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Protein Page:
APC (human)

Overview
APC a tumor suppressor. Defects in APC are a cause of familial adenomatous polyposis (FAP). Promotes rapid degradation of CTNNB1 and participates in Wnt signaling. Activity is correlated with its phosphorylation state. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Tumor suppressor
Cellular Component: kinetochore; centrosome; tight junction; cell-cell adherens junction; lamellipodium; cytoplasmic microtubule; cytoplasm; plasma membrane; nucleus; cytosol; beta-catenin destruction complex; lateral plasma membrane
Molecular Function: microtubule plus-end binding; protein binding; cadherin binding; gamma-catenin binding; microtubule binding; beta-catenin binding; protein kinase regulator activity; protein kinase binding
Biological Process: positive regulation of cell adhesion; apoptosis; somatic stem cell maintenance; positive regulation of apoptosis; positive regulation of microtubule polymerization; T cell differentiation in the thymus; Wnt receptor signaling pathway through beta-catenin; chromosome organization and biogenesis; cytoplasmic microtubule organization and biogenesis; muscle maintenance; anterior/posterior pattern formation; negative regulation of cell proliferation; regulation of osteoclast differentiation; hair follicle development; cytokinesis after mitosis; mitotic cell cycle spindle assembly checkpoint; positive regulation of epithelial cell differentiation; protein complex assembly; cell adhesion; kidney development; cell cycle arrest; proximal/distal pattern formation; cell structure disassembly during apoptosis; regulation of microtubule-based process; negative regulation of odontogenesis; cell migration; regulation of attachment of spindle microtubules to kinetochore; regulation of osteoblast differentiation; thymus development; negative regulation of microtubule depolymerization; negative regulation of MAPKKK cascade; axis specification; negative regulation of cyclin-dependent protein kinase activity; positive regulation of pseudopodium formation; axonogenesis; dorsal/ventral pattern formation; retina development in camera-type eye; positive regulation of cell division; positive regulation of protein catabolic process; regulation of nitrogen compound metabolic process; response to DNA damage stimulus; mitotic metaphase/anaphase transition; positive regulation of cell migration
