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TERT
telomerase reverse transcriptase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The holoenzyme consists of TERT and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced isoforms have been identified, although the full-length sequence of some variants has not been determined. Note: This description may include information from UniProtKB.
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| Protein type: DNA binding protein; EC 2.7.7.49; Transferase |
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Cellular Component: nucleoplasm; PML body; chromosome, telomeric region; nuclear telomere cap complex; telomerase holoenzyme complex; cytoplasm; nucleolus
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Molecular Function: telomerase activity; protein binding; protein homodimerization activity; metal ion binding; telomeric DNA binding; telomeric template RNA reverse transcriptase activity
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Biological Process: DNA strand elongation; telomere formation via telomerase; telomere maintenance via telomerase; telomere maintenance; negative regulation of apoptosis
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Reference #:
O14746 (UniProtKB)
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| Alt. Names/Synonyms: EST2; HEST2; TCS1; Telomerase catalytic subunit; Telomerase reverse transcriptase; Telomerase-associated protein 2; TERT; TP2; TRT |
| Gene Symbols: TERT |
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Molecular weight: 126,997 Da
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Basal Isoelectric point: 10.54
Predict pI for various phosphorylation states
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