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Protein Page:
APC (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
APC a tumor suppressor. Defects in APC are a cause of familial adenomatous polyposis (FAP). Promotes rapid degradation of CTNNB1 and participates in Wnt signaling. Activity is correlated with its phosphorylation state. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Tumor suppressor
Cellular Component: kinetochore; centrosome; cell-cell adherens junction; tight junction; lamellipodium; cytoplasmic microtubule; cytoplasm; plasma membrane; cytosol; beta-catenin destruction complex; nucleus; lateral plasma membrane
Molecular Function: microtubule plus-end binding; protein binding; cadherin binding; microtubule binding; gamma-catenin binding; beta-catenin binding; protein kinase regulator activity; protein kinase binding
Biological Process: positive regulation of cell adhesion; apoptosis; positive regulation of apoptosis; somatic stem cell maintenance; positive regulation of microtubule polymerization; T cell differentiation in the thymus; Wnt receptor signaling pathway through beta-catenin; chromosome organization and biogenesis; cytoplasmic microtubule organization and biogenesis; anterior/posterior pattern formation; muscle maintenance; negative regulation of cell proliferation; regulation of osteoclast differentiation; hair follicle development; cytokinesis after mitosis; mitotic cell cycle spindle assembly checkpoint; positive regulation of epithelial cell differentiation; protein complex assembly; cell cycle arrest; cell adhesion; kidney development; proximal/distal pattern formation; cell structure disassembly during apoptosis; regulation of microtubule-based process; negative regulation of odontogenesis; cell migration; regulation of attachment of spindle microtubules to kinetochore; thymus development; regulation of osteoblast differentiation; negative regulation of microtubule depolymerization; negative regulation of MAPKKK cascade; axis specification; negative regulation of cyclin-dependent protein kinase activity; positive regulation of pseudopodium formation; axonogenesis; dorsal/ventral pattern formation; retina development in camera-type eye; positive regulation of cell division; positive regulation of protein catabolic process; regulation of nitrogen compound metabolic process; response to DNA damage stimulus; mitotic metaphase/anaphase transition; positive regulation of cell migration
Reference #:  P25054 (UniProtKB)
Alt. Names/Synonyms: adenomatosis polyposis coli tumor suppressor; adenomatous polyposis coli; Adenomatous polyposis coli protein; APC; BTPS2; Deleted in polyposis 2.5; DP2; DP2.5; DP3; GS; Protein APC
Gene Symbols: APC
