nucleoside diphosphate kinase A. Major role in the synthesis of nucleoside triphosphates other than ATP. Holoenzyme is a hexamer of the A and B subunits. Mutations have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; EC 188.8.131.52; Tumor suppressor; Kinase, other
Cellular Component: cytoplasm; cytosol; nucleus
Molecular Function: identical protein binding; protein binding; GTP binding; nucleoside diphosphate kinase activity; magnesium ion binding; deoxyribonuclease activity; ATP binding
Biological Process: regulation of apoptosis; GTP biosynthetic process; nervous system development; negative regulation of cell proliferation; CTP biosynthetic process; nucleobase, nucleoside and nucleotide metabolic process; nucleobase, nucleoside and nucleotide interconversion; UTP biosynthetic process; endocytosis; cell differentiation; positive regulation of epithelial cell proliferation; positive regulation of DNA binding
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.