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Protein Page:
Galectin-3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Galectin-3 galactose-specific lectin which binds IgE. Expressed at a high level in the colonic epithelium. Also abundant in activated macrophages. Note: This description may include information from UniProtKB.
Protein type: Extracellular matrix; Motility/polarity/chemotaxis; Cell surface
Cellular Component: spliceosome; extracellular matrix; extracellular space; proteinaceous extracellular matrix; membrane; mitochondrial inner membrane; cytoplasm; plasma membrane; immunological synapse; nucleus
Molecular Function: protein binding; laminin binding; IgE binding; carbohydrate binding; chemoattractant activity
Biological Process: neutrophil chemotaxis; extracellular matrix organization and biogenesis; RNA splicing; negative regulation of endocytosis; regulation of T cell proliferation; negative regulation of T cell receptor signaling pathway; macrophage chemotaxis; monocyte chemotaxis; positive chemotaxis; epithelial cell differentiation; eosinophil chemotaxis; innate immune response; mRNA processing; skeletal development
Reference #:  P17931 (UniProtKB)
Alt. Names/Synonyms: 35 kDa lectin; Carbohydrate-binding protein 35; CBP 35; CBP35; Gal-3; GAL3; Galactose-specific lectin 3; Galactoside-binding protein; GALBP; Galectin-3; GALIG; IgE-binding protein; L-31; L31; Laminin-binding protein; Lectin L-29; lectin, galactoside-binding, soluble, 3; LEG3; LGALS2; LGALS3; Mac-2 antigen; MAC2
Gene Symbols: LGALS3
Molecular weight: 26,152 Da
Basal Isoelectric point: 8.58  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Galectin-3

Protein Structure Not Found.


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Sites Implicated In
apoptosis, altered: Y79‑p, Y118‑p
apoptosis, inhibited: S6‑p
carcinogenesis, induced: Y79‑p, Y118‑p
cell cycle regulation: S6‑p
cell motility, altered: Y107‑p
intracellular localization: S6‑p
molecular association, regulation: S6‑p
protein conformation: S6‑p, S12‑p, Y107‑p, Y118‑p
protein stabilization: Y79‑p, Y118‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
7 1 S6-p __MADNFsLHDALsG
1 0 H8 MADNFsLHDALsGSG
3 1 S12-p FsLHDALsGSGNPNP
2 1 Y79-p GAPAPGVyPGPPSGP
3 0 Y107-p AYPATGPyGAPAGPL
3 1 Y118-p AGPLIVPyNLPLPGG
0 1 T175-p RRVIVCNtkLDNNWG
0 1 K176-ac RVIVCNtkLDNNWGR
0 2 K176-ub RVIVCNtkLDNNWGR
0 1 R183 kLDNNWGREERQsVF
0 2 S188-p WGREERQsVFPFESG
0 1 S194 QsVFPFESGkPFKIQ
0 1 K196-sc VFPFESGkPFKIQVL
0 1 Y221-p NDAHLLQyNHRVKKL
0 1 Y247-p IDLTSASyTMI____
  mouse

 
S6 __MADSFSLNDALAG
N8 MADSFSLNDALAGSG
A12 FSLNDALAGSGNPNP
Y89 GPTAPGAYPGQPAPG
Y121 GYPAAGPYGVPAGPL
Y132 AGPLTVPYDLPLPGG
T189 RRVIVCNTKQDNNWG
K190 RVIVCNTKQDNNWGk
K190 RVIVCNTKQDNNWGk
K197-ac KQDNNWGkEERQsAF
S202-p WGkEERQsAFPFEsG
S208-p QsAFPFEsGKPFKIQ
K210 AFPFEsGKPFKIQVL
Y235 NDAHLLQYNHRMKNL
H261 ITLTSANHAMI____
  rat

 
S6 __MADGFSLNDALAG
N8 MADGFSLNDALAGSG
A12 FSLNDALAGSGNPNP
F89 GPTAPGAFPGQPGGP
F119 AYPATGPFGAPTGPL
Y130 TGPLTVPYDMPLPGG
T187 RRVIVCNTKQDNNWG
K188 RVIVCNTKQDNNWGR
K188 RVIVCNTKQDNNWGR
R195 KQDNNWGREERQSAF
S200 WGREERQSAFPFESG
S206 QSAFPFESGKPFKIQ
K208 AFPFESGKPFKIQVL
Y233 NDVHLLQYNHRMKNL
H259 ITLTSASHAMI____
  chicken

 
S6-p __MSDGFsLsDALPA
S8-p MSDGFsLsDALPAHN
A13 sLsDALPAHNPGAPP
Y80 PGGPPGPYPGGPPGP
- gap
Y108 AAPLKVPYDLPLPAG
S165 KRVIVCNSMFQNNWG
M166 RVIVCNSMFQNNWGK
M166 RVIVCNSMFQNNWGK
K173 MFQNNWGKEERTAPR
T177 NWGKEERTAPRFPFE
P185 APRFPFEPGTPFKLQ
T187 RFPFEPGTPFKLQVL
F212 NDAHLLQFNFREKKL
T238 ITLTSVLTSMI____
  dog

 
S6-p __MADSFsLNDALsG
N8 MADSFsLNDALsGSG
S12-p FsLNDALsGSGNPNP
Y90 GQAPPGGYPGQAPPG
F153 AYPAAGPFGIPAGPL
Y164 AGPLTVPYDLPLPGG
T221 KRVIVCNTKLDNIWG
K222 RVIVCNTKLDNIWGK
K222 RVIVCNTKLDNIWGK
K229 KLDNIWGKEERQAAF
A234 WGKEERQAAFPFESG
S240 QAAFPFESGKPFKIQ
K242 AFPFESGKPFKIQVL
Y267 NDAHLLQYNHRMKNL
Y293 IDLTSASYAMI____
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