Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
TERT (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TERT telomerase reverse transcriptase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The holoenzyme consists of TERT and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced isoforms have been identified, although the full-length sequence of some variants has not been determined. Note: This description may include information from UniProtKB.
Protein type: Transferase; DNA binding protein; EC 2.7.7.49
Cellular Component: nucleoplasm; chromosome, telomeric region; PML body; nuclear telomere cap complex; telomerase holoenzyme complex; cytoplasm; nucleolus
Molecular Function: telomerase activity; protein binding; protein homodimerization activity; metal ion binding; telomeric DNA binding; telomeric template RNA reverse transcriptase activity
Biological Process: DNA strand elongation; telomere formation via telomerase; telomere maintenance via telomerase; telomere maintenance
Reference #:  O14746 (UniProtKB)
Alt. Names/Synonyms: EST2; HEST2; TCS1; Telomerase catalytic subunit; Telomerase reverse transcriptase; Telomerase-associated protein 2; TERT; TP2; TRT
Gene Symbols: TERT
Molecular weight: 126,997 Da
Basal Isoelectric point: 10.54  Predict pI for various phosphorylation states
Select Structure to View Below

TERT

Protein Structure Not Found.


STRING  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  DISEASE  |  Scansite  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  InnateDB


Sites Implicated In
apoptosis, altered: Y707‑p
enzymatic activity, induced: S227‑p, S824‑p
intracellular localization: Y707‑p
molecular association, regulation: Y707‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 T26-p REVLPLAtFVRRLGP
1 0 K78 FRQVSCLKELVARVL
1 0 K94 RLCERGAKNVLAFGF
0 1 Y122-p FTTSVRSyLPNTVTD
0 1 S134-p VTDALRGsGAWGLLL
2 0 S227-p GARRRGGsASRSLPL
1 0 K236 SRSLPLPKRPRRGAA
1 0 K329 PPVYAETKHFLYSSG
1 0 K338 FLYSSGDKEQLRPSF
4 0 Y707-p QDPPPELyFVKVDVT
0 1 T767-p KSHVSTLtDLQPYMR
2 0 S824-p AVRIRGKsYVQCQGI
0 1 S948-p EVQSDYSsyARTSIR
0 1 Y949-p VQSDYSsyARTSIRA
0 1 G976 NMRRKLFGVLRLKCH
0 1 K1059-ac AGMSLGAkGAAGPLP
0 1 T1113-p KLPGTTLtALEAAAN
0 1 S1125-p AANPALPsDFKTILD
0 1 - gap
  TERT iso2  
T26 REVLPLATFVRRLGP
K78 FRQVSCLKELVARVL
K94 RLCERGAKNVLAFGF
Y122 FTTSVRSYLPNTVTD
S134 VTDALRGSGAWGLLL
S227 GARRRGGSASRSLPL
K236 SRSLPLPKRPRRGAA
K329 PPVYAETKHFLYSSG
K338 FLYSSGDKEQLRPSF
Y707 QDPPPELYFVKVDVT
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S797-p EQAVCGDsAGRAAPA
  TERT iso3  
T26 REVLPLATFVRRLGP
K78-ub FRQVSCLkELVARVL
K94-ub RLCERGAkNVLAFGF
Y122 FTTSVRSYLPNTVTD
S134 VTDALRGSGAWGLLL
S227 GARRRGGSASRSLPL
K236-ub SRSLPLPkRPRRGAA
K329-ub PPVYAETkHFLYSSG
K338-ub FLYSSGDkEQLRPSF
Y707 QDPPPELYFVKVDVT
T767 KSHVSTLTDLQPYMR
S824 AVRIRGKSYVQCQGI
S885 THAKTFLSYARTSIR
Y886 HAKTFLSYARTSIRA
G913 NMRRKLFGVLRLKCH
K996 AGMSLGAKGAAGPLP
T1050 KLPGTTLTALEAAAN
S1062 AANPALPSDFKTILD
- gap
  mouse

 
T26 REVWPLATFVRRLGP
K78 FHQVSSLKELVARVV
R94 RLCERNERNVLAFGF
Y122 FTSSVRSYLPNTVIE
S134 VIETLRVSGAWMLLL
L236 GTKRHLSLTSTSVPS
K245 STSVPSAKKARCYPV
R333 LRPFIETRHFLYSRG
Q343 LYSRGDGQERLNPSF
Y697 LDQTPRMYFVKADVT
S758 RRQVTTLSDLQPYMG
C817 VVKIGDRCYTQCQGI
G941 EVFCDYSGYAQTSIK
Y942 VFCDYSGYAQTSIKT
S969-p TMRNKLLsVLRLKCH
S1052 PGMTLKASGSFPPEA
T1103 KLPEATMTILKAAAD
T1115 AADPALSTDFQTILD
- gap
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.