Molecular weight: 311,646 Da
Basal Isoelectric point: 7.92  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  ESC Pluripotency and Differentiation  |  Microtubule Dynamics  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

APC

Protein Structure Not Found.


STRING  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  DISEASE  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Sites Implicated In
cell cycle regulation: S1360‑p
transcription, altered: S1279‑p, S1392‑p
intracellular localization: S2034‑p, S2054‑p
molecular association, regulation: S1279‑p, S1505‑p, S1507‑p, S2789‑p, S2793‑p
phosphorylation: S1501‑p, S1505‑p, S1507‑p, S1510‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S92 VKLRSKMSLRsyGsR
0 1 S95-p RSKMSLRsyGsREGS
0 3 Y96-p SKMSLRsyGsREGSV
0 3 S98-p MSLRsyGsREGSVSS
0 2 S107-p EGSVSSRsGECsPVP
0 3 S111-p SSRsGECsPVPMGSF
0 1 T297-p SVLSSSStHSAPRRL
0 5 Y316-p GTKVEMVysLLSMLG
0 1 S317-p TKVEMVysLLSMLGT
0 1 S331-p THDKDDMsRtLLAMS
0 1 T333-p DKDDMsRtLLAMSSS
0 1 S552-p ASVLRNLsWRADVNS
0 1 K561-m2 RADVNSKkTLREVGS
0 1 T562 ADVNSKkTLREVGSV
0 1 K580-m2 MECALEVkKESTLKS
0 1 T600-p WNLSAHCtENKADIC
0 5 S744-p YKDANIMsPGSsLPS
0 3 S748-p NIMsPGSsLPSLHVR
0 10 S780-p FDNIDNLsPKASHRS
0 3 S794-p SKQRHKQsLyGDyVF
0 5 Y796-p QRHKQsLyGDyVFDT
0 11 Y799-p KQsLyGDyVFDTNRH
0 1 S851-p SRSEKDRsLERERGI
0 44 Y863-p RGIGLGNyHPAtENP
0 2 T867-p LGNyHPAtENPGtSs
0 1 T872-p PAtENPGtSsKRGLQ
0 1 S874-p tENPGtSsKRGLQIS
0 1 T883-p RGLQISTtAAQIAKV
0 1 S895-p AKVMEEVsAIHtSQE
0 1 T899-p EEVsAIHtSQEDRSS
0 1 S908-p QEDRSSGsTTELHCV
0 2 Y935-p AHTHSNTyNFTKSEN
0 31 Y951-p NRTCSMPyAKLEYKR
0 2 S963-p YKRSSNDsLNSVSSS
0 1 S985 QMKPSIESYsEDDES
0 1 S987-p KPSIESYsEDDESKF
0 1 S1032-p INYSLKYsDEQLNsG
0 6 S1038-p YsDEQLNsGRQsPsQ
0 8 S1042-p QLNsGRQsPsQNERW
0 1 S1044-p NsGRQsPsQNERWAR
0 8 Y1078-p QSTTYPVyTEsTDDK
0 1 S1081-p TYPVyTEsTDDKHLK
0 11 S1100-p FGQQECVsPyRSRGA
0 8 Y1102-p QQECVsPyRSRGANG
0 1 S1180 VDQPIDYSLKyATDI
0 1 Y1183-p PIDYSLKyATDIPSS
0 3 S1194-p IPSSQKQsFSFSKSS
0 1 S1196 SSQKQsFSFSKSSSG
0 2 S1212 SSKTEHMSSssENts
0 1 S1214-p KTEHMSSssENtstP
0 1 S1215-p TEHMSSssENtstPs
0 1 T1218-p MSSssENtstPssNA
0 1 S1219-p SSssENtstPssNAK
0 8 T1220-p SssENtstPssNAKR
0 1 S1222-p sENtstPssNAKRQN
0 1 S1223-p ENtstPssNAKRQNQ
0 1 S1278-p FSRCSSLssLSSAED
1 0 S1279-p SRCSSLssLSSAEDE
0 1 T1292-p DEIGCNQtTQEADSA
0 1 T1301-p QEADSANtLQIAEIK
0 2 S1344-p LQGSSLSsEsARHKA
0 1 S1346-p GSSLSsEsARHKAVE
1 7 S1360-p EFSSGAKsPsKsGAQ
0 1 S1362-p SSGAKsPsKsGAQtP
0 2 S1364-p GAKsPsKsGAQtPKs
0 2 T1368-p PsKsGAQtPKsPPEH
0 7 S1371-p sGAQtPKsPPEHYVQ
0 2 T1380-p PEHYVQEtPLMFsRC
1 3 S1385-p QEtPLMFsRCTsVSs
1 1 S1389-p LMFsRCTsVSsLDSF
2 1 S1392-p sRCTsVSsLDSFESR
0 1 S1436-p QTMPPSRsKtPPPPP
0 7 T1438-p MPPSRsKtPPPPPQT