Reference #:  P25054 (UniProtKB)
Alt. Names/Synonyms: adenomatosis polyposis coli tumor suppressor; adenomatous polyposis coli; Adenomatous polyposis coli protein; APC; BTPS2; Deleted in polyposis 2.5; DP2; DP2.5; DP3; GS; Protein APC
Gene Symbols: APC
Molecular weight: 311,646 Da
Basal Isoelectric point: 7.92  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  ESC Pluripotency and Differentiation  |  Microtubule Dynamics  |  Wnt/├č-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

APC

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Sites Implicated In
cell cycle regulation: S1360‑p
transcription, altered: S1279‑p, S1392‑p
intracellular localization: S2034‑p, S2054‑p
molecular association, regulation: S1279‑p, S1505‑p, S1507‑p, S2789‑p, S2793‑p
phosphorylation: S1501‑p, S1505‑p, S1507‑p, S1510‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 Y96-p SKMSLRSyGsREGSV
0 3 S98-p MSLRSyGsREGSVSS
0 1 S107-p EGSVSSRsGECsPVP
0 2 S111-p SSRsGECsPVPMGSF
0 4 Y316-p GTKVEMVySLLSMLG
0 3 S744-p YKDANIMsPGSsLPS
0 1 S748-p NIMsPGSsLPSLHVR
0 8 S780-p FDNIDNLsPKASHRS
0 3 S794-p SKQRHKQsLyGDyVF
0 5 Y796-p QRHKQsLyGDyVFDT
0 11 Y799-p KQsLyGDyVFDTNRH
0 36 Y863-p RGIGLGNyHPAtENP
0 2 T867-p LGNyHPAtENPGTSS
0 1 S895-p AKVMEEVsAIHtSQE
0 1 T899-p EEVsAIHtSQEDRSS
0 1 S908-p QEDRSSGsTTELHCV
0 2 Y935-p AHTHSNTyNFTKSEN
0 28 Y951-p NRTCSMPyAKLEYKR
0 2 S963-p YKRSSNDsLNSVSSS
0 1 S985 QMKPSIESYSEDDES
0 1 S1032-p INYSLKYsDEQLNsG
0 4 S1038-p YsDEQLNsGRQsPSQ
0 7 S1042-p QLNsGRQsPSQNERW
0 10 Y1078-p QSTTYPVyTESTDDK
0 11 S1100-p FGQQECVsPyRSRGA
0 8 Y1102-p QQECVsPyRSRGANG
0 1 S1180 VDQPIDYSLKyATDI
0 1 Y1183-p PIDYSLKyATDIPSS
0 2 S1194 IPSSQKQSFSFSKSS
0 2 S1212 SSKTEHMSSSSENTS
0 7 T1220-p SSSENTStPSSNAKR
1 0 S1279-p SRCSSLSsLSSAEDE
0 1 S1344-p LQGSSLSsESARHKA
1 6 S1360-p EFSSGAKsPsKsGAQ
0 1 S1362-p SSGAKsPsKsGAQtP
0 2 S1364-p GAKsPsKsGAQtPKs
0 1 T1368-p PsKsGAQtPKsPPEH
0 5 S1371-p sGAQtPKsPPEHYVQ
0 2 T1380-p PEHYVQEtPLMFsRC
