLVFSRCTSVSS
S1388 LVFSRCTSVSSLDSF
S1391 SRCTSVSSLDSFESR
T1437 MPPSRSKTPPPPPQT
S1500 ESTPDGFSCSSSLSA
S1502 TPDGFSCSSSLSALS
S1503 PDGFSCSSSLSALSL
S1504 DGFSCSSSLSALSLD
S1506 FSCSSSLSALSLDEP
S1509 SSSLSALSLDEPFIQ
- gap
S1557 KEVEKPDSEKDLLDD
S1608 PPVARKPSQLPVYKL
Y1613 KPSQLPVYKLLPAQN
T1631 AQKHVSFTPGDDVPR
S1662 LSDLTIESPPNELAT
T1695 IPTEGRSTDDAQRGK
T1708 GKISSIVTPDLDDNK
N1714 VTPDLDDNKAEEGDI
T1771 DTKKKKPTSPVKPMP
S1772 TKKKKPTSPVKPMPQ
Y1844 ALDSPHHYTPIEGTP
Y1852 TPIEGTPYCFSRNDS
S1859 YCFSRNDSLSSLDFD
S1861 FSRNDSLSSLDFDDD
S1862 SRNDSLSSLDFDDDD
T1930 PVLQKQPTFPQSSKD
S1994 KEAEPANSQGEPSKP
S2021-p EDTPVCFsRNSSLSS
S2033 LSSLSIDSEDDLLQE
S2053 MPKKKRPSRLKSESE
S2057 KRPSRLKSESEKQSP
S2087-p KDLQRPDsEHAFsPD
S2092-p PDsEHAFsPDSENFD
S2095 EHAFsPDSENFDWKA
S2125 AAAAACLSRQASSDS
S2129 ACLSRQASSDSDSIL
S2130 CLSRQASSDSDSILS
S2132 SRQASSDSDSILSLK
S2140 DSILSLKSGISLGSP
S2146 KSGISLGSPFHLTPD
T2151 LGSPFHLTPDQEEKP
S2260 LKTPASKSPSEGPGA
S2262 TPASKSPSEGPGATT
S2270 EGPGATTSPRGTKPA
S2283 PAGKSELSPITRQTS
S2290 SPITRQTSQISGSNK
S2330 SPGRNSISPGRNGIS
S2337 SPGRNGISPPNKLSQ
S2349 LSQLPRTSSPSTAST
Y2366 SGSGKMSYTSPGRQL
S2368 SGKMSYTSPGRQLSQ
S2374 TSPGRQLSQQNLTKQ
S2421 VELSRMSSTKSSGSE
S2441 RPALVRQSTFIKEAP
T2442 PALVRQSTFIKEAPS
S2449 TFIKEAPSPTLRRKL
T2451 IKEAPSPTLRRKLEE
S2461 RKLEESASFESLSPS
S2464 EESASFESLSPSSRP
S2473 SPSSRPDSPTRSQAQ
T2475 SSRPDSPTRSQAQTP
S2512 RKLPPNLSPTIEYND
S2533 HDIARSHSESPSRLP
S2535 IARSHSESPSRLPIN
S2569 STWRRTGSSSSILSA
P2607 QMKENQVPTKGTWRK
T2611 NQVPTKGTWRKIKES
Y2645 AESKPLIYQMAPPVS
S2671 CPINNPRSGRSPTGN
S2674 NNPRSGRSPTGNTPP
T2676 PRSGRSPTGNTPPVI
T2679 GRSPTGNTPPVIDSV
S2710 KQSVGSGSPVQTVGL
S2723 GLETRLNSFVQVEAP
S2763 AERTPFSSSSSSKHS
S2767 PFSSSSSSKHSSPSG
S2771 SSSSKHSSPSGTVAA
S2788 TPFNYNPSPRKSSAD
S2792 YNPSPRKSSADSTSA
T2819 TKKRDSKTDSTESSG
T2822 RDSKTDSTESSGAQS
- gap
S2834 AQSPKRHSGSYLVTS
S2836 SPKRHSGSYLVTSV_
Y2837 PKRHSGSYLVTSV__