0 1 T1448-p PPPQTAQtKREVPKN
0 1 T1459-p VPKNKAPtAEKRESG
1 0 S1501-p ESTPDGFsCsssLsA
1 0 S1503-p TPDGFsCsssLsALs
1 0 S1504-p PDGFsCsssLsALsL
2 0 S1505-p DGFsCsssLsALsLD
2 0 S1507-p FsCsssLsALsLDEP
1 0 S1510-p sssLsALsLDEPFIQ
0 1 T1556-p QEKEAEKtIDSEKDL
0 1 S1559 EAEKtIDSEKDLLDD
0 16 S1610-p PPVARKPsQLPVyKL
0 4 Y1615-p KPsQLPVyKLLPSQN
0 1 T1633-p PQKHVSFtPGDDMPR
0 1 S1664 LSDLTIESPPNELAA
0 1 T1697 IPTEGRSTDEAQGGK
0 1 I1710 GKTSSVTIPELDDNK
0 1 N1716 TIPELDDNKAEEGDI
0 1 S1737-p SAMPKGKsHKPFRVK
0 1 T1773-p DGKKKKPtsPVKPIP
0 3 S1774-p GKKKKPtsPVKPIPQ
0 1 Y1785 PIPQNTEYRTRVRKN
0 1 S1842-p RGSFAFDsPHHytPI
0 2 Y1846-p AFDsPHHytPIEGtP
0 2 T1847-p FDsPHHytPIEGtPy
0 2 T1852-p HytPIEGtPyCFSRN
0 5 Y1854-p tPIEGtPyCFSRNDs
0 4 S1861-p yCFSRNDsLssLDFD
0 3 S1863-p FSRNDsLssLDFDDD
0 4 S1864-p SRNDsLssLDFDDDD
0 1 S1906-p ELTSNQQsANKTQAI
0 1 T1932-p PILQKQStFPQSSKD
0 1 S1995 KETEPPDSQGEPSKP
0 1 S2011-p ASGYAPKsFHVEDTP
0 3 S2022-p EDTPVCFsRNSSLSS
1 0 S2034-p LSSLSIDsEDDLLQE
2 0 S2054-p MPKKKKPsRLKGDNE
0 2 G2058 KKPsRLKGDNEKHSP
0 1 S2064 KGDNEKHSPRNMGGI
0 5 S2088-p KDIQRPDsEHGLsPD
0 7 S2093-p PDsEHGLsPDsENFD
0 3 S2096-p EHGLsPDsENFDWKA
0 1 S2110-p AIQEGANsIVsSLHQ
0 1 S2113-p EGANsIVsSLHQAAA
0 6 S2125-p AAAAACLsRQAssDs
0 33 S2129-p ACLsRQAssDsDSIL
0 5 S2130-p CLsRQAssDsDSILS
0 3 S2132-p sRQAssDsDSILSLK
0 3 S2140-p DSILSLKsGIsLGsP
0 2 S2143-p LSLKsGIsLGsPFHL
0 10 S2146-p KsGIsLGsPFHLtPD
0 8 T2151-p LGsPFHLtPDQEEKP
0 1 S2183-p LETKKIEsEsKGIkG
0 1 S2185-p TKKIEsEsKGIkGGk
0 1 K2189-ac EsEsKGIkGGkKVYK
0 1 K2192-ac sKGIkGGkKVYKSLI
0 1 T2255-p KKGPPLKtPASKsPs
0 5 S2260-p LKtPASKsPsEGQtA
0 3 S2262-p tPASKsPsEGQtATT
0 1 T2266-p KsPsEGQtATTsPRG
0 4 S2270-p EGQtATTsPRGAKPs
0 1 S2277-p sPRGAKPsVKsELsP
0 1 S2280-p GAKPsVKsELsPVAR
0 7 S2283-p PsVKsELsPVARQTs
0 1 A2286 KsELsPVARQTsQIG
0 13 S2290-p sPVARQTsQIGGSSK
0 1 S2323-p PLSRPIQsPGRNSIs
0 1 S2330-p sPGRNSIsPGRNGIs
0 2 S2337-p sPGRNGIsPPNKLSQ
0 3 S2349 LSQLPRTSSPSTAST
0 1 S2350 SQLPRTSSPSTASTK
0 20 Y2366-p SGSGKMSyTsPGRQM
0 2 S2368-p SGKMSyTsPGRQMsQ
0 16 S2374-p TsPGRQMsQQNLTKQ
0 1 S2390-p GLSKNASsIPRSEsA
0 2 S2396-p SsIPRSEsASKGLNQ
0 1 N2405 SKGLNQMNNGNGANK
0 1 A2410 QMNNGNGANKKVELS
0 10 S2421-p VELSRMSsTKSSGSE
0 1 T2422 ELSRMSsTKSSGSES
0 1 S2432 SGSESDRSERPVLVR
0 3 S2441-p RPVLVRQstFIKEAP
0 18 T2442-p PVLVRQstFIKEAPs
0 18 S2449-p tFIKEAPsPtLRRKL
0 2 T2451-p IKEAPsPtLRRKLEE
0 1 S2461-p RKLEESAsFEsLSPS
0 1 S2464-p EESAsFEsLSPSSRP
0 2 S2473-p SPSSRPAsPTRSQAQ
0 1 T2475 SSRPAsPTRSQAQTP
0 4 S2512-p RKLPPNLsPTIEYND
0 1 T2514 LPPNLsPTIEYNDGR
0 6 S2533-p HDIARSHsEsPSRLP
0 4 S2535-p IARSHsEsPSRLPIN
0 1 S2569-p STWRRTGssSSILSA
0 1 S2570-p TWRRTGssSSILSAS
0 1 S2580-p ILSASSEssEKAKSE
0 1 S2581-p LSASSEssEKAKSED
0 1 S2594-p EDEKHVNsISGTKQS
0 3 S2607-p QSKENQVsAKGtWRK