0 3 S1385-p QEtPLMFsRCTSVSs
0 1 S1389 LMFsRCTSVSsLDSF
1 1 S1392-p sRCTSVSsLDSFESR
0 6 T1438-p MPPSRSKtPPPPPQT
1 0 S1501-p ESTPDGFsCsssLsA
1 0 S1503-p TPDGFsCsssLsALs
1 0 S1504-p PDGFsCsssLsALsL
2 0 S1505-p DGFsCsssLsALsLD
2 0 S1507-p FsCsssLsALsLDEP
1 0 S1510-p sssLsALsLDEPFIQ
0 1 T1556-p QEKEAEKtIDSEKDL
0 1 S1559 EAEKtIDSEKDLLDD
0 9 S1610-p PPVARKPsQLPVyKL
0 4 Y1615-p KPsQLPVyKLLPSQN
0 1 T1633-p PQKHVSFtPGDDMPR
0 1 S1664 LSDLTIESPPNELAA
0 1 T1697 IPTEGRSTDEAQGGK
0 1 I1710 GKTSSVTIPELDDNK
0 1 N1716 TIPELDDNKAEEGDI
0 1 T1773-p DGKKKKPtsPVKPIP
0 3 S1774-p GKKKKPtsPVKPIPQ
0 2 Y1846-p AFDSPHHytPIEGtP
0 1 T1847-p FDSPHHytPIEGtPy
0 1 T1852-p HytPIEGtPyCFSRN
0 5 Y1854-p tPIEGtPyCFSRNDs
0 4 S1861-p yCFSRNDsLssLDFD
0 3 S1863-p FSRNDsLssLDFDDD
0 4 S1864-p SRNDsLssLDFDDDD
0 1 T1932-p PILQKQStFPQSSKD
0 1 S1995 KETEPPDSQGEPSKP
0 2 S2022-p EDTPVCFsRNSSLSS
1 0 S2034-p LSSLSIDsEDDLLQE
2 0 S2054-p MPKKKKPsRLKGDNE
0 2 G2058 KKPsRLKGDNEKHSP
0 3 S2088-p KDIQRPDsEHGLsPD
0 5 S2093-p PDsEHGLsPDsENFD
0 2 S2096-p EHGLsPDsENFDWKA
0 5 S2125-p AAAAACLsRQAssDS
0 29 S2129-p ACLsRQAssDSDSIL
0 4 S2130-p CLsRQAssDSDSILS
0 2 S2132 sRQAssDSDSILSLK
0 2 S2140-p DSILSLKsGISLGsP
0 9 S2146-p KsGISLGsPFHLtPD
0 7 T2151-p LGsPFHLtPDQEEKP
0 4 S2260-p LKTPASKsPsEGQTA
0 3 S2262-p TPASKsPsEGQTATT
0 3 S2270-p EGQTATTsPRGAKPS
0 4 S2283-p PSVKSELsPVARQTs
0 11 S2290-p sPVARQTsQIGGSSK
0 1 S2330-p SPGRNSIsPGRNGIs
0 1 S2337-p sPGRNGIsPPNKLSQ
0 3 S2349 LSQLPRTSSPSTAST
0 18 Y2366-p SGSGKMSyTsPGRQM
0 2 S2368-p SGKMSyTsPGRQMsQ
0 11 S2374-p TsPGRQMsQQNLTKQ
0 1 S2396-p SSIPRSEsASKGLNQ
0 10 S2421-p VELSRMSsTKSSGSE
0 3 S2441-p RPVLVRQstFIKEAP
0 17 T2442-p PVLVRQstFIKEAPs
0 17 S2449-p tFIKEAPsPtLRRKL
0 2 T2451-p IKEAPsPtLRRKLEE
0 1 S2461-p RKLEESAsFEsLSPS
0 1 S2464-p EESAsFEsLSPSSRP
0 2 S2473-p SPSSRPAsPTRSQAQ
0 1 T2475 SSRPAsPTRSQAQTP
0 3 S2512-p RKLPPNLsPTIEYND
0 4 S2533-p HDIARSHsEsPSRLP
0 4 S2535-p IARSHsEsPSRLPIN
0 1 S2569-p STWRRTGsSSSILSA
0 3 S2607-p QSKENQVsAKGtWRK
0 5 T2611-p NQVsAKGtWRKIKEN
0 153 Y2645-p AESKTLIyQMAPAVS
0 4 S2671-p CPINNPRsGRsPtGN
0 4 S2674-p NNPRsGRsPtGNtPP
0 4 T2676-p PRsGRsPtGNtPPVI
0 4 T2679-p GRsPtGNtPPVIDSV
0 5 V2711 QNVGNGSVPMRTVGL
0 10 S2724-p GLENRLNsFIQVDAP
