nucleoside diphosphate kinase A. Major role in the synthesis of nucleoside triphosphates other than ATP. Holoenzyme is a hexamer of the A and B subunits. Mutations have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Nucleotide Metabolism - pyrimidine; EC 22.214.171.124; Nucleotide Metabolism - purine; Kinase, other; Kinase, nucleoside diphosphate; Tumor suppressor; Other group; NDK family
Cellular Component: centrosome; membrane; mitochondrion; perinuclear region of cytoplasm; cytoplasm; cytosol; nucleus
Molecular Function: identical protein binding; gamma-tubulin binding; protein binding; GTP binding; nucleoside diphosphate kinase activity; deoxyribonuclease activity; intermediate filament binding; magnesium ion binding; protein kinase binding; ribosomal small subunit binding; single-stranded DNA binding; ATP binding
Biological Process: GTP biosynthetic process; lactation; response to cAMP; nucleobase, nucleoside and nucleotide metabolic process; nucleobase, nucleoside and nucleotide interconversion; negative regulation of myeloid leukocyte differentiation; UTP biosynthetic process; hippocampus development; nucleoside diphosphate phosphorylation; endocytosis; response to testosterone stimulus; DNA catabolic process; regulation of apoptosis; negative regulation of cell proliferation; CTP biosynthetic process; positive regulation of epithelial cell proliferation; response to amine stimulus; positive regulation of DNA binding
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.