0 5 T2611-p NQVsAKGtWRKIKEN
0 1 S2621-p KIKENEFsPTNSTSQ
0 157 Y2645-p AESKTLIyQMAPAVS
0 6 S2671-p CPINNPRsGRsPtGN
0 5 S2674-p NNPRsGRsPtGNtPP
0 6 T2676-p PRsGRsPtGNtPPVI
0 5 T2679-p GRsPtGNtPPVIDSV
0 6 V2711 QNVGNGSVPMRTVGL
0 14 S2724-p GLENRLNsFIQVDAP
0 1 S2764-p VERTPFSsSSSsKHS
0 1 S2768-p PFSsSSSsKHSsPSG
0 5 S2772-p SSSsKHSsPSGtVAA
0 1 T2776-p KHSsPSGtVAARVtP
0 1 T2782-p GtVAARVtPFNYNPs
2 5 S2789-p tPFNYNPsPRKssAD
1 0 S2793-p YNPsPRKssADSTSA
0 1 S2794-p NPsPRKssADSTSAR
0 1 T2807-p ARPSQIPtPVNNNTK
0 1 T2820 TKKRDSKTDstEsSG
0 1 S2822-p KRDSKTDstEsSGtQ
0 2 T2823-p RDSKTDstEsSGtQs
0 1 S2825-p SKTDstEsSGtQsPK
0 1 T2828-p DstEsSGtQsPKRHs
0 1 S2830-p tEsSGtQsPKRHsGs
0 5 S2835-p tQsPKRHsGsyLVts
0 1 S2837-p sPKRHsGsyLVtsV_
0 2 Y2838-p PKRHsGsyLVtsV__
0 1 T2841-p HsGsyLVtsV_____
0 1 S2842-p sGsyLVtsV______
  mouse

► Hide Isoforms
 
S90-p VKLRSKMsLRSyGsR
S93 RSKMsLRSyGsREGS
Y94-p SKMsLRSyGsREGSV
S96-p MsLRSyGsREGSVSS
S105-p EGSVSSRsGECsPVP
S109-p SSRsGECsPVPMGSF
T295 SVLSSSGTHSAPRRL
Y314 GTKVEMVYSLLSMLG
S315 TKVEMVYSLLSMLGT
S329 THDKDDMSRTLLAMS
T331 DKDDMSRTLLAMSSS
S550 ASVLRNLSWRADVNS
K559 RADVNSKKtLREVGS
T560-p ADVNSKKtLREVGSV
K578 MECALEVKKESTLKS
T598 WNLSAHCTENKADIC
S742-p YKDANIMsPGSsLPS
S746-p NIMsPGSsLPSLHVR
S778-p FDNIDNLsPKASHRS
- gap
Y794 QRHKQNLYGDYAFDA
Y797 KQNLYGDYAFDANRH
S849 SRSEKDRSLERERGI
Y861 RGIGLSAYHPTTENA
T865 LSAYHPTTENAGTSS
T870 PTTENAGTSSKRGLQ
S872 TENAGTSSKRGLQIT
T881 RGLQITTTAAQIAKV
S893 AKVMEEVSAIHTSQD
T897 EEVSAIHTSQDDRSS
S906 QDDRSSASTTEFHCV
Y933 SHTHSNTYNFTKSEN
Y949 NRTCSMPYAKVEYKR
S961-p YKRSSNDsLNSVTSS
S983-p QMKPSVEsYSEDDES
S985 KPSVEsYSEDDESKF
S1030 INYSLKYSDEQLNsG
S1036-p YSDEQLNsGRQsPSQ
S1040-p QLNsGRQsPSQNERW
S1042 NsGRQsPSQNERWAR
Y1076 QNTSYPVYSENTDDK
- gap
S1098-p FGQQECVsPYRSRGT
Y1100 QQECVsPYRSRGTSG
S1179 VDQPIDYSLKYATDI
Y1182 PIDYSLKYATDISSS
S1193-p ISSSQKPsFsFSKNS
S1195-p SSQKPsFsFSKNSSA
S1211-p STKPEHLsPSSENTA
S1213 KPEHLsPSSENTAVP
S1214 PEHLsPSSENTAVPP
T1217 LsPSSENTAVPPSNA
- gap
- gap
- gap
S1222 ENTAVPPSNAKRQNQ
S1276 FSRCSSLSSLSSADD
S1277 SRCSSLSSLSSADDE
T1290 DEIGCDQTTQEADSA
T1299 QEADSANTLQTAEVK
S1342 LQASGLSSESTRHNK
S1344 ASGLSSESTRHNKAV
S1359-p EFSSGAKsPSKsGAQ
S1361 SSGAKsPSKsGAQTP
S1363-p GAKsPSKsGAQTPKs
T1367 PSKsGAQTPKsPPEH
S1370-p sGAQTPKsPPEHYVQ
T1379-p PEHYVQEtPLVFsRC
S1384-p QEtPLVFsRCTsVSs
S1388-p LVFsRCTsVSsLDSF
S1391-p sRCTsVSsLDSFESR
S1435 QTMPPSRSKtPPPPP
T1437-p MPPSRSKtPPPPPQT
- gap
- gap
S1500 ESTPDGFSCSSSLSA
S1502 TPDGFSCSSSLSALS
S1503 PDGFSCSSSLSALSL
S1504 DGFSCSSSLSALSLD
S1506 FSCSSSLSALSLDEP
S1509 SSSLSALSLDEPFIQ
- gap
S1557-p KEVEKPDsEKDLLDD
S1608-p PPVARKPsQLPVYKL
Y1613 KPsQLPVYKLLPAQN
T1631 AQKHVSFTPGDDVPR
S1662-p LSDLTIEsPPNELAT
T1695 IPTEGRSTDDAQRGK
T1708-p GKISSIVtPDLDDNK
N1714 VtPDLDDNKAEEGDI
S1735 SAMPKGKSHKPFRVK