0 1 S2764-p VERTPFSsSSSsKHS
0 1 S2768-p PFSsSSSsKHSsPSG
0 3 S2772-p SSSsKHSsPSGTVAA
2 4 S2789-p TPFNYNPsPRKsSAD
1 0 S2793-p YNPsPRKsSADSTSA
0 1 T2820 TKKRDSKTDStESSG
0 1 T2823-p RDSKTDStESSGtQS
0 1 T2828-p DStESSGtQSPKRHs
0 4 S2835-p tQSPKRHsGsyLVTS
0 1 S2837-p SPKRHsGsyLVTSV_
0 2 Y2838-p PKRHsGsyLVTSV__
  mouse

► Hide Isoforms
 
Y94-p SKMSLRSyGsREGSV
S96-p MSLRSyGsREGSVSS
S105-p EGSVSSRsGECsPVP
S109-p SSRsGECsPVPMGSF
Y314 GTKVEMVYSLLSMLG
S742-p YKDANIMsPGSsLPS
S746-p NIMsPGSsLPSLHVR
S778-p FDNIDNLsPKASHRS
- gap
Y794 QRHKQNLYGDYAFDA
Y797 KQNLYGDYAFDANRH
Y861 RGIGLSAYHPTTENA
T865 LSAYHPTTENAGTSS
S893 AKVMEEVSAIHTSQD
T897 EEVSAIHTSQDDRSS
S906 QDDRSSASTTEFHCV
Y933 SHTHSNTYNFTKSEN
Y949 NRTCSMPYAKVEYKR
S961-p YKRSSNDsLNSVTSS
S983-p QMKPSVEsYSEDDES
S1030 INYSLKYSDEQLNsG
S1036-p YSDEQLNsGRQsPSQ
S1040-p QLNsGRQsPSQNERW
Y1076 QNTSYPVYSENTDDK
S1098-p FGQQECVsPYRSRGT
Y1100 QQECVsPYRSRGTSG
S1179 VDQPIDYSLKYATDI
Y1182 PIDYSLKYATDISSS
S1193-p ISSSQKPsFSFSKNS
S1211-p STKPEHLsPSSENTA
- gap
S1277 SRCSSLSSLSSADDE
S1342 LQASGLSSESTRHNK
S1359-p EFSSGAKsPSKsGAQ
S1361 SSGAKsPSKsGAQTP
S1363-p GAKsPSKsGAQTPKs
T1367 PSKsGAQTPKsPPEH
S1370-p sGAQTPKsPPEHYVQ
T1379-p PEHYVQEtPLVFsRC
S1384-p QEtPLVFsRCTsVSs
S1388-p LVFsRCTsVSsLDSF
S1391-p sRCTsVSsLDSFESR
T1437-p MPPSRSKtPPPPPQT
S1500 ESTPDGFSCSSSLSA
S1502 TPDGFSCSSSLSALS
S1503 PDGFSCSSSLSALSL
S1504 DGFSCSSSLSALSLD
S1506 FSCSSSLSALSLDEP
S1509 SSSLSALSLDEPFIQ
- gap
S1557-p KEVEKPDsEKDLLDD
S1608-p PPVARKPsQLPVYKL
Y1613 KPsQLPVYKLLPAQN
T1631 AQKHVSFTPGDDVPR
S1662-p LSDLTIEsPPNELAT
T1695 IPTEGRSTDDAQRGK
T1708-p GKISSIVtPDLDDNK
N1714 VtPDLDDNKAEEGDI
T1771-p DTKKKKPtSPVKPMP
S1772 TKKKKPtSPVKPMPQ
Y1844 ALDSPHHYTPIEGTP
T1845 LDSPHHYTPIEGTPY
T1850 HYTPIEGTPYCFSRN
Y1852 TPIEGTPYCFSRNDs
S1859-p YCFSRNDsLssLDFD
S1861-p FSRNDsLssLDFDDD
S1862-p SRNDsLssLDFDDDD
T1930-p PVLQKQPtFPQSSKD
S1994-p KEAEPANsQGEPSKP
S2021 EDTPVCFSRNSSLSS
S2033 LSSLSIDSEDDLLQE
S2053 MPKKKRPSRLKsESE
S2057-p KRPSRLKsESEKQSP
S2087 KDLQRPDSEHAFsPG
S2092-p PDSEHAFsPGSENFD
S2095 EHAFsPGSENFDWKA
S2125-p AAAAACLsRQAssDs
S2129-p ACLsRQAssDsDSIL
S2130-p CLsRQAssDsDSILS
S2132-p sRQAssDsDSILSLK
S2140-p DSILSLKsGISLGsP
S2146-p KsGISLGsPFHLtPD
T2151-p LGsPFHLtPDQEEKP
