nucleoside diphosphate kinase A. Major role in the synthesis of nucleoside triphosphates other than ATP. Holoenzyme is a hexamer of the A and B subunits. Mutations have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC 22.214.171.124; Tumor suppressor; Kinase, other; Nucleotide Metabolism - pyrimidine; Nucleotide Metabolism - purine; Kinase, nucleoside diphosphate; Other group; NDK family
Cellular Component: centrosome; perinuclear region of cytoplasm; cytoplasm; cytosol; nucleus
Molecular Function: identical protein binding; gamma-tubulin binding; protein binding; GTP binding; magnesium ion binding; deoxyribonuclease activity; intermediate filament binding; nucleoside diphosphate kinase activity; protein kinase binding; ATP binding; single-stranded DNA binding; ribosomal small subunit binding
Biological Process: GTP biosynthetic process; response to cAMP; nucleobase, nucleoside and nucleotide interconversion; nucleobase, nucleoside and nucleotide metabolic process; negative regulation of myeloid leukocyte differentiation; UTP biosynthetic process; hippocampus development; endocytosis; response to testosterone stimulus; DNA catabolic process; regulation of apoptosis; negative regulation of cell proliferation; CTP biosynthetic process; positive regulation of epithelial cell proliferation; positive regulation of DNA binding; response to amine stimulus
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.