T1771-p DTKKKKPtSPVKPMP
S1772 TKKKKPtSPVKPMPQ
Y1783-p PMPQNTEyRTRVRKN
S1840 RGTFALDSPHHYTPI
Y1844 ALDSPHHYTPIEGTP
T1845 LDSPHHYTPIEGTPY
T1850 HYTPIEGTPYCFSRN
Y1852 TPIEGTPYCFSRNDs
S1859-p YCFSRNDsLssLDFD
S1861-p FSRNDsLssLDFDDD
S1862-p SRNDsLssLDFDDDD
- gap
T1930-p PVLQKQPtFPQSSKD
S1994-p KEAEPANsQGEPSKP
S2010 ASGYAPKSFHVEDTP
S2021 EDTPVCFSRNSSLSS
S2033 LSSLSIDSEDDLLQE
S2053 MPKKKRPSRLKsESE
S2057-p KRPSRLKsESEKQsP
S2063-p KsESEKQsPRKVGGI
S2087 KDLQRPDSEHAFsPG
S2092-p PDSEHAFsPGSENFD
S2095 EHAFsPGSENFDWKA
S2109 AIQEGANSIVSSLHQ
S2112 EGANSIVSSLHQAAA
S2125-p AAAAACLsRQAssDs
S2129-p ACLsRQAssDsDSIL
S2130-p CLsRQAssDsDSILS
S2132-p sRQAssDsDSILSLK
S2140-p DSILSLKsGIsLGsP
S2143-p LSLKsGIsLGsPFHL
S2146-p KsGIsLGsPFHLtPD
T2151-p LGsPFHLtPDQEEKP
S2183 LEAKKIESENKGIKG
- gap
K2189 ESENKGIKGGKKVYK
K2192 NKGIKGGKKVYKSLI
T2255 KKGPPLKTPASKsPs
S2260-p LKTPASKsPsEGPGA
S2262-p TPASKsPsEGPGATT
- gap
S2270-p EGPGATTsPRGTKPA
A2277 sPRGTKPAGKSELsP
S2280 GTKPAGKSELsPItR
S2283-p PAGKSELsPItRQTs
T2286-p KSELsPItRQTsQIS
S2290-p sPItRQTsQISGSNK
S2323 PLSRPMQSPGRNSIS
S2330 SPGRNSISPGRNGIS
S2337 SPGRNGISPPNKLSQ
S2349-p LSQLPRTssPSTAST
S2350-p SQLPRTssPSTASTK
Y2366 SGSGKMSYTsPGRQL
S2368-p SGKMSYTsPGRQLsQ
S2374-p TsPGRQLsQQNLTKQ
S2390 SLSKNASSIPRSESA
S2396 SSIPRSESASKGLNQ
S2405-p SKGLNQMsNGNGsNK
S2410-p QMsNGNGsNKKVELS
S2421-p VELSRMSstKSSGSE
T2422-p ELSRMSstKSSGSES
S2432-p SGSESDSsERPALVR
S2441 RPALVRQSTFIKEAP
T2442 PALVRQSTFIKEAPs
S2449-p TFIKEAPsPtLRRKL
T2451-p IKEAPsPtLRRKLEE
S2461-p RKLEESAsFESLSPS
S2464 EESAsFESLSPSSRP
S2473-p SPSSRPDsPtRSQAQ
T2475-p SSRPDsPtRSQAQTP
S2512-p RKLPPNLsPtIEYND
T2514-p LPPNLsPtIEYNDGR
S2533 HDIARSHSESPSRLP
S2535 IARSHSESPSRLPIN
S2569 STWRRTGSSSSILSA
S2570 TWRRTGSSSSILSAS
S2580 ILSASSESSEKAKSE
S2581 LSASSESSEKAKSED
S2594 EDERHVSSMPAPRQM
P2607 QMKENQVPTKGTWRK
T2611 NQVPTKGTWRKIKES
S2621 KIKESDISPTGMASQ
Y2645 AESKPLIYQMAPPVS
S2671-p CPINNPRsGRSPtGN
S2674 NNPRsGRSPtGNtPP
T2676-p PRsGRSPtGNtPPVI
T2679-p GRSPtGNtPPVIDSV
S2713-p KQSVGSGsPVQTVGL
S2726 GLETRLNSFVQVEAP
S2766 AERTPFSSSSSSKHS
S2770 PFSSSSSSKHSsPSG
S2774-p SSSSKHSsPSGTVAA
T2778 KHSsPSGTVAARVTP
T2784 GTVAARVTPFNYNPS
S2791 TPFNYNPSPRKSSAD
S2795 YNPSPRKSSADSTSA
S2796 NPSPRKSSADSTSAR
T2809 ARPSQIPTPVSTNTK
T2822-p TKKRDSKtDItESSG
I2824 KRDSKtDItESSGAQ
T2825-p RDSKtDItESSGAQS
S2827 SKtDItESSGAQSPK
- gap
S2832 tESSGAQSPKRHSGS
S2837 AQSPKRHSGSYLVTS
S2839 SPKRHSGSYLVTSV_
Y2840 PKRHSGSYLVTSV__
T2843 HSGSYLVTSV_____
S2844 SGSYLVTSV______
  APC iso5  
S90 VKLRSKMSLRSYGSR
S93 RSKMSLRSYGSREGS
Y94 SKMSLRSYGSREGSV
S96 MSLRSYGSREGSVSS
S105 EGSVSSRSGECSPVP
S109 SSRSGECSPVPMGSF
T295 SVLSSSGTHSAPRRL
Y314 GTKVEMVYSLLSMLG
S315 TKVEMVYSLLSMLGT
S329 THDKDDMSRTLLAMS
T331 DKDDMSRTLLAMSSS
S550 ASVLRNLSWRADVNS
K559 RADVNSKKTLREVGS