S2260-p LKTPASKsPsEGPGA
S2262-p TPASKsPsEGPGATT
S2270-p EGPGATTsPRGTKPA
S2283-p PAGKSELsPITRQTs
S2290-p sPITRQTsQISGSNK
S2330 SPGRNSISPGRNGIS
S2337 SPGRNGISPPNKLSQ
S2349-p LSQLPRTsSPSTAST
Y2366 SGSGKMSYTsPGRQL
S2368-p SGKMSYTsPGRQLsQ
S2374-p TsPGRQLsQQNLTKQ
S2396 SSIPRSESASKGLNQ
S2421-p VELSRMSsTKSSGSE
S2441 RPALVRQSTFIKEAP
T2442 PALVRQSTFIKEAPs
S2449-p TFIKEAPsPtLRRKL
T2451-p IKEAPsPtLRRKLEE
S2461-p RKLEESAsFESLSPS
S2464 EESAsFESLSPSSRP
S2473-p SPSSRPDsPtRSQAQ
T2475-p SSRPDsPtRSQAQTP
S2512-p RKLPPNLsPTIEYND
S2533 HDIARSHSESPSRLP
S2535 IARSHSESPSRLPIN
S2569 STWRRTGSSSSILSA
P2607 QMKENQVPTKGTWRK
T2611 NQVPTKGTWRKIKES
Y2645 AESKPLIYQMAPPVS
S2671-p CPINNPRsGRSPtGN
S2674 NNPRsGRSPtGNtPP
T2676-p PRsGRSPtGNtPPVI
T2679-p GRSPtGNtPPVIDSV
S2713-p KQSVGSGsPVQTVGL
S2726 GLETRLNSFVQVEAP
S2766 AERTPFSSSSSSKHS
S2770 PFSSSSSSKHSsPSG
S2774-p SSSSKHSsPSGTVAA
S2791 TPFNYNPSPRKSSAD
S2795 YNPSPRKSSADSTSA
T2822-p TKKRDSKtDItESSG
T2825-p RDSKtDItESSGAQS
- gap
S2837 AQSPKRHSGSYLVTS
S2839 SPKRHSGSYLVTSV_
Y2840 PKRHSGSYLVTSV__
  APC iso5  
Y94 SKMSLRSYGSREGSV
S96 MSLRSYGSREGSVSS
S105 EGSVSSRSGECSPVP
S109 SSRSGECSPVPMGSF
Y314 GTKVEMVYSLLSMLG
S742 YKDANIMSPGSSLPS
S746 NIMSPGSSLPSLHVR
S778 FDNIDNLSPKASHRS
- gap
Y794 QRHKQNLYGDYAFDA
Y797 KQNLYGDYAFDANRH
Y861 RGIGLSAYHPTTENA
T865 LSAYHPTTENAGTSS
S893 AKVMEEVSAIHTSQD
T897 EEVSAIHTSQDDRSS
S906 QDDRSSASTTEFHCV
Y933 SHTHSNTYNFTKSEN
Y949 NRTCSMPYAKVEYKR
S961 YKRSSNDSLNSVTSS
S983 QMKPSVESYSEDDES
S1030 INYSLKYSDEQLNSG
S1036 YSDEQLNSGRQSPSQ
S1040 QLNSGRQSPSQNERW
Y1076 QNTSYPVYSENTDDK
S1098 FGQQECVSPYRSRGT
Y1100 QQECVSPYRSRGTSG
S1179 VDQPIDYSLKYATDI
Y1182 PIDYSLKYATDISSS
S1193 ISSSQKPSFSFSKNS
S1211 STKPEHLSPSSENTA
- gap
S1277 SRCSSLSSLSSADDE
S1342 LQASGLSSESTRHNK
S1359 EFSSGAKSPSKSGAQ
S1361 SSGAKSPSKSGAQTP
S1363 GAKSPSKSGAQTPKS
T1367 PSKSGAQTPKSPPEH
S1370 SGAQTPKSPPEHYVQ
T1379 PEHYVQETPLVFSRC
S1384 QETPLVFSRCTSVSS
S1388 LVFSRCTSVSSLDSF
S1391 SRCTSVSSLDSFESR
T1437 MPPSRSKTPPPPPQT
S1500 ESTPDGFSCSSSLSA
S1502 TPDGFSCSSSLSALS
S1503 PDGFSCSSSLSALSL
S1504 DGFSCSSSLSALSLD
S1506 FSCSSSLSALSLDEP
S1509 SSSLSALSLDEPFIQ
- gap
S1557 KEVEKPDSEKDLLDD
S1608 PPVARKPSQLPVYKL
Y1613 KPSQLPVYKLLPAQN
T1631 AQKHVSFTPGDDVPR
S1662 LSDLTIESPPNELAT
T1695 IPTEGRSTDDAQRGK