  human

 
Y96-p SKMSLRSyGsREGSV
S98-p MSLRSyGsREGSVSS
S107-p EGSVSSRsGECsPVP
S111-p SSRsGECsPVPMGSF
Y316-p GTKVEMVySLLSMLG
S744-p YKDANIMsPGSsLPS
S748-p NIMsPGSsLPSLHVR
S780-p FDNIDNLsPKASHRS
S794-p SKQRHKQsLyGDyVF
Y796-p QRHKQsLyGDyVFDT
Y799-p KQsLyGDyVFDTNRH
Y863-p RGIGLGNyHPAtENP
T867-p LGNyHPAtENPGTSS
S895-p AKVMEEVsAIHtSQE
T899-p EEVsAIHtSQEDRSS
S908-p QEDRSSGsTTELHCV
Y935-p AHTHSNTyNFTKSEN
Y951-p NRTCSMPyAKLEYKR
S963-p YKRSSNDsLNSVSSS
S985 QMKPSIESYSEDDES
S1032-p INYSLKYsDEQLNsG
S1038-p YsDEQLNsGRQsPSQ
S1042-p QLNsGRQsPSQNERW
Y1078-p QSTTYPVyTESTDDK
S1100-p FGQQECVsPyRSRGA
Y1102-p QQECVsPyRSRGANG
S1180 VDQPIDYSLKyATDI
Y1183-p PIDYSLKyATDIPSS
S1194 IPSSQKQSFSFSKSS
S1212 SSKTEHMSSSSENTS
T1220-p SSSENTStPSSNAKR
S1279-p SRCSSLSsLSSAEDE
S1360-p EFSSGAKsPsKsGAQ
S1362-p SSGAKsPsKsGAQTP
S1364-p GAKsPsKsGAQTPKs
S1371-p sGAQTPKsPPEHYVQ
T1380-p PEHYVQEtPLMFsRC
S1385-p QEtPLMFsRCTSVSs
S1389 LMFsRCTSVSsLDSF
S1392-p sRCTSVSsLDSFESR
T1438-p MPPSRSKtPPPPPQT
S1501-p ESTPDGFsCsssLsA
S1503-p TPDGFsCsssLsALs
S1504-p PDGFsCsssLsALsL
S1505-p DGFsCsssLsALsLD
S1507-p FsCsssLsALsLDEP
S1510-p sssLsALsLDEPFIQ
T1556-p QEKEAEKtIDSEKDL
S1559 EAEKtIDSEKDLLDD
S1610-p PPVARKPsQLPVyKL
Y1615-p KPsQLPVyKLLPSQN
T1633-p PQKHVSFtPGDDMPR
S1664 LSDLTIESPPNELAA
T1697 IPTEGRSTDEAQGGK
I1710 GKTSSVTIPELDDNK
N1716 TIPELDDNKAEEGDI
T1773-p DGKKKKPtsPVKPIP
S1774-p GKKKKPtsPVKPIPQ
Y1846-p AFDSPHHyTPIEGTP
Y1854-p TPIEGTPyCFSRNDs
S1861-p yCFSRNDsLssLDFD
S1863-p FSRNDsLssLDFDDD
S1864-p SRNDsLssLDFDDDD
T1932-p PILQKQStFPQSSKD
S1995 KETEPPDSQGEPSKP
S2022-p EDTPVCFsRNSSLSS
S2034-p LSSLSIDsEDDLLQE
S2054-p MPKKKKPsRLKGDNE
G2058 KKPsRLKGDNEKHSP
S2088-p KDIQRPDsEHGLsPD
S2093-p PDsEHGLsPDsENFD
S2096-p EHGLsPDsENFDWKA
S2125-p AAAAACLsRQAssDS
S2129-p ACLsRQAssDSDSIL
S2130-p CLsRQAssDSDSILS
S2132 sRQAssDSDSILSLK
S2140-p DSILSLKsGISLGsP
S2146-p KsGISLGsPFHLtPD
T2151-p LGsPFHLtPDQEEKP