T560 ADVNSKKTLREVGSV
K578 MECALEVKKESTLKS
T598 WNLSAHCTENKADIC
S742 YKDANIMSPGSSLPS
S746 NIMSPGSSLPSLHVR
S778 FDNIDNLSPKASHRS
- gap
Y794 QRHKQNLYGDYAFDA
Y797 KQNLYGDYAFDANRH
S849 SRSEKDRSLERERGI
Y861 RGIGLSAYHPTTENA
T865 LSAYHPTTENAGTSS
T870 PTTENAGTSSKRGLQ
S872 TENAGTSSKRGLQIT
T881 RGLQITTTAAQIAKV
S893 AKVMEEVSAIHTSQD
T897 EEVSAIHTSQDDRSS
S906 QDDRSSASTTEFHCV
Y933 SHTHSNTYNFTKSEN
Y949 NRTCSMPYAKVEYKR
S961 YKRSSNDSLNSVTSS
S983 QMKPSVESYSEDDES
S985 KPSVESYSEDDESKF
S1030 INYSLKYSDEQLNSG
S1036 YSDEQLNSGRQSPSQ
S1040 QLNSGRQSPSQNERW
S1042 NSGRQSPSQNERWAR
Y1076 QNTSYPVYSENTDDK
- gap
S1098 FGQQECVSPYRSRGT
Y1100 QQECVSPYRSRGTSG
S1179 VDQPIDYSLKYATDI
Y1182 PIDYSLKYATDISSS
S1193 ISSSQKPSFSFSKNS
S1195 SSQKPSFSFSKNSSA
S1211 STKPEHLSPSSENTA
S1213 KPEHLSPSSENTAVP
S1214 PEHLSPSSENTAVPP
T1217 LSPSSENTAVPPSNA
- gap
- gap
- gap
S1222 ENTAVPPSNAKRQNQ
S1276 FSRCSSLSSLSSADD
S1277 SRCSSLSSLSSADDE
T1290 DEIGCDQTTQEADSA
T1299 QEADSANTLQTAEVK
S1342 LQASGLSSESTRHNK
S1344 ASGLSSESTRHNKAV
S1359 EFSSGAKSPSKSGAQ
S1361 SSGAKSPSKSGAQTP
S1363 GAKSPSKSGAQTPKS
T1367 PSKSGAQTPKSPPEH
S1370 SGAQTPKSPPEHYVQ
T1379 PEHYVQETPLVFSRC
S1384 QETPLVFSRCTSVSS
S1388 LVFSRCTSVSSLDSF
S1391 SRCTSVSSLDSFESR
S1435 QTMPPSRSKTPPPPP
T1437 MPPSRSKTPPPPPQT
- gap
- gap
S1500 ESTPDGFSCSSSLSA
S1502 TPDGFSCSSSLSALS
S1503 PDGFSCSSSLSALSL
S1504 DGFSCSSSLSALSLD
S1506 FSCSSSLSALSLDEP
S1509 SSSLSALSLDEPFIQ
- gap
S1557 KEVEKPDSEKDLLDD
S1608 PPVARKPSQLPVYKL
Y1613 KPSQLPVYKLLPAQN
T1631 AQKHVSFTPGDDVPR
S1662 LSDLTIESPPNELAT
T1695 IPTEGRSTDDAQRGK
T1708 GKISSIVTPDLDDNK
N1714 VTPDLDDNKAEEGDI
S1735 SAMPKGKSHKPFRVK
T1771 DTKKKKPTSPVKPMP
S1772 TKKKKPTSPVKPMPQ
Y1783 PMPQNTEYRTRVRKN
S1840 RGSFALDSPHHYTPI
Y1844 ALDSPHHYTPIEGTP
T1845 LDSPHHYTPIEGTPY
T1850 HYTPIEGTPYCFSRN
Y1852 TPIEGTPYCFSRNDS
S1859 YCFSRNDSLSSLDFD
S1861 FSRNDSLSSLDFDDD
S1862 SRNDSLSSLDFDDDD
- gap
T1930 PVLQKQPTFPQSSKD
S1994 KEAEPANSQGEPSKP
S2010 ASGYAPKSFHVEDTP
S2021-p EDTPVCFsRNSSLSS
S2033 LSSLSIDSEDDLLQE
S2053 MPKKKRPSRLKSESE
S2057 KRPSRLKSESEKQSP
S2063 KSESEKQSPRKVGGI
S2087-p KDLQRPDsEHAFsPD
S2092-p PDsEHAFsPDSENFD
S2095 EHAFsPDSENFDWKA
S2109 AIQEGANSIVSSLHQ
S2112 EGANSIVSSLHQAAA
S2125 AAAAACLSRQASSDS
S2129 ACLSRQASSDSDSIL
S2130 CLSRQASSDSDSILS
S2132 SRQASSDSDSILSLK
S2140 DSILSLKSGISLGSP
S2143 LSLKSGISLGSPFHL
S2146 KSGISLGSPFHLTPD
T2151 LGSPFHLTPDQEEKP
S2183 LEAKKIESENKGIKG
- gap
K2189 ESENKGIKGGKKVYK
K2192 NKGIKGGKKVYKSLI
T2255 KKGPPLKTPASKSPS
S2260 LKTPASKSPSEGPGA
S2262 TPASKSPSEGPGATT
- gap
S2270 EGPGATTSPRGTKPA
A2277 SPRGTKPAGKSELSP
S2280 GTKPAGKSELSPITR
S2283 PAGKSELSPITRQTS
T2286 KSELSPITRQTSQIS
S2290 SPITRQTSQISGSNK
S2323 PLSRPMQSPGRNSIS
S2330 SPGRNSISPGRNGIS
S2337 SPGRNGISPPNKLSQ
S2349 LSQLPRTSSPSTAST
S2350 SQLPRTSSPSTASTK
Y2366 SGSGKMSYTSPGRQL
S2368 SGKMSYTSPGRQLSQ
S2374 TSPGRQLSQQNLTKQ