T1708 GKISSIVTPDLDDNK
N1714 VTPDLDDNKAEEGDI
T1771 DTKKKKPTSPVKPMP
S1772 TKKKKPTSPVKPMPQ
Y1844 ALDSPHHYTPIEGTP
T1845 LDSPHHYTPIEGTPY
T1850 HYTPIEGTPYCFSRN
Y1852 TPIEGTPYCFSRNDS
S1859 YCFSRNDSLSSLDFD
S1861 FSRNDSLSSLDFDDD
S1862 SRNDSLSSLDFDDDD
T1930 PVLQKQPTFPQSSKD
S1994 KEAEPANSQGEPSKP
S2021-p EDTPVCFsRNSSLSS
S2033 LSSLSIDSEDDLLQE
S2053 MPKKKRPSRLKSESE
S2057 KRPSRLKSESEKQSP
S2087-p KDLQRPDsEHAFsPD
S2092-p PDsEHAFsPDSENFD
S2095 EHAFsPDSENFDWKA
S2125 AAAAACLSRQASSDS
S2129 ACLSRQASSDSDSIL
S2130 CLSRQASSDSDSILS
S2132 SRQASSDSDSILSLK
S2140 DSILSLKSGISLGSP
S2146 KSGISLGSPFHLTPD
T2151 LGSPFHLTPDQEEKP
S2260 LKTPASKSPSEGPGA
S2262 TPASKSPSEGPGATT
S2270 EGPGATTSPRGTKPA
S2283 PAGKSELSPITRQTS
S2290 SPITRQTSQISGSNK
S2330 SPGRNSISPGRNGIS
S2337 SPGRNGISPPNKLSQ
S2349 LSQLPRTSSPSTAST
Y2366 SGSGKMSYTSPGRQL
S2368 SGKMSYTSPGRQLSQ
S2374 TSPGRQLSQQNLTKQ
S2396 SSIPRSESASKGLNQ
S2421 VELSRMSSTKSSGSE
S2441 RPALVRQSTFIKEAP
T2442 PALVRQSTFIKEAPS
S2449 TFIKEAPSPTLRRKL
T2451 IKEAPSPTLRRKLEE
S2461 RKLEESASFESLSPS
S2464 EESASFESLSPSSRP
S2473 SPSSRPDSPTRSQAQ
T2475 SSRPDSPTRSQAQTP
S2512 RKLPPNLSPTIEYND
S2533 HDIARSHSESPSRLP
S2535 IARSHSESPSRLPIN
S2569 STWRRTGSSSSILSA
P2607 QMKENQVPTKGTWRK
T2611 NQVPTKGTWRKIKES
Y2645 AESKPLIYQMAPPVS
S2671 CPINNPRSGRSPTGN
S2674 NNPRSGRSPTGNTPP
T2676 PRSGRSPTGNTPPVI
T2679 GRSPTGNTPPVIDSV
S2710 KQSVGSGSPVQTVGL
S2723 GLETRLNSFVQVEAP
S2763 AERTPFSSSSSSKHS
S2767 PFSSSSSSKHSSPSG
S2771 SSSSKHSSPSGTVAA
S2788 TPFNYNPSPRKSSAD
S2792 YNPSPRKSSADSTSA
T2819 TKKRDSKTDSTESSG
T2822 RDSKTDSTESSGAQS
- gap
S2834 AQSPKRHSGSYLVTS
S2836 SPKRHSGSYLVTSV_
Y2837 PKRHSGSYLVTSV__
  rat

 
Y94 SKMSLRSYGSREGSV
S96 MSLRSYGSREGSVSS
S105 EGSVSSRSGECSPVP
S109 SSRSGECSPVPMGSF
Y314 GTKVEMVYSLLSMLG
S742 YKDANIMSPGSSLPS
S746 NIMSPGSSLPSLHVR
S778-p FDNIDNLsPKASHRS
- gap
Y794 QRHKQNLYGDYVFDA
Y797 KQNLYGDYVFDASRH
Y861 RGIGLSTYHSATENP
T865 LSTYHSATENPGTSS
S893 AKVMEEVSALHTSQD
T897 EEVSALHTSQDDRSP
S906 QDDRSPASAAELHCV
H933 SHTHPNTHNFAKSES
Y949 NRTCSMPYAKVEYKR
S961 YKRSSNDSLNSVTSS
S983 QMKPSVESYSEDDEG
S1030 INYSLKYSDEQLNSG
S1036 YSDEQLNSGRQSPSQ
S1040 QLNSGRQSPSQNERW
Y1076 QNTNFPVYSENTDDK
S1098 FGQQECVSPYRSRGT
Y1100 QQECVSPYRSRGTNG
S1178-p VDQPIDYsLKYATDI
Y1181 PIDYsLKYATDISSS