S2260-p LKTPASKsPsEGQTA
S2262-p TPASKsPsEGQTATT
S2270-p EGQTATTsPRGAKPS
S2283-p PSVKSELsPVARQTs
S2290-p sPVARQTsQIGGSSK
S2330-p SPGRNSIsPGRNGIs
S2337-p sPGRNGIsPPNKLSQ
S2349 LSQLPRTSSPSTAST
Y2366-p SGSGKMSyTsPGRQM
S2368-p SGKMSyTsPGRQMsQ
S2374-p TsPGRQMsQQNLTKQ
S2421-p VELSRMSsTKSSGSE
S2441-p RPVLVRQstFIKEAP
T2442-p PVLVRQstFIKEAPs
S2449-p tFIKEAPsPtLRRKL
T2451-p IKEAPsPtLRRKLEE
S2461-p RKLEESAsFEsLSPS
S2464-p EESAsFEsLSPSSRP
S2473-p SPSSRPAsPTRSQAQ
T2475 SSRPAsPTRSQAQTP
S2512-p RKLPPNLsPTIEYND
S2533-p HDIARSHsEsPSRLP
S2535-p IARSHsEsPSRLPIN
S2569-p STWRRTGsSSSILSA
S2607-p QSKENQVsAKGtWRK
T2611-p NQVsAKGtWRKIKEN
Y2645-p AESKTLIyQMAPAVS
S2671-p CPINNPRsGRsPtGN
S2674-p NNPRsGRsPtGNtPP
T2676-p PRsGRsPtGNtPPVI
T2679-p GRsPtGNtPPVIDSV
V2711 QNVGNGSVPMRTVGL
S2724-p GLENRLNsFIQVDAP
S2764-p VERTPFSsSSSsKHS
S2768-p PFSsSSSsKHSsPSG
S2772-p SSSsKHSsPSGTVAA
S2789-p TPFNYNPsPRKsSAD
S2793-p YNPsPRKsSADSTSA
T2820 TKKRDSKTDStESSG
T2823-p RDSKTDStESSGtQS
T2828-p DStESSGtQSPKRHs
S2835-p tQSPKRHsGsyLVTS
S2837-p SPKRHsGsyLVTSV_
Y2838-p PKRHsGsyLVTSV__
  rat

 
Y94 SKMSLRSYGSREGSV
S96 MSLRSYGSREGSVSS
S105 EGSVSSRSGECSPVP
S109 SSRSGECSPVPMGSF
Y314 GTKVEMVYSLLSMLG
S742 YKDANIMSPGSSLPS
S746 NIMSPGSSLPSLHVR
S778-p FDNIDNLsPKASHRS
- gap
Y794 QRHKQNLYGDYVFDA
Y797 KQNLYGDYVFDASRH
Y861 RGIGLSTYHSATENP
T865 LSTYHSATENPGTSS
S893 AKVMEEVSALHTSQD
T897 EEVSALHTSQDDRSP
S906 QDDRSPASAAELHCV
H933 SHTHPNTHNFAKSES
Y949 NRTCSMPYAKVEYKR
S961 YKRSSNDSLNSVTSS
S983 QMKPSVESYSEDDEG
S1030 INYSLKYSDEQLNSG
S1036 YSDEQLNSGRQSPSQ
S1040 QLNSGRQSPSQNERW
Y1076 QNTNFPVYSENTDDK
S1098 FGQQECVSPYRSRGT
Y1100 QQECVSPYRSRGTNG
S1178-p VDQPIDYsLKYATDI
Y1181 PIDYsLKYATDISSS
S1192 ISSSQKPSFSFSKTP
S1210 GTKTEHNSPSSEAAS
- gap
S1276 SRCSSLSSLSSAEDE
S1357 EFSSGAKSPSKSGAQ
S1359 SSGAKSPSKSGAQTP
S1361 GAKSPSKSGAQTPKS
S1368 SGAQTPKSPPEHYVQ
T1377 PEHYVQETPLVFSRC
S1382 QETPLVFSRCTSVSS
S1386 LVFSRCTSVSSLDSF