S2390 SLSKNASSIPRSESA
S2396 SSIPRSESASKGLNQ
S2405 SKGLNQMSNGNGSNK
S2410 QMSNGNGSNKKVELS
S2421 VELSRMSSTKSSGSE
T2422 ELSRMSSTKSSGSES
S2432 SGSESDRSERPALVR
S2441 RPALVRQSTFIKEAP
T2442 PALVRQSTFIKEAPS
S2449 TFIKEAPSPTLRRKL
T2451 IKEAPSPTLRRKLEE
S2461 RKLEESASFESLSPS
S2464 EESASFESLSPSSRP
S2473 SPSSRPDSPTRSQAQ
T2475 SSRPDSPTRSQAQTP
S2512 RKLPPNLSPTIEYND
T2514 LPPNLSPTIEYNDGR
S2533 HDIARSHSESPSRLP
S2535 IARSHSESPSRLPIN
S2569 STWRRTGSSSSILSA
S2570 TWRRTGSSSSILSAS
S2580 ILSASSESSEKAKSE
S2581 LSASSESSEKAKSED
S2594 EDERHVSSMPAPRQM
P2607 QMKENQVPTKGTWRK
T2611 NQVPTKGTWRKIKES
S2621 KIKESDISPTGMASQ
Y2645 AESKPLIYQMAPPVS
S2671 CPINNPRSGRSPTGN
S2674 NNPRSGRSPTGNTPP
T2676 PRSGRSPTGNTPPVI
T2679 GRSPTGNTPPVIDSV
S2710 KQSVGSGSPVQTVGL
S2723 GLETRLNSFVQVEAP
S2763 AERTPFSSSSSSKHS
S2767 PFSSSSSSKHSSPSG
S2771 SSSSKHSSPSGTVAA
T2775 KHSSPSGTVAARVTP
T2781 GTVAARVTPFNYNPS
S2788 TPFNYNPSPRKSSAD
S2792 YNPSPRKSSADSTSA
S2793 NPSPRKSSADSTSAR
T2806 ARPSQIPTPVSTNTK
T2819 TKKRDSKTDSTESSG
S2821 KRDSKTDSTESSGAQ
T2822 RDSKTDSTESSGAQs
S2824 SKTDSTESSGAQsPK
- gap
S2829-p TESSGAQsPKRHSGS
S2834 AQsPKRHSGSYLVTS
S2836 sPKRHSGSYLVTSV_
Y2837 PKRHSGSYLVTSV__
T2840 HSGSYLVTSV_____
S2841 SGSYLVTSV______
  rat

 
S90 VKLRSKMSLRSYGSR
S93 RSKMSLRSYGSREGS
Y94 SKMSLRSYGSREGSV
S96 MSLRSYGSREGSVSS
S105 EGSVSSRSGECSPVP
S109 SSRSGECSPVPMGSF
T295 GVLSSSGTHSAPRRL
Y314 GTKVEMVYSLLSMLG
S315 TKVEMVYSLLSMLGT
S329 THDKDDMSRTLLAMS
T331 DKDDMSRTLLAMSSS
S550 ASVLRNLSWRADVNS
K559 RADVNSKKTLREVGS
T560 ADVNSKKTLREVGSV
K578 MECALEVKKESTLKS
T598 WNLSAHCTENKADIC
S742 YKDANIMSPGSSLPS
S746 NIMSPGSSLPSLHVR
S778-p FDNIDNLsPKASHRS
- gap
Y794 QRHKQNLYGDYVFDA
Y797 KQNLYGDYVFDASRH
S849 SRSEKDRSLERERGI
Y861 RGIGLSTYHSATENP
T865 LSTYHSATENPGTSS
T870 SATENPGTSSKRGLQ
S872 TENPGTSSKRGLQLS
T881 RGLQLSATAAQIAKV
S893 AKVMEEVSALHTSQD
T897 EEVSALHTSQDDRSP
S906 QDDRSPASAAELHCV
H933 SHTHPNTHNFAKSES
Y949 NRTCSMPYAKVEYKR
S961 YKRSSNDSLNSVTSS
S983 QMKPSVESYSEDDEG
S985 KPSVESYSEDDEGKF
S1030 INYSLKYSDEQLNSG
S1036 YSDEQLNSGRQSPSQ
S1040 QLNSGRQSPSQNERW
S1042 NSGRQSPSQNERWAR
Y1076 QNTNFPVYSENTDDK
- gap
S1098 FGQQECVSPYRSRGT
Y1100 QQECVSPYRSRGTNG
S1178-p VDQPIDYsLKYATDI
Y1181 PIDYsLKYATDISSS
S1192 ISSSQKPSFSFSKTP
S1194 SSQKPSFSFSKTPSV
S1210 GTKTEHNSPSSEAAS
S1212 KTEHNSPSSEAASAP
S1213 TEHNSPSSEAASAPS
- gap
S1217 SPSSEAASAPSSNAK
- gap
S1220 SEAASAPSSNAKRQS
S1221 EAASAPSSNAKRQSQ
S1275 FSRCSSLSSLSSAED
S1276 SRCSSLSSLSSAEDE
T1289 DEIGCDQTTQEADSA
T1298 QEADSANTLQIAEIK
S1341 LQASGLASESARHKA
S1343 ASGLASESARHKAVE
S1357 EFSSGAKSPSKSGAQ
S1359 SSGAKSPSKSGAQTP
S1361 GAKSPSKSGAQTPKS
T1365 PSKSGAQTPKSPPEH
S1368 SGAQTPKSPPEHYVQ
T1377 PEHYVQETPLVFSRC
S1382 QETPLVFSRCTSVSS
S1386 LVFSRCTSVSSLDSF
S1389 SRCTSVSSLDSFESR
S1433 QTMPPSRSKtPPPPP
T1435-p MPPSRSKtPPPPPPP
T1447 PPPQPVQTKREVPKT