S1192 ISSSQKPSFSFSKTP
S1210 GTKTEHNSPSSEAAS
- gap
S1276 SRCSSLSSLSSAEDE
S1341 LQASGLASESARHKA
S1357 EFSSGAKSPSKSGAQ
S1359 SSGAKSPSKSGAQTP
S1361 GAKSPSKSGAQTPKS
T1365 PSKSGAQTPKSPPEH
S1368 SGAQTPKSPPEHYVQ
T1377 PEHYVQETPLVFSRC
S1382 QETPLVFSRCTSVSS
S1386 LVFSRCTSVSSLDSF
S1389 SRCTSVSSLDSFESR
T1435-p MPPSRSKtPPPPPPP
S1500 ESTPDGFSCSSSLSA
S1502 TPDGFSCSSSLSALS
S1503 PDGFSCSSSLSALSL
S1504 DGFSCSSSLSALSLD
S1506 FSCSSSLSALSLDEP
S1509 SSSLSALSLDEPFIQ
- gap
S1557 KEVEKPDSEKDLLDD
S1608 PPVARKPSQLPVYKL
Y1613 KPSQLPVYKLLPSQS
T1631 AQKHVSFTPGDDVPR
S1662 LSDLTIESPPNELAA
T1695-p IPTEGRStDEAQRGK
I1708 GKVSSIAIPDLDGsK
S1714-p AIPDLDGsKAEEGDI
T1771 DTKKKKPTSPVKPMP
S1772 TKKKKPTSPVKPMPQ
Y1844 TFDSPHHYAPIEGTP
A1845 FDSPHHYAPIEGTPY
T1850 HYAPIEGTPYCFSRN
Y1852 APIEGTPYCFSRNDS
S1859 YCFSRNDSLSSLDFD
S1861 FSRNDSLSSLDFDDD
S1862 SRNDSLSSLDFDDDD
T1930 PLLQEQPTFPQSSKD
- gap
S2021 EDTPVCFSRNSSLSS
S2033 LSSLSIDSEDDLLRE
S2053 MPKKRRPSRLKGEGE
- gap
S2087 KDIQRPESEHGLSPD
S2092 PESEHGLSPDSENFD
S2095 EHGLSPDSENFDWKA
S2125 AAAAACLSRQASSDS
S2129 ACLSRQASSDSDSIL
S2130 CLSRQASSDSDSILS
S2132 SRQASSDSDSILSLK
S2140 DSILSLKSGVSLGSP
S2146 KSGVSLGSPFHLTPD
T2151 LGSPFHLTPDQEEKP
S2260 LKTPASKSPSEGPVA
S2262 TPASKSPSEGPVATT
S2270 EGPVATTSPRGTKPA
S2283 PAVKSELSPITRQTS
S2290 SPITRQTSHISGSNK
S2330 SPGRNSISPGRNGIS
S2337 SPGRNGISTPNKLSQ
S2349 LSQLPRTSSPSTAST
Y2366 SGSGKMSYTSPGRQL
S2368 SGKMSYTSPGRQLSQ
S2374 TSPGRQLSQQNLSKQ
S2396 SSIPRSESASKGLNQ
S2421 VELSRMSSTKSSGSE
S2441 RPALVRQSTFIKEAP
T2442 PALVRQSTFIKEAPS
S2449 TFIKEAPSPTLRRKL
T2451 IKEAPSPTLRRKLEE
S2461 RKLEESASFESLSPS
S2464 EESASFESLSPSSRP
S2473 SPSSRPDSPTRSQAQ
T2475 SSRPDSPTRSQAQTP
S2512 RKLPPNLSPTIEYSD
S2533 HDIARSHSESPSRLP
S2535 IARSHSESPSRLPVN
S2569 STWRRTGSSSSILSA
P2607 QMKENQVPTKGTWRK
T2611 NQVPTKGTWRKIKES
Y2645 AESKTLIYQMAPAVS
S2671 CPINNPRSGRSPTGN
S2674 NNPRSGRSPTGNTPP
T2676 PRSGRSPTGNTPPVI
T2679 GRSPTGNTPPVIDSI
S2710-p KQSVGSGsPVQTVGL
S2723 GLENRLNSFIQVEAP
S2763 AERTPFSSSSSSKHS
S2767 PFSSSSSSKHSsPSG
S2771-p SSSSKHSsPSGTVAA
S2788 TPFNYNPSPRKSSAD
S2792 YNPSPRKSSADSTSA
T2819 TKKRDSKTDSTESSG
T2822 RDSKTDSTESSGAQS
- gap
S2834 AQSPKRHSGSYLVTS
S2836 SPKRHSGSYLVTSV_
Y2837 PKRHSGSYLVTSV__
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