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Protein Page:
NME1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
NME1 nucleoside diphosphate kinase A. Major role in the synthesis of nucleoside triphosphates other than ATP. Holoenzyme is a hexamer of the A and B subunits. Mutations have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Nucleotide Metabolism - purine; Kinase, nucleoside diphosphate; EC 2.7.4.6; Tumor suppressor; Kinase, other; Nucleotide Metabolism - pyrimidine; Other group; NDK family
Cellular Component: centrosome; mitochondrion; perinuclear region of cytoplasm; cytoplasm; cytosol; nucleus
Molecular Function: identical protein binding; gamma-tubulin binding; protein binding; GTP binding; magnesium ion binding; deoxyribonuclease activity; nucleoside diphosphate kinase activity; intermediate filament binding; protein kinase binding; ATP binding; ribosomal small subunit binding; single-stranded DNA binding
Biological Process: lactation; GTP biosynthetic process; response to cAMP; nucleobase, nucleoside and nucleotide metabolic process; nucleobase, nucleoside and nucleotide interconversion; UTP biosynthetic process; negative regulation of myeloid leukocyte differentiation; hippocampus development; nucleoside diphosphate phosphorylation; endocytosis; response to testosterone stimulus; DNA catabolic process; regulation of apoptosis; negative regulation of cell proliferation; CTP biosynthetic process; positive regulation of epithelial cell proliferation; positive regulation of DNA binding; response to amine stimulus
Reference #:  P15531 (UniProtKB)
Alt. Names/Synonyms: AWD; GAAD; Granzyme A-activated DNase; Metastasis inhibition factor nm23; NB; NBS; NDK A; NDKA; NDP kinase A; NDPK-A; NDPKA; NM23; nm23-H1; NME1; NME1A; non-metastatic cells 1, protein (NM23A) expressed in; Nucleoside diphosphate kinase A; Tumor metastatic process-associated protein
Gene Symbols: NME1
Molecular weight: 17,149 Da
Basal Isoelectric point: 5.83  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

NME1

Protein Structure Not Found.


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Sites Implicated In
cell growth, altered: S44‑p, S120‑p
enzymatic activity, induced: S120‑p
molecular association, regulation: S120‑p
protein conformation: S120‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 107 K12-ub ERTFIAIkPDGVQRG
0 4 K26-ac GLVGEIIkRFEQkGF
0 3 K26-ub GLVGEIIkRFEQkGF
0 3 K31-ac IIkRFEQkGFRLVGL
0 2 K39-ub GFRLVGLkFMQAsED
4 2 S44-p GLkFMQAsEDLLkEH
0 2 K49-ac QAsEDLLkEHyVDLk
0 9 K49-ub QAsEDLLkEHyVDLk
0 9 Y52-p EDLLkEHyVDLkDRP
0 2 K56-ac kEHyVDLkDRPFFAG
0 67 K56-ub kEHyVDLkDRPFFAG
0 1 K56-sc kEHyVDLkDRPFFAG
0 2 K66-ac PFFAGLVkyMHSGPV
0 12 K66-ub PFFAGLVkyMHSGPV
0 1 Y67-p FFAGLVkyMHSGPVV
0 1 K85-ac WEGLNVVkTGRVMLG
0 2 K85-ub WEGLNVVkTGRVMLG
1 33 T94-p GRVMLGEtNPADskP
0 15 S99-p GEtNPADskPGTIRG
0 12 K100-ac EtNPADskPGTIRGD
0 97 K100-ub EtNPADskPGTIRGD
6 0 H118-p QVGRNIIhGsDsVEs
6 6 S120-p GRNIIhGsDsVEsAE
1 7 S122-p NIIhGsDsVEsAEKE
0 2 E124 IhGsDsVEsAEKEIG
0 11 E124 IhGsDsVEsAEKEIG
0 1 E124 IhGsDsVEsAEKEIG
0 2 S125-p hGsDsVEsAEKEIGL
0 1 K128 DsVEsAEKEIGLWFH
0 3 K128 DsVEsAEKEIGLWFH
0 1 Y151 SCAQNWIYE______
  mouse

 
K12-ub ERTFIAIkPDGVQRG
K26-ac GLVGEIIkRFEQkGF
K26-ub GLVGEIIkRFEQkGF
K31-ac IIkRFEQkGFRLVGL
K39-ub GFRLVGLkFLQASED
S44 GLkFLQASEDLLkEH
K49-ac QASEDLLkEHYTDLk
K49-ub QASEDLLkEHYTDLk
Y52 EDLLkEHYTDLkDRP
K56-ac kEHYTDLkDRPFFTG
K56-ub kEHYTDLkDRPFFTG
K56 kEHYTDLKDRPFFTG
K66 PFFTGLVKYMHSGPV
K66 PFFTGLVKYMHSGPV
Y67 FFTGLVKYMHSGPVV
K85 WEGLNVVKTGRVMLG
K85 WEGLNVVKTGRVMLG
T94-p GRVMLGEtNPADskP
S99-p GEtNPADskPGTIRG
K100-ac EtNPADskPGTIRGD
K100-ub EtNPADskPGTIRGD
H118 QVGRNIIHGsDsVkS
S120-p GRNIIHGsDsVkSAE
S122-p NIIHGsDsVkSAEkE
K124-ac IHGsDsVkSAEkEIS
K124-ub IHGsDsVkSAEkEIS
K124-sc IHGsDsVkSAEkEIS
S125 HGsDsVkSAEkEISL
K128-ac DsVkSAEkEISLWFQ
K128-ub DsVkSAEkEISLWFQ
Y151-p SCAQNWIyE______
  rat

 
K12-ub ERTFIAIkPDGVQRG
K26 GLVGEIIKRFEQKGF
K26 GLVGEIIKRFEQKGF
K31 IIKRFEQKGFRLVGL
K39 GFRLVGLKFIQASED
S44 GLKFIQASEDLLKEH
K49 QASEDLLKEHYIDLk
K49 QASEDLLKEHYIDLk
Y52 EDLLKEHYIDLkDRP
K56 KEHYIDLKDRPFFSG
K56-ub KEHYIDLkDRPFFSG
K56 KEHYIDLKDRPFFSG
K66 PFFSGLVKYMHSGPV
K66 PFFSGLVKYMHSGPV
Y67 FFSGLVKYMHSGPVV
K85 WEGLNVVKTGRVMLG
K85 WEGLNVVKTGRVMLG
T94-p GRVMLGEtNPADSKP
S99 GEtNPADSKPGTIRG
K100 EtNPADSKPGTIRGD
K100 EtNPADSKPGTIRGD
H118 QVGRNIIHGsDSVES
S120-p GRNIIHGsDSVESAE
S122 NIIHGsDSVESAEkE
E124 IHGsDSVESAEkEIS
E124 IHGsDSVESAEkEIS
E124 IHGsDSVESAEkEIS
S125 HGsDSVESAEkEISL
K128 DSVESAEKEISLWFQ
K128-ub DSVESAEkEISLWFQ
Y151 SCAQNWIYE______
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