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Protein Page:
AMPKB2 (human)

Overview
AMPKB2 a non-catalytic subunit of AMPK, a conserved kinase of the CAMKL family. AMPK is an energy-sensing protein that plays a key role in regulating cellular energy homeostasis. Environmental stress, such as heat shock, nutrient deprivation, hypoxia and ischemia, indirectly activate AMPK by the depletion of cellular ATP and the concomitant rise of ADP and AMP levels. Allosteric activation is achieved primarily by rising ADP levels, and not solely by AMP levels as previously thought. Activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton, probably by indirectly activating myosin. AMPK is a heterotrimer of an alpha catalytic subunit (AMPKA1 or -2), a beta (AMPKB1 or -2) and a gamma non-catalytic subunit (AMPKG1, -2 or -3). Different possible combinations of subunits give rise to 12 different holoenzymes. Beta subunits act as scaffolds on which the AMPK complex assembles, via its C-terminus that bridges alpha and gamma subunits. AMPK-beta1 or -beta2 subunits are required for assembling of AMPK heterotrimers and are important for regulating enzyme activity and cellular localization. AMPK beta1beta2 null mouse muscles reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise. Phosphorylation by ULK1 and ULK2 inhibits AMPK activity. Note: This description may include information from UniProtKB.
Protein type: Autophagy; Protein kinase, regulatory subunit
Cellular Component: nucleoplasm; cytosol; AMP-activated protein kinase complex
Molecular Function: AMP-activated protein kinase activity; identical protein binding; protein binding
Biological Process: regulation of fatty acid biosynthetic process; energy reserve metabolic process; insulin receptor signaling pathway; cellular lipid metabolic process; carnitine shuttle; signal transduction; cell cycle arrest; protein amino acid phosphorylation; fatty acid biosynthetic process
Reference #:  O43741 (UniProtKB)
Alt. Names/Synonyms: 5'-AMP-activated protein kinase subunit beta-2; 5'-AMP-activated protein kinase, beta-2 subunit; AAKB2; AMPK beta 2; AMPK beta-2 chain; AMPK subunit beta-2; MGC61468; PRKAB2; protein kinase, AMP-activated, beta 2 non-catalytic subunit
Gene Symbols: PRKAB2
Molecular weight: 30,302 Da
Basal Isoelectric point: 5.99  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

AMPKB2

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 9 S39-p EHKIMVGstDDPSVF
1 5 T40-p HKIMVGstDDPSVFs
0 1 S47-p tDDPSVFsLPDSKLP
0 1 S61-p PGDKEFVsWQQDLED
1 0 S69 WQQDLEDSVKPTQQA
0 2 S93-p GGKEVFIsGsFNNWS
0 2 S95-p KEVFIsGsFNNWSTK
0 25 S108-p TKIPLIKsHNDFVAI
0 2 T148-p VVTSQLGtINNLIHV
0 4 S158-p NLIHVKKsDFEVFDA
0 1 S170-p FDALKLDsMEsSETS
0 1 S173-p LKLDsMEsSETSCRD
1 0 S174 KLDsMEsSETSCRDL
0 4 S182-p ETSCRDLsssPPGPy
0 4 S183-p TSCRDLsssPPGPyG
1 23 S184-p SCRDLsssPPGPyGQ
0 1 Y189-p sssPPGPyGQEMyAF
0 1 Y194-p GPyGQEMyAFRSEER
0 1 Y242 HVMLNHLYALSIKDS
0 6 Y263-p THRYKKKyVTTLLYK
  mouse

 
S38-p EHKIMVGstDDPSVF
T39-p HKIMVGstDDPSVFS
S46 tDDPSVFSLPDSKLP
P60 PGDKEFVPWQQDLDD
S68 WQQDLDDSVKPAQQA
S92 GGKEVFISGSFNNWS
S94 KEVFISGSFNNWSTK
S107-p TKIPLIKsHNDFVAI
T147 VVTSQLGTINNLIHV
S157-p NLIHVKKsDFEVFDA
S169 FDALKLDSMESSETS
S172 LKLDSMESSETSCRD
S173 KLDSMESSETSCRDL
S181-p ETSCRDLsssPPGPY
S182-p TSCRDLsssPPGPYG
S183-p SCRDLsssPPGPYGQ
Y188 sssPPGPYGQEMYVF
Y193 GPYGQEMYVFRSEER
Y241-p HVMLNHLyALSIKDS
Y262-p THRYKKKyVTTLLYK
  rat

 
S38-p EHKIMVGstDDPSVF
T39-p HKIMVGstDDPSVFS
S46 tDDPSVFSLPDSKLP
P60 PGDKEFVPWQQDLDD
S68-p WQQDLDDsVKPTQQA
S92 GGKEVFISGSFNNWS
S94 KEVFISGSFNNWSTK
S107 TKIPLIKSHNDFVAI
T147 VVTSQLGTINNLIHV
S157 NLIHVKKSDFEVFDA
S169 FDALKLDSMESsETS
S172 LKLDSMESsETSCRD
S173-p KLDSMESsETSCRDL
S181 ETSCRDLSSsPPGPY
S182 TSCRDLSSsPPGPYG
S183-p SCRDLSSsPPGPYGQ
Y188 SSsPPGPYGQEMYVF
Y193 GPYGQEMYVFRSEER
Y241 HVMLNHLYALSTKDS
Y262 THRYKKKYVTTLLYK
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