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Protein Page:
Galectin-3 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
Galectin-3 galactose-specific lectin which binds IgE. Expressed at a high level in the colonic epithelium. Also abundant in activated macrophages. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Extracellular matrix; Cell surface
Cellular Component: spliceosome; extracellular matrix; proteinaceous extracellular matrix; extracellular space; cytoplasm; mitochondrial inner membrane; plasma membrane; nucleus
Molecular Function: protein binding; IgE binding; carbohydrate binding; chemoattractant activity
Biological Process: monocyte chemotaxis; neutrophil chemotaxis; extracellular matrix organization and biogenesis; epithelial cell differentiation; positive chemotaxis; RNA splicing; eosinophil chemotaxis; innate immune response; mRNA processing; skeletal development; macrophage chemotaxis
Reference #:  P17931 (UniProtKB)
Alt. Names/Synonyms: 35 kDa lectin; Carbohydrate-binding protein 35; CBP 35; CBP35; Gal-3; GAL3; Galactose-specific lectin 3; Galactoside-binding protein; GALBP; Galectin-3; GALIG; IgE-binding protein; L-31; L31; Laminin-binding protein; Lectin L-29; lectin, galactoside-binding, soluble, 3; LEG3; LGALS2; LGALS3; Mac-2 antigen; MAC2
Gene Symbols: LGALS3
Molecular weight: 26,152 Da
Basal Isoelectric point: 8.58  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Galectin-3

Protein Structure Not Found.


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Sites Implicated In
apoptosis, altered: Y79‑p, Y118‑p
apoptosis, inhibited: S6‑p
carcinogenesis, induced: Y79‑p, Y118‑p
cell cycle regulation: S6‑p
cell motility, altered: Y107‑p
intracellular localization: S6‑p
molecular association, regulation: S6‑p
protein conformation: S6‑p, S12‑p, Y107‑p, Y118‑p
protein stabilization: Y79‑p, Y118‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
7 1 S6-p __MADNFsLHDALsG
1 0 H8 MADNFsLHDALsGSG
3 1 S12-p FsLHDALsGSGNPNP
2 1 Y79-p GAPAPGVyPGPPSGP
3 0 Y107-p AYPATGPyGAPAGPL
3 1 Y118-p AGPLIVPyNLPLPGG
0 2 K176-u RVIVCNTkLDNNWGR
0 2 S188-p WGREERQsVFPFESG
0 1 S194 QsVFPFESGKPFKIQ
0 1 Y247-p IDLTSASyTMI____
  mouse

 
S6 __MADSFSLNDALAG
N8 MADSFSLNDALAGSG
A12 FSLNDALAGSGNPNP
Y89 GPTAPGAYPGQPAPG
Y121 GYPAAGPYGVPAGPL
Y132 AGPLTVPYDLPLPGG
K190 RVIVCNTKQDNNWGK
S202-p WGKEERQsAFPFEsG
S208-p QsAFPFEsGKPFKIQ
H261 ITLTSANHAMI____
  rat

 
S6 __MADGFSLNDALAG
N8 MADGFSLNDALAGSG
A12 FSLNDALAGSGNPNP
F89 GPTAPGAFPGQPGGP
F119 AYPATGPFGAPTGPL
Y130 TGPLTVPYDMPLPGG
K188 RVIVCNTKQDNNWGR
S200 WGREERQSAFPFESG
S206 QSAFPFESGKPFKIQ
H259 ITLTSASHAMI____
  chicken

 
S6-p __MSDGFsLsDALPA
S8-p MSDGFsLsDALPAHN
A13 sLsDALPAHNPGAPP
Y80 PGGPPGPYPGGPPGP
- gap
Y108 AAPLKVPYDLPLPAG
M166 RVIVCNSMFQNNWGK
T177 NWGKEERTAPRFPFE
P185 APRFPFEPGTPFKLQ
T238 ITLTSVLTSMI____
  dog

 
S6-p __MADSFsLNDALsG
N8 MADSFsLNDALsGSG
S12-p FsLNDALsGSGNPNP
Y90 GQAPPGGYPGQAPPG
F153 AYPAAGPFGIPAGPL
Y164 AGPLTVPYDLPLPGG
K222 RVIVCNTKLDNIWGK
A234 WGKEERQAAFPFESG
S240 QAAFPFESGKPFKIQ
Y293 IDLTSASYAMI____
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