S1389 SRCTSVSSLDSFESR
T1435-p MPPSRSKtPPPPPPP
S1500 ESTPDGFSCSSSLSA
S1502 TPDGFSCSSSLSALS
S1503 PDGFSCSSSLSALSL
S1504 DGFSCSSSLSALSLD
S1506 FSCSSSLSALSLDEP
S1509 SSSLSALSLDEPFIQ
- gap
S1557 KEVEKPDSEKDLLDD
S1608 PPVARKPSQLPVYKL
Y1613 KPSQLPVYKLLPSQS
T1631 AQKHVSFTPGDDVPR
S1662 LSDLTIESPPNELAA
T1695-p IPTEGRStDEAQRGK
I1708 GKVSSIAIPDLDGsK
S1714-p AIPDLDGsKAEEGDI
T1771 DTKKKKPTSPVKPMP
S1772 TKKKKPTSPVKPMPQ
Y1844 TFDSPHHYAPIEGTP
Y1852 APIEGTPYCFSRNDS
S1859 YCFSRNDSLSSLDFD
S1861 FSRNDSLSSLDFDDD
S1862 SRNDSLSSLDFDDDD
T1930 PLLQEQPTFPQSSKD
- gap
S2021 EDTPVCFSRNSSLSS
S2033 LSSLSIDSEDDLLRE
S2053 MPKKRRPSRLKGEGE
- gap
S2087 KDIQRPESEHGLSPD
S2092 PESEHGLSPDSENFD
S2095 EHGLSPDSENFDWKA
S2125 AAAAACLSRQASSDS
S2129 ACLSRQASSDSDSIL
S2130 CLSRQASSDSDSILS
S2132 SRQASSDSDSILSLK
S2140 DSILSLKSGVSLGSP
S2146 KSGVSLGSPFHLTPD
T2151 LGSPFHLTPDQEEKP
S2260 LKTPASKSPSEGPVA
S2262 TPASKSPSEGPVATT
S2270 EGPVATTSPRGTKPA
S2283 PAVKSELSPITRQTS
S2290 SPITRQTSHISGSNK
S2330 SPGRNSISPGRNGIS
S2337 SPGRNGISTPNKLSQ
S2349 LSQLPRTSSPSTAST
Y2366 SGSGKMSYTSPGRQL
S2368 SGKMSYTSPGRQLSQ
S2374 TSPGRQLSQQNLSKQ
S2421 VELSRMSSTKSSGSE
S2441 RPALVRQSTFIKEAP
T2442 PALVRQSTFIKEAPS
S2449 TFIKEAPSPTLRRKL
T2451 IKEAPSPTLRRKLEE
S2461 RKLEESASFESLSPS
S2464 EESASFESLSPSSRP
S2473 SPSSRPDSPTRSQAQ
T2475 SSRPDSPTRSQAQTP
S2512 RKLPPNLSPTIEYSD
S2533 HDIARSHSESPSRLP
S2535 IARSHSESPSRLPVN
S2569 STWRRTGSSSSILSA
P2607 QMKENQVPTKGTWRK
T2611 NQVPTKGTWRKIKES
Y2645 AESKTLIYQMAPAVS
S2671 CPINNPRSGRSPTGN
S2674 NNPRSGRSPTGNTPP
T2676 PRSGRSPTGNTPPVI
T2679 GRSPTGNTPPVIDSI
S2710-p KQSVGSGsPVQTVGL
S2723 GLENRLNSFIQVEAP
S2763 AERTPFSSSSSSKHS
S2767 PFSSSSSSKHSsPSG
S2771-p SSSSKHSsPSGTVAA
S2788 TPFNYNPSPRKSSAD
S2792 YNPSPRKSSADSTSA
T2819 TKKRDSKTDSTESSG
T2822 RDSKTDSTESSGAQS
- gap
S2834 AQSPKRHSGSYLVTS
S2836 SPKRHSGSYLVTSV_
Y2837 PKRHSGSYLVTSV__
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