- gap
S1500 ESTPDGFSCSSSLSA
S1502 TPDGFSCSSSLSALS
S1503 PDGFSCSSSLSALSL
S1504 DGFSCSSSLSALSLD
S1506 FSCSSSLSALSLDEP
S1509 SSSLSALSLDEPFIQ
- gap
S1557 KEVEKPDSEKDLLDD
S1608 PPVARKPSQLPVYKL
Y1613 KPSQLPVYKLLPSQS
T1631 AQKHVSFTPGDDVPR
S1662 LSDLTIESPPNELAA
T1695-p IPTEGRStDEAQRGK
I1708 GKVSSIAIPDLDGsK
S1714-p AIPDLDGsKAEEGDI
S1735 SALPKGRSHKPFRVK
T1771 DTKKKKPTSPVKPMP
S1772 TKKKKPTSPVKPMPQ
Y1783 PMPQNTEYRTRVRKN
S1840 RGGFTFDSPHHYAPI
Y1844 TFDSPHHYAPIEGTP
A1845 FDSPHHYAPIEGTPY
T1850 HYAPIEGTPYCFSRN
Y1852 APIEGTPYCFSRNDS
S1859 YCFSRNDSLSSLDFD
S1861 FSRNDSLSSLDFDDD
S1862 SRNDSLSSLDFDDDD
S1904 EPSSSQQSARKAQAS
T1930 PLLQEQPTFPQSSKD
- gap
S2010 ASGYAPKSFHVEDTP
S2021 EDTPVCFSRNSSLSS
S2033 LSSLSIDSEDDLLRE
S2053 MPKKRRPSRLKGEGE
- gap
S2063 KGEGEWQSPRKVGSV
S2087 KDIQRPESEHGLSPD
S2092 PESEHGLSPDSENFD
S2095 EHGLSPDSENFDWKA
S2109 AIQEGANSIVSSLHQ
S2112 EGANSIVSSLHQAAA
S2125 AAAAACLSRQASSDS
S2129 ACLSRQASSDSDSIL
S2130 CLSRQASSDSDSILS
S2132 SRQASSDSDSILSLK
S2140 DSILSLKSGVSLGSP
S2143 LSLKSGVSLGSPFHL
S2146 KSGVSLGSPFHLTPD
T2151 LGSPFHLTPDQEEKP
S2183 LEAKKIESENKGIKG
- gap
K2189 ESENKGIKGGKKVYK
K2192 NKGIKGGKKVYKSLI
T2255 KKGPPLKTPASKSPS
S2260 LKTPASKSPSEGPVA
S2262 TPASKSPSEGPVATT
- gap
S2270 EGPVATTSPRGTKPA
A2277 SPRGTKPAVKSELSP
S2280 GTKPAVKSELSPITR
S2283 PAVKSELSPITRQTS
T2286 KSELSPITRQTSHIS
S2290 SPITRQTSHISGSNK
S2323 PLSRPMQSPGRNSIS
S2330 SPGRNSISPGRNGIS
S2337 SPGRNGISTPNKLSQ
S2349 LSQLPRTSSPSTAST
S2350 SQLPRTSSPSTASTK
Y2366 SGSGKMSYTSPGRQL
S2368 SGKMSYTSPGRQLSQ
S2374 TSPGRQLSQQNLSKQ
S2390 GLSKNASSIPRSESA
S2396 SSIPRSESASKGLNQ
N2405 SKGLNQMNNSNGSNK
S2410 QMNNSNGSNKKVELS
S2421 VELSRMSSTKSSGSE
T2422 ELSRMSSTKSSGSES
S2432 SGSESDRSERPALVR
S2441 RPALVRQSTFIKEAP
T2442 PALVRQSTFIKEAPS
S2449 TFIKEAPSPTLRRKL
T2451 IKEAPSPTLRRKLEE
S2461 RKLEESASFESLSPS
S2464 EESASFESLSPSSRP
S2473 SPSSRPDSPTRSQAQ
T2475 SSRPDSPTRSQAQTP
S2512 RKLPPNLSPTIEYSD
T2514 LPPNLSPTIEYSDGR
S2533 HDIARSHSESPSRLP
S2535 IARSHSESPSRLPVN
S2569 STWRRTGSSSSILSA
S2570 TWRRTGSSSSILSAS
S2580 ILSASSESSEKAKSE
S2581 LSASSESSEKAKSED
S2594 EDEKHVNSVPGPRQM
P2607 QMKENQVPTKGTWRK
T2611 NQVPTKGTWRKIKES
S2621 KIKESEISPTNTVSQ
Y2645 AESKTLIYQMAPAVS
S2671 CPINNPRSGRSPTGN
S2674 NNPRSGRSPTGNTPP
T2676 PRSGRSPTGNTPPVI
T2679 GRSPTGNTPPVIDSI
S2710-p KQSVGSGsPVQTVGL
S2723 GLENRLNSFIQVEAP
S2763 AERTPFSSSSSSKHS
S2767 PFSSSSSSKHSsPSG
S2771-p SSSSKHSsPSGTVAA
T2775 KHSsPSGTVAARVTP
T2781 GTVAARVTPFNYNPS
S2788 TPFNYNPSPRKSSAD
S2792 YNPSPRKSSADSTSA
S2793 NPSPRKSSADSTSAR
T2806 ARPSQIPTPVGSSTK
T2819 TKKRDSKTDSTESSG
S2821 KRDSKTDSTESSGAQ
T2822 RDSKTDSTESSGAQS
S2824 SKTDSTESSGAQSPK
- gap
S2829 TESSGAQSPKRHSGS
S2834 AQSPKRHSGSYLVTS
S2836 SPKRHSGSYLVTSV_
Y2837 PKRHSGSYLVTSV__
T2840 HSGSYLVTSV_____
S2841 SGSYLVTSV______
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